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Time course of H2A.X phosphorylation after SAHA and Actinomycin D treatment. LA1-55n cells were treated (+) or not (-) with 0.1 nM of actinomycin D (ActD) in the presence (+) or in the absence (-) of 1 μ M SAHA. Indicated protein expression was determined by Western blot analysis at the indicated times after the treatment. (DOCX 710 kb

Additional file 1: Figure S1. of Effect of low doses of actinomycin D on neuroblastoma cell lines

Cell cycle distribution after actinomycin D treatment. Indicated cell lines were treated with 10 nM of actinomycin D in the presence or in the absence of 20 μM of Oph-QVD for 24 h or 48 h. Cell cycle distribution was detected by the propidium iodide staining method and indicated in the histograms. (DOCX 866 kb