Medical Information Management System (MIMS): An automated hospital information system

Flexible system of computer programs allows manipulation and retrieval of data related to patient care. System is written in version of FORTRAN developed for CDC-6600 computer

LEAD Program Evaluation: Recidivism Report

The LEAD program was established in 2011 as a means of diverting those suspected of low-level drug and prostitution criminal activity to case management and other supportive services instead of jail and prosecution. The primary aim of the LEAD program is to reduce criminal recidivism. Secondary aims include reductions in criminal justice service utilization and associated costs as well as improvements for psychosocial, housing and quality-of-life outcomes. Because LEAD is the first known pre-booking diversion program of its kind in the United States, an evaluation is critically needed to inform key stakeholders, policy makers, and other interested parties of its impact. The evaluation of the LEAD program described in this report represents a response to this need.Background: This report was written by the University of Washington LEAD Evaluation Team at the request of the LEAD Policy Coordinating Group and fulfills the first of three LEAD evaluation aims. Purpose: This report describes findings from a quantitative analysis comparing outcomes for LEAD participants versus "system-as-usual" control participants on shorter- and longer-term changes on recidivism outcomes, including arrests (i.e., being taken into custody by legal authority) and criminal charges (i.e., filing of a criminal case in court). Arrests and criminal charges were chosen as the recidivism outcomes because they likely reflect individual behavior more than convictions, which are more heavily impacted by criminal justice system variables external to the individual. Findings: Analyses indicated statistically significant recidivism improvement for the LEAD group compared to the control group on some shorter- and longer-term outcomes

Comparative Analysis Of Zebrafish And Planarian Model Systems For Developmental Neurotoxicity Screens Using An 87-Compound Library

There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents valuable opportunities to evaluate how systems complement each other. In this article, we compare a chemical library of 87-compounds in two such systems, developing zebrafish and freshwater planarians, by screening for developmental neurotoxic effects. We show that the systems’ toxicological profiles are complementary to each other, with zebrafish yielding more detailed morphological endpoints and planarians more behavioral endpoints. Overall, zebrafish was more sensitive to this chemical library, yielding 86/87 hits, compared to 50/87 hits in planarians. The difference in sensitivity could not be attributed to molecular weight, Log Kow or the bioconcentration factor. Of the 87 chemicals, 28 had previously been evaluated in mammalian developmental neuro- (DNT), neuro- or developmental toxicity studies. Of the 28, 20 were hits in the planarian, and 27 were hits in zebrafish. Eighteen of the 28 had previously been identified as DNT hits in mammals and were highly associated with activity in zebrafish and planarian behavioral assays in this study. Only 1 chemical (out of 28) was a false negative in both zebrafish and planarian systems. Differences in endpoint coverage and system sensitivity illustrate the value of a dual systems approach to rapidly query a large chemical-bioactivity space and provide weight-of-evidence for prioritization of chemicals for further testing

Quantum Gloves

The slogan "information is physical" has been so successful that it led to some excess. Classical and quantum information can be thought of independently of any physical implementation. Pure information tasks can be realized using such abstract c- and qu-bits, but physical tasks require appropriate physical realizations of c- or qu-bits. As illustration we consider the problem of communicating chirality. We discuss in detail the physical resources this necessitates, and introduce the natural concept of "quantum gloves", i.e. rotationally invariant quantum states that encode as much as possible the concept of chirality and nothing more.Comment: 9 page

Just passing through: Archaeological investigations of a late Holocene open site in the Mitchell Grass Downs, inland northwest Queensland

Comparatively little is known about the archaeology of the Mitchell Grass Downs region of inland Queensland. This paper reports the results of investigations of an open site complex therein, comprising numerous hearths, a human burial, middens, stone arrangements and a stone artefact assemblage. Analysis reveals the stone artefact assemblage is a palimpsest, representing multiple events in the late Holocene compressed into a single non-stratified archaeological surface assemblage. The evidence suggests use of the area was by highly mobile, transient populations passing through on an occasional seasonal basis when environmental conditions were amenable to travel; suggestions for a semi-sedentary population are not supported. Clear evidence for the extensive removal, weathering, reuse and recycling of artefacts has implications for our ability to reconstruct past human behaviours and landscape use in this region

A stochastic model for early placental development

In the human, placental structure is closely related to placental function and consequent pregnancy outcome. Studies have noted abnormal placental shape in small-for-gestational age infants which extends to increased lifetime risk of cardiovascular disease. The origins and determinants of placental shape are incompletely under-stood and are difficult to study in vivo. In this paper we model the early development of the placenta in the human, based on the hypothesis that this is driven by dynamics dominated by a chemo-attractant effect emanating from proximal spiral arteries in the decidua. We derive and explore a two-dimensional stochastic model for these events, and investigate the effects of loss of spiral arteries in regions near to the cord insertion on the shape of the placenta. This model demonstrates that placental shape is highly variable and disruption of spiral arteries can exert profound effects on placental shape, particularly if this disruption is close to the cord insertion. Thus, placental shape reflects the underlying maternal vascular bed. Abnormal placental shape may reflect an abnormal uterine environment, which predisposes to pregnancy complications

Tear film thickness variations and the role of the tear meniscus

A mathematical model is developed to investigate the two-dimensional variations in the thickness of tear fluid deposited on the eye surface during a blink. Such variations can become greatly enhanced as the tears evaporate during the interblink period.\ud The four mechanisms considered are: i) the deposition of the tear film from the upper eyelid meniscus, ii) the flow of tear fluid from under the eyelid as it is retracted and from the lacrimal gland, iii) the flow of tear fluid around the eye within the meniscus and iv) the drainage of tear fluid into the canaliculi through the inferior and superior puncta.\ud There are two main insights from the modelling. First is that the amount of fluid within the tear meniscus is much greater than previously employed in models and this significantly changes the predicted distribution of tears. Secondly the uniformity of the tear film for a single blink is: i) primarily dictated by the storage in the meniscus, ii) quite sensitive to the speed of the blink and the ratio of the viscosity to the surface tension iii) less sensitive to the precise puncta behaviour, the flow under the eyelids or the specific distribution of fluid along the meniscus at the start of the blink. The modelling briefly examines the flow into the puncta which interact strongly with the meniscus and acts to control the meniscus volume. In addition it considers flow from the lacrimal glands which appears to occurs continue even during the interblink period when the eyelids are stationary

Stochastic resonance in bistable systems: The effect of simultaneous additive and multiplicative correlated noises

We analyze the effect of the simultaneous presence of correlated additive and multiplicative noises on the stochastic resonance response of a modulated bistable system. We find that when the correlation parameter is also modulated, the system's response, measured through the output signal-to-noise ratio, becomes largely independent of the additive noise intensity.Comment: RevTex, 10 pgs, 3 figure