70 research outputs found
Recommended from our members
Story and history in the Breton ballads: the case of Iannik Kokard
- Author
- Publication venue
- Publication date
- 01/01/1994
- Field of study
'The bounds of female reach': Catherine Hutton's fiction and her tours in Wales
- Author
- Publication venue
- 'Cardiff University Press'
- Publication date
- 01/06/2017
- Field of study
Thoughts on oral tradition
- Author
- Publication venue
- Publication date
- 01/10/2003
- Field of study
It is easier, I think, to say what oral tradition can be rather than what it is. I have been working in the field of Celtic literature for a dozen or so years, and have been moving in and out of more or less oral genres from the start. If, as I do, you are basically working with texts, it is of course the "more or less" that shapes one's sense of orality, and mine has shifted with each new project.Not
Introduction: Romanticism, Travel and the Celtic Languages
- Publication venue
- John Hopkins University Press
- Publication date
- 01/07/2024
- Field of study
âExcuse the Spelling Which is Probably Wrongâ: Wordsworth and Tourismâs Welsh Languages
- Publication venue
- John Hopkins University Press
- Publication date
- 01/07/2024
- Field of study
Tuberculosis in Pediatric Antiretroviral Therapy Programs in Low- and Middle-Income Countries: Diagnosis and Screening Practices
- Author
- Abrams Elaine
- Abrams Elaine
- Ajayi Samuel
- Ajayi Samuel
- Ananworanich Jintanat
- Ananworanich Jintanat
- Anastos Kathryn
- Anastos Kathryn
- Ayaya Samuel
- Azondekon Alain
- Azondekon Alain
- Ballif Marie
- Ballif Marie
- Ballif Marie
- Bashi Jules
- Bashi Jules
- Biribonwoha Harriet Nuwagaba
- Biribonwoha Harriet Nuwagaba
- Bishai William
- Bishai William
- Boulle Andrew
- Boulle Andrew
- Braitstein Paula
- Braitstein Paula
- Cahn Pedro
- Cahn Pedro
- Carriquiry Gabriela
- Carriquiry Gabriela
- Carter Jane E.
- Carter Jane E.
- Cegielski Peter
- Cegielski Peter
- Cesar Carina
- Cesar Carina
- Chimbetete Cleophas
- Chimbetete Cleophas
- Ciaranello Andrea
- Ciaranello Andrea
- Claude Dusingize Jean
- Conrad Joseph
- Conrad Joseph
- Cortes Claudia
- Cortes Claudia
- Cortes Claudia P.
- Dabis François
- Dabis François
- Davies Mary-Ann
- Davies Mary-Ann
- Davies Mary-Ann
- Diero Lameck
- Diero Lameck
- Duda Stephany
- Duda Stephany
- Durier Nicolas
- Durier Nicolas
- Dusingize Jean Claude
- Dusingize Jean Claude
- Eboua Tanoh F.
- Eboua Tanoh F.
- Edmonds Andrew
- Edmonds Andrew
- Egger Matthias
- Egger Matthias
- Egger Matthias
- Feinstein Lydia
- Feinstein Lydia
- Fenner Lukas
- Fenner Lukas
- Fenner Lukas
- Frieda Behets Melanie Bacon
- Frieda Behets Melanie Bacon
- Gasser Adrian
- Gasser Adrian
- Geng Elvin
- Geng Elvin
- Gnokori Joachim Charles
- Gnokori Joachim Charles
- Graber Claire
- Graber Claire
- Graber Claire
- Hardwicke Laura
- Hardwicke Laura
- Hazra Rohan
- Hazra Rohan
- Hoffmann Chris
- Hoffmann Chris
- Hoover Don
- Hoover Don
- Huebner Robin
- Huebner Robin
- Kancheya Nzali
- Kancheya Nzali
- Keiser Olivia
- Keiser Olivia
- Kiertiburanakul Sasisopin
- Kiertiburanakul Sasisopin
- Kim Peter
- Kim Peter
- Kumara Wati Ketut Dewi
- Lameck Diero
- Lameck Diero
- Leroy Valeriane
- Leroy Valeriane
- Leroy Valeriane
- Leroy Valériane
- Leroy Valériane
- Lewden Charlotte
- Lewden Charlotte
- Lindegren Mary Lou
- Lindegren Mary Lou
- Magneres Maria Cecilia
- Magneres Maria Cecilia
- Mandalakas Anna
- Mandalakas Anna
- Mandalakas Anna M.
- Maskew Mhairi
- Maskew Mhairi
- McGowan Catherine
- McGowan Catherine
- McGowan Catherine C.
- McKaig Rosemary
- McKaig Rosemary
- Messerschmidt Liesl
- Messerschmidt Liesl
- Mofenson Lynne
- Mofenson Lynne
- Mofenson Lynne M.
- Mpoudi-Etame Mireille
- Mpoudi-Etame Mireille
- Nallusamy Revathy
- Okwara Benson
- Okwara Benson
- Petit April
- Petit April
- Phiri Sam
- Phiri Sam
- Prasitsuebsai Wasana
- Prasitsuebsai Wasana
- Prozesky Hans
- Prozesky Hans
- Reid Stewart E.
- Reid Stewart E.
- Renner Lorna
- Renner Lorna
- Renner Lorna
- Reubenson Gary
- Reubenson Gary
- Reubenson Gary
- Sharp Gerald
- Sharp Gerald
- Sohn Annette
- Sohn Annette
- Sterling Timothy
- Sterling Timothy
- Vo Quynh
- Vo Quynh
- Vreeman Rachel
- Vreeman Rachel
- Walker Dana
- Walker Dana
- Wehbe Firas
- Wehbe Firas
- Wejse Christian
- Wejse Christian
- Wester William
- Wester William
- Williams Carlie
- Williams Carlie
- Wood Robin
- Wood Robin
- Wools-Kaloustian Kara
- Wools-Kaloustian Kara
- Wools-Kaloustian Kara
- Worrell Carol
- Worrell Carol
- Yao Zhang
- Yao Zhang
- Yiannoutsos Constantine
- Yiannoutsos Constantine
- Yunihastuti Evy
- Yunihastuti Evy
- Zwickl Beth
- Zwickl Beth
- Publication venue
- Publication date
- 02/08/2017
- Field of study
Background The global burden of childhood tuberculosis (TB) is estimated to be 0.5 million new cases per year. Human immunodeficiency virus (HIV)-infected children are at high risk for TB. Diagnosis of TB in HIV-infected children remains a major challenge. Methods We describe TB diagnosis and screening practices of pediatric antiretroviral treatment (ART) programs in Africa, Asia, the Caribbean, and Central and South America. We used web-based questionnaires to collect data on ART programs and patients seen from March to July 2012. Forty-three ART programs treating children in 23 countries participated in the study. Results Sputum microscopy and chest Radiograph were available at all programs, mycobacterial culture in 40 (93%) sites, gastric aspiration in 27 (63%), induced sputum in 23 (54%), and Xpert MTB/RIF in 16 (37%) sites. Screening practices to exclude active TB before starting ART included contact history in 41 sites (84%), symptom screening in 38 (88%), and chest Radiograph in 34 sites (79%). The use of diagnostic tools was examined among 146 children diagnosed with TB during the study period. Chest Radiograph was used in 125 (86%) children, sputum microscopy in 76 (52%), induced sputum microscopy in 38 (26%), gastric aspirate microscopy in 35 (24%), culture in 25 (17%), and Xpert MTB/RIF in 11 (8%) children. Conclusions Induced sputum and Xpert MTB/RIF were infrequently available to diagnose childhood TB, and screening was largely based on symptom identification. There is an urgent need to improve the capacity of ART programs in low- and middle-income countries to exclude and diagnose TB in HIV-infected childre
Recommended from our members
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis
- Author
- Albert Marilyn S.
- Albin Roger L.
- Alkaade Samer
- Amann Stephen T.
- Anderson Michelle A.
- Apostolova Liana G.
- Arnold Steven E.
- Baillie John
- Baldwin Clinton T.
- Banks Peter A.
- Barber Robert
- Barmada M. Michael
- Barnes Lisa L.
- Beach Thomas G.
- Beecham Gary W.
- Beekly Duane
- Bennett David A.
- Bigio Eileen H.
- Bird Thomas D.
- Blacker Deborah
- Boxer Adam
- Brand Randall E.
- Burke James R.
- Buxbaum Joseph D.
- Cairns Nigel J.
- Cantwell Laura B.
- Cao Chuanhai
- Carney Regina M.
- Carroll Steven L.
- Chui Helena C.
- Clark David G.
- Conwell Darwin
- Cotton Peter B.
- Coté Gregory A.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- DeCarli Charles
- Demirci F. Yesim
- Devlin Bernie
- Dick Malcolm
- Dickson Dennis W.
- DiSario James
- Duara Ranjan
- Ertekin-Taner Nilufer
- Faber Kelley M.
- Fallon Kenneth B.
- Farlow Martin R.
- Farrer Lindsay A.
- Ferris Steven
- Foroud Tatiana M.
- Forsmark Chris E.
- Frosch Matthew P.
- Galasko Douglas R.
- Ganguli Mary
- Gardner Timothy B.
- Gearing Marla
- Gelrud Andres
- Geschwind Daniel H.
- Ghetti Bernardino
- Gilbert John R.
- Gilman Sid
- Glass Jonathan D.
- Goate Alison M.
- Graff-Radford Neill R.
- Green Robert C.
- Greenhalf William
- Growdon John H.
- Guda Nalini M.
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Harrell Lindy E.
- Hartman Douglas J.
- Hawes Robert A.
- Head Elizabeth
- Honig Lawrence S.
- Hulette Christine M.
- Hyman Bradley T.
- Jicha Gregory A.
- Jin Lee-Way
- Johnstone Marianne
- Jun Gyungah
- Kamboh M. Ilyas
- Karydas Anna
- Kaye Jeffrey A.
- Kienholz Michelle L.
- Kim Ronald
- Klei Lambertus
- Koo Edward H.
- Kowall Neil W.
- Kramer Joel H.
- Kramer Patricia
- Krasinskas Alyssa M.
- Kukull Walter A.
- LaFerla Frank M.
- Lah James J.
- LaRusch Jessica
- Lawrence Christopher
- Lerch Markus M.
- Leverenz James B.
- Levey Allan I.
- Lewis Michele
- Li Ge
- Lieberman Andrew P.
- Lin Chiao-Feng
- Lopez Oscar L.
- Lunetta Kathryn L.
- Lyketsos Constantine G.
- Mack Wendy J.
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Mayerle Julia
- Mayeux Richard
- McKee Ann C.
- Melhem Nadine M.
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Money Mary E.
- Montine Thomas J.
- Morris John C.
- Muniraj Thiruvengadam
- Murrell Jill R.
- Naj Adam C.
- Neoptolemos John P.
- O'Connell Michael R.
- Olichney John M.
- Orlichenko Lidiya
- Papachristou Georgios I.
- Parisi Joseph E.
- Pericak-Vance Margaret A.
- Peskind Elaine
- Petersen Ronald C.
- Pierce Aimee
- Poon Wayne W.
- Potter Huntington
- Quinn Joseph F.
- Raj Ashok
- Raskind Murray
- Reiman Eric M.
- Reisberg Barry
- Reitz Christiane
- Ringman John M.
- Roberson Erik D.
- Roeder Kathryn
- Romagnuolo Joseph
- Rosen Howard J.
- Rosenberg Roger N.
- Sandhu Bimaljit S.
- Sano Mary
- Saykin Andrew J.
- Schellenberg Gerard D.
- Schneider Julie A.
- Schneider Lon S.
- Seeley William W.
- Sherman Stuart
- Simon Peter
- Singh Vijay K.
- Slivka Adam
- Smith Amanda G.
- Smith Jill P.
- Sonnen Joshua A.
- Spina Salvatore
- Stern Robert A.
- Stolz Donna
- Sutton Robert
- Tanzi Rudolph E.
- Tector Matt
- Trojanowski John Q.
- Troncoso Juan C.
- Tsuang Debby W.
- Valladares Otto
- Van Deerlin Vivianna M.
- Van Eldik Linda J.
- Vardarajan Badri N.
- Vinters Harry V.
- Vonsattel Jean Paul
- Wang Li-San
- Weintraub Sandra
- Weiss Frank Ulrich
- Welsh-Bohmer Kathleen A.
- Whitcomb David C.
- Wilcox C. Mel
- Williamson Jennifer
- Wisniewski Stephen R.
- Woltjer Randall L.
- Wright Clinton B.
- Yadav Dhiraj
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zarnescu Narcis Octavian
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 13/02/2014
- Field of study
Pancreatitis is a complex, progressively destructive inflammatory disorder. Alcohol was long thought to be the primary causative agent, but genetic contributions have been of interest since the discovery that rare PRSS1, CFTR, and SPINK1 variants were associated with pancreatitis risk. We now report two significant genome-wide associations identified and replicated at PRSS1-PRSS2 (1Ă10-12) and x-linked CLDN2 (p < 1Ă10-21) through a two-stage genome-wide study (Stage 1, 676 cases and 4507 controls; Stage 2, 910 cases and 4170 controls). The PRSS1 variant affects susceptibility by altering expression of the primary trypsinogen gene. The CLDN2 risk allele is associated with atypical localization of claudin-2 in pancreatic acinar cells. The homozygous (or hemizygous male) CLDN2 genotype confers the greatest risk, and its alleles interact with alcohol consumption to amplify risk. These results could partially explain the high frequency of alcohol-related pancreatitis in men â male hemizygous frequency is 0.26, female homozygote is 0.07
Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease
- Author
- Abner Erin
- Adams Hieab H
- Adams Perrie M.
- Aguilar Miquel
- Ahmad Shahzad
- Al-Chalabi Ammar
- Albert Marilyn S.
- Albin Roger L.
- Allen Mariet
- Alvarez Victoria
- Amin Najaf
- Amouyel Philippe
- Apostolova Liana G.
- Arcaro Marina
- Arnold Steven E.
- Aspelund Thor
- Asthana Sanjay
- Atwood Craig S.
- Bacq Delphine
- Badarinarayan Nandini
- Baldwin Clinton T.
- Barber Imelda S.
- Barber Robert C.
- Barnes Lisa L.
- Barral Sandra
- Beach Thomas G.
- Becker James T.
- Beecham Gary W.
- Beekly Duane
- Behrens Timothy W.
- Beiser Alexa S.
- Bellenguez CĂ©line
- Benito Yoland Aladro
- Bennett David A.
- Berr Claudine
- Bigio Eileen H.
- Bird Thomas D.
- Bis Joshua C.
- Blacker Deborah
- Blesa Rafael
- Boada Merce
- Boccardi Virginia
- Boerwinkle Eric
- Boeve Bradley F.
- Boland Anne
- Bonuccelli Ubaldo
- Bosco Paolo
- BossĂč Paola
- Bowen James D.
- Boxer Adam
- Braae Anne
- Braddel Amy
- Bras Jose
- Brayne Carol
- Brice Alexis
- Brody Jennifer A
- Brookes Keeley
- Brown Kristelle
- Brundin Rosemarie
- Bruni Amalia Cecilia
- Bullido MarĂa J.
- Burgess Jeremy D.
- Burke James R.
- Burns Jeffrey M.
- Buxbaum Joseph D.
- Caffarra Paolo
- Cairns Nigel J.
- Caltagirone Carlo
- Campion Dominique
- Cantwell Laura B.
- Cao Chuanhai
- Carlson Chris S.
- Carlsson Cynthia M.
- Carney Regina M.
- Carrasquillo Minerva M.
- Carrell David
- Carroll Steven L.
- Cecchetti Roberta
- Chakrabarty Paramita
- Chapman Jade
- Chen Yuning
- Choi Seung-Hoan
- Chouraki Vincent
- Chui Helena C.
- Ciaramella Antonio
- ClarimĂłn Jordi
- Clark David G.
- Collinge John
- Combarros Onofre
- Concari Letizia
- Corcoran Chris
- Coto Eliecer
- Craig David
- Crane Paul K.
- Cribbs David H.
- Crocco Elizabeth A.
- Cruchaga Carlos
- Cupidi Chiara
- Cupples L Adrienne
- Daniele Antonio
- Daniilidou Makrina
- Dartigues Jean-François
- De Deyn Peter P.
- De Jager Philip L
- Decarli Charles
- Deleuze Jean-François
- Denning Nicola
- Derbois CĂ©line
- Dermecourt Vincent
- Destefano Anita L.
- Diaz Carolina Ceballos
- Dichgans Martin
- Dick Malcolm
- Dickson Dennis W
- Dombroski Beth
- Doody Rachelle S.
- Duara Ranjan
- Dubois Bruno
- Dufouil Carole
- Dulary CĂ©cile
- Dunstan Melanie
- Dupuis Josée
- Eiriksdottir Gudny
- Emilsson Valur
- Engelborghs Sebastien
- Epelbaum Jacques
- Ertekin-Taner Nilufer
- Escott-Price Valentina
- Evans Denis A.
- Faber Kelley M.
- Fairchild Thomas J.
- FairĂ©n MĂČnica DĂez
- Fallon Kenneth B.
- Fardo David W.
- Farlow Martin R.
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernadez Carmen Muñoz
- Ferris Steven
- Fievet Nathalie
- Fitzpatrick Annette L.
- Fornage Myriam
- Foroud Tatiana M.
- Forsell Charlotte
- Forstner Andreas J.
- Fortea Juan
- Fox Nick C.
- Frank-GarcĂa Ana
- Fratiglioni Laura
- Frosch Matthew P.
- Funk Cory C.
- Galasko Douglas R.
- Galimberti Daniela
- Gallo Maura
- Garcia Florentino Sanchez
- Garcia Melissa E.
- Garzia Fabienne
- Gearing Marla
- Gerrish Amy
- Geschwind Daniel H.
- Ghetti Bernardino
- Giedraitis Vilmantas
- Giegling Ina
- Gilbert John R.
- Gill Michael
- Goate Alison M.
- Golamaully Feroze
- Golde Todd E.
- Graff Caroline
- Graff-Radford Neill R.
- Graham Robert R
- Green Robert C.
- Grenier-Boley Benjamin
- Grove Megan L.
- Growdon John H.
- Gu Wei
- Gudnason Vilmundur
- Guerreiro Rita
- Haapasalo Annakaisa
- Haines Jonathan L.
- Hakonarson Hakon
- Hamilton Ronald L.
- Hamilton-Nelson Kara L.
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hardy John
- Harold Denise
- Harrell Lindy E.
- Hartmann Annette M.
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- HenĂĄndez Isabel
- Herms Stefan
- Heun Reinhard
- Hill Matt
- Hiltunen Mikko
- Himali Jayanadra J.
- Hodges Angela
- Hoffmann Per
- Hofman Albert
- Holmes Clive
- Honig Lawrence S.
- Huebinger Ryan M.
- Huentelman Matthew J.
- Hughes Joseph T.
- Hulette Christine M.
- Hyman Bradley T.
- Ikram M Arfan
- Ingelsson Martin
- Jakobsdottir Johanna
- Jarvik Gail P.
- Jessen Frank
- Jian Xueqiu
- Jin Lee-Way
- Johnston Janet
- Jones Lesley
- Jr W T Longstreth
- Jun Gyungah
- Kamboh M Ilyas
- Karydas Anna
- Katz Mindy J.
- Kauwe John Keoni
- Kaye Jeffrey A.
- Keene C Dirk
- Keller Lina
- Kilander Lena
- Kim Ronald
- Kinhult-StÀhlbom Anne
- Kloszewska Iwona
- Koivisto Anne Maria
- Kornhuber Johannes
- Kowall Neil W.
- Kramer Joel H.
- Kukull Walter A.
- Kunkle Brian W.
- Kuzma Amanda B.
- Laferla Frank M.
- Lah James J.
- Lambert Jean-Charles
- Lannfelt Lars
- Larson Eric B.
- Lawlor Brian
- Leber Markus
- Leverenz James B.
- Levey Allan I.
- Levy Daniel
- Li Ge
- Li Hongdong
- Li Shuo
- Lieberman Andrew P.
- Lilius Lena
- Lin Honghuang
- Lipton Richard B.
- LleĂł Alberto
- Lopez Oscar L.
- Lord Jenny
- Lovestone Simon
- Lunetta Kathryn L.
- Lupton Michelle K.
- Lyketsos Constantine G.
- Lynch Aoibhinn
- Maier Wolfgang
- Majounie Elisa
- Malamon John
- Maletta Raffaele Giovanni
- Mancuso Michelangelo
- Marshall Rachel
- Marson Daniel C.
- Martin Eden R.
- Martiniuk Frank
- Mash Deborah C.
- Masliah Eliezer
- Masullo Carlo
- Mayeux Richard
- Mayhaus Manuel
- McCormick Wayne C.
- McCurry Susan M.
- McDavid Andrew N.
- McGuinness Bernadette
- McKee Ann C.
- Mead Simon
- Mecocci Patrizia
- Medway Christopher
- Meggy Alun
- Mesulam Marsel
- Miller Bruce L.
- Miller Carol A.
- Miller Joshua W.
- Moebus Susanne
- Montine Thomas J.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Taniesha
- Morris John C.
- Mosley Thomas H.
- Mukherjee Shubhabrata
- Munger Ron
- Murrell Jill R.
- Myers Amanda J.
- Nacmias Benedetta
- Naj Adam C
- Naranjo Maria Candida Deniz
- Norton Maria
- Nöthen Markus M.
- O'Bryant Sid
- O'Donnell Christopher J.
- O'Donovan Michael C.
- Olaso Robert
- Olichney John M.
- Orfei Maria Donata
- Ortega-Cubero Sara
- Owen Michael J.
- Pankratz Vernon S.
- Panza Francesco
- Parisi Joseph E.
- Pasquier Florence
- Passmore Peter
- Pastor Pau
- Patel Yogen
- Paulson Henry L.
- Pericak-Vance Margaret A.
- Perry William
- Peskind Elaine
- Peters Oliver
- Petersen Ronald C.
- Pichler Sabrina
- Pierce Aimee
- Pilotto Alberto
- Poon Wayne W.
- Potter Huntington
- Powell John
- Price Nathan D.
- Proitsi Petra
- Psaty Bruce M.
- Qu Liming
- Quinn Joseph F.
- Raj Ashok
- Ramirez Alfredo
- Raskind Murray
- Raybould Rachel
- Reiman Eric M.
- Reisberg Barry
- Reisch Joan S.
- Reitz Christiane
- Riedel-Heller Steffi
- Riemenschneider Matthias
- Ringman John M.
- Ritchie Karen
- Rivadeneira Fernando
- Roberson Erik D.
- Rogaeva Ekaterina
- Rosen Howard J.
- Rosenberg Roger N.
- Rotter Jerome I.
- Royall Donald R.
- Rubinsztein David C
- Ruiz Agustin
- Rujescu Dan
- Sacchinelli Eleonora
- Sager Mark A.
- Sano Mary
- Satizabal Claudia L.
- Saykin Andrew J.
- Scarpini Elio
- Schellenberg Gerard D.
- Scherer Martin
- Schmidt Helena
- Schmidt Reinhold
- Schneider Julie A.
- Schneider Lon S.
- Seeley William W.
- Septier Gislain
- Seripa Davide
- Serpente Maria
- Seshadri Sudha
- Shaw Christopher E.
- Sims Rebecca
- Sleegers Kristel
- Smith Albert V.
- Smith Amanda G.
- Soininen Hilkka
- Solfrizzi Vincenzo
- Sonnen Joshua A.
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spina Salvatore
- Squassina Alessio
- St George-Hyslop Peter
- Stern Robert A.
- Sussams Rebecca
- Swerdlow Russell H.
- SĂĄnchez-Juan Pascual
- Tanzi Rudolph E.
- Tarraga Lluis
- Taylor Sarah
- Thomas Charlene
- Thomas Rhodri
- Thonberg Hakan
- Thornton-Wells Tricia A.
- Todd Stephen
- Trojanowski John Q.
- Troncoso Juan C.
- Tschanz Joann
- Tsolaki Magda
- Tsuang Debby W.
- Turton James
- Tzourio Christophe
- Tzourio Christophe
- Uitterlinden Andre G.
- Uphill James
- Urbano Maria
- Valladares Otto
- Van Broeckhoven Christine
- Van Deerlin Vivianna M.
- Van Der Lee Sven J
- Van Duijn Cornelia M.
- Van Eldik Linda J.
- Vandenberghe Rik
- Vardarajan Badri N.
- Vellas Bruno
- Vinters Harry V.
- Vonsattel Jean Paul
- Vronskaya Maria
- Wallon David
- Wang Li-San
- Wang Xue
- Weintraub Sandra
- Welsh-Bohmer Kathleen A.
- White Charles C.
- Whitehead Patrice
- Wilhelmsen Kirk C.
- Williams Julie
- Williamson Jennifer
- Wingo Thomas S.
- Winslow Ashley R.
- Wolters Frank J
- Woltjer Randall L.
- Wright Clinton B.
- Wu Chuang-Kuo
- Yang Qiong
- Younkin Steven G.
- Yu Chang-En
- Yu Lei
- Zhao Yi
- Publication venue
- Publication date
- 01/01/2017
- Field of study
We identified rare coding variants associated with Alzheimerâs disease (AD) in a 3-stage case-control study of 85,133 subjects. In stage 1, 34,174 samples were genotyped using a whole-exome microarray. In stage 2, we tested associated variants (P<1Ă10-4) in 35,962 independent samples using de novo genotyping and imputed genotypes. In stage 3, an additional 14,997 samples were used to test the most significant stage 2 associations (P<5Ă10-8) using imputed genotypes. We observed 3 novel genome-wide significant (GWS) AD associated non-synonymous variants; a protective variant in PLCG2 (rs72824905/p.P522R, P=5.38Ă10-10, OR=0.68, MAFcases=0.0059, MAFcontrols=0.0093), a risk variant in ABI3 (rs616338/p.S209F, P=4.56Ă10-10, OR=1.43, MAFcases=0.011, MAFcontrols=0.008), and a novel GWS variant in TREM2 (rs143332484/p.R62H, P=1.55Ă10-14, OR=1.67, MAFcases=0.0143, MAFcontrols=0.0089), a known AD susceptibility gene. These protein-coding changes are in genes highly expressed in microglia and highlight an immune-related protein-protein interaction network enriched for previously identified AD risk genes. These genetic findings provide additional evidence that the microglia-mediated innate immune response contributes directly to AD development
Finishing the euchromatic sequence of the human genome
- Author
- . Haifeng
- . Magner
- . Yin
- Abbott Scott
- Abbott-Ozersky Amanda
- Abdellah Zahra
- Abouelleil Amr
- Abrajano Anne
- Adachi Tamami
- Adam Catherine
- Adams Charles Q.
- Adamson Aaron
- Adekoya Emmanuel
- Adio-Oduola Babajide
- Aerts Andrea
- Aggarwal Arun
- Ahmadi Alireza
- Ahmed Shahana
- Aimable Matthew
- Ainscough Rachael
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- Kremmidiotis Gabriel
- Krogh Anders
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- Kube Michael
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- Kuehl Jennifer
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- Lander Eric S.
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- Lowry Stephen
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- Madabhushi Ramki
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- Un Chun
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- Walsh Jennifer
- Walsham Natalie
- Wan Ma
- Wang Chunyan
- Wang Dong
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- Wang Guangxin
- Wang Guihai
- Wang Guihai
- Wang Hongjuan
- Wang Hongwei
- Wang Huanjie
- Wang Huifeng
- Wang Huifeng
- Wang Jian
- Wang Jian
- Wang Jian
- Wang Jie
- Wang Jing
- Wang Jingqiang
- Wang Jingqiang
- Wang Jinhua
- Wang Joann
- Wang Juan
- Wang Jun
- Wang Jun
- Wang Jun
- Wang Li
- Wang Lijie
- Wang Lijuan
- Wang Lijun
- Wang Ling
- Wang Liqun
- Wang Mei
- Wang Qiaoyan
- Wang Shifen
- Wang Shu
- Wang Suzhen
- Wang Wenjun
- Wang Xiaoling
- Wang Xiaoning
- Wang Xuefei
- Wang Xuegang
- Wang Yan
- Wang Yimin
- Wang Ying
- Wang Ying
- Wang Yuanyuan
- Wangchuck Tsering
- Wangdi Tsering
- Ward-Moore Stephanie
- Warren Graham
- Warren James T.
- Warry Georgina
- Watanabe Hidemi
- Watanabe Saki
- Waterston Robert H.
- Watson Andy
- Watt Nicola
- Webb Anthony
- Webb Jeannette
- Webber Caleb
- Weber Ryan J.
- Wehri Edward
- Wei Shulin
- Wei Xuehong
- Weidenbach Richard
- Weinstock George
- Weinstock Keith
- Weir John
- Weissenbach Jean
- Wells Alan
- Wells Sarah
- Welton Robert
- Wen Gaiping
- Wendi Mike
- Weng Li
- Wenning Sarah
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- Wesley Mary Melissa
- West Paul
- West Tony
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- Wheatley Angela
- Wheatley Carl
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- Wheeler Gideon
- Wheeler Jeremy
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- White P. Scott
- White Scott P.
- White Simon
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- Whiteley Matthew
- Whitmore Scott
- Whittaker Adam
- Whittaker Charles
- Whittaker Pamela
- Wickremasinghe Manosha I.
- Widaa Sara
- Wiegel Sarah
- Wild Anna
- Wilkinson Jane
- Wilkinson Jane
- Wilkinson Paul
- Willey David
- Williams Albert L.
- Williams Andy
- Williams Bill
- Williams Gabrielle A.
- Williams Leanne
- Williamson Angela L.
- Williamson Helen
- Wills Patricia L.
- Wills Richard
- Wilmer Tamsin
- Wilming Laurens
- Wilson Brian
- Wilson Gareth
- Wilson Margaret
- Wilson Nyree
- Wilson Piers
- Wilson Richard K.
- Wilson Siobhan
- Wilson Steve
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- Window Philip
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- Winzar Claire
- Witt James
- Wleczyk Regina
- Wobus Fred
- Woessner Jeffrey
- Wohldmann Patty
- Wollard Jessica
- Womack Andrew W.
- Wong Benjamin
- Wong Gane K-S
- Wood Diane
- Wood Emma
- Wood Joe
- Wooden Hailey S.
- Wooden Steven H.
- Woodeson Sharon
- Woodfine Kathryn
- Woodmansey Rebecca
- Woods Eric
- Woodwark Cara
- Wooster Richard
- Worley Kim Carlyle
- Woyke Tanja
- Wray Matthew
- Wray Paul
- Wright Charmain
- Wright Debbie
- Wright Kathrine
- Wright Kristin
- Wright Rita A.
- Wu Chungen
- Wu Dongying
- Wu Jiaqian
- Wu Jung-Rung
- Wu Kevin
- Wu Qingfa
- Wu Qingfa
- Wu Ruiming
- Wu Xiao
- Wu Xiaojing
- Wu Zaining
- Wyatt Julia
- Wycoff-Montenegro Melissa
- Wylie Kris
- Wyman Dudley
- Wyman Stacia
- Xi Yan
- Xi Yingying
- Xie Fei
- Xie Gary
- Xie Jane
- Xiong Hui
- Xiong Yuqing
- Xu Alex
- Xu Jing
- Xu Jing
- Xu Ruqin
- Xu Shuhua
- Xu Wei
- Xu Xinlai
- Xu Yan
- Xu Yuning
- Xu Zhihong
- Xu Zuyuan
- Xuan Yali
- Xuan Zhenyu
- Xue Rui
- Yada Tetsushi
- Yadav Shailendra
- Yakub Syed
- Yamamoto Lynn
- Yamamoto Noriko
- Yamamoto Yuko
- Yamashita Yasue
- Yamazaki Satoru
- Yang Hao
- Yang Huanming
- Yang Huanming
- Yang Joan
- Yang Shiaw-Pyng
- Yang Shudong
- Yang Xiaonan
- Yang Xiaonan
- Yang Xiaoping
- Yang Yongkui
- Yano Candance
- Yao Zhijian
- Yao Zhijian
- Yaspo Marie-Laure
- Ye Chen
- Yeager Shane
- Yeh Mimi
- Yen Jennifer
- Yeshitela Rahel Retta
- Yoakum Martin
- Yokobata Kathy
- Yokoyama Jennifer
- Yonezawa Miho
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- Yoon Vivienne
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- You Bo
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- Yu Jun
- Yu Jun
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- Yue Shujie
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- Yun Rui
- Zainoun Joanne
- Zembeck Lisa
- Zeng Yixin
- Zhai Dong
- Zhan Guoping
- Zhang Bo
- Zhang Caimin
- Zhang Fengmei
- Zhang Guangyu
- Zhang Guohua
- Zhang Guohua
- Zhang Haiqing
- Zhang Haiqing
- Zhang Haiqing
- Zhang Hongbo
- Zhang Hongbo
- Zhang Jingjing
- Zhang Jingjing
- Zhang Jingkun
- Zhang Jiuchun
- Zhang Jiuchun
- Zhang Lanzhi
- Zhang Li
- Zhang Li
- Zhang Meihua
- Zhang Meng
- Zhang Ming
- Zhang Qing
- Zhang Ruhua
- Zhang Shaojie
- Zhang Tiezhen
- Zhang Wei
- Zhang Wei
- Zhang Xianglin
- Zhang Xianglin
- Zhang Xiaoliang
- Zhang Xiuqing
- Zhang Yan
- Zhang Yi
- Zhang Yilin
- Zhang Yilin
- Zhang Ying
- Zhang Yuansen
- Zhang Yuzhi
- Zhang Zhengdong
- Zhao Hongmei
- Zhao Lijian
- Zhao Shenru
- Zhao Zhijing
- Zhen Zhicheng
- Zheng Haibo
- Zhong Ming
- Zhou Carol
- Zhou Haixia
- Zhou Jianling
- Zhou Nannan
- Zhou Xinfeng
- Zhou Yan
- Zhou Yang
- Zhou Yi
- Zhu Bingying
- Zhu Bofeng
- Zhu Fenghua
- Zhu Genfeng
- Zhu Genfeng
- Zhu Miao
- Zhu Ning
- Zhu Yongge
- Zhu Zhen
- Zhuang Shitao
- Zierten Deborah
- Zimmer Andrew
- Zody Michael C.
- Zollo Massimo
- Zorrilla Sara E.
- Zuo Lin
- Publication venue
- LSU Digital Commons
- Publication date
- 21/10/2004
- Field of study
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Robust SARS-CoV-2 TÂ cell responses with common TCR?? motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells
- Author
- Allen Lilith F.
- Anderson Mary Ann
- Bond Katherine A.
- Cabug Aira F.
- Cain Natalie L.
- Chang So Young
- Chaurasia Priyanka
- Chee Lynette
- Christensen Britt
- Chua Brendon Y.
- Clemens E. Bridie
- Crane Megan
- Crawford Jeremy Chase
- Gibney Grace
- Habel Jennifer R.
- Hensen Luca
- Huang Han
- James Fiona
- Jia Xiaoxiao
- Karapanagiotidis Theo
- Kedzierska Katherine
- Kedzierski Lukasz
- Kent Stephen J.
- Krammer Florian
- Lasica Masa
- Lim Chhay
- McQuilten Hayley A.
- Menon Tejas
- Minervina Anastasia A.
- Mitchell Jeni
- Mordant Francesca L.
- Neil Jessica A.
- Nguyen Thi H.O.
- Nicholson Suellen
- Petersen Jan
- Pogorelyy Mikhail V.
- Rossjohn Jamie
- Rowntree Louise C.
- Saunders Natalie R.
- Seymour John F.
- Slavin Monica A.
- Subbarao Kanta
- Tam Constantine S.
- Tan Hyon-Xhi
- Teh Benjamin W.
- Tennakoon G. Surekha
- Thomas Paul G.
- Thursky Karin A.
- Trevillyan Janine M.
- Trubiano Jason A.
- Vo Lynn K.
- Wheatley Adam K.
- Whitechurch Ashley
- Williamson Deborah A.
- Zhang Wuji
- Publication venue
- 'Elsevier BV'
- Publication date
- 18/04/2023
- Field of study
Immunocompromised hematology patients are vulnerable to severe COVID-19 and respond poorly to vaccination. Relative deficits in immunity are, however, unclear, especially after 3 vaccine doses. We evaluated immune responses in hematology patients across three COVID-19 vaccination doses. Seropositivity was low after a first dose of BNT162b2 and ChAdOx1 (âŒ26%), increased to 59%â75% after a second dose, and increased to 85% after a third dose. While prototypical antibody-secreting cells (ASCs) and T follicular helper (Tfh) cell responses were elicited in healthy participants, hematology patients showed prolonged ASCs and skewed Tfh2/17 responses. Importantly, vaccine-induced expansions of spike-specific and peptide-HLA tetramer-specific CD4+/CD8+ T cells, together with their T cell receptor (TCR) repertoires, were robust in hematology patients, irrespective of B cell numbers, and comparable to healthy participants. Vaccinated patients with breakthrough infections developed higher antibody responses, while T cell responses were comparable to healthy groups. COVID-19 vaccination induces robust T cell immunity in hematology patients of varying diseases and treatments irrespective of B cell numbers and antibody response
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