A new functional role for lateral inhibition in the striatum: Pavlovian conditioning

The striatum has long been implicated in reinforcement learning and has been suggested by several neurophysiological studies as the substrate for encoding the reward value of stimuli. Reward prediction error (RPE) has been used in several basal ganglia models as the underlying learning signal, which leads to Pavlovian conditioning abilities that can be simulated by the Rescorla-Wagner model.

Lateral inhibition between striatal projection neurons was once thought to have a winner-take-all function, useful in selecting between possible actions. However, it has been noted that the necessary reciprocal connections for this interpretation are too few, and the relative strength of these synaptic connections is weak. Still, modeling studies show that lateral inhibition does have an overall suppression effect on striatal activity and may play an important role in striatal processing. 

Neurophysiological recordings show task-relevant ensembles of responsive neurons at specific points in a behavioral paradigm (Barnes et al., 2005), which appear to be induced by lateral inhibition (see Ponzi and Wickens, 2010). We have developed a similarly responding, RPE-based model of the striatum by incorporating lateral inhibition. Model neurons are assigned to either the direct or the indirect pathway but lateral connections occur within and between these groups, leading to competition between both the individual neurons and their pathways. We successfully applied this model to the simulation of Pavlovian phenomena beyond those of the Rescorla-Wagner model, including negative patterning, unovershadowing, and external inhibition

Design and testing of electromechanical actuator for aerospace applications

Electromechanical actuators are gaining interest in the aerospace industry within the More Electrical Aircraft (MEA) architecture. The end-goal of fully electric aircraft includes Electromechanical actuation for flight control systems. The design and testing of a flight control system for helicopter swashplate is presented in this work. The mechanical system is driven by electrical machines and controlled by dedicated power electronics, both of which fit challenging space requirements and environmental conditions. The predicted performances are validated by experimental testing of prototypes

Modular invariance, lattice field theories and finite size corrections

We give a lattice theory treatment of certain one and two dimensional quantum field theories. In one dimension we construct a combinatorial version of a non-trivial field theory on the circle which is of some independent interest in itself while in two dimensions we consider a field theory on a toroidal triangular lattice. We take a continuous spin Gaussian model on a toroidal triangular lattice with periods $L_0$ and $L_1$ where the spins carry a representation of the fundamental group of the torus labeled by phases $u_0$ and $u_1$. We compute the {\it exact finite size and lattice corrections}, to the partition function $Z$, for arbitrary mass $m$ and phases $u_i$. Summing $Z^{-1/2}$ over a specified set of phases gives the corresponding result for the Ising model on a torus. An interesting property of the model is that the limits $m\rightarrow0$ and $u_i\rightarrow0$ do not commute. Also when $m=0$ the model exhibits a {\it vortex critical phase} when at least one of the $u_i$ is non-zero. In the continuum or scaling limit, for arbitrary $m$, the finite size corrections to $-\ln Z$ are {\it modular invariant} and for the critical phase are given by elliptic theta functions. In the cylinder limit $L_1\rightarrow\infty$ the ``cylinder charge'' $c(u_0,m^2L_0^2)$ is a non-monotonic function of $m$ that ranges from $2(1+6u_0(u_0-1))$ for $m=0$ to zero for $m\rightarrow\infty$ but from which one can determine the central charge $c$. The study of the continuum limit of these field theories provides a kind of quantum theoretic analog of the link between certain combinatorial and analytic topological quantities.Comment: 25 pages Plain Te

Dataflow of underwater noise measurements: from OBSEA to EMODnet

Underwater noise has been significantly raising in the past decades due to an increment of human-related activities in the oceans such as shipping, industrial activities, seismic explorations, etc. These activities may have adverse effects on fish and mammals, such as communications masking and modifying predator– prey interactions. In order to assess and limit the impact of these, the European Commission approved the Marine Strategy Framework Directive (MSFD) which aims to achieve a good environmental status in European waters. Within this directive different environmental challenges are addressed, including the long-term monitoring of underwater noise throughout European waters. EMODnet Physics, one of the European Marine Observation and Data network thematic portals, which is is currently providing easy access to data and products of: wave height and period; temperature and salinity of the water column; wind speed and direction; horizontal velocity of the water column; light attenuation; sea ice coverage and sea level trends. EMODnet Physics is continuously increasing the number and type of platforms in the system by unlocking and providing high quality data from a growing network. EMODnet Physics has recently started working on water noise with the aim of making available more operational data (in terms of parameters and format that are close to MSFD I.11 requirements), offer a single European entry point to impulsive noise registries (MSFD I.11.1) and work on (regional) sound maps are three key identified activities for Physics. Furthermore the very first operational under water noise data (i.e. Sound Pressure Level – SPL), and HELCOM and OSPAR impulsive sounds registry were connected and are now available on the portal. Exploiting the LIDO (Listen to Deep Ocean) knowledge and the BIAS project (https://biasproject. wordpress.com/) experience EMODnet Physics will develop and make available monthly sound maps. In this presentation, we give an overview of how EMODnet Physics is organized, with a particular focus on this new data flow and its perspectives.Peer Reviewe

The genetic basis for adaptation of model-designed syntrophic co-cultures.

Understanding the fundamental characteristics of microbial communities could have far reaching implications for human health and applied biotechnology. Despite this, much is still unknown regarding the genetic basis and evolutionary strategies underlying the formation of viable synthetic communities. By pairing auxotrophic mutants in co-culture, it has been demonstrated that viable nascent E. coli communities can be established where the mutant strains are metabolically coupled. A novel algorithm, OptAux, was constructed to design 61 unique multi-knockout E. coli auxotrophic strains that require significant metabolite uptake to grow. These predicted knockouts included a diverse set of novel non-specific auxotrophs that result from inhibition of major biosynthetic subsystems. Three OptAux predicted non-specific auxotrophic strains-with diverse metabolic deficiencies-were co-cultured with an L-histidine auxotroph and optimized via adaptive laboratory evolution (ALE). Time-course sequencing revealed the genetic changes employed by each strain to achieve higher community growth rates and provided insight into mechanisms for adapting to the syntrophic niche. A community model of metabolism and gene expression was utilized to predict the relative community composition and fundamental characteristics of the evolved communities. This work presents new insight into the genetic strategies underlying viable nascent community formation and a cutting-edge computational method to elucidate metabolic changes that empower the creation of cooperative communities

Discovery and Early Evolution of ASASSN-19bt, the First TDE Detected by TESS

We present the discovery and early evolution of ASASSN-19bt, a tidal disruption event (TDE) discovered by the All-Sky Automated Survey for Supernovae (ASAS-SN) at a distance of $d\simeq115$ Mpc and the first TDE to be detected by TESS. As the TDE is located in the TESS Continuous Viewing Zone, our dataset includes 30-minute cadence observations starting on 2018 July 25, and we precisely measure that the TDE begins to brighten $\sim8.3$ days before its discovery. Our dataset also includes 18 epochs of Swift UVOT and XRT observations, 2 epochs of XMM-Newton observations, 13 spectroscopic observations, and ground data from the Las Cumbres Observatory telescope network, spanning from 32 days before peak through 37 days after peak. ASASSN-19bt thus has the most detailed pre-peak dataset for any TDE. The TESS light curve indicates that the transient began to brighten on 2019 January 21.6 and that for the first 15 days its rise was consistent with a flux $\propto t^2$ power-law model. The optical/UV emission is well-fit by a blackbody SED, and ASASSN-19bt exhibits an early spike in its luminosity and temperature roughly 32 rest-frame days before peak and spanning up to 14 days that has not been seen in other TDEs, possibly because UV observations were not triggered early enough to detect it. It peaked on 2019 March 04.9 at a luminosity of $L\simeq1.3\times10^{44}$ ergs s$^{-1}$ and radiated $E\simeq3.2\times10^{50}$ ergs during the 41-day rise to peak. X-ray observations after peak indicate a softening of the hard X-ray emission prior to peak, reminiscent of the hard/soft states in X-ray binaries.Comment: 23 pages, 14 figures, 5 tables. A machine-readable table containing the host-subtracted photometry presented in this manuscript is included as an ancillary fil

Prison wardens\u27 perceptions of sex offenders, sex offender registration, community notification, and residency restrictions.

There is relatively little known about how criminal justice system actors perceive sex offenders and the fairness, efficacy, and scope of policies aimed at sex offenders. Similarly, there is sparse research that specifically examines the attitudes, beliefs, and experiences of prison wardens. Following in the footsteps of earlier research (Tewksbury & Mustaine, 2011; Tewksbury, Mustaine, & Payne, 2011, in press), the present study addresses these gaps by considering the attitudes and beliefs toward sex offenders held by wardens. This examination includes perceptions about sex offenders as prison inmates, sex offender registration, community notification, and residency restrictions. Further, this research assesses the utility of the 18-item Community Attitudes Toward Sex Offenders (CATSO) scale (Church, Wakeman, Miller, Clements, & Sun, 2008), which was advocated for use with criminal justice system actors, to determine whether or not the instrument can be effectively utilized with wardens. Findings and policy implications are discussed