Numerical and experimental studies of multi-ply woven carbon fibre prepreg forming process

Woven carbon fibre prepreg is being increasingly used in high-performance aerospace and automotive applications, primarily because of its superior mechanical properties and formability. A wide range of forming simulation options are available for predicting material deformation during the prepreg forming process, particularly change in fibre orientation. Development of a robust validated simulation model requires comprehensive material characterisation and reliable experimental validation techniques. This paper presents experimental and numerical methods for studying the fibre orientation in multi-ply woven carbon fibre prepreg forming process, using a double-dome geometry. The numerical study is performed using the commercial forming simulation software PAM-FORM and the material input data are generated from a comprehensive experimental material characterisation. Two experimental validation methods are adopted for fibre shear angle measurement: an optical method for measuring only the surface plies, and a novel CT scan method for measuring both the surface plies and the internal plies. The simulation results are compared against the experimental results in terms of fibre shear angle and the formation of wrinkles to assess the validity of the model

Entrepreneurial Leadership and Teamwork: The Key to Innovation in the 21st Century

Entrepreneurial leadership and continuous innovation are vital components of 21st century communities and organizations. Entrepreneurial leaders must realize the importance of environmental, social and global issues while creating an atmosphere of innovation designed to help followers become more entrepreneurial themselves. Entrepreneurial individuals and teams have the ability to recognize and capitalize on opportunities, innovate, take risks, adapt to rapid change and marshal resources to achieve their goals. When individuals come together as an effective team, they can produce a synergy to meet the demands of a rapidly changing and competitive work environment. Therefore, entrepreneurial leaders must develop entrepreneurial individuals and teams while integrating innovation throughout their organizational culture. This interactive session will present research-based information on entrepreneurial leaders and teams. The session will also provide opportunities for discussion and active learning designed to increase the entrepreneurial leadership capacity of individuals and teams with a specific focus on innovation

Targeting tauopathy with engineered tau-degrading intrabodies

BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau have been demonstrated to be beneficial in decreasing tauopathy in animal models. We previously found that passive immunotherapy with anti-tau antibody to human tau or expression of an anti-tau secreted single-chain variable fragment (scFv) in the central nervous system of a mouse model of tauopathy decreased but did not remove all tau-associated pathology. Although these and other studies demonstrate that conventional immunotherapeutic approaches targeting tau can influence tau pathogenesis, the majority of pathological tau remains in the cytosol of cells, not typically accessible to an extracellular antibody. Therefore, we reasoned targeting intracellular tau might be more efficacious in preventing or decreasing tauopathy. METHODS: By utilizing our anti-tau scFv, we generated anti-tau intrabodies for the expression in the cytosol of neurons. To enhance the degradation capacity of conventional intrabodies, we engineered chimeric anti-tau intrabodies fused to ubiquitin harboring distinct mutations that shuttle intracellular tau for either the proteasome or lysosomal mediated degradation. To evaluate the efficacy in delaying or eliminating tauopathy, we expressed our tau degrading intrabodies or controls in human tau transgenic mice by adeno-associated virus prior to overt tau pathology and after tau deposition. RESULTS: Our results demonstrate, the expression of chimeric anti-tau intrabodies significantly reduce tau protein levels in primary neuronal cultures expression human tau relative to a non-modified anti-tau intrabody. We found the expression of engineered tau-degrading intrabodies destined for proteasomal-mediated degradation are more effective in delaying or eliminating tauopathy than a conventional intrabody in aged human tau transgenic mice. CONCLUSION: This study, harnesses the strength of intrabodies that are amendable for targeting specific domains or modifications with the cell-intrinsic mechanisms that regulate protein degradation providing a new immunotherapeutic approach with potentially improved efficacy

Measuring the Efficacy of Leaders to Assess Information and Make Decisions in a Crisis: The C-LEAD Scale.

Based on literature and expert interviews, we developed the Crisis Leader Efficacy in Assessing and Deciding scale (C-LEAD) to capture the efficacy of leaders to assess information and make decisions in a public health and safety crisis. In Studies 1 and 2, we find that C-LEAD predicts decision-making difficulty and confidence in a crisis better than a measure of general leadership efficacy. In Study 3, C-LEAD predicts greater motivation to lead in a crisis, more crisis leader role-taking, and more accurate performance while in a crisis leader role. These findings support the scale’s construct validity and broaden our theoretical understanding of the nature of crisis leader efficacy

Writing quality predicts Chinese learning

To examine the importance of manual character writing to reading in a new writing system, 48 adult Chinese-as-a-foreign-language students were taught characters in either a character writing-to-read or an alphabet typing-to-read condition, and engaged in corresponding handwriting or typing training for five consecutive days. Prior knowledge of orthography and phonology was assessed before training. At the end of each training day, improved orthographic quality was assessed via increased skill in producing Chinese characters at both the component and global levels. In addition, pretests and posttests were administered at each training day, and the proportional changes were used as the measure of learning gains. Outcomes replicated earlier findings of improved phonological knowledge following pinyin-typing practice and improved semantic knowledge following handwriting practice. Improvement in handwriting quality played a significant role in predicting reading gains after controlling for prior knowledge

Talk and Let Talk: The Effects of Language Proficiency on Speaking up and Competence Perceptions in Multinational Teams

Collaboration within multinational teams necessitates the adoption of a common language, typically English, which often leads to significant differences in language proficiency across members. We develop and test a multilevel model of the effects of language proficiency within multinational teams. An experimental study of 51 teams (102 American and 102 Chinese participants) revealed that, at the individual level, members with higher levels of language proficiency were more likely to speak up, which led to more positive perceptions of their competence. At the team level, greater dispersion in language proficiency across members was associated with less accurate competence recognition, which, in turn, led to lower overall team performance. Moreover, communication medium moderated these relationships, such that the effects of language proficiency were more potent in face-to-face than in computer-mediated teams. We discuss the implications of these findings for future research and for managing participation, competence, and technology in multinational teams

How Well has Land-Use Planning Worked Under Different Governance Regimes? A Case Study in the Portland, OR-Vancouver, WA Metropolitan Area, USA

We examine land use planning outcomes over a 30-year period in the Portland, OR-Vancouver, WA (USA) metropolitan area. The four-county study region enables comparisons between three Oregon counties subject to Oregon’s 1973 Land Use Act (Senate Bill 100) and Clark County, WA which implemented land use planning under Washington’s 1990 Growth Management Act. We describe county-level historical land uses from the mid-1970s to the mid-2000s, including low-density residential and urban development, both outside and inside of current urban growth boundaries. We use difference-in-differences models to test whether differences in the proportions of developed land resulting from implementation of urban growth boundaries are statistically significant and whether they vary between Oregon and Washington. Our results suggest that land use planning and urban growth boundaries now mandated both in Oregon and Washington portions of the study area have had a measurable and statistically significant effect in containing development and conserving forest and agricultural lands in the Portland-Vancouver metropolitan area. Our results also suggest, however, that these effects differ across the four study-area counties, likely owing in part to differences in counties’ initial levels of development, distinctly different land use planning histories, and how restrictive their urban growth boundaries were drawn

Determinants of Performance in Smallholder Farmer Groups in Uganda

The performance of farmer groups is critical for the success of the farmer-led Agricultural Extension approach currently used in Uganda. This study examines factors affecting performance of farmer groups accessing agricultural extension and advisory services from the National Agricultural Advisory Services in Eastern Uganda. The study collected data 200 members of 19 farmer groups in Eastern Uganda. Performance of farmer groups was the dependent variable, which was perceived to be influenced by individual members’ objectives, participation culture, power distance, structure of task, perceived equity, reward allocation and participation in group activities. Farmer group performance had a statistically significant positive relationship with power distance and perceived equity. Group participation culture and structure of tasks had a statistically negative relationship with group performance. Members tended to deflect group losses to factors beyond the seasonality of group activities, quality of farm inputs, and poor training delivered by advisory service providers. The advisory service providers and farmer group members need to use the political and social capital possessed by the local leadership, groups and community members for enhancing support and collective participation of the community in farmer groups. Since farmer groups are a sub-set of wider community, this empirical study brings into perspective the role of community culture in influencing performance of farmer groups in smallholder farming communities

Ovarian Cancer Incidence Corrected for Oophorectomy

Current reported incidence rates for ovarian cancer may significantly underestimate the true rate because of the inclusion of women in the calculations who are not at risk for ovarian cancer due to prior benign salpingo-oophorectomy (SO). We have considered prior SO to more realistically estimate risk for ovarian cancer. Kentucky Health Claims Data, International Classification of Disease 9 (ICD-9) codes, Current Procedure Terminology (CPT) codes, and Kentucky Behavioral Risk Factor Surveillance System (BRFSS) Data were used to identify women who have undergone SO in Kentucky, and these women were removed from the at-risk pool in order to re-assess incidence rates to more accurately represent ovarian cancer risk. The protective effect of SO on the population was determined on an annual basis for ages 5–80+ using data from the years 2009–2013. The corrected age-adjusted rates of ovarian cancer that considered SO ranged from 33% to 67% higher than age-adjusted rates from the standard population. Correction of incidence rates for ovarian cancer by accounting for women with prior SO gives a better understanding of risk for this disease faced by women. The rates of ovarian cancer were substantially higher when SO was taken into consideration than estimates from the standard population