Deterministic Illusion in the Organizational Sciences: Service or Sabotage?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68881/2/10.1177_105256298000500309.pd

The phenotype of Floating-Harbor syndrome: Clinical characterization of 52 individuals with mutations in exon 34 of SRCAP

Background: Floating-Harbor syndrome (FHS) is a rare condition characterized by short stature, delays in expressive language, and a distinctive facial appearance. Recently, heterozygous truncating mutations in SRCAP were determined to be disease-causing. With the availability of a DNA based confirmatory test, we set forth to define the clinical features of this syndrome. Methods and results. Clinical information on fifty-two individuals with SRCAP mutations was collected using standardized questionnaires. Twenty-four males and twenty-eight females were studied with ages ranging from

Solution techniques for the Quadratic Assignment Problem and the development of a general purpose simulated annealing algorithm

For diskette accompanying this thesis please apply direct to the issuing universitySIGLEAvailable from British Library Document Supply Centre-DSC:DX194026 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Swift monitoring of NGC 5548: X-ray reprocessing and short-term UV/optical variability

Lags measured from correlated X-ray/UV/optical monitoring of AGN allow us to determine whether UV/optical variability is driven by reprocessing of X-rays or X-ray variability is driven by UV/optical seed photon variations. We present the results of the largest study to date of the relationship between the X-ray, UV and optical variability in an AGN with 554 observations, over a 750 d period, of the Seyfert 1 galaxy NGC 5548 with Swift. There is a good overall correlation between the X-ray and UV/optical bands, particularly on short time-scales (tens of days). The UV/optical bands lag the X-ray band with lags which are proportional to wavelength raised to the power 1.23 ± 0.31. This power is very close to the power (4/3) expected if short time-scale UV/optical variability is driven by reprocessing of X-rays by a surrounding accretion disc. The observed lags, however, are longer than expected from a standard Shakura–Sunyaev accretion disc with X-ray heating, given the currently accepted black hole mass and accretion rate values, but can be explained with a slightly larger mass and accretion rate, and a generally hotter disc. Some long-term UV/optical variations are not paralleled exactly in the X-rays, suggesting an additional component to the UV/optical variability arising perhaps from accretion rate perturbations propagating inwards through the disc

Reduced Vascular Endothelial Growth Factor Expression in Contusive Spinal Cord Injury

Vascular endothelial growth factor (VEGF) is being investigated as a potential interventional therapy for spinal cord injury (SCI). In the current study, we examined SCI-induced changes in VEGF protein levels using Western blot analysis around the epicenter of injury. Our results indicate a significant decrease in the levels of VEGF165 and other VEGF isoforms at the lesion epicenter 1 day after injury, which was maintained up to 1 month after injury. We also examined if robust VEGF165 decrease in injured spinal cords affects neuronal survival, given that a number of reported studies show neuroprotective effect of this VEGF isoform. However, exogenously administered VEGF165 at the time of injury did not affect the number of sparred neurons. In contrast, exogenous administration of VEGF antibody that inhibits actions of not only VEGF165 but also of several other VEGF isoforms, significantly decreased number of sparred neurons after SCI. Together these results indicate a general reduction of VEGF isoforms following SCI and that isoforms other than VEGF165 (e.g., VEGF121 and/or VEGF189) provide neuroprotection, suggesting that VEGF165 isoform is likely involved in other pathophysiological process after SCI