Gaining from Improved Dairy Cow Nutrition: Economic, environmental and animal health benefits

A majority of UK dairy herds have the potential to increase profitability by improving the ration of their cows. This paper reports that gains averaging around £100 per cow have been made within one year of adopting the Keenan Hi-Fibre ration by 239 UK herds in 2006 and 2007. Larger gains have been made by herds in France. The key performance indicator underlying these gains is Feed Conversion Efficiency, whereby the same, or even a smaller amount of Dry Matter Intake generates higher yields per cow. Importantly, the gains are associated with large improvements in animal health and reductions in greenhouse gases per litre of milk produced.Feed conversion efficiency, cattle nutrition, greenhouse gas emissions, animal health., Livestock Production/Industries,

Depositional History and Neotectonics in Great Salt Lake, Utah, from High-Resolution Seismic Stratigraphy

High-resolution seismic-reflection data from Great Salt Lake show that the basinal sediment sequence is cut by numerous faults with N–S and NE–SW orientations. This faulting shows evidence of varied timing and relative offsets, but includes at least three events totaling about 12 m following the Bonneville phase of the lake (since about 13.5 ka). Several faults displace the uppermost sediments and the lake floor. Bioherm structures are present above some faults, which suggests that the faults served as conduits for sublacustrine discharge of fresh water. A shallow, fault-controlled ridge between Carrington Island and Promontory Point, underlain by a well-cemented pavement, separates the main lake into two basins. The pavement appears to be early Holocene in age and younger sediments lap onto it. Onlap–offlap relationships, reflection truncations, and morphology of the lake floor indicate a low lake, well below the present level, during the early Holocene, during which most of the basin was probably a playa. This low stand is represented by irregular reflections in seismic profiles from the deepest part of the basin. Other prominent reflectors in the profiles are correlated with lithologic changes in sediment cores related to the end of the Bonneville stage of the lake, a thick mirabilite layer in the northern basin, and the Mazama tephra. Reflections below those penetrated by sediment cores document earlier lacustrine cycles

Valproate Protein Binding Is Highly Variable in ICU Patients and Not Predicted by Total Serum Concentrations: A Case Series and Literature Review

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/136503/1/phar1912-sup-0001-SupInfo.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136503/2/phar1912_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/136503/3/phar1912.pd

A luminescent 1D silver polymer containing [2.2]paracyclophane ligands

Funding: UK EPSRC Grant Number(s) EP/P014082/1, EP/M02105X/1, EP/R035164/1).[2.2]Paracyclophane scaffolds have seen limited use as building blocks in supramolecular chemistry. Here, we report the synthesis and characterization of a 1D coordination polymer consisting of silver(I) ions bound to a [2.2]paracyclophane scaffold functionalized with two 4-pyridyl units. The structure of the polymer has been determined from single crystal X-ray diffraction analysis and reveals two different silver coordination motifs that alternate along the 1D coordination polymer. The coordination polymer exhibits strong blue and sky-blue fluorescence in solution and in the crystalline solid state, respectively.Publisher PDFPeer reviewe

Cadherin activity is required for activity-induced spine remodeling

Neural activity induces the remodeling of pre- and postsynaptic membranes, which maintain their apposition through cell adhesion molecules. Among them, N-cadherin is redistributed, undergoes activity-dependent conformational changes, and is required for synaptic plasticity. Here, we show that depolarization induces the enlargement of the width of spine head, and that cadherin activity is essential for this synaptic rearrangement. Dendritic spines visualized with green fluorescent protein in hippocampal neurons showed an expansion by the activation of AMPA receptor, so that the synaptic apposition zone may be expanded. N-cadherin-venus fusion protein laterally dispersed along the expanding spine head. Overexpression of dominant-negative forms of N-cadherin resulted in the abrogation of the spine expansion. Inhibition of actin polymerization with cytochalasin D abolished the spine expansion. Together, our data suggest that cadherin-based adhesion machinery coupled with the actin-cytoskeleton is critical for the remodeling of synaptic apposition zone

Let’s celebrate recovery. Inclusive Cities working together to support social cohesion

Recovery from illicit drug and alcohol use takes place over time and is characterised by a dynamic interaction between internal and external components. An integral part of all recovery journeys is effective community reintegration. After all, recovery is not mainly an issue of personal motivation rather it is about acceptance by family, by friends and by a range of organisations and professionals across the community. Therefore to support pathways to recovery, structural and contextual endeavours are needed to supplement individually-oriented interventions and programmes. One way to do this, is by introducing Inclusive Cities. An Inclusive City promotes participation, inclusion, full and equal citizenship to all her citizens, including those in recovery, based on the idea of community capital. The aim of building recovery capital at a community level through connections and 'linking social capital' to challenge stigmatisation and exclusion, is seen as central to this idea. Inclusive Cities is an initiative to support the creation of Recovery-Oriented Systems of Care at a city level, that starts with but extends beyond substance using populations. This paper describes (and gives examples of) how it is possible to use recovery as a starting point for generating social inclusion, challenging the marginalisation of other excluded populations as well by building community connections