Complex crater formation by oblique impacts on the Earth and Moon

Almost all meteorite impacts occur at oblique incidence angles, but the effect of impact angle on crater size is not well understood, especially for large craters. To improve oblique impact crater scaling, we present a suite of simulations of complex crater formation on Earth and the Moon over a range of impact angles, velocities and impactor sizes. We show that crater diameter is larger than predicted by existing scaling relationships for oblique impacts; there is little dependence on obliquity for impacts steeper than 45° from the horizontal. Crater depth, volume and diameter depend on impact angle in different ways—relatively shallower craters are formed by more oblique impacts. Our simulation results have implications for how crater populations are determined from impactor populations and vice-versa. They suggest that existing approaches to account for impact obliquity may underestimate the number of complex craters larger than a given size by as much as one-third

The effects of peculiar velocities in SN Ia environments on the local H0 measurement

The discrepancy between estimates of the Hubble Constant ($H_{0}$) measured from local ($z \lesssim 0.1$) scales and from scales of the sound horizon is a crucial problem in modern cosmology. Peculiar velocities of standard candle distance indicators can systematically affect local $H_{0}$ measurements. We here use 2MRS galaxies to measure the local galaxy density field, finding a notable $z < 0.05$ under-density in the SGC-6dFGS region of $27 \pm 2$ %. However, no strong evidence for a 'Local Void' pertaining to the full 2MRS sky coverage is found. Galaxy densities are used to measure a density parameter, $\Delta \phi_{+-}$, which acts as a proxy for peculiar velocity ($v_{pec}$) by quantifying density gradients along a line-of-sight. $\Delta \phi_{+-}$ is found to correlate strongly with local $H_{0}$ estimates from Union 2.1 Type Ia SNe ($0.02 < z < 0.04$). Density structures on scales of $\sim 50$ Mpc are found to correlate most strongly with $H_{0}$ estimates in both the observational data and in mock data from the MDPL2-Galacticus simulation. Interpolating SN Ia $H_{0}$ estimates to their $\Delta \phi_{+-} = 0$ values, we can correct for the effects of density structure on the local $H_{0}$ estimates, even in the presence of biased peculiar velocities. For these particular observational data, we reveal a $< 0.1 \,\rm km\,s^{-1} Mpc^{-1}$ difference in the sample mean estimate compared to the value uncorrected for peculiar velocities. Our best estimate is then $74.9 \,\rm km\,s^{-1} Mpc^{-1}$. Using the mock data, the systematic uncertainty from these peculiar velocity corrections is estimated to be $0.3 \,\rm km\,s^{-1} Mpc^{-1}$. The dominant source of uncertainty in our estimate instead relates to Cepheid-based calibrations of distance moduli ($1.7 \,\rm km\,s^{-1} Mpc^{-1}$) and SN photometry ($0.7 \,\rm km\,s^{-1} Mpc^{-1}$)

The effects of asteroid layering on ejecta mass-velocity distribution and implications for impact momentum transfer

Most bodies in the Solar System do not have a homogeneous structure. Understanding the outcome of an impact into regolith layers of different properties is especially important for NASA’s Double Asteroid Redirection Test (DART) and ESA’s Hera missions. Here we used the iSALE shock physics code to simulate the DART impact into three different target scenarios in the strength regime: a homogeneous porous half-space; layered targets with a porous weak layer overlying a stronger bedrock; and targets with exponentially decreasing porosity with depth. For each scenario we determined the sensitivity of crater morphology, ejecta mass-velocity distribution and momentum transferred from the impact for deflection, , to target properties and structure. We found that for a homogeneous porous half-space, cohesion and porosity play a significant role and the DART impact is expected to produce a between 1 and 3. In a two-layer target scenario, the presence of a less porous, stronger lower layer close to the surface can cause both amplification and reduction of ejected mass and momentum relative to the homogeneous upper-layer case. For the case of DART, the momentum enhancement can change by up to 90%. Impacts into targets with an exponentially decreasing porosity with depth only produced an enhancement in the ejected mass and momentum for sharp decreases in porosity that occur within 6 m of the asteroid surface. Together with measurements of the DART crater by the Hera mission, these results can be used to test the predictive capabilities of numerical models of asteroid deflection

Ejecta distribution and momentum transfer from oblique impacts on asteroid surfaces

NASA’s Double Asteroid Redirection Test (DART) mission will impact its target asteroid, Dimorphos, at an oblique angle that will not be known prior to the impact. We computed iSALE-3D simulations of DARTlike impacts on asteroid surfaces at different impact angles and found that the vertical momentum transfer efficiency, , is similar for different impact angles, however, the imparted momentum is reduced as the impact angle decreases. It is expected that the momentum imparted from a 45◦ impact is reduced by up to 50% compared to a vertical impact. The direction of the ejected momentum is not normal to the surface, however it is observed to ‘straighten up’ with crater growth. iSALE-2D simulations of vertical impacts provide context for the iSALE-3D simulation results and show that the ejection angle varies with both target properties and with crater growth. While the ejection angle is relatively insensitive to the target porosity, it varies by up to 30◦ with target coefficient of internal friction. The simulation results presented in this paper can help constrain target properties from the DART crater ejecta cone, which will be imaged by the LICIACube. The results presented here represent the basis for an empirical scaling relationship for oblique impacts and can be used as a framework to determine an analytical approximation of the vertical component of the ejecta momentum, − 1, given known target properties

From brand congruence to the ‘virtuous circle’: branding and the commercialization of public service broadcasting

In debates about the commercialization of public service broadcasting little attention has been paid to the ways in which the public might experience the commercial and public service activities of public service broadcasters and the impact that this may have on attitudes towards public service broadcasting. This is despite the fact that public service broadcasters increasingly depend on public support for their continued survival. Using the case study of the BBC, this article examines the ways in which the corporation has adopted strategic brand management to negotiate the relationship between its commercial and public service activities. Focusing on specific examples of the BBC’s commercial and public services, the article reveals a tension between the corporation’s attempts to ensure that all activities support its public purposes and its need to ensure separation between public and commercial work. Focusing on the consumer’s experience of the BBC brand, the article argues that rather than seeing commercial activity and public service broadcasting as inherently contradictory, we should be looking at the ways in which public service broadcasters can better communicate the relationship between their commercial and public service activities while continuing to argue for the social and cultural value of publicly funded broadcasting

Cervical dysplasia in patients with systemic lupus erythematosus

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Effect on Adherence to Nicotine Replacement Therapy of Informing Smokers Their Dose Is Determined by Their Genotype: A Randomised Controlled Trial

BACKGROUND: The behavioural impact of pharmacogenomics is untested. We tested two hypotheses concerning the behavioural impact of informing smokers their oral dose of NRT is tailored to analysis of DNA. METHODS AND FINDINGS: We conducted an RCT with smokers in smoking cessation clinics (N = 633). In combination with NRT patch, participants were informed that their doses of oral NRT were based either on their mu-opioid receptor (OPRM1) genotype, or their nicotine dependence questionnaire score (phenotype). The proportion of prescribed NRT consumed in the first 28 days following quitting was not significantly different between groups: (68.5% of prescribed NRT consumed in genotype vs 63.6%, phenotype group, difference = 5.0%, 95% CI -0.9,10.8, p = 0.098). Motivation to make another quit attempt among those (n = 331) not abstinent at six months was not significantly different between groups (p = 0.23). Abstinence at 28 days was not different between groups (p = 0.67); at six months was greater in genotype than phenotype group (13.7% vs 7.9%, difference = 5.8%, 95% CI 1.0,10.7, p = 0.018). CONCLUSIONS: Informing smokers their oral dose of NRT was tailored to genotype not phenotype had a small, statistically non-significant effect on 28-day adherence to NRT. Among those still smoking at six months, there was no evidence that saying NRT was tailored to genotype adversely affected motivation to make another quit attempt. Higher abstinence rate at six months in the genotype arm requires investigation. TRIAL REGISTRATION: Controlled-Trials.com ISRCTN14352545.</p

Notch-induced T cell development requires phosphoinositide-dependent kinase 1

Phosphoinositide-dependent kinase l (PDK1) phosphorylates and activates multiple AGC serine kinases, including protein kinase B (PKB), p70Ribosomal S6 kinase (S6K) and p90Ribosomal S6 kinase (RSK). PDK1 is required for thymocyte differentiation and proliferation, and herein, we explore the molecular basis for these essential functions of PDK1 in T lymphocyte development. A key finding is that PDK1 is required for the expression of key nutrient receptors in T cell progenitors: CD71 the transferrin receptor and CD98 a subunit of L-amino acid transporters. PDK1 is also essential for Notch-mediated trophic and proliferative responses in thymocytes. A PDK1 mutant PDK1 L155E, which supports activation of PKB but no other AGC kinases, can restore CD71 and CD98 expression in pre-T cells and restore thymocyte differentiation. However, PDK1 L155E is insufficient for thymocyte proliferation. The role of PDK1 in thymus development thus extends beyond its ability to regulate PKB. In addition, PDK1 phosphorylation of AGC kinases such as S6K and RSK is also necessary for thymocyte development

A Sensitive Branched DNA HIV-1 Signal Amplification Viral Load Assay with Single Day Turnaround

Branched DNA (bDNA) is a signal amplification technology used in clinical and research laboratories to quantitatively detect nucleic acids. An overnight incubation is a significant drawback of highly sensitive bDNA assays. The VERSANT® HIV-1 RNA 3.0 Assay (bDNA) (“Versant Assay”) currently used in clinical laboratories was modified to allow shorter target incubation, enabling the viral load assay to be run in a single day. To dramatically reduce the target incubation from 16–18 h to 2.5 h, composition of only the “Lysis Diluent” solution was modified. Nucleic acid probes in the assay were unchanged. Performance of the modified assay (assay in development; not commercially available) was evaluated and compared to the Versant Assay. Dilution series replicates (>950 results) were used to demonstrate that analytical sensitivity, linearity, accuracy, and precision for the shorter modified assay are comparable to the Versant Assay. HIV RNA-positive clinical specimens (n = 135) showed no significant difference in quantification between the modified assay and the Versant Assay. Equivalent relative quantification of samples of eight genotypes was demonstrated for the two assays. Elevated levels of several potentially interfering endogenous substances had no effect on quantification or specificity of the modified assay. The modified assay with drastically improved turnaround time demonstrates the viability of signal-amplifying technology, such as bDNA, as an alternative to the PCR-based assays dominating viral load monitoring in clinical laboratories. Highly sensitive bDNA assays with a single day turnaround may be ideal for laboratories with especially stringent cost, contamination, or reliability requirements