The Human Sweet Tooth

Humans love the taste of sugar and the word "sweet" is used to describe not only this basic taste quality but also something that is desirable or pleasurable, e.g., la dolce vita. Although sugar or sweetened foods are generally among the most preferred choices, not everyone likes sugar, especially at high concentrations. The focus of my group's research is to understand why some people have a sweet tooth and others do not. We have used genetic and molecular techniques in humans, rats, mice, cats and primates to understand the origins of sweet taste perception. Our studies demonstrate that there are two sweet receptor genes (TAS1R2 and TAS1R3), and alleles of one of the two genes predict the avidity with which some mammals drink sweet solutions. We also find a relationship between sweet and bitter perception. Children who are genetically more sensitive to bitter compounds report that very sweet solutions are more pleasant and they prefer sweet carbonated beverages more than milk, relative to less bitter-sensitive peers. Overall, people differ in their ability to perceive the basic tastes, and particular constellations of genes and experience may drive some people, but not others, toward a caries-inducing sweet diet. Future studies will be designed to understand how a genetic preference for sweet food and drink might contribute to the development of dental caries

Engineering design of a Permeator Against Vacuum mock-up with niobium membrane

Permeator Against Vacuum (PAV) is one of the technologies proposed for the Tritium Extraction and Removal System (TERS) of the Water-Cooled Lithium Lead Breeding Blanket (WCLL BB). The paper presents the activity aimed at the engineering design of a PAV mock-up with a niobium membrane, in order to later assemble and qualify it. Experience gained in the engineering design of the mock-up, the heating system, the instrumentation, and the vacuum line is illustrated. This experience will be useful for the preliminary design, the manufacturing and the operation of the PAV with niobium membrane for DEMO. Niobium was selected as membrane material of this mock-up because of its high permeability and for its lower cost compared to vanadium, the other candidate material for membranes. Besides, niobium has a lower tendency to oxidation than vanadium. Oxidation would reduce the hydrogen isotopes permeation flux. In this paper, the solution adopted to manufacture the PAV mock-up, a complex component with niobium and P22 parts, is illustrated. The Nb/P22 welding issues are also presented, in particular related to the compatibility of the welded joints with LiPb. In the chosen design, the LiPb flows with two passages in 16 (8 + 8) niobium “U” shaped pipes installed in a vacuum chamber and welded to a P22 plate. The U-pipes configuration was selected to minimize the welding area, the volume of the component and the membrane thickness while trying to preserve the highest possible extraction efficiency

Design and Integration of the WCLL Tritium Extraction and Removal System into the European DEMO Tokamak Reactor

The latest progress in the design of the water-cooled lithium-lead (WCLL) tritium extraction and removal (TER) system for the European DEMO tokamak reactor is presented. The implementation and optimization of the conceptual design of the TER system are performed in order to manage the tritium concentration in the LiPb and ancillary systems, to control the LiPb chemistry, to remove accumulated corrosion and activated products (in particular, the helium generated in the BB), to store the LiPb, to empty the BB segments, to shield the equipment due to LiPb activation, and to accommodate possible overpressure of the LiPb. The LiPb volumes in the inboard (IB) and outboard (OB) modules of the BB are separately managed due to the different pressure drops and required mass flow rates in the different plasma operational phases. Therefore, the tritium extraction is managed by 6 LiPb loops: 4 loops for the OB segments and 2 loops for the IB segments. Each one is a closed loop with forced circulation of the liquid metal through the TER and the other ancillary systems. The design presents the new CAD drawings and the integration of the TEU into the tokamak building, designed on the basis of an experimental characterization carried out for the permeator against vacuum (PAV) and gas-liquid contactor (GLC) technologies, the two most promising technologies for tritium extraction from liquid metal

Design and Integration of the EU-DEMO Water-Cooled Lead Lithium Breeding Blanket

The water-cooled lead lithium breeding blanket (WCLL BB) is one of two BB candidate concepts to be chosen as the driver blanket of the EU-DEMO fusion reactor. Research activities carried out in the past decade, under the umbrella of the EUROfusion consortium, have allowed a quite advanced reactor architecture to be achieved. Moreover, significant efforts have been made in order to develop the WCLL BB pre-conceptual design following a holistic approach, identifying interfaces between components and systems while respecting a system engineering approach. This paper reports a description of the current WCLL BB architecture, focusing on the latest modifications in the BB reference layout aimed at evolving the design from its pre-conceptual version into a robust conceptual layout. In particular, the main rationale behind design choices and the BB’s overall performances are highlighted. The present paper also gives an overview of the integration between the BB and the different in-vessel systems interacting with it. In particular, interfaces with the tritium extraction and removal (TER) system and the primary heat transfer system (PHTS) are described. Attention is also paid to auxiliary systems devoted to heat the plasma, such as electron cyclotron heating (ECH). Indeed, the integration of this system in the BB will strongly impact the segment design since it envisages the introduction of significant cut-outs in the BB layout. A preliminary CAD model of the central outboard blanket (COB) segment housing the ECH cut-out has been set up and is reported in this paper. The chosen modeling strategy, adopted loads and boundary conditions, as well as obtained results, are reported in the paper and critically discussed

A proposal of definition of early symptomatic knee osteoarthritis (ESKOA). Results from an international consensus promoted by the Italian society of rheumatology (SIR)

Background: In the literature, no validated definition of Early Symptomatic Knee OsteoArthritis (ESKOA) is available. Objectives: The Italian Society of Rheumatology (SIR) organized an international consensus to provide a proposal of a definition of ESKOA. Methods: A set of focus groups were held with expert clinicians, basic science researchers, and patients in order to identify signs, symptoms, and risk factors of ESKOA. In parallel, a systematic literature reviewed the existing definitions of ESKOA. An international panel of experts, convened by the SIR, identified a set of disease constructs; these constructs underwent two Delphi rounds for prioritisation and weighting of items to include in a definition of ESKOA. Finally, during a face to face meeting, the panel agreed on a final proposal for the definition of ESKOA. Results: The systematic review failed to identify any validated definition of ESKOA. The focus groups identified 46 items, among risk factors, signs, and symptoms, which could reflect a pre-radiographic stage of knee OA. After the first expert meeting, these items were reduced to 15, then two Delphi rounds, by the weighting of items, led to the ranking of the criteria. A further evaluation led to a final definition of an algorithm for the identification of patients affected by ESKOA (Figure 1). Conclusions: The diagnosis of ESKOA is today possible and opens a relevant problem that is the identification of the therapeutic regimens needed to slow down disease progression. The early identification of ESKOA patients might allow a better quality of life significantly reducing the social and health systems costs. A validation study aimed to confirm the appropriateness of these criteria is warranted. (Figure Presented)