Implant treatment for a patient with aggressive periodontitis associated to diabetes mellitus. Clinical case report. Surgical phase

ABSTRACTDiabetes mellitus is a chronic degenerative disease characterized by a set of metabolic disorders and presence of hyperglycemia. When analyzing the effect of diabetes on implants, bone remodeling process alteration and deficient mineralization have been observed: these factors result in poorer bone integration. The aim of the present study was to describe surgical and implant treatment conducted in order to re-establish function and esthetics of a patient's periodontal and general circumstances. Resulting ridge (flange) preservation as well as elevation of the maxillary sinus achieved a suitable flange to place implants, by means of a tomographic surgical guide in preparation for further rehabilitation of implant-supported prostheses. As a conclusion we might propose that late diagnosis of aggressive periodontitis can lead to edentulism in young patients, which could be solved with endo-osseous implants

Supraspinal modulation of neuronal synchronization by nociceptive stimulation induces an enduring reorganization of dorsal horn neuronal connectivity

Despite a profusion of information on the molecular and cellular mechanisms involved in the central sensitization produced by intense nociceptive stimulation, the changes in the patterns of functional connectivity between spinal neurones associated with the development of secondary hyperalgesia and allodynia remain largely unknown. Here we show that the state of central sensitization produced by the intradermal injection of capsaicin is associated with structured transformations in neuronal synchronization that lead to an enduring reorganization of the functional connectivity within a segmentally distributed ensemble of dorsal horn neurones. These changes are transiently reversed by the systemic administration of small doses of lidocaine, a clinically effective procedure to treat neuropathic pain. Lidocaine also reduces the capsaicin-induced facilitation of the spinal responses evoked by weak mechanical stimulation of the skin in the region of secondary but not primary hyperalgesia. The effects of both intradermic capsaicin and systemic lidocaine on the segmental correlation and coherence between ongoing cord dorsum potentials and on the responses evoked by tactile stimulation in the region of secondary hyperalgesia are greatly attenuated in spinalized preparations, showing that supraspinal influences are involved in the reorganization of the nociceptive-induced structured patterns of dorsal horn neuronal connectivity. We conclude that the structured reorganization of the functional connectivity between the dorsal horn neurones induced by capsaicin nociceptive stimulation results from cooperative interactions between supraspinal and spinal networks, a process that may have a relevant role in the shaping of the spinal state in the pathogenesis of chronic pain and analgesia.Peer ReviewedPostprint (author's final draft

On the Digital Age from Humanistic Psychology

Facing the digital age, mankind is facing new nodes in the social and psychological fields. The emergence of Internet addiction, depression associated with excessive use of equipment and the loss of real space conducive to increasing virtuality, coupled with the depletion of natural resources, have warned about health and lifestyle in society. Fast and direct life seems to place people in new spaces, and the impact of these spaces is still beyond the knowledge of social science. It is here that humanistic psychology, which officially appeared in 1961, can give us a more humanized face. Returning to human experience, emotion, personal values and sense of self-realization can lay a foundation for new thinking to reveal current problems. That is why the purpose of this work is to point out some problems in the digital age and then teach them the views provided by humanistic psychology in order to revitalize efforts to achieve a healthier life among individuals and in the environment

Supraspinal shaping of adaptive transitions in the state of functional connectivity between segmentally distributed dorsal horn neuronal populations in response to nociception and antinociception

In the anesthetized cat the correlation between the ongoing cord dorsum potentials(CDPs) recorded from different lumbar spinal segments has a non-random structure,suggesting relatively stable patterns of functional connectivity between the dorsalhorn neuronal ensembles involved in the generation of these potentials. During thenociception induced by the intradermic injection of capsaicin, the patterns of segmentalcorrelation between the spontaneous CDPs acquire other non-random configurationsthat are temporarily reversed to their pre-capsaicin state by the systemic injectionof lidocaine, a procedure known to decrease the manifestation of neuropathic painin both animals and humans. We have now extended these studies and utilizedmachine learning for the automatic extraction and selection of particular classes ofCDPs according to their shapes and amplitudes. By using a Markovian analysis, wedisclosed the transitions between the different kinds of CDPs induced by capsaicinand lidocaine and constructed a global model based on the changes in the behaviorof the CDPs generated along the whole set of lumbar segments. This allowed theidentification of the different states of functional connectivity within the whole ensembleof dorsal horn neurones attained during nociception and their transitory reversal bysystemic administration of lidocaine in preparations with the intact neuroaxis and afterspinalization. The present observations provide additional information on the stateof self-organized criticality that leads to the adaptive behavior of the dorsal hornneuronal networks during nociception and antinociception both shaped by supraspinaldescending influencesPeer ReviewedPostprint (published version

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. En los departamentos Bolívar y Sucre.

El presente informe ofrece un cúmulo de acciones orientadas al manejo de herramientas, instrumentos y técnicas apropiados para diagnosticar situaciones problémicas cotidianas especialmente eventos traumáticos y situaciones en crisis, que desde el rol del Psicólogo social comunitario se deben implementar en propuestas de acompañamiento e intervención psicosocial. Se evidencia la implementación de la estrategia metodológica (ABE) Aprendizaje Basado en Escenario, cuyos componentes teórico, práctico y ético complementan el ejercicio de profundización del diplomado como acompañamiento psicosocial en escenarios de violencia adscrito al programa de psicología de la Universidad Nacional Abierta y a Distancia UNAD. Psicólogos en formación tienen oportunidad de interactuar en escenarios reales a través de foto voz, lenguaje narrativo; que, a su vez, ayudan a emerger voces particulares, procesos de movilización, relatos de historias que reivindican al ser humano, propendiendo por darle voz a esos lenguajes que, hasta ahora instituciones estatales, sociedad en general, han mantenido en silencio; y si han surgido voces, estas están descontextualizadas y de esa forma difícilmente pueden trascender. Se destaca el invaluable valor en la narración de la memoria histórica y memoria vincular, se sugiere trabajarlas en forma simultaneas para lograr transformación del acontecimiento traumático, donde sobreabundan duelos no resueltos, siendo necesario hacer lecturas subjetivas que trasciendan más allá del rol de víctima, dignificándolas desde una postura ética que permita estar a la altura del dolor del otro, minimizando la violencia y simplificando el dolor. La intervención psicosocial requiere elaborar experiencias vitales y colectivas para desarticular ciclos de violencia, descifrando tramas que puedan repetirse en nuevos escenarios de violencia, proponiendo recursos novedosos para superar procesos de polarización social. El psicólogo social a su vez, se cualifica e integra a su análisis disciplinar, perspectivas socio críticas y abordajes contemporáneos en el campo de la subjetividad, con alternativas que potencien recursos de afrontamiento colectivo e individual enriqueciendo su acompañamiento psicosocial a víctimas en escenarios de violencia y en situaciones de crisis para que estas se puedan empoderar y el para qué de sus sufrimientos tenga sentido y razón para trascender a nuevos contextos donde el recuerdo deje de ser nostalgia y se convierta en liberación.This report provides a cluster of Actions aimed at tool management, appropriate tools and techniques to diagnose everyday problem situations, especially traumatic events and crisis situations, which from the role of the Community Social Psychologist should be implemented in proposals for accompaniment and psychosocial intervention. It shows the implementation of methodological stratologics (ABE) Scenario-Based Learning, whose theoretical, practical and ethical components complement the exercise of deepening diplomacy as psychosocial accompaniment in violence scenarios attached to the psychology program National Open University and UNAD Distance. Psychologists in training have the opportunity to interact in real settings through photo voice, narrative language; that, in turn, help to emerge particular voices, mobilization processes, stories of stories that vindicate the human being, tending to give voice to those languages that, until now, State institutions, society in general, have kept silent; And if voices have emerged, they are decontextualized and thus can hardly transcend. The Invaluable value in the narrative of historical memory and memory link, it is suggested to work them simultaneously to achieve transformation of the traumatic event, where there are no-duels decided, it being necessary to make subjective readings that transcend beyond the role of victim, denifying them from an ethical posture that allows to live up to the pain of the other, minimizing violence and simplifying pain. Psychosocial intervention requires developing vital and collective experiences to dismantle cycles of violence, deciphering plots that can repeat in new scenarios of violence, proposing novel resources to overcome processes of social polarization. The social psychologist, in turn, qualifies and integrates into his disciplinary analysis, critical socio perspectives and contemporary approaches in the field of subjectivity, with alternatives that enhance collective and individual coping resources enriching their psychosocial accompaniment to victims in situations of violence and crisis situations so that they can be empowered and the for which of their sufferings makes sense and reason to transcend new contexts where remembrance ceases to be nostalgia and becomes liberation

Markovian analysis of the sequential behavior of the spontaneous spinal cord dorsum potentials induced by acute nociceptive stimulation in the anesthetized cat

In a previous study we developed a Machine Learning procedure for the automatic identification and classification of spontaneous cord dorsum potentials (CDPs). This study further supported the proposal that in the anesthetized cat, the spontaneous CDPs recorded from different lumbar spinal segments are generated by a distributed network of dorsal horn neurons with structured (non-random) patterns of functional connectivity and that these configurations can be changed to other non-random and stable configurations after the noceptive stimulation produced by the intradermic injection of capsaicin in the anesthetized cat. Here we present a study showing that the sequence of identified forms of the spontaneous CDPs follows a Markov chain of at least order one. That is, the system has memory in the sense that the spontaneous activation of dorsal horn neuronal ensembles producing the CDPs is not independent of the most recent activity. We used this markovian property to build a procedure to identify portions of signals as belonging to a specific functional state of connectivity among the neuronal networks involved in the generation of the CDPs. We have tested this procedure during acute nociceptive stimulation produced by the intradermic injection of capsaicin in intact as well as spinalized preparations. Altogether, our results indicate that CDP sequences cannot be generated by a renewal stochastic process. Moreover, it is possible to describe some functional features of activity in the cord dorsum by modeling the CDP sequences as generated by a Markov order one stochastic process. Finally, these Markov models make possible to determine the functional state which produced a CDP sequence. The proposed identification procedures appear to be useful for the analysis of the sequential behavior of the ongoing CDPs recorded from different spinal segments in response to a variety of experimental procedures including the changes produced by acute nociceptive stimulation. They are envisaged as a useful tool to examine alterations of the patterns of functional connectivity between dorsal horn neurons under normal and different pathological conditions, an issue of potential clinical concern.Peer ReviewedPostprint (published version

Sistema de gestión de encuestas turísticas en línea para el análisis de segmento meta en la Riviera Maya

Actualmente hay una gran competencia para la generación de encuestas en línea, existen formatos diversos. Sin embargo, en algunos casos se requiere realizar una encuesta a la medida, como en el caso del sector turismo, donde en cada zona se aplican distintos criterios de acuerdo a la ubicación geográfica para posteriormente aplicar algoritmos de clasificación para detectar las clases que reflejen el segmento de mercado. Por lo que en este trabajo se propone un sistema que permite generar encuestas para posteriormente transformar los datos resultantes a un esquema compatible con Weka para la realización de análisis de datos

Evaluation of Culture Conditions for Tannase Production by Aspergillus niger GH1

Ispitana je ekstracelularna i intracelularna proizvodnja tanaze submerznim uzgojem plijesni Aspergillus niger GH1 u tekućoj te površinskim uzgojem na čvrstoj podlozi pri različitim temperaturama (30, 40 i 50 °C). Istražen je utjecaj koncentracije početnog supstrata (taninske kiseline), vremena inkubacije i temperature na proizvodnju tanaze pri uzgoju na čvrstoj podlozi. Soj A. niger GH1 proizveo je najviše tanaze (2291 U/L) tijekom prvih 20 sati uzgoja pri koncentraciji taninske kiseline od 50 g/L. U tim uvjetima proizvodnje enzim je u potpunosti bio ekstracelularan. Opadanje aktivnosti tanaze nakon 20 sati ugoja povezano je s pratećim porastom aktivnosti proteaze.Extra- and intracellular tannase production by Aspergillus niger GH1 has been evaluated using submerged (SmF) and solid-state fermentation (SSF) at different temperatures (30, 40 and 50 °C). Effects of initial substrate (tannic acid) concentration, incubation time and temperature on tannase production in SSF have been studied. A. niger GH1 produced the highest tannase level (2291 U/L) in SSF at 30 °C during the first 20 h of culture at tannic acid concentration of 50 g/L, and under these conditions enzyme production was entirely extracellular. The decline in tannase activity after 20 h of incubation was associated with a concomitant increase in protease activity

Prebiotics, Probiotics, Synbiotics and Functional Foods in Control and Treatment of Type II Diabetes Mellitus and Colorectal Cancer

Prebiotics, probiotics and synbiotics are components that enhance human health by several mechanisms. Patients suffering from type II diabetes mellitus (T2DM) and colorectal cancer have seen benefits when treated with a prebiotic, probiotic or synbiotic therapy. These benefits include the improvement of their lipid profile, oxidative stress status, as well as the modulation of the inflammatory and immune responses. The associated benefits of prebiotic, probiotic or synbiotic functional foods have been studied, showing promising results into the prevention or control of diabetes and colorectal cancer. This novelty research provides new evidence that the use of functional foods along with medical therapy could be used to further enhance patient’s health