Network-wide assessment of 4D trajectory adjustments using an agent-based model

This paper presents results from the SESAR ER3 Domino project. It focuses on an ECAC-wide assessment of two 4D-adjustment mechanisms, implemented separately and conjointly. These reflect flight behaviour en-route and at-gate, optimising given (cost) objective functions. New metrics designed to capture network effects are used to analyse the results of a microscopic, agent based model. The results show that some implementations of the mechanisms allow the protection of the network from ‘domino’ effects. Airlines focusing on costs may trigger additional side-effects on passengers, displaying, in some instances, clear trade-offs between passenger- and flight-centric metrics

Regge Poles in High-Energy Electron Scattering

The possibility that the photon is described by a Regge trajectory is considered, and the effect of this assumption on the analysis of electron-pion, electron-nucleon, and electron-helium scattering is examined in some detail. Partial-wave projections for the various amplitudes are made in the annihilation channel, and a multiparticle unitarity condition is formally imposed by use of the N/D matrix formulation. Since the photon does not have a fixed spin of one, the spin matrix structure is considerably more complicated than in the conventional theory. The amplitudes are written in terms of the Regge poles corresponding to the photon, ρ-ω meson, etc., and the resulting cross sections are given in the interesting high-energy limit. In contrast to the usual analysis, where form factors depend only on the momentum transfer, we find a larger number of independent functions which depend on the energy as well, however, in a characteristic manner. That is, the essential change due to the Regge behavior of the photon is an over-all nonintegral power of the energy occurring in the cross section. The effect of this factor can be experimentally tested and this possibility is discussed

Evolutionary and Physical Properties of Meteoroids

Astrophysical models for meteoroid formation and stellar and planetary evolutions are developed from simulation composition studies

Approximate Killing Vectors on S^2

We present a new method for computing the best approximation to a Killing vector on closed 2-surfaces that are topologically S^2. When solutions of Killing's equation do not exist, this method is shown to yield results superior to those produced by existing methods. In addition, this method appears to provide a new tool for studying the horizon geometry of distorted black holes.Comment: 4 pages, 3 figures, submitted to Physical Review D, revtex

Image-orthicon spectra of Geminids in 1969

The spectra of 25 meteors, recorded with an image orthicon technique in December 1969, are studied in relation to similar records made in August of the same year. Of 19 Geminid meteors in the absolute visual magnitude range 0 to +2, only one showed any evidence of the forbidden line of oxygen at 5577 A, while all Perseid meteors recorded in August exhibited the oxygen line, a result of the large difference in geocentric velocity between the two showers. Atoms identified in faint Geminid meteors include neutral iron, magnesium, calcium and sodium. The molecular bands of nitrogen are also observed

Tunable negative refraction without absorption via electromagnetically induced chirality

We show that negative refraction with minimal absorption can be obtained by means of quantum interference effects similar to electromagnetically induced transparency. Coupling a magnetic dipole transition coherently with an electric dipole transition leads to electromagnetically induced chirality, which can provide negative refraction without requiring negative permeability, and also suppresses absorption. This technique allows negative refraction in the optical regime at densities where the magnetic susceptibility is still small and with refraction/absorption ratios that are orders of magnitude larger than those achievable previously. Furthermore, the value of the refractive index can be fine-tuned via external laser fields, which is essential for practical realization of sub-diffraction-limit imaging.Comment: 4 pages, 5 figures (shortened version, submitted to PRL

An unusual meteor spectrum

An extraordinary spectrum of a meteor at a velocity of about 18.5 + or - 1.0 km/s was observed with an image orthicon camera. The radiant of the meteor was at an altitude of about 49 deg. It was first seen showing a yellow red continuous spectrum alone at a height of 137 + or - 8 km which is ascribed to the first positive group of nitrogen bands. After the meteor had descended to 116 + or - 6 km above sea level it brightened rapidly from its previous threshold brightness into a uniform continuum, the D-line of neutral sodium appeared, and at height 105 + or - 5 km all the other lines of the spectrum also appeared. The continuum remained dominant to the end. Water of hydration and entrained carbon flakes of characteristic dimension about 0.2 micron or less are proposed as constituents of the meteoroid to explain these phenomena

Multimodal optical characterisation of collagen photodegradation by femtosecond infrared laser ablation.

Collagen is a structural component of the human body, as a connective tissue it can become altered as a result of pathophysiological conditions. Although the collagen degradation mechanism is not fully understood, it plays an important role in ageing, disease progression and applications in therapeutic laser treatments. To fully understand the mechanism of collagen alteration, in our study photo-disruptive effects were induced in collagen I matrix by point-irradiation with a femtosecond Ti-sapphire laser under controlled laser ablation settings. This was followed by multi-modal imaging of the irradiated and surrounding areas to analyse the degradation mechanism. Our multi-modal methodology was based on second harmonic generation (SHG), scanning electron microscope (SEM), autofluorescence (AF) average intensities and the average fluorescence lifetime. This allowed us to quantitatively characterise the degraded area into four distinct zones: (1) depolymerised zone in the laser focal spot as indicated by the loss of SHG signal, (2) enhanced crosslinking zone in the inner boundary of the laser induced cavity as represented by the high fluorescence ring, (3) reduced crosslinking zone formed the outer boundary of the cavity as marked by the increased SHG signal and (4) native collagen. These identified distinct zones were in good agreement with the expected photochemical changes shown using Raman spectroscopy. In addition, imaging using polarisation-resolved SHG (p-SHG) revealed both a high degree of fibre re-orientation and a SHG change in tensor ratios around the irradiation spot. Our multi-modal optical imaging approach can provide a new methodology for defining distinct zones that can be used in a clinical setting to determine suitable thresholds for applying safe laser treatments without affecting the surrounding tissues. Furthermore this technique can be extended to address challenges observed in collagen based tissue engineering and used as a minimally invasive diagnostic tool to characterise diseased and non-diseased collagen rich tissues

Long-term safety and efficacy of trifarotene 50 μg/g cream, a first-in-class RAR-γ selective topical retinoid, in patients with moderate facial and truncal acne.

BackgroundTreatment for both facial and truncal acne has not sufficiently been studied.ObjectivesTo evaluate the long-term safety and efficacy of trifarotene in both facial and truncal acne.MethodsIn a multicentre, open-label, 52-week study, patients with moderate facial and truncal acne received trifarotene 50 μg/g cream (trifarotene). Assessments included local tolerability, safety, investigator and physician's global assessments (IGA, PGA) and quality of life (QOL). A validated QOL questionnaire was completed by the patient at Baseline, Week 12, 26 and 52/ET.ResultsOf 453 patients enrolled, 342 (75.5%) completed the study. Trifarotene-related treatment-emergent adverse events (TEAEs) were reported in 12.6% of patients, and none was serious. Most related TEAEs were cutaneous and occurred during the first 3 months. Signs and symptoms of local tolerability were mostly mild or moderate and severe signs, and symptoms were reported for 2.2% to 7.1% of patients for the face and 2.5% to 5.4% for the trunk. Local irritation increased during the first week of treatment on the face and up to Weeks 2 to 4 on the trunk with both decreasing thereafter. At Week 12, IGA and PGA success rates were 26.6% and 38.6%, respectively. Success rates increased to 65.1% and 66.9%, respectively at Week 52. Overall success (both IGA and PGA success in the same patient) was 57.9% at Week 52. At Week 52 visit, 92/171 (53.8%) patients who had completed their assessments had scores from 0 to 1 (i.e. no effect of acne on their QOL) vs. 47/208 (22.6%) patients at Baseline visit.ConclusionIn this 52-week study, trifarotene was safe, well tolerated and effective in moderate facial and truncal acne

Investigations of fast neutron production by 190 GeV/c muon interactions on different targets

The production of fast neutrons (1 MeV - 1 GeV) in high energy muon-nucleus interactions is poorly understood, yet it is fundamental to the understanding of the background in many underground experiments. The aim of the present experiment (CERN NA55) was to measure spallation neutrons produced by 190 GeV/c muons scattering on carbon, copper and lead targets. We have investigated the energy spectrum and angular distribution of spallation neutrons, and we report the result of our measurement of the neutron production differential cross section.Comment: 19 pages, 11 figures ep