3,044 research outputs found
Leadership for Emergence: Exploring organisations through a living system lens
In this article, we outline a research project with adolescent-focused NGOs (non-government organisations) in Christchurch, New Zealand. This project involved 25 managers who used appreciative inquiry process methodology to explore their leadership practices, beliefs, and values. Throughout the article, we construct a conceptual leadership frame for fostering the emergence of adaptive, innovative and responsive organisational capacity that allows organisations to more readily adapt to the complex and changing conditions in which they operate. We describe this frame as a living system lens that is based on viewing organisations as complex adaptive systems of the kind readily found in the natural world. We go on to outline the leaders’ reflections as they drew strong connections between the dynamics found in complex adaptive systems and their own organisations. Proactive mentoring, fostering interaction and shared learning, strategies for distributing power and decentralising control, and exploration and articulation of deeply held values emerged as the key leadership enactments that these leaders implemented in their roles
Simulation support for internet-based energy services
The rapidly developing Internet broadband network offers new opportunities for deploying a range of energy, environment and health-related services for people in their homes and workplaces. Several of these services can be enabled or enhanced through the application of building simulation. This paper describes the infrastructure for e-services under test within a European research project and shows the potential for simulation support for these services
HIGH BAY CAPACITY UTILIZATION TOOL
Northrop Grumman’s Space Park facility has many inefficiencies in their high bay scheduling processes. Additionally, it is very hard for project managers to figure out the capabilities of each high bay in order to schedule their specific project. The purpose of this project is to develop a tool that can be used across the facility to easily create projects, assign projects, view room capabilities, and view a master schedule of the rooms. After researching commercially available tools, our approach to designing this system was to use tools that are already utilized at the facility (Microsoft Suite and Tableau) and engineer the system to do exactly what we need it to do for this facility. The design is a relational database managed in Microsoft Access that links to Tableau for a detailed schedule for all the rooms along with facility layouts on Microsoft Visio to show each facility at any time. These three programs are tied together with a user interface in Microsoft Access and available across the entire network at the Space Park facility via SharePoint. While our system would have higher initial cost to train employees on, it would save significant operating costs each year. If this system were to be installed and utilized into Northrop Grumman’s current operations, we estimate a cost savings between 25,000 over a ten year period. However, we ran into problems with the implementation of our tool due to having to use assumed data for our project. Although it is possible to expand this system, it is a lengthy process to add parameters for rooms and change the base layout of our design. Our largest recommendation for this system is that Northrop Grumman uses the base layout of our system (including the relational database design, user interface, and data visualization) to create a new system that has actual parameters of the room. This will yield the same results as installing the system that we have developed
The learning experiences of health and social care paraprofessionals on a foundation degree
Foundation degrees have been developed in the UK as a means of meeting the learning needs of paraprofessionals in health and social care and the services within which they work in a cost-effective fashion. Workplace learning is an intrinsic component to these degrees. Taking a socio-cultural perspective, this paper examines how the students' workplaces, life circumstances and sense of career trajectory shaped their learning experience and motivation. A small-scale evaluation study, using semi-structured interviews, focused on the learning experiences of a group of paraprofessionals enrolled in a foundation degree in health and social care. Data revealed fragmented employment patterns, underpinned by consistent vocational drives. While the study resonated with vocation, participants were ambivalent or lacked information about career progression. Workplace conditions, relationships and limited time shaped learning and coping strategies. A strategic and focused approach to student learning is required and includes attention to career pathways, workforce development strategy, the requirements of a range of stakeholders, workplace supervision and support for learning
Transcriptome analysis suggests a role for the differential expression of cerebral aquaporins and the MAPK signalling pathway in human temporal lobe epilepsy
Epilepsies are common disorders of the central nervous system (CNS), affecting up to 2% of the global population. Pharmaco-resistance is a major clinical challenge affecting about 30% of temporal lobe epilepsy (TLE) patients. Water homeostasis has been shown crucial for regulation of neuronal excitability. The control of water movement is achieved through a family of small integral membrane channel proteins called aquaporins (AQPs). Despite the fact that changes in water homeostasis occur in sclerotic hippocampi of people with TLE, the expression of AQPs in the epileptic brain is not fully characterised. This study uses microarray and ELISA methods to analyse the mRNA and protein expression of the human cerebral AQPs in sclerotic hippocampi (TLE-HS) and adjacent neocortex tissue (TLE-NC) of TLE patients. The expression of AQP1 and AQP4 transcripts was significantly increased, while that of the AQP9 transcript was significantly reduced in TLE-HS compared to TLE-NC. AQP4 protein expression was also increased while expression of AQP1 protein remained unchanged, and AQP9 was undetected. Microarray data analysis identified 3,333 differentially regulated genes and suggested the involvement of the MAPK signalling pathway in TLE pathogenesis. Proteome array data validated the translational profile for 26 genes and within the MAPK pathway (e.g. p38, JNK) that were identified as differentially expressed from microarray analysis. ELISA data showed that p38 and JNK inhibitors decrease AQP4 protein levels in cultured human primary cortical astrocytes. Elucidating the mechanism of selective regulation of different AQPs and associated regulatory proteins may provide a new therapeutic approach to epilepsy treatment. This article is protected by copyright. All rights reserved
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