637 research outputs found
Generalised Space-time and Gauge Transformations
We consider the generalised space-time introduced by the author in 2003 in
the context of the non-linear realisation of the semi-direct product of E11 and
its first fundamental representation. For all the fields we propose gauge
transformations which are compatible with the underlying E11 structure. A
crucial role is played by the generalised vielbein that the generalised
space-time possess. We work out the explicit form of the gauge transformations,
at low levels, in four, five and eleven dimensions.Comment: 33 page
Counting supersymmetric branes
Maximal supergravity solutions are revisited and classified, with particular
emphasis on objects of co-dimension at most two. This class of solutions
includes branes whose tension scales with g_s^{-\sigma} for \sigma>2. We
present a group theory derivation of the counting of these objects based on the
corresponding tensor hierarchies derived from E11 and discrete T- and U-duality
transformations. This provides a rationale for the wrapping rules that were
recently discussed for \sigma<4 in the literature and extends them. Explicit
supergravity solutions that give rise to co-dimension two branes are
constructed and analysed.Comment: 1+33 pages. To the memory of Laurent Houart. v2: Published version
with added reference
Bound States of String Theory and Beyond
All bound states of fundamental strings, D-branes and NS-branes of string
theory, both type-IIA and type-IIB, which may be described by a null geodesic
motion on the coset G/K(G) where G is a group of type A, D or E embedded within
E(11) are presented.Comment: 54+1 pages, 6 figures, 3 data files; typos corrected, added extended
discussion of the temporal involutio
Limited effect of patient and disease characteristics on compliance with hospital antimicrobial guidelines
Objective: Physicians frequently deviate from guidelines that promote prudent use of antimicrobials. We explored to what extent patient and disease characteristics were associated with compliance with guideline recommendations for three common infections. Methods: In a 1-year prospective observational study, 1,125 antimicrobial prescriptions were analysed for compliance with university hospital guidelines. Results: Compliance varied significantly between and within the groups of infections studied. Compliance was much higher for lower respiratory tract infections (LRTIs; 79%) than for sepsis (53%) and urinary tract infections (UTIs; 40%). Only predisposing illnesses and active malignancies were associated with more compliant prescribing, whereas alcohol/ intravenous drug abuse and serum creatinine levels > 130 mu mol/l were associated with less compliant prescribing. Availability of culture results had no impact on compliance with guidelines for sepsis but was associated with more compliance in UTIs and less in LRTIs. Narrowing initial broad-spectrum antimicrobial therapy to cultured pathogens was seldom practised. Most noncompliant prescribing concerned a too broad spectrum of activity when compared with guideline-recommended therapy. Conclusion: Patient characteristics had only a limited impact on compliant prescribing for a variety of reasons. Physicians seemed to practise defensive prescribing behaviour, favouring treatment success in current patients over loss of effectiveness due to resistance in future patients
E11, generalised space-time and equations of motion in four dimensions
We construct the non-linear realisation of the semi-direct product of E11 and
its first fundamental representation at low levels in four dimensions. We
include the fields for gravity, the scalars and the gauge fields as well as the
duals of these fields. The generalised space-time, upon which the fields
depend, consists of the usual coordinates of four dimensional space-time and
Lorentz scalar coordinates which belong to the 56-dimensional representation of
E7. We demand that the equations of motion are first order in derivatives of
the generalised space-time and then show that they are essentially uniquely
determined by the properties of the E11 Kac-Moody algebra and its first
fundamental representation. The two lowest equations correctly describe the
equations of motion of the scalars and the gauge fields once one takes the
fields to depend only on the usual four dimensional space-time
Higher derivative type II string effective actions, automorphic forms and E11
By dimensionally reducing the ten-dimensional higher derivative type IIA
string theory effective action we place constraints on the automorphic forms
that appear in the effective action in lower dimensions. We propose a number of
properties of such automorphic forms and consider the prospects that E11 can
play a role in the formulation of the higher derivative string theory effective
action.Comment: 34 page
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