8,628 research outputs found
Pattern formation by lateral inhibition with feedback: a mathematical model of Delta-Notch intercellular signalling
In many developing tissues, adjacent cells diverge in character so as to create a fine-grained pattern of cells in contrasting states of differentiation. It has been proposed that such patterns can be generated through lateral inhibition—a type cells–cell interaction whereby a cell that adopts a particular fate inhibits its immediate neighbours from doing likewise. Lateral inhibition is well documented in flies, worms and vertebrates. In all of these organisms, the transmembrane proteins Notch and Delta (or their homologues) have been identified as mediators of the interaction—Notch as receptor, Delta as its ligand on adjacent cells. However, it is not clear under precisely what conditions the Delta-Notch mechanism of lateral inhibition can generate the observed types of pattern, or indeed whether this mechanism is capable of generating such patterns by itself. Here we construct and analyse a simple and general mathematical model of such contact-mediated lateral inhibition. In accordance with experimental data, the model postulates that receipt of inhibition (i.e. activation of Notch) diminishes the ability to deliver inhibition (i.e. to produce active Delta). This gives rise to a feedback loop that can amplify differences between adjacent cells. We investigate the pattern-forming potential and temporal behavior of this model both analytically and through numerical simulation. Inhomogeneities are self-amplifying and develop without need of any other machinery, provided the feedback is sufficiently strong. For a wide range of initial and boundary conditions, the model generates fine-grained patterns similar to those observed in living systems
Magnetic Structure of Rapidly Rotating FK Comae-Type Coronae
We present a three-dimensional simulation of the corona of an FK Com-type
rapidly rotating G giant using a magnetohydrodynamic model that was originally
developed for the solar corona in order to capture the more realistic,
non-potential coronal structure. We drive the simulation with surface maps for
the radial magnetic field obtained from a stellar dynamo model of the FK Com
system. This enables us to obtain the coronal structure for different field
topologies representing different periods of time. We find that the corona of
such an FK Com-like star, including the large scale coronal loops, is dominated
by a strong toroidal component of the magnetic field. This is a result of part
of the field being dragged by the radial outflow, while the other part remains
attached to the rapidly rotating stellar surface. This tangling of the magnetic
field,in addition to a reduction in the radial flow component, leads to a
flattening of the gas density profile with distance in the inner part of the
corona. The three-dimensional simulation provides a global view of the coronal
structure. Some aspects of the results, such as the toroidal wrapping of the
magnetic field, should also be applicable to coronae on fast rotators in
general, which our study shows can be considerably different from the
well-studied and well-observed solar corona. Studying the global structure of
such coronae should also lead to a better understanding of their related
stellar processes, such as flares and coronal mass ejections, and in
particular, should lead to an improved understanding of mass and angular
momentum loss from such systems.Comment: Accepted to ApJ, 10 pages, 6 figure
Bistable molecular conductors with a field-switchable dipole group
A class of bistable "stator-rotor" molecules is proposed, where a stationary
bridge (stator) connects the two electrodes and facilitates electron transport
between them. The rotor part, which has a large dipole moment, is attached to
an atom of the stator via a single sigma bond. Hydrogen bonds formed between
the rotor and stator make the symmetric orientation of the dipole unstable. The
rotor has two potential minima with equal energy for rotation about the sigma
bond. The dipole orientation, which determines the conduction state of the
molecule, can be switched by an external electric field that changes the
relative energy of the two potential minima. Both orientation of the rotor
correspond to asymmetric current-voltage characteristics that are the reverse
of each other, so they are distinguishable electrically. Such bistable
stator-rotor molecules could potentially be used as parts of molecular
electronic devices.Comment: 8 pages, 7 figure
Incidence of rough and irregular atmospheric ice particles from Small Ice Detector 3 measurements
NERC, NE/E011225/1 © Author(s) 2013. This work is distributed under the Creative Commons Attribution 3.0 LicenseThe knowledge of properties of ice crystals such as size, shape, concavity and roughness is critical in the context of radiative properties of ice and mixed phase clouds. Limitations of current cloud probes to measure these properties can be circumvented by acquiring two-dimensional light scattering patterns instead of particle images. Such patterns were obtained in situ for the first time using the Small Ice Detector 3 (SID-3) probe during several flights in a variety of mid-latitude mixed phase and cirrus clouds. The patterns are analyzed using several measures of pattern texture, selected to reveal the magnitude of particle roughness or complexity. The retrieved roughness is compared to values obtained from a range of well-characterized test particles in the laboratory. It is found that typical in situ roughness corresponds to that found in the rougher subset of the test particles, and sometimes even extends beyond the most extreme values found in the laboratory. In this study we do not differentiate between small-scale, fine surface roughness and large-scale crystal complexity. Instead, we argue that both can have similar manifestations in terms of light scattering properties and also similar causes. Overall, the in situ data is consistent with ice particles with highly irregular or rough surfaces being dominant. Similar magnitudes of roughness were found in growth and sublimation zones of cirrus. The roughness was found to be negatively correlated with the halo ratio, but not with other thermodynamic or microphysical properties found in situ. Slightly higher roughness was observed in cirrus forming in clean oceanic airmasses than in a continental, polluted one. Overall, the roughness and complexity is expected to lead to increased shortwave cloud reflectivity, in comparison with cirrus composed of more regular, smooth ice crystal shapes. These findings put into question suggestions that climate could be modified through aerosol seeding to reduce cirrus cover and optical depth, as the seeding may result in decreased shortwave reflectivity.Peer reviewe
Working relationships for sustainability: Improving work-based relationships in local government to bring about sustainability goals
Theres no escape: we are always in relationship. Being aware of this matters. Doing something to build constructive relationships for sustainability, matters even more. This paper considers the connection between good relationships and effective sustainability work in local government. It draws on the collective experiences of four practitioners who have worked over many years in, with or for local government and argues that a good deal of project success is contingent upon the development of positive relationships with stakeholders, contractors, communities, businesses, colleagues, partners and other agencies and agency officers
Instrumentation for hydrogen slush storage containers
Hydrogen liquid and slush tank continuous inventory during ground storag
Lunar Surface Potential Changes Possible Associated with Traversals of the Bow Shock
We report an analysis of seven Apollo 14 Apollo Lunar Surface Experiments Package (ALSEP) Suprathermal Ion Detector Experiment (SIDE) "resonance" events from January 1972 through January 1973. The events appear to be associated with traversals of the Moon through the terrestrial bow shock
The Angular Momentum Evolution of Very Low Mass Stars
We present theoretical models of the angular momentum evolution of very low
mass stars (0.1 - 0.5 M_sun) and solar analogues (0.6 - 1.1 M_sun). We
investigate the effect of rotation on the effective temperature and luminosity
of these stars. We find that the decrease in T_eff and L can be significant at
the higher end of our mass range, but becomes negligible below 0.4 M_sun.
Formulae for relating T_eff to mass and v_rot are presented.
We compare our models to rotational data from young open clusters of
different ages to infer the rotational history of low mass stars, and the
dependence of initial conditions and rotational evolution on mass. We find that
the qualitative conclusions for stars below 0.6 M_sun do not depend on the
assumptions about internal angular momentum transport, which makes these low
mass stars ideal candidates for the study of the angular momentum loss law and
distribution of initial conditions. We find that neither models with solid body
nor differential rotation can simultaneously reproduce the observed stellar
spin down in the 0.6 to 1.1 M_sun mass range and for stars between 0.1 and 0.6
M_sun. The most likely explanation is that the saturation threshold drops more
steeply at low masses than would be predicted with a simple Rossby scaling. In
young clusters there is a systematic increase in the mean rotation rate with
decreased temperature below 3500 K (0.4 M_sun). This suggests either
inefficient angular momentum loss or mass-dependent initial conditions for
stars near the fully convective boundary. (abridged)Comment: To appear in the May 10, 2000 Ap
- …