7 research outputs found
Attention deficit hyperactivity disorder symptoms and cannabis use after 1 year among students of the i-Share cohort
ADHD; Cannabis; StudentsTDAH; Canabis; EstudiantesTDAH; CĂ nnabis; EstudiantsBackground
Cannabis use in university students is associated with academic achievement failure and health issues. The objective of the study was to evaluate the association between attention deficit hyperactivity disorder (ADHD) symptoms and cannabis use after 1 year among students according to previous cannabis use.
Methods
Students in France were recruited from February 2013 to July 2020 in the i-Share cohort. 4,270 participants were included (2,135 who never used cannabis at inclusion and 2,135 who did). The Adult ADHD Self-Report Scale (ASRS) was used to assess ADHD symptoms at inclusion. Cannabis use frequency was evaluated 1 year after inclusion. Multinomial regressions were conducted to assess the association between inclusion ADHD symptoms and cannabis use after 1 year.
Results
Increase in ASRS scores was linked with a greater probability to use cannabis after 1 year and to have a higher cannabis use frequency (once a yearâonce a month adjusted odds ratio [OR]: 1.24 (1.15â1.34), more than once a month adjusted OR: 1.43 (1.27â1.61)). Among participants who never used cannabis at inclusion, this association disappeared (once a yearâonce a month adjusted OR: 1.15 (0.95â1.39), more than once a month adjusted OR: 1.16 (0.67â2)) but remained in participants who ever used cannabis at inclusion (once a yearâonce a month adjusted OR: 1.17 (1.06â1.29), more than once a month adjusted OR: 1.35 (1.18â1.55)).
Conclusions
High levels of ADHD symptoms in students could lead to continued cannabis use rather than new initiations.The preparation and initiation of the i-Share project was funded by the program âInvest for futureâ (reference ANR-10-COHO-05). The i-Share Project is currently supported by an unrestricted grant from the Nouvelle-Aquitaine Regional Council (Conseil RĂ©gional Nouvelle-Aquitaine) (grant number: 4370420) and by the Bordeaux âInitiatives dâexcellenceâ (IdEx) program of the University of Bordeaux (ANR-10-IDEX-03-02). It has also received grants from the Nouvelle-Aquitaine Regional Health Agency (Agence RĂ©gionale de SantĂ© Nouvelle-Aquitaine, grant N°6066R-8 R-8), Public Health France (SantĂ© Publique France, grant number: 19DPPP023â0), the National Cancer Institute (Insitut national du cancer, grant number: INCa_11502), and the Medical Research Foundation (Fondation pour la recherche)
Co-translational assembly and localized translation of nucleoporins in nuclear pore complex biogenesis
mRNA translation is coupled to multiprotein complex assembly in the cytoplasm or to protein delivery into intracellular compartments. Here, by combining systematic RNA immunoprecipitation and single-molecule RNA imaging in yeast, we have provided a complete depiction of the co-translational events involved in the biogenesis of a large multiprotein assembly, the nuclear pore complex (NPC). We report that binary interactions between NPC subunits can be established during translation, in the cytoplasm. Strikingly, the nucleoporins Nup1/Nup2, together with a number of nuclear proteins, are instead translated at nuclear pores, through a mechanism involving interactions between their nascent N-termini and nuclear transport receptors. Uncoupling this co-translational recruitment further triggers the formation of cytoplasmic foci of unassembled polypeptides. Altogether, our data reveal that distinct, spatially segregated modes of co-translational interactions foster the ordered assembly of NPC subunits and that localized translation can ensure the proper delivery of proteins to the pore and the nucleus
Medical conditions and Attention-Deficit/Hyperactivity Disorder symptoms from early childhood to adolescence
The comorbidity between physical and mental health conditions is challenging and frequently goes unrecognized in practice. Associations between Attention-Deficit/Hyperactivity Disorder (ADHD) and physical conditions have been reported in youth. However, prior research failed to: (1) address the patterns of associations in early childhood, middle childhood, and adolescence within the same population sample; (2) consider a large set of physical disorders at the same time; (3) take confounders into account. Our goal was to assess the associations between ADHD symptoms and a broad set of physical conditions across developmental periods. This birth cohort study (n = 2057) is the first to explore the associations between ADHD and a wide range of medical conditions by encompassing the whole early development from 5 months to 17 years in the same sample and relying on innovative network analyses. We found significant associations between ADHD symptoms and several physical conditions, some of which were observed in early childhood, middle childhood, and adolescence (e.g., asthma, sleep problems) or were confounded by socioeconomic status or psychiatric comorbidities (e.g., body mass index, dental caries). The study calls for an effective integrated care model encompassing mental and general healthcare across the developmental period.</p
Patientâs early satisfaction with care: a predictor of health-related quality of life change among outpatients with substance dependence
International audienc
Attention deficit hyperactivity disorder symptoms and cannabis use after 1 year among students of the i-Share cohort
Cannabis use in university students is associated with academic achievement failure and health issues. The objective of the study was to evaluate the association between attention deficit hyperactivity disorder (ADHD) symptoms and cannabis use after 1 year among students according to previous cannabis use. Students in France were recruited from February 2013 to July 2020 in the i-Share cohort. 4,270 participants were included (2,135 who never used cannabis at inclusion and 2,135 who did). The Adult ADHD Self-Report Scale (ASRS) was used to assess ADHD symptoms at inclusion. Cannabis use frequency was evaluated 1 year after inclusion. Multinomial regressions were conducted to assess the association between inclusion ADHD symptoms and cannabis use after 1 year. Increase in ASRS scores was linked with a greater probability to use cannabis after 1 year and to have a higher cannabis use frequency (once a year-once a month adjusted odds ratio [OR]: 1.24 (1.15-1.34), more than once a month adjusted OR: 1.43 (1.27-1.61)). Among participants who never used cannabis at inclusion, this association disappeared (once a year-once a month adjusted OR: 1.15 (0.95-1.39), more than once a month adjusted OR: 1.16 (0.67-2)) but remained in participants who ever used cannabis at inclusion (once a year-once a month adjusted OR: 1.17 (1.06-1.29), more than once a month adjusted OR: 1.35 (1.18-1.55)). High levels of ADHD symptoms in students could lead to continued cannabis use rather than new initiations
Des données urbaines
Le Dossier sâintĂ©resse Ă la fabrique de donnĂ©es urbaines et Ă leurs usages pour analyser les conditions numĂ©riques de la transformation de la ville. Les Notes de recherche portent sur le pĂ©titionnement en ligne, lâidentitĂ©, la dĂ©sinformation et la polarisation idĂ©ologique sur Facebook, lâĂ©conomie des images dans un parc Ă thĂšme hollywoodien et la place des blogs dans lâĂ©conomie vitivinicole. La rubrique En VO questionne le rĂŽle de Facebook dans la communication des partis politiques. Deux Focus proposent une lecture approfondie dâune Ćuvre rĂ©cente â LâĂre du clash de Christian Salmon â et dâune Ćuvre plus ancienne â The Fall of the Public Man de Richard Sennett. Les Notes de lecture recensent 50 publications. The Issue explores the city in a digital context. He questions the production of data and their uses (representations, interpretations, circulations, ethics, knowledge statuses) by âdoersâ and researchers to analyze the digital conditions of the urban transformation. The five Research Notes cover online petitioning, identity through the case of the writer Max Jacob, disinformation and ideological polarization on Facebook, the economics of images in a Hollywood theme park and the place of the blogs in the economy of the wine sector. The section In Original Version examines Facebookâs role in the communication of political parties. Two Focus provide an in-depth reading of a recent work by Christian Salmon â LâĂre du clash â and of an older one by Richard Sennett â The Fall of the Public Man. The Book Reviews offer succinct overviews and analyses of 50 publications