How people matter why it affects health, happiness, love, work, and society

"This deeply illuminating volume is essential reading for those interested in mattering, meaning in life, happiness, and mental health. The authors provide a wonderfully comprehensive, integrative overview of mattering in a wide variety of life domains and its power to positively transform our love relationships and ourselves. I warmly recommend this groundbreaking book as the go-to resource for students, professionals, researchers, and the general public interested in better understanding how to approach the topic of mattering and how to use the useful insights provided by the authors in order to reach a happier and more meaningful life. MarioMikulincer, Founding Dean, Baruch Ivcher School of Psychology, Interdisciplinary Center (IDC), Herzliya; author of Human Learned Helplessness and Attachment in Adulthood: Structure, Dynamics, and Change; editor of the Herzliya APA Series on Personality and Social Psychology"-

How people thrive promoting the synergy of wellness, fairness, and worthiness

"While most definitions of happiness (e.g., Ryan & Deci, 2017; Ryff, 1989), flourishing (Seligman, 2011), and thriving (Brown et al., 2017; Carver, 1998; Kleine et al., 2018; Seppälä et al., 2020) acknowledge the role of interpersonal relations; there is not much discussion of other contextual factors, such as experiences of fairness and equality, let alone the role of power or capitalism. And yet, injustice (Prilleltensky, 2012), inequality (Payne, 2017), power differentials (Ponsford et al., 2021; Prilleltensky, 2008), exclusion (Riva & Eck, 2016), neoliberal ideologies (Adams et al., 2019) and capitalism (Kasser at al., 2007) play a considerable role in our ability to live life to the fullest"-

Civetta, Taylor, & Kirby's manual of critical care

Includes index

Conan Doyle's best books : in three volumes : illustrated : A study in scarlet and other stories.

Forms part of the Core Materials of the C. Frederick Kittle Collection of Doyleana at the Newberry Library.Contemporary blind-stamped dark gray cloth binding; Steele's portrait of Sherlock Holmes smoking a pipe, stamped in black and gold, and signed [by engraver?] "DD", in center of upper board.Vol. I, "A study in scarlet and other stories", has frontispiece photographic portrait of Conan Doyle, inscribed "Yours as of yore, Arthur Conan Doyle." Vols. II and III, "The sign of the four and other stories", and "The White Company. Beyond the city", respectively, contain black and orange frontispiece illustrations of Sherlock Holmes by Frederic Dorr Steele, one of which is dated 1903.Dummy contains frontispieces and title pages in orange and black from each v.; a list of stories contained in the three volumes; and excerpts from two works: p. 137-160 of "A study in scarlet"; and p. 49-72 of "The sign of the four."Publisher's dummy issued for the Sherlock Holmes ed. of "Conan Doyle's best books", a collection of 24 stories published as a 3 v. set by P.F. Collier & Son around 1904. Included in v. 1 of the set was an introduction by Dr. Harold Emery Jones, "The original of Sherlock Holmes."Mode of access: Internet.C. Frederick Kittle, M.D.

Citation analysis of scientific categories

Databases catalogue the corpus of research literature into scientific categories and report classes of bibliometric data such as the number of citations to articles, the number of authors, journals, funding agencies, institutes, references, etc. The number of articles and citations in a category are gauges of productivity and scientific impact but a quantitative basis to compare researchers between categories is limited. Here, we compile a list of bibliometric indicators for 236 science categories and citation rates of the 500 most cited articles of each category. The number of citations per paper vary by several orders of magnitude and are highest in multidisciplinary sciences, general internal medicine, and biochemistry and lowest in literature, poetry, and dance. A regression model demonstrates that citation rates to the top articles in each category increase with the square root of the number of articles in a category and decrease proportionately with the age of the references: articles in categories that cite recent research are also cited more frequently. The citation rate correlates positively with the number of funding agencies that finance the research. The category h-index correlates with the average number of cites to the top 500 ranked articles of each category (R2=0.997). Furthermore, only a few journals publish the top 500 cited articles in each category: four journals publish 60% (σ=±20%) of these and ten publish 81% (σ=±15%)

Genetic effects on gene expression across human tissues.

Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels across individuals and diverse tissues of the human body, many of which are not easily accessible. Here we describe genetic effects on gene expression levels across 44 human tissues. We find that local genetic variation affects gene expression levels for the majority of genes, and we further identify inter-chromosomal genetic effects for 93 genes and 112 loci. On the basis of the identified genetic effects, we characterize patterns of tissue specificity, compare local and distal effects, and evaluate the functional properties of the genetic effects. We also demonstrate that multi-tissue, multi-individual data can be used to identify genes and pathways affected by human disease-associated variation, enabling a mechanistic interpretation of gene regulation and the genetic basis of disease

L-α-Glycerophosphocholine Contributes to Meat's Enhancement of Nonheme Iron Absorption

In this research, our aim was to isolate and characterize the substance known as “meat factor,” which is reported to enhance nonheme iron absorption. We used various analytical techniques, and the final step was a human study to measure the effect of a candidate compound on iron absorption. Lean beef was selected for study, as it is known to increase nonheme iron absorption. Cooked ground beef was homogenized and aliquots were taken through a simulated gastric and intestinal digestion. This was followed by purification using fast protein liquid chromatography. The fractions were collected and applied to a Caco-2 cell system designed to measure iron absorption using radioiron. Fractions with an enhancing effect were analyzed by mass spectrometry, nuclear magnetic resonance, and HPLC, and a proposed empirical formula was obtained for the substance in the most active fraction (C8H20 NO6P). Tandem mass spectrometry was used to identify the compound as L-α-glycerophosphocholine (L-α) by comparing the spectra against authentic material. We added a commercially available food grade source of L-α to vegetarian lasagna, with and without 100 mg ascorbic acid (a known enhancer of nonheme iron absorption), at the same enhancer:iron molar ratio (2:1), and fed meals to 13 women of child-bearing age with low iron stores. The nonheme iron was labeled with stable isotopes of iron to provide a total dose per meal of 10 mg iron, and absorption was measured from erythrocyte incorporation. Nonheme iron absorption from lasagna was increased by the addition of either ascorbic acid (P = 0.010) or L-α (P = 0.023). We have identified L-α as a component of muscle tissue that enhances nonheme iron absorption, and this finding provides new opportunities for iron fortification of foods