Building a future...An exploration of the contribution of educational provision to clients’ well-being at Southwark Day Centre for Asylum Seekers

This research project builds on previous work, ‘Beneath the Surface’ (Cogo, Inman, McCormack, Rogers 2018) which focussed on how clients at Southwark Day Centre for Asylum Seekers (SDCAS) understood and evaluated their well-being. One of the areas touched on in that research was the role of educational activities in developing the well-being of clients. This report describes in depth the ways in which the educational provision offered in the centre contributes to the well-being of clients and how this contribution might be enhanced. The report focuses on two areas of education provision; gardening and storytelling and explains how they contribute to the well-being of the clients. The interview data confirms that the activities in these two areas help to build clients’ psychological, physical and social resources and have a positive effect on how clients feel and how they function in the world. The report ends with recommendations as to how SDCAS might ensure that gardening and storytelling continue to benefit the well-being of clients and also as to what might be put in place to strengthen the activities

Stories from lockdown: the impact of the Covid19 pandemic on the well-being of clients at Southwark Day Centre for Asylum Seekers (SDCAS)

The report describes the findings of research on how the Covid 19 related lockdowns affected the well-being of clients at the Southwark Day Centre for Asylum Seekers. A small number of clients were interviewed about the practical issues of housing, food, money and about their physical and mental health during the periods of lockdowns. They were also asked about support from the Southwark Day Centre for Asylum Seekers. The report describes the experiences of these clients between March 2020 and March 202

Direct numerical simulation of supersonic and hypersonic turbulent boundary layers at moderate-high Reynolds numbers and isothermal wall condition

We study the structure of high-speed zero-pressure-gradient turbulent boundary layers up to friction Reynolds number Reτ ≈ 2000 using direct numerical simulation of the Navier-Stokes equations. Both supersonic and hypersonic conditions with nominal free-stream Mach numbers M∞ = 2, M∞ = 5.86 and heat transfer at the wall are considered. The present simulations extend the database currently available for wall-bounded flows, enabling us to explore high-Reynolds-number effects even in the hypersonic regime. We first analyse the instantaneous fields to characterize the structure of both velocity and temperature fluctuations. In all cases elongated strips of uniform velocity and temperature (superstructures) are observed in the outer portion of the boundary layer, characterized by a clear association between low-/high-speed momentum and high/low temperature streaks. The results highlight important deviations from the typical organization observed in the inner region of adiabatic boundary layers, revealing that the near-wall temperature streaks disappear in strongly non-adiabatic flow cases. We also focus on the structural properties of regions of uniform streamwise momentum (De Silva, Hutchins & Marusic, J. Fluid Mech., vol. 786, 2016, pp. 309.331) observed in turbulent boundary layers, confirming the presence of such zones in the high-speed regime at high Reynolds number and revealing the existence of similar regions for the temperature field. The accuracy of different compressibility transformations and temperature-velocity relations is assessed extending their range of validation to moderate/high Reynolds numbers. Spanwise spectral densities of the velocity and temperature fluctuations at various wall distances have been calculated revealing the energy content and the size of the turbulent eddies across the boundary layer. Finally, we propose a revised scaling for the characteristic length scales, that is based on the local mean shear computed according to the recent theory by Griffin, Fu & Moin [Proc. Natl Acad. Sci. USA, vol. 118 (34)]

Disaturated-phosphatidylcholine and Surfactant protein-B turnover in human acute lung injury and in control patients

<p>Abstract</p> <p>Background</p> <p>Patients with Adult Respiratory Distress Syndrome (ARDS) and Acute Lung Injury (ALI) have low concentrations of disaturated-phosphatidylcholine and surfactant protein-B in bronchoalveolar lavage fluid. No information is available on their turnover.</p> <p>Objectives</p> <p>To analyze disaturated-phosphatidylcholine and surfactant protein-B turnover in patients with ARDS/ALI and in human adults with normal lungs (controls).</p> <p>Methods</p> <p>²H₂O as precursor of disaturated-phosphatidylcholine-palmitate and 1¹³C-Leucine as precursor of surfactant protein-B were administered intravenously to 12 patients with ARDS/ALI and to 8 controls. Disaturated-phosphatidylcholine and surfactant protein-B were isolated from serial tracheal aspirates, and their fractional synthetic rate was derived from the ²H and ¹³C enrichment curves, obtained by gas chromatography mass spectrometry. Disaturated-phosphatidylcholine, surfactant protein-B, and protein concentrations in tracheal aspirates were also measured.</p> <p>Results</p> <p>1) Surfactant protein-B turned over at faster rate than disaturated-phosphatidylcholine both in ARDS/ALI patients and in controls. 2) In patients with ARDS/ALI the fractional synthesis rate of disaturated-phosphatidylcholine was 3.1 times higher than in controls (p < 0.01), while the fractional synthesis rate of surfactant protein-B was not different. 3) In ARDS/ALI patients the concentrations of disaturated-phosphatidylcholine and surfactant protein-B in tracheal aspirates were markedly and significantly reduced (17% and 40% of the control values respectively).</p> <p>Conclusions</p> <p>1) Disaturated-phosphatidylcholine and surfactant protein-B have a different turnover both in healthy and diseased lungs. 2) In ARDS/ALI the synthesis of these two surfactant components may be differently regulated.</p

Respiratory Effects of Exposure to Traffic-Related Air Pollutants During Exercise

Traffic-related air pollution (TRAP) is increasing worldwide. Habitual physical activity is known to prevent cardiorespiratory diseases and mortality, but whether exposure to TRAP during exercise affects respiratory health is still uncertain. Exercise causes inflammatory changes in the airways, and its interaction with the effects of TRAP or ozone might be detrimental, for both athletes exercising outdoor and urban active commuters. In this Mini-Review, we summarize the literature on the effects of exposure to TRAP and/or ozone during exercise on lung function, respiratory symptoms, performance, and biomarkers. Ozone negatively affected pulmonary function after exercise, especially after combined exposure to ozone and diesel exhaust (DE). Spirometric changes after exercise during exposure to particulate matter and ultrafine particles suggest a decrease in lung function, especially in patients with chronic obstructive pulmonary disease. Ozone frequently caused respiratory symptoms during exercise. Women showed decreased exercise performance and higher symptom prevalence than men during TRAP exposure. However, performance was analyzed in few studies. To date, research has not identified reliable biomarkers of TRAP-related lung damage useful for monitoring athletes' health, except in scarce studies on airway cells obtained by induced sputum or bronchoalveolar lavage. In conclusion, despite partly counteracted by the positive effects of habitual exercise, the negative effects of TRAP exposure to pollutants during exercise are hard to assess: outdoor exercise is a complex model, for multiple and variable exposures to air pollutants and pollutant concentrations. Further studies are needed to identify pollutant and/or time thresholds for performing safe outdoor exercise in cities

Biochemical and Fatty Acids Composition of Water Buffalo (Bubalus Bubalis) Follicular Fluid

Aim of this study was to characterize the biochemical and fatty acids composition of follicular fluid collected from follicles of different sizes and in different phases of ovarian cycle in water buffalo farmed in Italy. Ovaries were collected at slaughterhouse during the breeding season; follicular fluid was aspirated dividing samples in small and large follicles (&lt; 6 mm and &gt; 6 mm respectively) and in luteal and follicular phase. Biochemical analysis and gas-chromatography were performed. Biochemical and fatty acids composition were greatly influenced by both follicular dimension and phase of ovarian cycle. Biochemical composition and its variations were in agreement with previously study conducted in buffalo and other species. This is the first report of the fatty acids composition of buffalo follicular fluid. Twenty-two fatty acids were identified in follicular fluid; nine were saturated fatty acids, six monounsatured fatty acids and seven polyunsatured fatty acids. The most dominant fatty acids were linoleic acid, oleic acid, palmitic acid, stearic acid and arachidonic acid. All the identified fatty acids concentrations vary at least because of follicle dimension or phase, with the exception of γ-linoleic acid and arachidonic acid which concentrations remain stable in all classes

Detecting neurodevelopmental trajectories in congenital heart diseases with a machine-learning approach

We aimed to delineate the neuropsychological and psychopathological profiles of children with congenital heart disease (CHD) and look for associations with clinical parameters. We conducted a prospective observational study in children with CHD who underwent cardiac surgery within five years of age. At least 18\ua0months after cardiac surgery, we performed an extensive neuropsychological (intelligence, language, attention, executive function, memory, social skills) and psychopathological assessment, implementing a machine-learning approach for clustering and influencing variable classification. We examined 74 children (37 with CHD and 37 age-matched controls). Group comparisons have shown differences in many domains: intelligence, language, executive skills, and memory. From CHD questionnaires, we identified two clinical subtypes of psychopathological profiles: a small subgroup with high symptoms of psychopathology and a wider subgroup of patients with ADHD-like profiles. No associations with the considered clinical parameters were found. CHD patients are prone to high interindividual variability in neuropsychological and psychological outcomes, depending on many factors that are difficult to control and study. Unfortunately, these dysfunctions are under-recognized by clinicians. Given that brain maturation continues through childhood, providing a significant window for recovery, there is a need for a lifespan approach to optimize the outcome trajectory for patients with CHD

Does #Tamojunto alter the dynamic between drug use and school violence among youth?: Secondary analysis from a large cluster-randomized trial

The present study investigated how intervention might alter the relationship between perpetrating violence and later drug use. A cluster-randomized controlled trial design involving 72 schools (38 intervention, 34 control) and 6390 students attending grades 7 and 8 was employed in Brazil. Drug use and violence were assessed at three points. A random-intercept cross-lagged panel model examined the reciprocal association between drug use and school violence domains across the three data collection waves. For both groups, we found that the cross-lagged effect of perpetration on further drug use in adolescents was stronger than the reverse, but the interrelationship was not statistically significant between #Tamojunto and control schools. The carry-over effects of drug use and violence were also not significantly different between groups. There is a lack of evidence showing that #Tamojunto can modify the dynamics between drug use and school violence across the 21-month period. The direction of the causal effect (i.e., the more perpetration behavior, the more subsequent drug use behavior) is present, but weak in both groups. The trial registration protocol at the national Brazilian Register of Clinical Trials (REBEC) is #RBR-4mnv5g.publishedVersio

Vellozia flavicans Mart. ex Schult. hydroalcoholic extract inhibits the neuromuscular blockade induced by Bothrops jararacussu venom

FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOBackground: Snakebite is a significant public health issue in tropical countries. In Brazil, some of the most common snake envenomations are from Bothrops. Bothrops bites trigger local and systemic effects including edema, pain, erythema, cyanosis, infections, and necrosis. Vellozia flavicans is a plant from the Brazilian " cerrado" (savanna) that is popularly used as an anti-inflammatory medicine. Since inflammation develops quickly after Bothrops bites, which can lead to infection, the aim of the present study was to observe possible anti-snake venom and antimicrobial activities of V. flavicans (Vf). Methods: The chromatographic profile of the main constituents from the Vf leaf hydroalcoholic extract was obtained by thin-layer chromatography (TLC). The anti-snake venom activity was measured by Vf's ability to neutralize the in vitro neuromuscular blockade caused by Bothrops jararacussu venom (Bjssu) in a mouse phrenic nerve-diaphragm model (PND). After a 20 min incubation, preparations of PND were added to Tyrode's solution (control); Vf (0.2, 0.5, 1, and 2 mg/mL); 40 μg/mL Bjssu; pre-incubation for 30 min with Bjssu and 1 mg/mL Vf; and a Bjssu pretreated preparation (for 10 min) followed by 1 mg/mL Vf. Myographic recording was performed, and the contractile responses were recorded. The antimicrobial activity (minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC]) was obtained for Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Enterococcus faecalis, using gentamicin and vancomycin as positive controls. Results: TLC analysis yielded several compounds from Vf, such as flavonoids (quercetin) and phenolic acids (chlorogenic acid). Bjssu completely blocked the contractile responses of PND preparations, while Vf preserved 97% (±10%) of the contractile responses when incubated with Bjssu. In the PND pretreated with Bjssu, Vf was able to inhibit the neuromuscular blockade progress. MIC and MBC of Vf ranged from 2.5 to 5.0 mg/mL for P. aeruginosa and S. aureus strains, while no antimicrobial activity was observed for E. coli and E. faecalis.Conclusions: The hydroalcoholic extract from Vf leaves was able to neutralize and decrease the in vitro neuromuscular blockade caused by Bjssu. However, it did not show significant antimicrobial activity against the tested bacteria. © 2014 Tribuiani et al.; licensee BioMed Central Ltd.Snakebite is a significant public health issue in tropical countries. In Brazil, some of the most common snake envenomations are from Bothrops. Bothrops bites trigger local and systemic effects including edema, pain, erythema, cyanosis, infections, and necrosis. Vellozia flavicans is a plant from the Brazilian "cerrado" (savanna) that is popularly used as an anti-inflammatory medicine. Since inflammation develops quickly after Bothrops bites, which can lead to infection, the aim of the present study was to observe possible anti-snake venom and antimicrobial activities of V. flavicans (Vf). The chromatographic profile of the main constituents from the Vf leaf hydroalcoholic extract was obtained by thin-layer chromatography (TLC). The anti-snake venom activity was measured by Vf's ability to neutralize the in vitro neuromuscular blockade caused by Bothrops jararacussu venom (Bjssu) in a mouse phrenic nerve-diaphragm model (PND). After a 20 min incubation, preparations of PND were added to Tyrode's solution (control); Vf (0.2, 0.5, 1, and 2 mg/mL); 40 μg/mL Bjssu; pre-incubation for 30 min with Bjssu and 1 mg/mL Vf; and a Bjssu pretreated preparation (for 10 min) followed by 1 mg/mL Vf. Myographic recording was performed, and the contractile responses were recorded. The antimicrobial activity (minimum inhibitory concentration [MIC] and minimum bactericidal concentration [MBC]) was obtained for Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, and Enterococcus faecalis, using gentamicin and vancomycin as positive controls. TLC analysis yielded several compounds from Vf, such as flavonoids (quercetin) and phenolic acids (chlorogenic acid). Bjssu completely blocked the contractile responses of PND preparations, while Vf preserved 97% (±10%) of the contractile responses when incubated with Bjssu. In the PND pretreated with Bjssu, Vf was able to inhibit the neuromuscular blockade progress. MIC and MBC of Vf ranged from 2.5 to 5.0 mg/mL for P. aeruginosa and S. aureus strains, while no antimicrobial activity was observed for E. coli and E. faecalis. The hydroalcoholic extract from Vf leaves was able to neutralize and decrease the in vitro neuromuscular blockade caused by Bjssu. However, it did not show significant antimicrobial activity against the tested bacteria14FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO2004/09705-8; 2007/53883-6; 2008/52643-4; 2008/11005-5; 2012/08271-0Neglected tropical diseases: Snakebite, , http://www.who.int/bloodproducts/animal_sera/Rabies.pdf?ua=1, WHO - World Health Organization(2009) Textos Básicos de Saúde (Cadernos de Atenção Básican. 22), , Health surveillance:zoonoses, Brasil. Ministério da SaúdeTeixeira, R., Forma grave do acidente por ofídios da sub-família Crotalinae (1979) An Acad Med Bahia, 2, pp. 109-135Vellard, J.A., Serpentes venenosas (1945) Terapêutica Clínica, pp. 265-273. , Buenos Aires: Libreria y Editorial 'El Ateneo, Cardini C, Beretervide JJAlves, E., (1956) Medicina de Urgência, pp. 1052-1055. , Rio de Janeiro: Livraria AtheneuBrazil, V., (1901) Do envenenamento ophidico e seu tratamento, pp. 31-55. , Colletanea dos trabalhos Instituto ButantanRodrigues-Simioni, L., Borgese, N., Ceccarelli, B., The effects of Bothrops jararacussu venom and its components on frog nerve-muscle preparation (1983) Neuroscience, 10, pp. 475-489Souza, C.D., Felfili, J.M., The utilization of medicinal plants in the region of Alto Paraíso of Goiás, GO, Brazil (2006) Acta Bot Bras, 20, pp. 133-142Stannard, B.L., (1995) Flora of the Pico das Almas: Chapada da Diamantina - Bahia, Brazil, pp. 43-78. , Great Britain: Whitstable Litho LtdBranco, A., Pinto, A.C., Braz Filho, R., Chemical constituents from Vellozia graminifolia (Velloziaceae) (2004) An Acad Bras Cienc, 76, pp. 505-518Harborne, J.B., Williams, C.A., Greenham, J., Eagles, J., Variations in the lipophilic and vacuola flavonoids of the genus Vellozia (1994) Phytochemistry, 35, pp. 1475-1480Williams, C.A., Harborne, J.B., Greenham, J., Eagles, J., Differences in flavonoids patterns between genera within the Velloziaceae (1994) Phytochemistry, 36, pp. 931-940Pinto, A.C., Scofield, T.C.V., Braz-Filho, R., Two new diterpenes with a rosane skeleton from Velloziaceae (1983) Tetrahedron Lett, 24, pp. 5043-5046Pinto, A.C., Queiroz, P.P.S., Garcez, W., Diterpenes from Vellozia bicolor (1991) J Braz Chem Soc, 2, pp. 25-30Pinto, A.C., Rezende, C.M., Antunes, O.A.C., Correia, C.R.D., Three isomeric diterpenes from Vellozia flavicans (1996) Phytochemistry, 42, pp. 767-769Peixoto, E.M., Pinchin, R., Pinto, A.C., Constituintes químicos de Vellozia piresiana (1979) Ciênc Cult, 32, pp. 125-127Barnes, R.A., Pereira, A.L., Scofield, T.C.V., Braz-Filho, R., Pinto, A.C., A new triterpene from Vellozia compacta (1984) Chem Pharm Bull, 32, pp. 3674-3677Dharmappa, K.K., Kumar, R.V., Nataraju, A., Mohamed, R., Shivaprasad, H.V., Vishwanath, B.S., Anti-inflammatory activity of oleanolic acid by inhibition of secretory phospholipase A2 (2009) Planta Med, 75, pp. 211-215Magalhães, A., Santos, G.B., Verdam, M.C., Fraporti, L., Malheiro, A., Lima, E.S., Dos-Santos, M.C., Inhibition of the inflammatory and coagulant action of Bothrops atrox venom by the plant species Marsypianthes chamaedrys (2011) J Ethnopharmacol, 134, pp. 82-88Sampaio, S.C., Sousa-e-Silva, M.C.C., Borelli, P., Curi, R., Cury, Y., Crotalus durissus terrificus snake venom regulates macrophage metabolism and function (2001) J Leukoc Biol, 70, pp. 551-558(2002) Portuguese Pharmacopoeia, , Lisboa: Infarmed Editors, Portugal, Portuguese Pharmacopoeia CommitteeHarborne, J.B., (1998) Phytochemical Methods: A Guide to Modern Techniques of Plants Analysis, , London: Chapman & HallCintra Francischinelli, M., Silva, M.G., Andréo Filho, N., Cintra, A.C.O., Leite, G.B., Cruz Höfling, M.A.D.A., Rodrigues Simioni, L., Oshima Franco, Y., Effects of commonly used solubilizing agents on a model nerve-muscle synapse (2008) Lat Am J Pharm, 27, pp. 721-726Siles Villaroel, M., Rolim Rosa, R., Zelante, F., Furlanetto, R.S., Padronização da avaliação da potência de antivenenos botrópicos, em camundongos (1978) Mem Inst Butantan, 42-43, pp. 325-336Bülbring, E., Observation on the isolated phrenic nerve diaphragm preparation of the rat (1946) Br J Pharmacol, 1, pp. 38-61Ferraz, M.C., Parrilha, L.A.C., Moraes, M.S.D., Amaral Filho, J., Cogo, J.C., Dos Santos, M.G., Franco, L.M., Oshima Franco, Y., The effect of lupane triterpenoids (Dipteryx alata Vogel) in the in vitro neuromuscular blockade and myotoxicity of two snake venoms (2012) Curr Org Chem, 16, pp. 2717-2723Puebla, P., Oshima-Franco, Y., Franco, L.M., Santos, M.G., Silva, R.V., Rubem-Mauro, L., Feliciano, A.S., Chemical constituents of the bark of Dipteryx alata Vogel, an active species against Bothrops jararacussu venom (2010) Molecules, 15, pp. 8193-8204Gottlieb, O., Kaplan, M.A., Das plantas medicinais aos fármacos naturais (1993) Cienc Hoje, 15, pp. 51-54Souza Brito, A.R.M., How to study the pharmacology of medicinal plants in underdeveloped countries (1996) J Ethnopharmacol, 54, pp. 131-138Martini, N.D., Katerere, D.R., Eloff, J.N., Biological activity of five antibacterial flavonoids from Combretum erythrophyllum (Combretaceae) (2004) J Ethnopharmacol, 93, pp. 207-212Rates, S.M.K., Plants as source of drugs (2001) Toxicon, 39, pp. 603-613Soares, A.M., Ticli, F.K., Marcussi, S., Lourenço, M.V., Januário, A.H., Sampaio, S.V., Giglio, J.R., Pereira, O.S., Medicinal plants with inhibitory properties against snake venoms (2005) Curr Med Chem, 12, pp. 2625-2641Mors, W.B., Do Nascimento, M.C., Pereira, B.M.R., Pereira, N.A., Plant natural products active against snake bite - the molecular approach (2000) Phytochemistry, 55, pp. 627-642Barbosa, A.M., Villaverde, A.B., Guimarães Souza, L., Ribeiro, W., Cogo, J.C., Zamuner, S.R., Effect of low-level laser therapy in the inflammatory response induced by Bothrops jararacussu snake venom (2008) Toxicon, 1 (51), pp. 1236-1244Oshima-Franco, Y., Hyslop, S., Cintra, A.C., Giglio, J.R., da Cruz-Höfling, M.A., Rodrigues-Simioni, L., Neutralizing capacity of commercial bothropic antivenom against Bothrops jararacussu venom and bothropstoxin-I. (2000) Muscle Nerve, 23, pp. 1832-1839Oshima Franco, Y., Rosa, L.J.R., Silva, G.A.A., Amaral Filho, J., Silva, M.G., Lopes, P.S., Cogo, J.C., Da Cruz Höfling, M.A., Antibothropic action of Camellia sinensis extract against the neuromuscular blockade by Bothrops jararacussu snake venom and its mais toxin, bothropstoxin-I (2012) Pharmacology, pp. 469-489. , Croatia: Intech, Gallelli LMilani Júnior, R., Jorge, M.T., de Campos, F.P., Martins, F.P., Bousso, A., Cardoso, J.L., Ribeiro, L.A., Warrell, D.A., Snake bites by the jararacuçu (Bothrops jararacussu): clinic pathological studies of 29 proven cases in São Paulo State (1997) Brazil. QJM, 90, pp. 323-334Petricevich, V.L., Teixeira, C.F.P., Tambourghi, D.V., Gutiérrez, J.M., Increments in serum cytokine and nitric oxide levels in mice injected with Bothrops asper and Bothrops jararaca snake venom (2000) Toxicon, 38, pp. 1253-1266(2007) Rabies and envenomings: a neglected public health issue, , http://www.who.int/bloodproducts/animal_sera/Rabies.pdf, Available from: WHO - World Health OrganizationMalomouzh, A.I., Mukhtarov, M.R., Nikolsky, E.E., Vyskocil, F., Lieberman, E.M., Urazaev, A.K., Glutamate regulation of non-quantal release of acetylcholine in the rat neuromuscular junction (2003) J Neurochem, 85, pp. 206-213Rubem Mauro, L., Rocha, D.S., Barcelos, C.C., Varca, G.H., Andréo Filho, N., Barberato Filho, S., Oshima Franco, Y., Phenobarbital pharmacological findings on the nerve-muscle basis (2009) Lat Am J Pharm, 28, pp. 211-218. , Vila MMDCCintra-Francischinelli, M., Silva, M.G., Andréo-Filho, N., Gerenutti, M., Cintra, A.C.O., Giglio, J.R., Leite, G.B., Oshima-Franco, Y., Antibothropic action of Casearia sylvestris Sw. (Flacourtiaceae) extracts (2008) Phytother Res, 22, pp. 784-790Camargo, T.M., Nazato, V.S., Silva, M.G., Cogo, J.C., Groppo, F.C., Oshima-Franco, Y., Bothrops jararacussu venom-induced neuromuscular blockade inhibited by Casearia gossypiosperma Briquet hydroalcoholic extract (2010) J Venom Anim Toxins incl Trop Dis, 16, pp. 432-441Nazato, V.S., Rubem Mauro, L., Vieira, N.A.G., Rocha Junior, D., Dos, S., Silva, M.G., Lopes, P.S., Oshima Franco, Y., vitro antiophidian properties of Dipteryx alata Vogel bark extracts (2010) Molecules, 15, pp. 5956-5970Melo, R.F., Farrapo, N.M., Rocha Junior, D.S., Silva, M.G., Cogo, J.C., Dal Belo, C.A., Rodrigues Simioni, L., Oshima Franco, Y., Antiophidian mechanisms of medicinal plants (2009) Flavonoids: Biosynthesis, Biological Effects and Dietary Sources, pp. 249-262. , New York: Nova Science Publishers, Keller RBFarrapo, N.M., Silva, G.A.A., Costa, K.N., Silva, M.G., Cogo, J.C., Dal Belo, C.A., Dos Santos, M.G., Oshima Franco, Y., Inhibition of Bothrops jararacussu venom activities by Plathymenia reticulata Benth extracts (2011) J Venom Res, 2, pp. 52-58Cos, P., Vlietinc, A.J., Berghe, D.V., Maes, L., Anti-infective potential of natural products: how to develop a stronger in vitro 'proof-of-concept' (2006) J Ethnopharmacol, 103, pp. 290-302Mishra, U.S., Mishra, A., Kumari, R., Murthy, P.N., Naik, B.S., Antibacterial activity of ethanol extract of Andrographis paniculata (2009) Indian J Pharm Sci, 71, pp. 436-438Premendran, S.J., Salwe, K.J., Pathak, S., Brahmane, R., Manimekalai, K., Anti-cobra venom activity of plant Andrographis paniculata and its comparison with polyvalent anti-snake venom (2011) J Nat Sci Biol Med, 2, pp. 198-204Mahadeswaraswamy, Y.H., Nagaraju, S., Girish, K.S., Kemparaju, K., Local tissue destruction and procoagulation properties of Echis carinatus venom: inhibition by Vitis vinifera seed methanol extract (2008) Phytother Res, 22, pp. 963-969Oliveira, D.A., Salvador, A.A., Smânia, A., Smânia, E.F., Maraschin, M., Ferreira, S.R., Antimicrobial activity and composition profile of grape (Vitis vinifera) pomace extracts obtained by supercritical fluids (2013) J Biotechnol, 164, pp. 423-43

Does #Tamojunto alter the dynamic between drug use and school violence among youth? Secondary analysis from a large cluster-randomized trial

The present study investigated how intervention might alter the relationship between perpetrating violence and later drug use. A cluster-randomized controlled trial design involving 72 schools (38 intervention, 34 control) and 6390 students attending grades 7 and 8 was employed in Brazil. Drug use and violence were assessed at three points. A random-intercept cross-lagged panel model examined the reciprocal association between drug use and school violence domains across the three data collection waves. For both groups, we found that the cross-lagged effect of perpetration on further drug use in adolescents was stronger than the reverse, but the interrelationship was not statistically significant between #Tamojunto and control schools. The carry-over effects of drug use and violence were also not significantly different between groups. There is a lack of evidence showing that #Tamojunto can modify the dynamics between drug use and school violence across the 21-month period. The direction of the causal effect (i.e., the more perpetration behavior, the more subsequent drug use behavior) is present, but weak in both groups. The trial registration protocol at the national Brazilian Register of Clinical Trials (REBEC) is #RBR-4mnv5g