25 research outputs found

    Allocation de ressources et fusion de données dans un système multi-capteurs pour la classification

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    - Ce travail est une proposition d'une architecture modulaire avec gestion des interactions pour l'allocation des ressources capteurs dans un système multi-capteurs et multi-pistes de classification aérienne. Chaque acteur processus du système suit une piste et tente de classifier la cible correspondante. En fonction des hypothèses en course, il propose une liste ordonnées de requêtes vis-à-vis des capteurs. Un superviseur central ou distribué rassemble les requêtes à l'instant t et alloue les ressources capteurs aux différents acteurs

    Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth.

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    Glucose utilization increases in tumors, a metabolic process that is observed clinically by <sup>18</sup> F-fluorodeoxyglucose positron emission tomography ( <sup>18</sup> F-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are implicated in vivo? In a genetically-engineered mouse model of lung adenocarcinoma, we show that the deletion of only one highly expressed glucose transporter, Glut1 or Glut3, in cancer cells does not impair tumor growth, whereas their combined loss diminishes tumor development. <sup>18</sup> F-FDG-PET analyses of tumors demonstrate that Glut1 and Glut3 loss decreases glucose uptake, which is mainly dependent on Glut1. Using <sup>13</sup> C-glucose tracing with correlated nanoscale secondary ion mass spectrometry (NanoSIMS) and electron microscopy, we also report the presence of lamellar body-like organelles in tumor cells accumulating glucose-derived biomass, depending partially on Glut1. Our results demonstrate the requirement for two glucose transporters in lung adenocarcinoma, the dual blockade of which could reach therapeutic responses not achieved by individual targeting

    From littérature engagée to engaged translation : staging Jean-Paul Sartre’s theatre as a challenge to Franco’s rule in Spain

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    The practice of creating translations that ‘rouse, inspire, witness, mobilize, and incite to rebellion’ is described by Maria Tymoczko, following Jean-Paul Sartre's littérature engagée, as ‘engaged translation’. In Spain, under the Franco dictatorship (1939–1975), the theatre became a site of opposition to his rule and the creation of ‘engaged’ translations of foreign plays was one of the ways in which alternative social and political realities were transmitted to local audiences. This was particularly evident during the so-called apertura period (1962–1969), when Spain's political leaders embraced more liberal and outward-facing cultural policies as part of their efforts to ensure the regime's continuity. Drawing on archival evidence from the state censorship files held at Archivo General de la Administración (AGA) in Alcalá de Henares, this article considers how ‘engaged’ translations of Sartre's theatre were employed as instruments of cultural opposition to the Spanish dictatorship. It also argues that an analysis of the files both helps us to understand the role of censorship in shaping an official version of the past, and shines a light on the memory of a little-studied aspect of cultural activism in the Spanish theatre.PostprintPeer reviewe

    Response of plasma arginine vasopressin levels to rapid changes in altitude

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    Plasma arginine vasopressin levels were studied in 15 normal working men exposed at 4-day intervals to a rapid increase or decrease in altitude of 2000 m. Plasma arginine vasopressin levels were significantly lower (P less than 0.001) at the higher altitude though plasma osmolality did not change. It is concluded that the important diuresis known to physiologically occur in response to high altitude may be related to a decrease in antidiuretic hormone release

    Placing the 'other' in our midst : immigrant Jews, gender and the British imperial imagination

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    This thesis traces cultural and socio-political responses to the alien Jew in Britain through the prism of genre, space and time. Beginning with the reports of persecution of Jews in Eastern Europe in the late nineteenth century, it examines how representations of these foreign Jews changed and developed as sympathy for their plight turned to anxiety at the prospect of their arrival in Britain. It shows how a Semitic discourse evolved alongside, and in response to, wider debates about the state of the self, nation and empire at the fin de siècle, arguing that the vocabulary and mentality of imperialism was a crucial tool for deciphering the nature of Jewish „difference‟. However, this thesis also enables fresh perspectives by considering the gender and spatial dynamics of Semitic representations in Britain during and beyond the period of mass immigration, from the end of the nineteenth century until the beginning of the twenty first. This extended view of the Jewish 'other', which follows the 'typical' Jewish migrant journey from the shtetl of Eastern Europe to the North London suburb of the present-day, considers how Jewish spatial and cultural practices have been interpreted and articulated by the British and the British-Jewish onlooker. The thesis' opening section, divided into three chapters, adopts an original approach to the aliens question by exploring how perspectives on the alien Jew were shaped and expressed within different mediums, or 'genres' at the fin de siècle. Through an assessment of newspapers, political debates, and fiction, this section offers a comparative analysis of how the particular dynamics and agendas of each of these genres operated to produce different textual and visual images of 'the Jew'. Building upon Bryan Cheyette's seminal work in relation to fiction, each of these chapters demonstrates not only the inherently ambivalent nature of Semitic representations but also reveal that, crucially, gender was an important moderator of Jewish „difference‟. This reading extends into the second section which, across four chapters, explores how gender functioned in conjunction with space to construct ideas in Britain about alien Jews as they traversed time and space from shtetl to suburb. Beginning with the point of departure, the opening chapter of the section reviews the long tradition of representing Eastern Europe by „the West‟, arguing that this tradition laid the foundation for a paradoxical view of the Jew in Eastern Europe as both territorialized and territorializing. This perceived struggle for spatial ownership amongst Jews also featured in narratives of the migrant journey – the topic of the second chapter. That perception generated the notion that migrating Jews were staging an alien invasion of Britain. Thus the prolonged fascination with London's Jewish 'ghetto' and its interior – 'alien' territory par excellence – provides the focus for the third chapter which, in turn, lays the foundation for the final chapter‟s exploration of the replacement of the urban with the suburban as the alien Jew's 'territory' of choice.EThOS - Electronic Theses Online ServiceGBUnited Kingdo
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