Preparação e caracterização reológica de um gel não-iônico preparado a partir de suspensões de nanocápsulas contendo benzofenona-3, revestidas ou não por quitosana

36

Quality evaluation of minoxidil topical solutions obtained from magistral pharmacies

The objective of this study was to evaluate quality parameters of magistral topical solutions containing minoxidil (A, B and C), comparing the results with the ones obtained for the industrial formulation. Organoleptic tests, evaluation of the pH and density, centrifuge test, drug content determination, comparison of indicated dosage and in vitro follicular penetration of minoxidil were performed. Regarding the organoleptic properties, differences in color and viscosity were observed between the magistral (composed of minoxidil sulfate) and the industrial formulations (composed of minoxidil base). For pH values, the magistral solutions presented considerably more acidic pH, compared to the industrial sample. For the density test, the samples with the highest ethanol percentages (B and C) presented lower density. In the centrifuge test, none of the samples showed changes. Considering the drug content test, only the industrial sample and the magistral sample C showed drug percentage within the expected (90-110%), indicating lack of correction factor determination by the magistral pharmacies. Furthermore, it was observed that the dosage indicated by the magistral pharmacies do not correspond to the dose indicated by the industry, being significantly lower. All topical solutions tested presented hair follicle penetration of minoxidil, without statistical difference. The results indicate that there is a failure in the magistral pharmacies regarding the production and the indication of dosage of minoxidil topical solutions

Quality evaluation of minoxidil topical solutions obtained from magistral pharmacies

The objective of this study was to evaluate quality parameters of magistral topical solutions containing minoxidil (A, B and C), comparing the results with the ones obtained for the industrial formulation. Organoleptic tests, evaluation of the pH and density, centrifuge test, drug content determination, comparison of indicated dosages and in vitro follicular penetration of minoxidil were performed. Regarding the organoleptic properties, differences in color and viscosity were observed between the magistral (composed of minoxidil sulfate) and the industrial formulations (composed of minoxidil base). For pH values, the magistral solutions presented considerably more acidic pH, compared to the industrial sample. For the density test, the samples with the highest ethanol percentages (B and C) presented lower density. In the centrifuge test, none of the samples showed changes. Considering the drug content test, only the industrial sample and the magistral sample C showed drug percentage within the expected (90-110%), indicating lack of correction factor determination by the magistral pharmacies. Furthermore, it was observed that the dosage indicated by the magistral pharmacies do not correspond to the dose indicated by the industry, being significantly lower. All topical solutions tested presented hair follicle penetration of minoxildil, without statistical difference. The results indicate that there is a failure in the magistral pharmacies regarding the production and the indication of dosage of minoxidil topical solutions

Extensión universitaria con plantas médicas : acercando diferentes realidades y construyendo prácticas educativas interprofesionales

Este texto convoca à reflexão sobre a importância da extensão universitária com plantas medicinais como ferramenta de aproximação da Universidade com os saberes populares e para a implementação da educação interprofissional. O ‘Projeto de Extensão Interprofissional: educação popular em saúde com plantas medicinais’ desenvolvido por estudantes e professoras da Universidade Federal do Rio Grande do Sul (UFRGS) e criado em 2020 é um exemplo concreto para a interprofissionalidade. Com a pandemia de Covid-19, este tem ocorrido de forma virtual e o grupo tem trabalhado na construção de cartilhas digitais com informações sobre uso, preparo e cultivo de plantas medicinais. Como resultado, o projeto tem possibilitado muitos aprendizados e evidenciado que a união de diferentes conhecimentos constitui uma potente estratégia para a mudança dos paradigmas de ensino e de saúde hegemônicos que estruturam as relações de cuidados em saúde e ainda se fazem presentes no Sistema Único de Saúde (SUS).This text calls for reflection on the importance of university extension with medicinal plants as a tool to bring the University closer to popular knowledge and to the implementation of interprofessional education. The ‘Interprofessional Extension Project: popular health education with medicinal plants’ developed by students and professors at the Federal University of Rio Grande do Sul (UFRGS) and created in 2020 is a concrete example for interprofessionality. With the Covid-19 pandemic, this has occurred virtually and the group has been working on the construction of digital booklets with information on the use, preparation and cultivation of medicinal plants. As a result, the project has enabled many learnings and has shown that the union of different knowledge is a powerful strategy for changing the hegemonic teaching and health paradigms that structure health care relationships and are still present in the Unified Health System (SUS).Este texto llama a la reflexión sobre la importancia de la extensión universitaria con plantas medicinales como herramienta para acercar la Universidad al conocimiento popular y para la implementación de la educación interprofesional. El ‘Proyecto de Extensión Interprofesional: educación en salud popular con plantas medicinales’ desarrollado por estudiantes y docentes de la Universidad Federal de Rio Grande do Sul (UFRGS) y creado en 2020 es un ejemplo concreto de interprofesionalidad. Con la pandemia de Covid-19 esto ha ocurrido de manera virtual y el grupo ha estado trabajando en la construcción de folletos digitales con información sobre el uso, preparación y cultivo de plantas medicinales. Como resultado, el proyecto ha permitido muchos aprendizajes y ha demostrado que la unión de diferentes saberes es una poderosa estrategia para cambiar los paradigmas hegemónicos de enseñanza y salud que estructuran las relaciones asistenciales y aún están presentes en el Sistema Único de Salud (SUS)

EXTENSÃO UNIVERSITÁRIA COM PLANTAS MEDICINAIS: APROXIMANDO DIFERENTES REALIDADES E CONSTRUINDO PRÁTICAS DE EDUCAÇÃO INTERPROFISSIONAL

Este texto convoca à reflexão sobre a importância da extensão universitária com plantas medicinais como ferramenta de aproximação da Universidade com os saberes populares e para a implementação da educação interprofissional. O ‘Projeto de Extensão Interprofissional: educação popular em saúde com plantas medicinais’ desenvolvido por estudantes e professoras da Universidade Federal do Rio Grande do Sul (UFRGS) e criado em 2020 é um exemplo concreto para a interprofissionalidade. Com a pandemia de Covid-19, este tem ocorrido de forma virtual e o grupo tem trabalhado na construção de cartilhas digitais com informações sobre uso, preparo e cultivo de plantas medicinais. Como resultado, o projeto tem possibilitado muitos aprendizados e evidenciado que a união de diferentes conhecimentos constitui uma potente estratégia para a mudança dos paradigmas de ensino e de saúde hegemônicos que estruturam as relações de cuidados em saúde e ainda se fazem presentes no Sistema Único de Saúde (SUS).Palavras-chave: Plantas Medicinais. Educação Interprofissional. Participação Popular. Extensão Comunitária

Nanoemulsion containing kojic dipalmitate and rosehip oil : a promising formulation to treat melasma

Melasma is a hard-to-treat hyperpigmentation disorder. Combined incorporation of kojic dipalmitate (KDP), the esterified form of kojic acid, and rosehip oil, an oil with antioxidant and skin-regenerating properties, into nanocarrier systems appears to be a suitable strategy to develop high-performance formulations. A high-energy method (Ultra-Turrax®) was used to develop nanoemulsions containing up to 2 mg/mL KDP, 5% rosehip oil, and 7.5% surfactant. Formulations were characterized regarding droplet size, size distribution, pH, density, morphology, KDP content, incorporation efficiency, and stability under different temperature conditions. A scale-up study was conducted. Skin permeation, antioxidant potential, and tyrosinase inhibitory activity were assessed in vitro. Cell viability studies were also performed. Results showed that nanoemulsions containing 1 and 2 mg/mL KDP had incorporation efficiencies greater than 95%, droplet size smaller than 130 nm, suitable size distribution, zeta potential of approximately 10 mV, and good stability over 30 days of refrigerated storage. The nanoemulsion containing 1 mg/mL KDP was chosen for further evaluation because it had lower nanocrystal formation, greater scale-up feasibility and allowed KDP permeation up to the epidermis similarly than observed for 2 mg/mL KDP. This formulation (1 mg/mL KDP) showed antioxidant and depigmenting efficacy, close to that of 1 mM ascorbic acid. No cytotoxicity was observed in formulations concentrations ranging from 0.06% to 1%