Enforcement Evasion Highlights Need for Better Satellite‐Based Forest Governance

Our recent article, “Are Brazil’s Deforesters Avoiding Detection?” demonstrated that focusing illegal deforestation enforcement on the subset of forest monitored by the flagship PRODES system has caused PRODES to capture a declining share of deforestation in the Brazilian Amazon. Deforesters may be purposively seeking out forests not monitored for enforcement. Addressing the problem would help Brazil maintain a cutting‐edge forest governance model worthy of transfer to other nations. Two commentaries questioned our decision to investigate solely PRODES and not additional government monitoring systems. We focused on PRODES because it is the most salient deforestation monitoring system. Other key deforestation monitoring systems are all either limited to the same monitoring footprint as PRODES, not used for enforcement, or are rarely used for measuring forest loss in the Brazilian Amazon. We do agree with the commentaries that Brazil’s new satellite monitoring protocol for greenhouse gas emissions estimation is critical progress of the type we were advocating in our original article.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/138285/1/conl12379_am.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/138285/2/conl12379.pd

Recent cropping frequency, expansion, and abandonment in Mato Grosso, Brazil had selective land characteristics

This letter uses satellite remote sensing to examine patterns of cropland expansion, cropland abandonment, and changing cropping frequency in Mato Grosso, Brazil from 2001 to 2011. During this period, Mato Grosso emerged as a globally important center of agricultural production. In 2001, 3.3 million hectares of mechanized agriculture were cultivated in Mato Grosso, of which 500 000 hectares had two commercial crops per growing season (double cropping). By 2011, Mato Grosso had 5.8 million hectares of mechanized agriculture, of which 2.9 million hectares were double cropped. We found these agricultural changes to be selective with respect to land attributes —significant differences (p \u3c 0.001) existed between the land attributes of agriculture versus nonagriculture, single cropping versus double cropping, and expansion versus abandonment. Many of the land attributes (elevation, slope, maximum temperature, minimum temperature, initial soy transport costs, and soil) that were associated with an increased likelihood of expansion were associated with a decreased likelihood of abandonment (p \u3c 0.001). While land similar to agriculture and double cropping in 2001 was much more likely to be developed for agriculture than all other land, new cropland shifted to hotter, drier, lower locations that were more isolated from agricultural infrastructure (p \u3c 0.001). The scarcity of high quality remaining agricultural land available for agricultural expansion in Mato Grosso could be contributing to the slowdown in agricultural expansion observed there over 2006 to 2011. Land use policy analyses should control for land scarcity constraints on agricultural expansion

Phenotypic Variation and Bistable Switching in Bacteria

Microbial research generally focuses on clonal populations. However, bacterial cells with identical genotypes frequently display different phenotypes under identical conditions. This microbial cell individuality is receiving increasing attention in the literature because of its impact on cellular differentiation, survival under selective conditions, and the interaction of pathogens with their hosts. It is becoming clear that stochasticity in gene expression in conjunction with the architecture of the gene network that underlies the cellular processes can generate phenotypic variation. An important regulatory mechanism is the so-called positive feedback, in which a system reinforces its own response, for instance by stimulating the production of an activator. Bistability is an interesting and relevant phenomenon, in which two distinct subpopulations of cells showing discrete levels of gene expression coexist in a single culture. In this chapter, we address techniques and approaches used to establish phenotypic variation, and relate three well-characterized examples of bistability to the molecular mechanisms that govern these processes, with a focus on positive feedback.

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial

Background: Many patients with COVID-19 have been treated with plasma containing anti-SARS-CoV-2 antibodies. We aimed to evaluate the safety and efficacy of convalescent plasma therapy in patients admitted to hospital with COVID-19. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]) is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. The trial is underway at 177 NHS hospitals from across the UK. Eligible and consenting patients were randomly assigned (1:1) to receive either usual care alone (usual care group) or usual care plus high-titre convalescent plasma (convalescent plasma group). The primary outcome was 28-day mortality, analysed on an intention-to-treat basis. The trial is registered with ISRCTN, 50189673, and ClinicalTrials.gov, NCT04381936. Findings: Between May 28, 2020, and Jan 15, 2021, 11558 (71%) of 16287 patients enrolled in RECOVERY were eligible to receive convalescent plasma and were assigned to either the convalescent plasma group or the usual care group. There was no significant difference in 28-day mortality between the two groups: 1399 (24%) of 5795 patients in the convalescent plasma group and 1408 (24%) of 5763 patients in the usual care group died within 28 days (rate ratio 1·00, 95% CI 0·93–1·07; p=0·95). The 28-day mortality rate ratio was similar in all prespecified subgroups of patients, including in those patients without detectable SARS-CoV-2 antibodies at randomisation. Allocation to convalescent plasma had no significant effect on the proportion of patients discharged from hospital within 28 days (3832 [66%] patients in the convalescent plasma group vs 3822 [66%] patients in the usual care group; rate ratio 0·99, 95% CI 0·94–1·03; p=0·57). Among those not on invasive mechanical ventilation at randomisation, there was no significant difference in the proportion of patients meeting the composite endpoint of progression to invasive mechanical ventilation or death (1568 [29%] of 5493 patients in the convalescent plasma group vs 1568 [29%] of 5448 patients in the usual care group; rate ratio 0·99, 95% CI 0·93–1·05; p=0·79). Interpretation: In patients hospitalised with COVID-19, high-titre convalescent plasma did not improve survival or other prespecified clinical outcomes. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial

Background: In this study, we aimed to evaluate the effects of tocilizumab in adult patients admitted to hospital with COVID-19 with both hypoxia and systemic inflammation. Methods: This randomised, controlled, open-label, platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing several possible treatments in patients hospitalised with COVID-19 in the UK. Those trial participants with hypoxia (oxygen saturation <92% on air or requiring oxygen therapy) and evidence of systemic inflammation (C-reactive protein ≥75 mg/L) were eligible for random assignment in a 1:1 ratio to usual standard of care alone versus usual standard of care plus tocilizumab at a dose of 400 mg–800 mg (depending on weight) given intravenously. A second dose could be given 12–24 h later if the patient's condition had not improved. The primary outcome was 28-day mortality, assessed in the intention-to-treat population. The trial is registered with ISRCTN (50189673) and ClinicalTrials.gov (NCT04381936). Findings: Between April 23, 2020, and Jan 24, 2021, 4116 adults of 21 550 patients enrolled into the RECOVERY trial were included in the assessment of tocilizumab, including 3385 (82%) patients receiving systemic corticosteroids. Overall, 621 (31%) of the 2022 patients allocated tocilizumab and 729 (35%) of the 2094 patients allocated to usual care died within 28 days (rate ratio 0·85; 95% CI 0·76–0·94; p=0·0028). Consistent results were seen in all prespecified subgroups of patients, including those receiving systemic corticosteroids. Patients allocated to tocilizumab were more likely to be discharged from hospital within 28 days (57% vs 50%; rate ratio 1·22; 1·12–1·33; p<0·0001). Among those not receiving invasive mechanical ventilation at baseline, patients allocated tocilizumab were less likely to reach the composite endpoint of invasive mechanical ventilation or death (35% vs 42%; risk ratio 0·84; 95% CI 0·77–0·92; p<0·0001). Interpretation: In hospitalised COVID-19 patients with hypoxia and systemic inflammation, tocilizumab improved survival and other clinical outcomes. These benefits were seen regardless of the amount of respiratory support and were additional to the benefits of systemic corticosteroids. Funding: UK Research and Innovation (Medical Research Council) and National Institute of Health Research

The resilience of integrated agricultural systems to climate change

We reviewed studies addressing the extent to which more integrated agricultural systems (IAS) have been found to be more resilient to climate variability and climate change than more specialized agricultural systems. We found limited literature directly addressing the topic, necessitating the use of proxy measures to enlarge the sample. Where necessary, we used agricultural system richness and diversity as proxies for the presence of the sort of synergistic relationships that typify IAS, interannual climate variability for climate change, and myriad agricultural indicators for resilience. We found that (1) 37 papers addressed the topic either through mathematical modeling or statistical modeling; (2) in the statistical papers, integration was overwhelmingly (n=17/24) associated with increased climate resilience; (3) these findings stemmed mainly from comparisons of more versus less diverse or rich farming systems, while few studies investigated the influence of farm system synergies on resilience; (4) yield, revenue, profit, and yield variance were all used to demonstrate resilience; (5) modeling studies tended to investigate resilience across multiple years, while most statistical approaches tracked single-year outcomes; (6) the IAS-climate resilience links demonstrated were not generalizable across units of analysis, spatiotemporal scale, and from autonomous to directed integration; and (7) few of the articles reviewed identified and measured the mechanism by which IAS were shown to have conferred resilience. Our findings reveal suggestive, although by no means conclusive, evidence that farm system integration can enhance resilience and highlight the need for research to test whether integration policies can have similar outcomes. For further resources related to this article, please visit the WIREs website

Forest loss in Brazil increases maximum temperatures within 50 km

Forest cover loss in the tropics is well known to cause warming at deforested sites, with maximum temperatures being particularly sensitive. Forest loss causes warming by altering local energy balance and surface roughness, local changes that can propagate across a wide range of spatial scales. Consequently, temperature increases result from not only changes in forest cover at a site, but also by the aggregate effects of non-local forest loss. We explored such non-local warming within Brazil’s Amazon and Cerrado biomes, the region with the world’s single largest amount of forest loss since 2000. Two datasets, one consisting of in-situ air temperature observations and a second, larger dataset consisting of ATs derived from remotely-sensed observations of land surface temperature, were used to quantify changes in maximum temperature due to forest cover loss at varying length-scales. We considered undisturbed forest locations (1 km ^2 in extent), and forest loss trends in annuli (‘halos’), located 1–2 km, 2–4 km, 4–10 km and 10–50 km from these undisturbed sites. Our research finds significant and substantial non-local warming, suggesting that historical estimates of warming due to forest cover loss under-estimate warming or mis-attribute warming to local change, where non-local changes also influence the pattern of temperature warming