Cysteine 893 is a target of regulatory thiol modifications of GluA1 AMPA receptors

Recent studies indicate that glutamatergic signaling involves, and is regulated by, thiol modifying and redox-active compounds. In this study, we examined the role of a reactive cysteine residue, Cys-893, in the cytosolic C-terminal tail of GluA1 AMPA receptor as a potential regulatory target. Elimination of the thiol function by substitution of serine for Cys-893 led to increased steady-state expression level and strongly reduced interaction with SAP97, a major cytosolic interaction partner of GluA1 C-terminus. Moreover, we found that of the three cysteine residues in GluA1 C-terminal tail, Cys-893 is the predominant target for Snitrosylation induced by exogenous nitric oxide donors in cultured cells and lysates. Co-precipitation experiments provided evidence for native association of SAP97 with neuronal nitric oxide synthase (nNOS) and for the potential coupling of Ca2+- permeable GluA1 receptors with nNOS via SAP97. Our results show that Cys-893 can serve as a molecular target for regulatory thiol modifications of GluA1 receptors, including the effects of nitric oxide.Peer reviewe

Strange chiral nucleon form factors

We investigate the strange electric and magnetic form factors of the nucleon in the framework of heavy baryon chiral perturbation theory to third order in the chiral expansion. All counterterms can be fixed from data. In particular, the two unknown singlet couplings can be deduced from the parity-violating electron scattering experiments performed by the SAMPLE and the HAPPEX collaborations. Within the given uncertainties, our analysis leads to a small and positive electric strangeness radius, $= (0.05 \pm 0.09) fm^2$. We also deduce the consequences for the upcoming MAMI A4 experiment.Comment: 7 pp, REVTeX, uses epsf, minor correction

The personal belief in a just world and domain-specific beliefs about justice at school and in the family: A longitudinal study with adolescents

This article investigates the relationship between the personal belief in a just world (BJW) and domain-specific beliefs about justice and examines how justice cognitions impact on adolescents' development, particularly on their achievement at school and their subjective well-being. A longitudinal questionnaire study with German adolescents aged 14-19 years was conducted over a period of five to eight months. The pattern of results revealed that evaluations of the school climate and of the family climate as being just were two distinct phenomena, both of which impacted on the personal BJW, which in turn affected the domain-specific beliefs about justice. However, the domain-specific beliefs about justice did not impact on each other directly. Moreover, an evaluation of the family climate (but not of the school climate) as being just reduced depressive symptoms, whereas depressive symptoms did not weaken the evaluation of one's family as being just. The evaluation of the school climate as being just improved the grades received in the next school report, whereas the grades received did not affect the justice evaluation of the school climate. Finally, all relationships persisted when controlling for age and gender. In sum, the pattern of findings supports the notion that justice cognitions impact on development during adolescence

The pace of plutonism

Beneath volcanoes are magmas that never erupt but that become frozen into feldspar- and quartz-rich rocks broadly called granite. Where the crystallized magmas form bodies with distinctive textures, they are grouped into named units-plutons. The rate (pace) at which magmas accumulate into plutons is fundamental to understanding both how room is made for the magmas and how unerupted and erupted magmas are connected. Dating plutonic rocks suggests that plutons accumulate slowly. Although the pace of magma accumulation does not preclude direct connections between plutons and small volcanic eruptions, it appears to be far too slow to support connections between most plutons and supereruptions

TASI Lectures on the Cosmological Constant

The energy density of the vacuum, Lambda, is at least 60 orders of magnitude smaller than several known contributions to it. Approaches to this problem are tightly constrained by data ranging from elementary observations to precision experiments. Absent overwhelming evidence to the contrary, dark energy can only be interpreted as vacuum energy, so the venerable assumption that Lambda=0 conflicts with observation. The possibility remains that Lambda is fundamentally variable, though constant over large spacetime regions. This can explain the observed value, but only in a theory satisfying a number of restrictive kinematic and dynamical conditions. String theory offers a concrete realization through its landscape of metastable vacua.Comment: 39 pages, 3 figure

Thermal Decay of the Cosmological Constant into Black Holes

We show that the cosmological constant may be reduced by thermal production of membranes by the cosmological horizon, analogous to a particle ``going over the top of the potential barrier", rather than tunneling through it. The membranes are endowed with charge associated with the gauge invariance of an antisymmetric gauge potential. In this new process, the membrane collapses into a black hole, thus the net effect is to produce black holes out of the vacuum energy associated with the cosmological constant. We study here the corresponding Euclidean configurations ("thermalons"), and calculate the probability for the process in the leading semiclassical approximation.Comment: 14 pages, 6 figures. Minor correction

Is the classical Bukhvostov-Lipatov model integrable? A Painlev\'e analysis

In this work we apply the Weiss, Tabor and Carnevale integrability criterion (Painlev\'e analysis) to the classical version of the two dimensional Bukhvostov-Lipatov model. We are led to the conclusion that the model is not integrable classically, except at a trivial point where the theory can be described in terms of two uncoupled sine-Gordon models

Glueballs and k-strings in SU(N) gauge theories : calculations with improved operators

We test a variety of blocking and smearing algorithms for constructing glueball and string wave-functionals, and find some with much improved overlaps onto the lightest states. We use these algorithms to obtain improved results on the tensions of k-strings in SU(4), SU(6), and SU(8) gauge theories. We emphasise the major systematic errors that still need to be controlled in calculations of heavier k-strings, and perform calculations in SU(4) on an anisotropic lattice in a bid to minimise one of these. All these results point to the k-string tensions lying part-way between the `MQCD' and `Casimir Scaling' conjectures, with the power in 1/N of the leading correction lying in [1,2]. We also obtain some evidence for the presence of quasi-stable strings in calculations that do not use sources, and observe some near-degeneracies between (excited) strings in different representations. We also calculate the lightest glueball masses for N=2, ...,8, and extrapolate to N=infinity, obtaining results compatible with earlier work. We show that the N=infinity factorisation of the Euclidean correlators that are used in such mass calculations does not make the masses any less calculable at large N.Comment: 49 pages, 15 figure

The Magnetic Moments of the Octet Baryons in Quenched Chiral Perturbation Theory

We compute the magnetic moments of the octet baryons up to two orders in quenched chiral perturbation theory. In addition to the $\sim\sqrt{m_q}$ contributions that arise in QCD, there are lower-order contributions of the form $M_0^2\log m_q$ from loop diagrams involving hairpin interactions.Comment: 18 pages, 3 figures, late