Extracting the Mass Dependence and Quantum Numbers of Short-Range Correlated Pairs from A(e,e'p) and A(e,e'pp) Scattering

The nuclear mass dependence of the number of short-range correlated (SRC) proton-proton (pp) and proton-neutron (pn) pairs in nuclei is a sensitive probe of the dynamics of short-range pairs in the ground state of atomic nuclei. This work presents an analysis of electroinduced single-proton and two-proton knockout measurements off 12C, 27Al, 56Fe, and 208Pb in kinematics dominated by scattering off SRC pairs. The nuclear mass dependence of the observed A(e,e'pp)/12C(e,e'pp) cross-section ratios and the extracted number of pp- and pn-SRC pairs are much softer than the mass dependence of the total number of possible pairs. This is in agreement with a physical picture of SRC affecting predominantly nucleon-nucleon pairs in a nodeless relative-S state of the mean-field basis.Comment: 6 pages, 3 figure

Role of IRAK-M in Alcohol Induced Liver Injury

Increasing evidence suggests that innate immunity plays an important role in alcohol-induced liver injury and most studies have focused on positive regulation of innate immunity. The main objective of this study was to investigate the negative regulator of innate immunity, IL-1/Toll-like receptor (TLR) signaling pathways and interleukin receptor-associated kinase-M (IRAK-M) in alcoholic liver injury. We established an alcohol-induced liver injury model using wild type and IRAK-M deficient B6 mice and investigated the possible mechanisms. We found that in the absence of IRAK-M, liver damage by alcohol was worse with higher alanine transaminase (ALT), more immune cell infiltration and increased numbers of IFNγ producing cells. We also found enhanced phagocytic activity in CD68+ cells. Moreover, our results revealed altered gut bacteria after alcohol consumption and this was more striking in the absence of IRAK-M. Our study provides evidence that IRAK-M plays an important role in alcohol-induced liver injury and IRAK-M negatively regulates the innate and possibly the adaptive immune response in the liver reacting to acute insult by alcohol. In the absence of IRAK-M, the hosts developed worse liver injury, enhanced gut permeability and altered gut microbiota

The broad-line type Ic SN 2020bvc: signatures of an off-axis gamma-ray burst afterglow

Long-duration gamma-ray bursts (GRBs) are almost unequivocally associated with very energetic, broad-lined supernovae (SNe) of Type Ic-BL. While the gamma-ray emission is emitted in narrow jets, the SN emits radiation isotropically. Therefore, some SN Ic-BL not associated with GRBs have been hypothesized to arise from events with inner engines such as off-axis GRBs or choked jets. Here we present observations of the nearby ($d = 120$ Mpc) SN 2020bvc (ASAS-SN 20bs) which support this scenario. \textit{Swift} UVOT observations reveal an early decline (up to two days after explosion) while optical spectra classify it as a SN Ic-BL with very high expansion velocities ($\approx$ 70,000 km/s), similar to that found for the jet-cocoon emission in SN 2017iuk associated with GRB 171205A. Moreover, \textit{Swift} X-Ray Telescope and \textit{CXO} X-ray Observatory detected X-ray emission only three days after the SN and decaying onwards, which can be ascribed to an afterglow component. Cocoon and X-ray emission are both signatures of jet-powered GRBs. In the case of SN 2020bvc, we find that the jet is off axis (by $\approx$ 23 degrees), as also indicated by the lack of early ($\approx 1$ day) X-ray emission which explains why no coincident GRB was detected promptly or in archival data. These observations suggest that SN 2020bvc is the first orphan GRB detected through its associated SN emission.Comment: 9 pages, 6 figures, 5 tables. Accepted for publication in A&

Origin and evolution of the octoploid strawberry genome.

Cultivated strawberry emerged from the hybridization of two wild octoploid species, both descendants from the merger of four diploid progenitor species into a single nucleus more than 1 million years ago. Here we report a near-complete chromosome-scale assembly for cultivated octoploid strawberry (Fragaria × ananassa) and uncovered the origin and evolutionary processes that shaped this complex allopolyploid. We identified the extant relatives of each diploid progenitor species and provide support for the North American origin of octoploid strawberry. We examined the dynamics among the four subgenomes in octoploid strawberry and uncovered the presence of a single dominant subgenome with significantly greater gene content, gene expression abundance, and biased exchanges between homoeologous chromosomes, as compared with the other subgenomes. Pathway analysis showed that certain metabolomic and disease-resistance traits are largely controlled by the dominant subgenome. These findings and the reference genome should serve as a powerful platform for future evolutionary studies and enable molecular breeding in strawberry

Effectiveness and tolerability of pegylated interferon alfa2b in combination with ribavirin for treatment of chronic hepatitis C: the PegIntrust study

Background and study aims : Large international clinical trials conducted in the past 5 years rapidly improved the treatment of chronic hepatitis C; however, it is unclear whether the advances seen in clinical trials are being paralleled by similar improvements in routine clinical practice. PegIntrust is a Belgian community based trial evaluating the sustained virological response. Patients and Methods : Observational study of 219 patients receiving pegylated interferon alfa-2b (1.5 μg/kg/wk) and weight-based ribavirin (800-1200 mg/day) for 48 weeks. Primary study end point was sustained virological response (SVR), defined as undetectable HCV RNA 6 months after the completion of treatment. Results : In total, 108 patients (49.3 %) had undetectable HCV RNA at the end of therapy, 91 (41.6%) attaining SVR. Of the 111 patients without an end-of-treatment response, 28 were non-responders, and 21 had virological breakthrough. In total, 134 patients attained early virological response (EVR); 88 (65.7%) of those patients attained SVR. In contrast, 82 (96.5 %) of the 85 patients who did not attain EVR also did not attain SVR. Age, fibrosis score and baseline viral load were identified as important predictors of treatment outcome. The most frequently reported serious adverse events resulting in treatment discontinuation were anemia (n = 10), fatigue/asthenia/malaise (n = 6) and fever (n = 3). Conclusion : Our data indicate that treatment of chronic hepatitis C with PEG-IFN alfa-2b plus weight-based ribavirin results in favourable treatment outcomes in a Belgian cohort of patients treated in community- based clinical practice