Synergies, tensions and challenges in HIV prevention, treatment and cure research: exploratory conversations with HIV experts in South Africa

Background: The ethical concerns associated with HIV prevention and treatment research have been widely explored in South Africa over the past 3 decades. However, HIV cure research is relatively new to the region and significant ethical and social challenges are anticipated. There has been no published empirical enquiry in Africa into key informant perspectives on HIV cure research. Consequently, this study was conducted to gain preliminary data from South African HIV clinicians, researchers and activists. Methods: In-depth interviews were conducted on a purposive sample of fourteen key informants in South Africa. Audiotaped interviews were transcribed verbatim with concurrent thematic analysis. The perspectives of HIV clinicians, researchers and activists were captured. Analyst triangulation occurred as the data were analysed by three authors independently. Results: The rapid evolution of HIV cure research agendas was prominent with participants expressing some concern that the global North was driving the cure agenda. Participants described a symbiotic relationship between cure, treatment and prevention research necessitating collaboration. Assessing and managing knowledge and expectations around HIV cure research emerged as a central theme related to challenges to constructing ‘cure’ - how patients understand the idea of cure is important in explaining the complexity of cure research especially in the South African context where understanding of science is often challenging. Managing expectations and avoiding curative misconception will have implications for consent processes. Unique strategies in cure research could include treatment interruption, which has the potential to create therapeutic and ethical conflict and will be perceived as a significant risk. Ethical challenges in cure research will impact on informed consent and community engagement. Conclusions: It was encouraging to note the desire for synergy amongst researchers and clinicians working in the fields of prevention, treatment and cure. Translation of complex HIV cure science into lay language is critical. Moving forward, RECs must be adequately constituted with scientific expertise and community representation when reviewing cure protocols. It is hoped that knowledge and resource sharing in the context of collaboration between research scientists working in cure and those working in treatment and prevention will accelerate progress towards cur

Procedure for measurement of logarithmic growth

Measurement of logarithmic growt

Enhancing the ethical use of learning analytics in Australian higher education

Ensuring the ethical use of data about students is an important consideration in the use of learning analytics in Australian higher education. In early 2019 a discussion paper was published by a group of learning analytics specialists in the sector to help promote the conversation around the key ethical issues institutions need to address in order to ensure the ethical use of learning analytics. This panel session will explore these ethical issues in more detail and update the conversation with new perspectives and provocations. The panel will include authors of the discussion paper and structured so the audience will have an active role in considering the key issues and advancing the ongoing conversations about these important issues

Cost-effective Planning of Decarbonized Power-Gas Infrastructure to Meet the Challenges of Heating Electrification

Building heat electrification is central to economy-wide decarbonization efforts and directly affects energy infrastructure planning through increasing electricity demand and reduces the use of gas infrastructure that also serves the power sector. However, the simultaneous effects on both the power and gas systems have yet to be rigorously evaluated. Offering two key contributions, we develop a modeling framework to project end-use demand for electricity and gas in the buildings sector under various electrification pathways and evaluate their impact on co-optimized bulk power-gas infrastructure investments and operations under deep decarbonization scenarios. Applying the framework to study the U.S. New England region in 2050 across 20 weather scenarios, we find high electrification of the residential sector can increase sectoral peak and total electricity demands by up to 62-160% and 47-65% respectively relative to business-as-usual trajectories. Employing demand-side measures like building envelope improvements under high electrification, however, can reduce the magnitude and weather sensitivity of peak load as well as reduce combined power and gas demand by 29-31% relative to the present day. Notably, a combination of high electrification and envelope improvements yields the lowest bulk power-gas system cost outcomes. We also find that inter-annual weather-driven variations in demand result in up to 20% variation in optimal power sector investments, which highlights the importance of capturing weather sensitivity for planning purposes

Breaking the Mould: the Study Centre Approach

At an FE College in Worcester, the traditional library has been replaced by study centres with a significant increase in staff, in a move to focus on the learner. How did this radical change go down with the students, the staff and the teachers

OPTN/SRTR 2015 Annual Data Report: Heart

The number of heart transplant candidates and transplants performed continued to rise each year. In 2015, 2819 heart transplants were performed. In addition, the number of new adult candidates on the waiting list increased 51% since 2004. The number of adult heart transplant survivors continued to increase, and in 2015, 29,172 recipients were living with heart transplants. Patient mortality following transplant has declined. The number of pediatric candidates and transplants performed also increased. New listings for pediatric heart transplants increased from 451 in 2004 to 644 in 2015. The number of pediatric heart transplants performed each year increased from 297 in 2004 to 460 in 2015. Among pediatric patients who underwent transplant in 2014, death occurred in 7.2% at 6 months and 9.6% at 1 year.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135509/1/ajt14128.pd

Analysis of “Yes” Responses to Uniformed Police Marching in Pride: Perspectives From LGBTQ+ Communities in St. John’s, Newfoundland and Labrador, Canada

Recently, a number of Canadian police forces have been banned from Pride parades. A ban on uniformed police in these parades has proven to be contentious; the general public and lesbian, gay, bisexual, transgender, queer, and plus (LGBTQ+) communities have been split on the issue. Limited research has examined the perspectives of the general population or, until now, LGBTQ+ people on this matter. Using an online survey designed to gather ideas or opinions of LGBTQ+ community members regarding their hopes, aspirations, and vision for the St. John’s Pride board, 181 LGBTQ+ respondents responded to this question: Should the police be allowed to march in uniform at the St. John’s Pride parade? In total, 92 (51%) said “Yes.” A critical analysis of their qualitative responses revealed four interrelated themes: (a) power of Pride, (b) “they are we and we are they,” (c) “the police are on our side,” and (d) taking back Pride. Implications of the findings for police-LGBTQ+ community relations are discussed

OPTN/SRTR 2018 Annual Data Report: Heart

The new adult heart allocation policy was approved in 2016 and implemented in October 2018, so its effect was not yet evident in 2018 data. However, the more granular data being collected are anticipated to allow for improved analyses. In 2018, new listings continued to increase; 3883 new adult and 685 new pediatric candidates were added. In 2018, 3440 heart transplants were performed, an increase of 167 over 2017; 473 transplants occurred in pediatric recipients and 2967 in adult recipients. Short‐term and long‐term posttransplant mortality improved. Overall 1‐year survival for adults who underwent heart transplant in 2011‐2013 was 90.3%, 3‐year survival was 84.7%, and 5‐year survival was 79.6%. Mortality rates for pediatric recipients were 4.5% at 6 months and in 5.9% at 1 year posttransplant, 12.5% at 3 years for transplants in 2014‐2015, 14.8% at 5 years for transplants in 2012‐2013, and 29.8% at 10 years for transplants performed in 2008‐2009.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/153233/1/ajt15676.pd

Heart and lung organ offer acceptance practices of transplant programs are associated with waitlist mortality and organ yield

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/145354/1/ajt14885.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/145354/2/ajt14885_am.pd