On the Implementation of Location Obfuscation in openwifi and Its Performance

Wi-Fi sensing as a side-effect of communications is opening new opportunities for smart services integrating communications with environmental properties, first and foremost the position of devices and people. At the same time, this technology represents an unprecedented threat to people’s privacy, as personal information can be collected directly at the physical layer without any possibility to hide or protect it. Several works already discussed the possibility of safeguarding users’ privacy without hampering communication performance. Usually, some signal pre-processing at the transmitter side is needed to introduce pseudo-random (artificial) patterns in the channel response estimated at the receiver, preventing the extraction of meaningful information from the channel state. However, there is currently just one implementation of such techniques in a real system (openwifi), and it has never been tested for performance. In this work, we present the implementation of a location obfuscation technique within the openwifi project that enables fine manipulation of the radio signal at transmitter side and yields acceptable, if not good, performance. The paper discusses the implementation of the obfuscation subsystem, its performance, possible improvements, and further steps to allow authorized devices to “de-obfuscate” the signal and retrieve the sensed information

Pyrethroid resistance in Italian populations of the mite Varroa destructor: a focus on the Lombardy region

Varroa destructor Anderson et Trueman (Acari Varroidae) is a major pest of honey bees and synthetic acaricide treatments remain the most effective tool to contain its infestations. In 1991, pyrethroid resistance was first reported in Lombardy, and is now spread worldwide. Recently, three different mutations (L925V/I/M) occurring in the voltage-gated sodium channel have been associated with tau-fluvalinate resistance. Furthermore, in the literature, indirect evidence from laboratory bioassays have indicated that high levels of esterases may be involved in mites resistant to tau-fluvalinate. This study provides an update on the actual spread of target-site resistance to tau-fluvalinate in V. destructor samples collected in the Lombardy region. TaqMan assays showed that mutation L925V is present in this area, however only low frequencies of this resistant allele were detected. The majority of resistant mites were found in the homozygous form (11%), and only a small fraction possessed the heterozygous genotype (2%). Additionally, a protocol was set up to detect esterase activity directly in single mites. Slight variability was observed among different populations collected in Lombardy. Additional studies are needed to confirm the involvement of esterases in resistance to pyrethroids in V. destructor and whether this can be correlated to changes in enzyme activity

The Attrition of Young Physician-Scientists: Problems and Potential Solutions

Physician-scientists have played a prominent role as thought leaders in American medicine over the past century. This group has produced many basic scientific advances and pioneered the translation of these advances into clinical practice. Now that we are in the post-genomic era, there is a greater need than ever for the continued participation of this group because of their unique ability to bridge the "bench to bedside." However, the number of physicians pursuing this career is static and their average age is rising. Recent data indicate that the many benefits of this career path are seen as being outweighed by so many negative factors, as to prompt the question, "Is this a career that a reasonable person should undertake in 2007 and beyond?" The following analysis suggests that the current answer is "no." We have identified the lack of professional security as a major factor that prompts young physicians to abandon the physician-scientist track. Because this problem has not been sufficiently emphasized, we believe current efforts are unlikely to reverse this disturbing trend. We propose strategies that seek to address this problem and help sustain young physician-scientists at career transition points at which they are most vulnerable to give up

Probiotic bacteria regulate intestinal epithelial permeability in experimental ileitis by a TNF-dependent mechanism

Background: We previously showed that the probiotic mixture, VSL#3, prevents the onset of ileitis in SAMP/YitFc (SAMP) mice, and this effect was associated with stimulation of epithelial-derived TNF. The aim of this study was to determine the mechanism(s) of VSL#3-mediated protection on epithelial barrier function and to further investigate the "paradoxical" effects of TNF in preventing SAMP ileitis. Methods: Permeability was evaluated in SAMP mice prior to the onset of inflammation and during established disease by measuring transepithelial electrical resistance (TEER) on ex vivo-cultured ilea following exposure to VSL#3 conditioned media (CM), TNF or VSL#3-CM + anti-TNF. Tight junction (TJ) proteins were assessed by qRT-PCR, Western blot, and confocal microscopy, and TNFRI/TNFRII expression measured in freshly isolated intestinal epithelial cells (IEC) from SAMP and control AKR mice. Results: Culture with either VSL#3-CM or TNF resulted in decreased ileal paracellular permeability in pre-inflamed SAMP, but not SAMP with established disease, while addition of anti-TNF abrogated these effects. Modulation of the TJ proteins, claudin-2 and occludin, occurred with a significant decrease in claudin-2 and increase in occludin following stimulation with VSL#3-CM or TNF. TNF protein levels increased in supernatants of SAMP ilea incubated with VSL#3-CM compared to vehicle, while IEC-derived TNFR mRNA expression decreased in young, and was elevated in inflamed, SAMP versus AKR mice. Conclusions: Our data demonstrate that the previously established efficacy of VSL#3 in preventing SAMP ileitis is due to direct innate and homeostatic effects of TNF on the gut epithelium, modulation of the TJ proteins, claudin-2 and occludin, and overall improvement of intestinal permeability. © 2012 Corridoni et al

Previous Crop Impacts Winter Wheat Sowing Dates, Available Water at Sowing, and Grain Yield

Cropping systems choices can directly affect the sowing date for winter wheat, which is among the most important variables that determine attainable yields in the U.S. Central Great Plains. Our objective was to investigate the effect of the previous crop on winter wheat grain yield through the modulation of sowing date and its impact on plant available water at sowing, and temperatures during the critical period for yield determination. A no-tillage rainfed field experiment was established in 2019 at Ashland Bottoms, KS. Winter wheat was sown either after summer fallow, full-season soybean, double-cropped soybean, or corn—thus, resulting in a range in sowing dates of 270–326 days of the year (September 27 to November 22). The optimum sowing date for the site based on grain yield was estimated at day of year 296 ± 5 (October 18 to 28). Winter wheat after summer fallow and after a fullseason soybean crop resulted in the greatest yields, whether sown at the optimum date or slightly later than optimum. Winter wheat yield was positively related to plant available water at sowing. Later sowing dates were most likely to reduce plant available water at sowing, and could delay wheat’s development resulting in higher temperatures occurring during the critical period for yield determination (i.e., the days surrounding anthesis). Later sowing also shortened grain filling duration due to an overall later cycle and elevated temperatures. Thus, adjusting winter wheat sowing dates is the first step that determines the crop’s yield potential through improved plant available water at sowing, and reduced temperatures during the critical period for yield determination. When following a summer crop, winter wheat should be sown as soon as the previous crop is harvested to try to mitigate these negative effects of late sowing

Human iPSC-Derived 3D Hepatic Organoids in a Miniaturized Dynamic Culture System

The process of identifying and approving a new drug is a time-consuming and expensive procedure. One of the biggest issues to overcome is the risk of hepatotoxicity, which is one of the main reasons for drug withdrawal from the market. While animal models are the gold standard in preclinical drug testing, the translation of results into therapeutic intervention is often ambiguous due to interspecies differences in hepatic metabolism. The discovery of human induced pluripotent stem cells (hiPSCs) and their derivatives has opened new possibilities for drug testing. We used mesenchymal stem cells and hepatocytes both derived from hiPSCs, together with endothelial cells, to miniaturize the process of generating hepatic organoids. These organoids were then cultivated in vitro using both static and dynamic cultures. Additionally, we tested spheroids solely composed by induced hepatocytes. By miniaturizing the system, we demonstrated the possibility of maintaining the organoids, but not the spheroids, in culture for up to 1 week. This timeframe may be sufficient to carry out a hypothetical pharmacological test or screening. In conclusion, we propose that the hiPSCderived liver organoid model could complement or, in the near future, replace the pharmacological and toxicological tests conducted on animals

The Use of Sulfasalazine in Atrophie Blanche

Atrophie blanche can be a chronic condition for which there is no satisfactory treatment. Two patients with atrophie blanche who had not responded to various therapeutic modalities were given a trial of sulfasalazine 1 g three times daily. The ulcers healed within 3 months in both cases. In view of these positive results, patients should be treated with sulfasalazine to determine the efficacy of this drug in atrophie blanche.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/65527/1/j.1365-4362.1990.tb02594.x.pd