Local variations in spatial synchrony of influenza epidemics

Background: Understanding the mechanism of influenza spread across multiple geographic scales is not complete. While the mechanism of dissemination across regions and states of the United States has been described, understanding the determinants of dissemination between counties has not been elucidated. The paucity of high resolution spatial-temporal influenza incidence data to evaluate disease structure is often not available. Methodology and Findings: We report on the underlying relationship between the spread of influenza and human movement between counties of one state. Significant synchrony in the timing of epidemics exists across the entire state and decay with distance (regional correlation = 62%). Synchrony as a function of population size display evidence of hierarchical spread with more synchronized epidemics occurring among the most populated counties. A gravity model describing movement between two populations is a stronger predictor of influenza spread than adult movement to and from workplaces suggesting that non-routine and leisure travel drive local epidemics. Conclusions: These findings highlight the complex nature of influenza spread across multiple geographic scales. © 2012 Stark et al

Rapid Quantitative Analysis of Toxic Norditerpenoid Alkaloids in Larkspur (Delphinium spp.) by Flow Injection - Electrospray Ionization – Mass Spectrometry

A rapid flow injection - electrospray ionization – mass spectrometry (FI-ESI-MS) method for the quantitative and qualitative analysis of norditerpenoid alkaloids in larkspur plants was developed. The FI-ESI-MS method was calibrated for alkaloid concentrations with larkspur plant samples against an existing Fourier transform infrared spectroscopy FTIR method. There was a strong correlation (r = 0.9926, r = 0.9891) between the FTIR and FI-ESI-MS methods. The relative standard deviation (RSD) for all measurements were ≤ 6.2 % except for the sample with the lowest concentration which was 19%. The sample throughput of the FI-ESI-MS method is much higher than the FTIR method due to simpler sample preparation, autosampling capabilities, and short analysis times. Finally, the FIA-ESI-MS can be used to qualitatively analyze the alkaloids in larkspur samples since the data allows the observation of all ions that comprise the alkaloid signals

Effects of Bulk and Surface Conductivity on the Performance of CdZnTe Pixel Detectors

We studied the effects of bulk and surface conductivity on the performance of high-resistivity CdZnTe (CZT) pixel detectors with Pt contacts. We emphasize the difference in mechanisms of the bulk and surface conductivity as indicated by their different temperature behaviors. In addition, the existence of a thin (10-100 A) oxide layer on the surface of CZT, formed during the fabrication process, affects both bulk and surface leakage currents. We demonstrate that the measured I-V dependencies of bulk current can be explained by considering the CZT detector as a metal-semiconductor-metal system with two back-to-back Schottky-barrier contacts. The high surface leakage current is apparently due to the presence of a low-resistivity surface layer that has characteristics which differ considerably from those of the bulk material. This surface layer has a profound effect on the charge collection efficiency in detectors with multi-contact geometry; some fraction of the electric field lines originated on the cathode intersects the surface areas between the pixel contacts where the charge produced by an ionizing particle gets trapped. To overcome this effect we place a grid of thin electrodes between the pixel contacts; when the grid is negatively biased, the strong electric field in the gaps between the pixels forces the electrons landing on the surface to move toward the contacts, preventing the charge loss. We have investigated these effects by using CZT pixel detectors indium bump bonded to a custom-built VLSI readout chip

Differential Forms and Wave Equations for General Relativity

Recently, Choquet-Bruhat and York and Abrahams, Anderson, Choquet-Bruhat, and York (AACY) have cast the 3+1 evolution equations of general relativity in gauge-covariant and causal ``first-order symmetric hyperbolic form,'' thereby cleanly separating physical from gauge degrees of freedom in the Cauchy problem for general relativity. A key ingredient in their construction is a certain wave equation which governs the light-speed propagation of the extrinsic curvature tensor. Along a similar line, we construct a related wave equation which, as the key equation in a system, describes vacuum general relativity. Whereas the approach of AACY is based on tensor-index methods, the present formulation is written solely in the language of differential forms. Our approach starts with Sparling's tetrad-dependent differential forms, and our wave equation governs the propagation of Sparling's 2-form, which in the ``time-gauge'' is built linearly from the ``extrinsic curvature 1-form.'' The tensor-index version of our wave equation describes the propagation of (what is essentially) the Arnowitt-Deser-Misner gravitational momentum.Comment: REVTeX, 26 pages, no figures, 1 macr

Clustering of solutions in the random satisfiability problem

Using elementary rigorous methods we prove the existence of a clustered phase in the random $K$-SAT problem, for $K\geq 8$. In this phase the solutions are grouped into clusters which are far away from each other. The results are in agreement with previous predictions of the cavity method and give a rigorous confirmation to one of its main building blocks. It can be generalized to other systems of both physical and computational interest.Comment: 4 pages, 1 figur

Implications of the problem orientated medical record (POMR) for research using electronic GP databases: a comparison of the Doctors Independent Network Database (DIN) and the General Practice Research Database (GPRD).

Background The General Practice Research Database (GPRD) and Doctor's Independent Network Database (DIN), are large electronic primary care databases compiled in the UK during the 1990s. They provide a valuable resource for epidemiological and health services research. GPRD (based on VAMP) presents notes as a series of discrete episodes, whereas DIN is based on a system (MEDITEL) that used a Problem Orientated Medical Record (POMR) which links prescriptions to diagnostic problems. We have examined the implications for research of these different underlying philosophies. Methods Records of 40,183 children from 141 practices in DIN and 76,310 from 464 practices in GRPD who were followed to age 5 were used to compare the volume of recording of prescribing and diagnostic codes in the two databases. To assess the importance and additional value of the POMR within DIN, the appropriateness of diagnostic linking to skin emollient prescriptions was investigated. Results Variation between practices for both the number of days on which prescriptions were issued and diagnoses were recorded was marked in both databases. Mean number of "prescription days" during the first 5 years of life was similar in DIN (19.5) and in GPRD (19.8), but the average number of "diagnostic days" was lower in DIN (15.8) than in GPRD (22.9). Adjustment for linkage increased the average "diagnostic days" to 23.1 in DIN. 32.7% of emollient prescriptions in GPRD appeared with an eczema diagnosis on the same day compared to only 19.4% in DIN; however, 86.4% of prescriptions in DIN were linked to an earlier eczema diagnosis. More specifically 83% of emollient prescriptions appeared under a problem heading of eczema in the 121 practices that were using problem headings satisfactorily. Conclusion Prescribing records in DIN and GPRD are very similar, but the usage of diagnostic codes is more parsimonious in DIN because of its POMR structure. Period prevalence rates will be underestimated in DIN unless this structure is taken into account. The advantage of the POMR is that in 121 of 141 practices using problem headings as intended, most prescriptions can be linked to a problem heading providing a specific reason for their issue

Controllable Finite-Momenta Dynamical Quasicondensation in the Periodically Driven One-Dimensional Fermi-Hubbard Model

In the strongly interacting limit of the Hubbard model localized double-occupancies form effective hard-core bosonic excitations, called a doublons, which are long-lived due to energy conservation. Using time-dependent density-matrix renormalisation group we investigate numerically the dynamics of doublons arising from the sudden expansion of a spatially confined band-insulating state in one spatial dimension. By analysing the occupation scaling of the natural orbitals within the many-body state, we show that doublons dynamically quasicondense at the band edges, consistent with the spontaneous emergence of an eta-quasicondensate. Building on this, we study the effect of periodically driving the system during the expansion. Floquet analysis reveals that doublon-hopping and doublon-repulsion are strongly renormalised by the drive, breaking the eta-SU(2) symmetry of the Hubbard model. Numerical simulation of the driven expansion dynamics demonstrate that the momentum in which doublons quasicondense can be controlled by the driving amplitude. These results point to new pathways for engineering non-equilibrium condensates in fermionic cold-atom experiments and are potentially relevant to driven solid-state systems.Comment: 17 page