Collecting for a College: Gifts from David P. Becker

Catalog of an exhibition held at the Bowdoin College Museum of Art Apr. 20-June 4, 1995.https://digitalcommons.bowdoin.edu/art-museum-exhibition-catalogs/1028/thumbnail.jp

The Contribution of Melanoregulin to Microtubule-Associated Protein 1 Light Chain 3 (LC3) Associated Phagocytosis in Retinal Pigment Epithelium

A main requisite in the phagocytosis of ingestedmaterial is a coordinated series of maturation steps which leadto the degradation of ingested cargo. Photoreceptor outersegment (POS) renewal involves phagocytosis of the distaldisk membranes by the retinal pigment epithelium (RPE).Previously, we identified melanoregulin (MREG) as an intra-cellular cargo-sorting protein required for the degradation ofPOS disks. Here, we provide evidence that MREG-dependentprocessing links both autophagic and phagocytic processes inLC3-associated phagocytosis (LAP). Ingested POSphagosomes are associated with endogenous LC3 andMREG. The LC3 association with POSs exhibited propertiesof LAP; it was independent of rapamycin pretreatment, butdependent on Atg5. Loss of MREG resulted in a decrease inthe extent of LC3-POS association. Studies using DQ™-BSAsuggest that loss of MREG does not compromise the associ-ation and fusion of LC3-positive phagosomes with lysosomes.Furthermore, the mechanism of MREG action is likelythrough a protein complex that includes LC3, as determinedby colocalization and immunoprecipitation in both RPE cellsand macrophages. We posit that MREG participates incoordinating the association of phagosomes with LC3 forcontent degradation with the loss of MREG leading tophagosome accumulation

Attrition among Human Immunodeficiency Virus (HIV)- Infected Patients Initiating Antiretroviral Therapy in China, 2003–2010

BACKGROUND: Mortality and morbidity from HIV have dramatically decreased in both high- and low-income countries. However, some patients may not benefit from combination antiretroviral therapy (cART) because of inadequate access to HIV care, including attrition after care initiation. METHODOLOGY/PRINCIPAL FINDINGS: The study population included all HIV-infected patients receiving cART through the Chinese National Free Antiretroviral Treatment Program from 1 January 2003 to 31 December 2010 (n = 106,542). We evaluated retention in HIV care and used multivariable Cox proportional hazard models to identify independent factors predictive of attrition. The cumulative probability of attrition from cART initiation was 9% at 12 months, 13% at 18 months, 16% at 24 months and 24% at 60 months. A number of factors were associated with attrition, including younger age, male gender, and being single or divorced. Patients with higher CD4 cell counts at cART initiation were more likely to drop out of HIV care. The proportion of patients remaining in HIV care increased in more recent calendar years and among patients who initiated modern cART regimens. CONCLUSIONS/SIGNIFICANCE: Retention in HIV care is essential for optimizing individual and public health outcomes. Attrition, even the degree observed in our study, can lead to premature morbidity and mortality, and possibly affect further transmission of HIV and HIV resistant drug variants. Effective strategies to promote retention in HIV care programs are needed. In China these strategies may include focusing particularly on younger male patients and those with higher CD4 cell counts at therapy initiation

"To Tell the Story": Cultural Trauma and Holocaust Metanarrative

This article explores the aporia between the alleged inexplicability of the Holocaust and the wealth of narrative that has proceeded from the event in the years since 1945, proposing the existence of a generic Holocaust metanarrative that has been adopted and inscribed into Western cultural memory as the accepted framework for interpretation. Taking as a starting point the idea that culture itself has been somehow ‘ruptured’ in the wake of the Holocaust, this article explores the ways in which this rupture manifests itself, viewing the shattering impact of the Holocaust on the Western cultural imagination as macrocosmically comparable to the impact of psychic trauma on the individual survivor of the Holocaust. Just as an individual act of narration (the act of testimony) is believed to provide a cure for trauma, so a collective act of narration may hold the key to repairing the post-Holocaust cultural rupture. During the exploration of this process, it becomes apparent that cultural memory of the Holocaust is in fact informed by a metanarrative account that appears to offer the possibility of an engagement with the Holocaust, but which in fact acts as a screen between the event itself and the culture that would seek to memorialize it. Finally, this article explores the notion that the most appropriate narrative response is one that accepts the impossibility of its own position, rejecting the easy redemption offered by the assimilation of Holocaust metanarrative and instead inhabiting the dialectic between knowing and understanding that the Holocaust presents

Whose names count? Jacques Rancière on Alfredo Jaar’s Rwanda Project

This article focuses on Jacques Rancière’s reflections on Alfredo Jaar’s The Rwanda Project in the context of wider discussions of the politics of naming the dead. Against the claim that his reflections reveal a depoliticizing, universalist commitment to naming all the dead, it contends that foregrounding the relation between naming and counting in this discussion shows Rancière’s focus to be the policing and politics of naming. In an original argument, it focuses specifically on how, for Rancière, in this context, individualized proper names function politically and dissensually. To do so it explores (i) Rancière’s analysis of the role of the mainstream media during the Rwandan genocide in perpetuating the police order (or order of grievability) which divided nameable individuals from anonymous masses, thereby constituting living and dead Rwandans as of little or no account, and (ii) his account of how Jaar’s art is able to disrupt the ‘partition of the sensible’ underpinning this count. The article concludes by considering how Rancière’s ideas about the relationship between naming and counting and between politics and police serve as a useful supplement to and extension of existing discussions of grievability