1,525 research outputs found

    M-grid: Using Ubiquitous Web Technologies to create a Computational Grid

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    There are many potential users and uses for grid computing. However, the concept of sharing computing resources excites security concerns and, whilst being powerful and flexible, at least for novices, existing systems are complex to install and use. Together these represent a significant barrier to potential users who are interested to see what grid computing can do. This paper describes m-grid, a system for building a computational grid which can accept tasks from any user with access to a web browser and distribute them to almost any machine with access to the internet and manages to do this without the installation of additional software or interfering with existing security arrangements

    Bibliography on HIV/AIDS in Ethiopia and Ethiopians in the Diaspora: The 2006 Update

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    No Abstract. The Ethiopian Journal of Health Development Vol. 21 (1) 2007: pp. 70-9

    The declining representativeness of the British party system, and why it matters

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    In a recent article, Michael Laver has explained ‘Why Vote-Seeking Parties May Make Voters Miserable’. His model shows that, while ideological convergence may boost congruence between governments and the median voter, it can reduce congruence between the party system and the electorate as a whole. Specifically, convergence can increase the mean distance between voters and their nearest party. In this article we show that this captures the reality of today’s British party system. Policy scale placements in British Election Studies from 1987 to 2010 confirm that the pronounced convergence during the past decade has left the Conservatives and Labour closer together than would be optimal in terms of minimising the policy distance between the average voter and the nearest major party. We go on to demonstrate that this comes at a cost. Respondents who perceive themselves as further away from one of the major parties in the system tend to score lower on satisfaction with democracy. In short, vote-seeking parties have left the British party system less representative of the ideological diversity in the electorate, and thus made at least some British voters miserable

    The Distribution of Stellar Mass in the Pleiades

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    As part of an effort to understand the origin of open clusters, we present a statistical analysis of the currently observed Pleiades. Starting with a photometric catalog of the cluster, we employ a maximum likelihood technique to determine the mass distribution of its members, including single stars and both components of binary systems. We find that the overall binary fraction for unresolved pairs is 68%. Extrapolating to include resolved systems, this fraction climbs to about 76%, significantly higher than the accepted field-star result. Both figures are sensitive to the cluster age, for which we have used the currently favored value of 125 Myr. The primary and secondary masses within binaries are correlated, in the sense that their ratios are closer to unity than under the hypothesis of random pairing. We map out the spatial variation of the cluster's projected and three-dimensional mass and number densities. Finally, we revisit the issue of mass segregation in the Pleiades. We find unambiguous evidence of segregation, and introduce a new method for quantifying it.Comment: 41 pages, 14 figures To Be Published in The Astrophysical Journa

    Microbiological, histological, immunological, and toxin response to antibiotic treatment in the mouse model of Mycobacterium ulcerans disease.

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    Mycobacterium ulcerans infection causes a neglected tropical disease known as Buruli ulcer that is now found in poor rural areas of West Africa in numbers that sometimes exceed those reported for another significant mycobacterial disease, leprosy, caused by M. leprae. Unique among mycobacterial diseases, M. ulcerans produces a plasmid-encoded toxin called mycolactone (ML), which is the principal virulence factor and destroys fat cells in subcutaneous tissue. Disease is typically first manifested by the appearance of a nodule that eventually ulcerates and the lesions may continue to spread over limbs or occasionally the trunk. The current standard treatment is 8 weeks of daily rifampin and injections of streptomycin (RS). The treatment kills bacilli and wounds gradually heal. Whether RS treatment actually stops mycolactone production before killing bacilli has been suggested by histopathological analyses of patient lesions. Using a mouse footpad model of M. ulcerans infection where the time of infection and development of lesions can be followed in a controlled manner before and after antibiotic treatment, we have evaluated the progress of infection by assessing bacterial numbers, mycolactone production, the immune response, and lesion histopathology at regular intervals after infection and after antibiotic therapy. We found that RS treatment rapidly reduced gross lesions, bacterial numbers, and ML production as assessed by cytotoxicity assays and mass spectrometric analysis. Histopathological analysis revealed that RS treatment maintained the association of the bacilli with (or within) host cells where they were destroyed whereas lack of treatment resulted in extracellular infection, destruction of host cells, and ultimately lesion ulceration. We propose that RS treatment promotes healing in the host by blocking mycolactone production, which favors the survival of host cells, and by killing M. ulcerans bacilli

    Further Studies on Vibration Compaction of Cohesive Soils

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    The investigations described in this report are a continuation of previous work designed to determine the basic laws governing the compaction of cohesive soil by vibration. A report dated December, 1954, described the results of tests on sandy loam, while this report describes similar tests on a much more cohesive soil

    Computational Controversy

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    Climate change, vaccination, abortion, Trump: Many topics are surrounded by fierce controversies. The nature of such heated debates and their elements have been studied extensively in the social science literature. More recently, various computational approaches to controversy analysis have appeared, using new data sources such as Wikipedia, which help us now better understand these phenomena. However, compared to what social sciences have discovered about such debates, the existing computational approaches mostly focus on just a few of the many important aspects around the concept of controversies. In order to link the two strands, we provide and evaluate here a controversy model that is both, rooted in the findings of the social science literature and at the same time strongly linked to computational methods. We show how this model can lead to computational controversy analytics that have full coverage over all the crucial aspects that make up a controversy.Comment: In Proceedings of the 9th International Conference on Social Informatics (SocInfo) 201
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