Divergent mutational processes distinguish hypoxic and normoxic tumours.

Many primary tumours have low levels of molecular oxygen (hypoxia), and hypoxic tumours respond poorly to therapy. Pan-cancer molecular hallmarks of tumour hypoxia remain poorly understood, with limited comprehension of its associations with specific mutational processes, non-coding driver genes and evolutionary features. Here, as part of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium, which aggregated whole genome sequencing data from 2658 cancers across 38 tumour types, we quantify hypoxia in 1188 tumours spanning 27 cancer types. Elevated hypoxia associates with increased mutational load across cancer types, irrespective of underlying mutational class. The proportion of mutations attributed to several mutational signatures of unknown aetiology directly associates with the level of hypoxia, suggesting underlying mutational processes for these signatures. At the gene level, driver mutations in TP53, MYC and PTEN are enriched in hypoxic tumours, and mutations in PTEN interact with hypoxia to direct tumour evolutionary trajectories. Overall, hypoxia plays a critical role in shaping the genomic and evolutionary landscapes of cancer

The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 34.4

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The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 40.2

ASOR 2018 Annual Meeting, Paul J. Ray, Jr. New Collection, Constance E. Gane Al-Maktába: The Bookstore Random Surveyhttps://digitalcommons.andrews.edu/iaham-news/1078/thumbnail.jp

The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 39.3

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The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 36.2

The 2015 Excavations at Tall Jalul, Paul Gregor, Constance Gane, and Helena Gregor Silva Lecture, Justin Singleton Al-Maktába: The Bookstore Random Surveyhttps://digitalcommons.andrews.edu/iaham-news/1062/thumbnail.jp

The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 35.4

San Miceli 2014, Justin Singleton Jalul 2014, Paul Gregor, Constance Gane, and Helena Gregorhttps://digitalcommons.andrews.edu/iaham-news/1060/thumbnail.jp

The Institute of Archaeology & Siegfried H. Horn Museum Newsletter Volume 43.3

Khirbat Safra 2022, Paul Gregor, Robert Bates, Constance Gane, Trisha Broy, and Paul J. Ray, Jr. Random Surveyhttps://digitalcommons.andrews.edu/iaham-news/1091/thumbnail.jp