Desarrollo de un sistema informático de trazabilidad para las aceitunas de Córdoba : Primera etapa

La producción olivícola constituye una actividad relevante del sector noroeste de la provincia de Córdoba. Las empresas regionales no realizan un control sistemático de los procesos productivos de las aceitunas de mesa, lo que limita su espectro de comercialización. El propósito del proyecto es desarrollar un sistema de trazabilidad para las aceitunas de mesa con el objeto de cumplir con los estándares de calidad requeridos. Para esto se estudió inicialmente la normativa vigente, se realizó un relevamiento sobre antecedentes de trazabilidad en un grupo de industrias regionales y se efectuaron consultas a proveedores y clientes. En una segunda instancia, y en función del lay out del proceso, se midieron el alcance de las etapas definiendo un criterio lógico de agrupación y vinculación tanto interna como externa. Finalmente, se crearon planillas en soporte papel incluyendo en cada una el ámbito de aplicación, registro de las operaciones efectuadas y procedimientos de revisión y actualización. Además, se establecieron los mecanismos de comunicación intra e ínter empresas, estableciendo protocolos comunes acerca de la información a compartir. Así, se logró disponer en soporte papel de la estructura sistemática que dará origen al desarrollo informático a implementar en las empresas elaboradoras de aceitunas de Cruz del Eje, Córdoba.Olive industries constitute a relevant activity in the nor-western sector of Córdoba province. Local companies do not perform a systematic control of the productive processes of table olives, which limits their commercialization range. The purpose of the project is to develop a Traceability system for table olive to fulfill with the quality standards required. Toward this end the existing regulations were studied initially, an investigation of precedent application of traceability in the local industries was made and clients and suppliers of such companies were consulted on the matter. In a second phase the range of the stages was measured defining a logical criterion of grouping them and internal as well as external relations. Finally paper support of the data sheets was made including on them where they were filled, a complete record of the performed operations and the revision and update of the sheets. Besides communication mechanisms were established between industries and within themselves, implementing common protocols about the information to be shared. Doing so, the systematic structure that will sustained the informatics’ development to implement in the olive industries of Cruz del Eje Córdoba, was managed.Sociedad Argentina de Informática e Investigación Operativ

Uncovering obsessive-compulsive disorder risk genes in a pediatric cohort by high-resolution analysis of copy number variation

Abstract Background Obsessive-compulsive disorder (OCD) is a heterogeneous neuropsychiatric condition, thought to have a significant genetic component. When onset occurs in childhood, affected individuals generally exhibit different characteristics from adult-onset OCD, including higher prevalence in males and increased heritability. Since neuropsychiatric conditions are associated with copy number variations (CNVs), we considered their potential role in the etiology of OCD. Methods We genotyped 307 unrelated pediatric probands with idiopathic OCD (including 174 that were part of complete parent-child trios) and compared their genotypes with those of 3861 population controls, to identify rare CNVs (<0.5 % frequency) of at least 15 kb in size that might contribute to OCD. Results We uncovered de novo CNVs in 4/174 probands (2.3 %). Our case cohort was enriched for CNVs in genes that encode targets of the fragile X mental retardation protein (nominal p = 1.85 × 10−03; FDR=0.09), similar to previous findings in autism and schizophrenia. These results also identified deletions or duplications of exons in genes involved in neuronal migration (ASTN2), synapse formation (NLGN1 and PTPRD), and postsynaptic scaffolding (DLGAP1 and DLGAP2), which may be relevant to the pathogenesis of OCD. Four cases had CNVs involving known genomic disorder loci (1q21.1-21.2, 15q11.2-q13.1, 16p13.11, and 17p12). Further, we identified BTBD9 as a candidate gene for OCD. We also sequenced exomes of ten “CNV positive” trios and identified in one an additional plausibly relevant mutation: a 13 bp exonic deletion in DRD4. Conclusions Our findings suggest that rare CNVs may contribute to the etiology of OCD.http://deepblue.lib.umich.edu/bitstream/2027.42/134675/1/11689_2016_Article_9170.pd

Indagini Geofisiche

Nell'ambito del progetto per la Microzonazione sismica dell'area aquilana, coordinata dal DPC, il Gruppo di Lavoro ha condotto le indagini di MS nella Conca di Roio.Published336-3854T. Sismologia, geofisica e geologia per l'ingegneria sismic