1,615 research outputs found
Cottonfield Dance
https://digitalcommons.library.umaine.edu/mmb-ps/3233/thumbnail.jp
Inhibition of free radical-induced DNA damage by uric acid
AbstractSingle-strand DNA breaks were produced in isolated rat liver nuclei incubated with 3 separate oxygen free radical generating systems: xanthine oxidase-acetaldehyde plus Fe(II); hematin-R(H)OOH; Fe(II)-H2O2. Uric acid inhibited the induction of damage in the first two systems only. At concentrations below those found in human plasma, it was particularly effective against strand breaks produced by hematin-cumene hydroperoxide. These results offer additional evidence that uric acid may function as a cellular protective agent against Superoxide and hydroperoxyl free radical-induced cytotoxicity toxicity
Constant Approximation for -Median and -Means with Outliers via Iterative Rounding
In this paper, we present a new iterative rounding framework for many
clustering problems. Using this, we obtain an -approximation algorithm for -median with outliers, greatly
improving upon the large implicit constant approximation ratio of Chen [Chen,
SODA 2018]. For -means with outliers, we give an -approximation, which is the first -approximation for
this problem. The iterative algorithm framework is very versatile; we show how
it can be used to give - and -approximation
algorithms for matroid and knapsack median problems respectively, improving
upon the previous best approximations ratios of [Swamy, ACM Trans.
Algorithms] and [Byrka et al, ESA 2015].
The natural LP relaxation for the -median/-means with outliers problem
has an unbounded integrality gap. In spite of this negative result, our
iterative rounding framework shows that we can round an LP solution to an
almost-integral solution of small cost, in which we have at most two
fractionally open facilities. Thus, the LP integrality gap arises due to the
gap between almost-integral and fully-integral solutions. Then, using a
pre-processing procedure, we show how to convert an almost-integral solution to
a fully-integral solution losing only a constant-factor in the approximation
ratio. By further using a sparsification technique, the additive factor loss
incurred by the conversion can be reduced to any
Anxiety and Depression During Childhood and Adolescence: Testing Theoretical Models of Continuity and Discontinuity
The present study sought to clarify the trajectory (i.e., continuous vs. discontinuous) and expression (i.e., homotypic vs. heterotypic) of anxiety and depressive symptoms across childhood and adolescence. We utilized a state-of-the-science analytic approach to simultaneously test theoretical models that describe the development of internalizing symptoms in youth. In a sample of 636 children (53% female; M age = 7.04; SD age = 0.35) self-report measures of anxiety and depression were completed annually by youth through their freshman year of high school. For both anxiety and depression, a piecewise growth curve model provided the best fit for the data, with symptoms decreasing until age 12 (the âdevelopmental knotâ) and then increasing into early adolescence. The trajectory of anxiety symptoms was best described by a discontinuous homotypic pattern in which childhood anxiety predicted adolescent anxiety. For depression, two distinct pathways were discovered: A discontinuous homotypic pathway in which childhood depression predicted adolescent depression and a discontinuous heterotypic pathway in which childhood anxiety predicted adolescent depression. Analytical, methodological, and clinical implications of these findings are discussed
Exploration and exploitation in the presence of network externalities
This paper examines the conditions under which exploration of a new, incompatible technologyis
conducive to firm growth in the presence of network externalities. In particular,
this studyis motivated bythe divergent evolutions of the PC and the workstation markets in
response to a new technology: reduced instruction set computing (RISC). In the PC market,
Intel has developed new microprocessors bymaintaining compatibilitywith the established
architecture, whereas it was radicallyr eplaced byRISC in the workstation market. History
indicates that unlike the PC market, the workstation market consisted of a large number
of power users, who are less sensitive to compatibilitythan ordinaryusers. Our numerical
analysis indicates that the exploration of a new, incompatible technologyis more likelyto
increase the chance of firm growth when there are a substantial number of power users or
when a new technologyis introduced before an established technologytakes off.
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Turning points: the personal and professional circumstances that lead academics to become middle managers
In the current higher education climate, there is a growing perception that the pressures associated with being an academic middle manager outweigh the perceived rewards of the position. This article investigates the personal and professional circumstances that lead academics to become middle managers by drawing on data from life history interviews undertaken with 17 male and female department heads from a range of disciplines, in a post-1992 UK university. The data suggests that experiencing conflict between personal and professional identities, manifested through different socialization experiences over time, can lead to a âturning pointâ and a decision that affects a personâs career trajectory. Although the results of this study cannot be generalized, the findings may help other individuals and institutions move towards a firmer understanding of the academic who becomes head of departmentâin relation to theory, practice and research
NRG Oncology-Radiation Therapy Oncology Group Study 1014: 1-Year Toxicity Report From a Phase 2 Study of Repeat Breast-Preserving Surgery and 3-Dimensional Conformal Partial-Breast Reirradiation for In-Breast Recurrence.
PURPOSE: To determine the associated toxicity, tolerance, and safety of partial-breast reirradiation.
METHODS AND MATERIALS: Eligibility criteria included in-breast recurrence occurring \u3e1 year after whole-breast irradiation, \u3c3 \u3ecm, unifocal, and resected with negative margins. Partial-breast reirradiation was targeted to the surgical cavity plus 1.5 cm; a prescription dose of 45 Gy in 1.5 Gy twice daily for 30 treatments was used. The primary objective was to evaluate the rate of grade â„3 treatment-related skin, fibrosis, and/or breast pain adverse events (AEs), occurring â€1 year from re-treatment completion. A rate of â„13% for these AEs in a cohort of 55 patients was determined to be unacceptable (86% power, 1-sided α = 0.07).
RESULTS: Between 2010 and 2013, 65 patients were accrued, and the first 55 eligible and with 1 year follow-up were analyzed. Median age was 68 years. Twenty-two patients had ductal carcinoma in situ, and 33 had invasive disease: 19 â€1 cm, 13 \u3e1 to â€2 cm, and 1 \u3e2 cm. All patients were clinically node negative. Systemic therapy was delivered in 51%. All treatment plans underwent quality review for contouring accuracy and dosimetric compliance. All treatment plans scored acceptable for tumor volume contouring and tumor volume dose-volume analysis. Only 4 (7%) scored unacceptable for organs at risk contouring and organs at risk dose-volume analysis. Treatment-related skin, fibrosis, and/or breast pain AEs were recorded as grade 1 in 64% and grade 2 in 7%, with only 1 (
CONCLUSION: Partial-breast reirradiation with 3-dimensional conformal radiation therapy after second lumpectomy for patients experiencing in-breast failures after whole-breast irradiation is safe and feasible, with acceptable treatment quality achieved. Skin, fibrosis, and breast pain toxicity was acceptable, and grade 3 toxicity was rare
Fate of internal waves on a shallow shelf
Author Posting. © American Geophysical Union, 2020. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Journal of Geophysical Research: Oceans 125(5), (2020): e2019JC015377, doi:10.1029/2019JC015377.Internal waves strongly influence the physical and chemical environment of coastal ecosystems worldwide. We report novel observations from a distributed temperature sensing (DTS) system that tracked the transformation of internal waves from the shelf break to the surf zone over a narrow shelf slope region in the South China Sea. The spatially continuous view of temperature fields provides a perspective of physical processes commonly available only in laboratory settings or numerical models, including internal wave reflection off a natural slope, shoreward transport of dense fluid within trapped cores, and observations of internal rundown (nearâbed, offshoreâdirected jets of water preceding a breaking internal wave). Analysis shows that the fate of internal waves on this shelfâwhether transmitted into shallow waters or reflected back offshoreâis mediated by local water column density structure and background currents set by the previous shoaling internal waves, highlighting the importance of waveâwave interactions in nearshore internal wave dynamics.We are grateful for the support of the Dongsha Atoll Research Station (DARS) and the Dongsha Atoll Marine National Park, whose efforts made this research possible. The authors would also like to thank A. Hall, S. Tyler, and J. Selker from the Center for Transformative Environmental Monitoring Programs (CTEMPs) funded by the National Science Foundation (EAR awards 1440596 and 1440506), G. Lohmann from WHOI, A. Safaie from UC Irvine, G. Wong, L. Hou, F. Shiah, and K. Lee from Academia Sinica for providing logistical and field support, as well as E. Pawlak, S. Lentz, B. Sanders, and S. Grant for equipment, and B. Raubenheimer, S. Elgar, R. Walter and D. Lucas for informative discussions that improved this work. We acknowledge the US Army Research Laboratory DoD Supercomputing Resource Center for computer time on Excalibur, which was used for the numerical simulations in this work. Funding for this work supported by Academia Sinica and for K.D. and E.R. from NSFâOCE 1753317 and for O.F., J.R., and R.A. from ONR Grant 1182789â1âTDZZM. A portion of this work (R.A.) was performed under the auspices of the U.S. Department of Energy by Lawrence Livermore National Laboratory under Contract DEâAC52â07NA27344.2020-10-2
A "superstorm": When moral panic and new risk discourses converge in the media
This is an Author's Accepted Manuscript of an article published in Health, Risk and Society, 15(6), 681-698, 2013, copyright Taylor & Francis, available online at: http://www.tandfonline.com/10.1080/13698575.2013.851180.There has been a proliferation of risk discourses in recent decades but studies of these have been polarised, drawing either on moral panic or new risk frameworks to analyse journalistic discourses. This article opens the theoretical possibility that the two may co-exist and converge in the same scare. I do this by bringing together more recent developments in moral panic thesis, with new risk theory and the concept of media logic. I then apply this theoretical approach to an empirical analysis of how and with what consequences moral panic and new risk type discourses converged in the editorials of four newspaper campaigns against GM food policy in Britain in the late 1990s. The article analyses 112 editorials published between January 1998 and December 2000, supplemented with news stories where these were needed for contextual clarity. This analysis shows that not only did this novel food generate intense media and public reactions; these developed in the absence of the type of concrete details journalists usually look for in risk stories. Media logic is important in understanding how journalists were able to engage and hence how a major scare could be constructed around convergent moral panic and new risk type discourses. The result was a media âsuperstormâ of sustained coverage in which both types of discourse converged in highly emotive mutually reinforcing ways that resonated in a highly sensitised context. The consequence was acute anxiety, social volatility and the potential for the disruption of policy and social change
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