17 research outputs found
Early results and technical shortcomings in intravascular brachytherapy of coronary arteries: a radiotherapist's point of view
The introduction describes the problem of restenosis in coronary artery disease and the therapeutic options to
prevent it
In Part I of this thesis we evaluated clinical results. Chapter I describes the clinical results of patients treated in
Rotterdam, who were included in the BE
Efficacy of beta radiation in prevention of post-angioplasty restenosis
Restenosis remains a major limitation of coronary angioplasty in spite of major advances in techniques and technology. Recent studies have demonstrated that ionizing radiation may limit the degree of this problem. Gamma radiation has been shown to be effective in reducing in stent restenosis in humans, and beta radiation following encouraging results in animals has been shown to be feasible in humans. The objective of this study was to assess the feasibility of a 5 F non-centered catheter to deliver beta radiation emitting seeds to the lesion site post angioplasty and its effect on restenosis. Following successful angioplasty, patients were randomized to treatment with 12, 14 or 16 Gy at the angioplasty site. This was delivered with a 5 F non-centered catheter. Twelve beta radiation emitting seeds (90Sr/Y) were delivered to an area 3 cm in length to cover the angioplasty site. Angiographic follow-up was performed at 6 months. Baseline and follow-up angiograms were performed by blinded investigators at a core laboratory. This interim report comprises the first 35 patients to complete 6-month angiographic follow-up. There were no major radiation incidents. Four patients had evidence of angiographic restenosis. The MLD (mm) and percent stenosis were 0.77 +/- 0.27/72.5 +/- 8.6 pre angioplasty, 2.08 +/- 0.4/25.7 +/- 9.8 post angioplasty and radiation and 2.05 +/- 0.59/25.7 +/- 19.8 at follow-up respectively. CONCLUSION: Beta radiation can be feasibly and safely delivered post coronary angioplasty with a very encouraging reduction of restenosis
Geographic miss: a cause of treatment failure in radio-oncology applied to intracoronary radiation therapy
BACKGROUND: A recognized limitation of endovascular beta-radiation therapy
is the development of new stenosis at the edges of the irradiated area.
The combination of injury and low-dose radiation may be the precursor of
this phenomenon. We translated the radio-oncological concept of
"geographic miss" to define cases in which the radiation source did not
fully cover the injured area. The aims of the study were to determine the
incidence and causes of geographic miss and evaluate the impact of this
inadequate treatment on the outcome of patients treated with intracoronary
beta-radiation. METHODS AND RESULTS: We analyzed 50 consecutive patients
treated with beta-radiation after percutaneous coronary intervention. The
prescribed dose ranged between 12 and 20 Gy at 2 mm from the source axis.
By means of quantitative coronary angiography, the irradiated segment
(IRS) and both edges were studied before and after intervention and at
6-month follow-up. Edges that were injured during the procedure
constituted the geographic miss edges. Twenty-two edges were injured
during the intervention, mainly because of procedural complications that
extended the treatment beyond the margins of the IRS. Late loss was
significantly higher in geographic miss edges than in IRSs and uninjured
edges (0.84+/-0.6 versus 0.15+/-0.4 and 0.09+/-0.4 mm, respectively;
P<0.0001). Similarly, restenosis rate was significantly higher in the
injured edges (10% within IRS, 40.9% in geographic miss edges, and 1.9% in
uninjured edges; P<0.001). CONCLUSIONS: These data support the hypothesis
that the combination of injury and low-dose beta-radiation induces
deleterious outcome
Late coronary occlusion after intracoronary brachytherapy
BACKGROUND: Intracoronary brachytherapy appears to be a promising
technology to prevent restenosis. Presently, limited data are available
regarding the late safety of this therapeutic modality. The aim of the
study was to determine the incidence of late (>1 month) thrombosis after
PTCA and radiotherapy. METHODS AND RESULTS: From April 1997 to March 1999,
we successfully treated 108 patients with PTCA followed by intracoronary
beta-radiation. Ninety-one patients have completed at least 2 months of
clinical follow-up. Of these patients, 6.6% (6 patients) presented with
sudden thrombotic events confirmed by angiography 2 to 15 months after
intervention (2 balloon angioplasty and 4 stent). Some factors
(overlapping stents, unhealed dissection) may have triggered the
thrombosis process, but the timing of the event is extremely unusual.
Therefore, the effect of radiation on delaying the healing process and
maintaining a thrombogenic coronary surface is proposed as the most
plausible mechanism to explain such late events. CONCLUSIONS: Late and
sudden thrombosis after PTCA followed by intracoronary radiotherapy is a
new phenomenon in interventional cardiology
Geographic Miss
Background—A recognized limitation of endovascular ß-radiation therapy is the development of new stenosis at the edges of the irradiated area. The combination of injury and low-dose radiation may be the precursor of this phenomenon. We translated the radio-oncological concept of "geographic miss" to define cases in which the radiation source did not fully cover the injured area. The aims of the study were to determine the incidence and causes of geographic miss and evaluate the impact of this inadequate treatment on the outcome of patients treated with intracoronary ß-radiation.
Methods and Results—We analyzed 50 consecutive patients treated with ß-radiation after percutaneous coronary intervention. The prescribed dose ranged between 12 and 20 Gy at 2 mm from the source axis. By means of quantitative coronary angiography, the irradiated segment (IRS) and both edges were studied before and after intervention and at 6-month follow-up. Edges that were injured during the procedure constituted the geographic miss edges. Twenty-two edges were injured during the intervention, mainly because of procedural complications that extended the treatment beyond the margins of the IRS. Late loss was significantly higher in geographic miss edges than in IRSs and uninjured edges (0.84±0.6 versus 0.15±0.4 and 0.09±0.4 mm, respectively; P<0.0001). Similarly, restenosis rate was significantly higher in the injured edges (10% within IRS, 40.9% in geographic miss edges, and 1.9% in uninjured edges; P<0.001).
Conclusions—These data support the hypothesis that the combination of injury and low-dose ß-radiation induces deleterious outcome
Positive geometric vascular remodeling is seen after catheter-based radiation followed by conventional stent implantation but not after radioactive stent implantation
BACKGROUND: Recent reports demonstrate that intracoronary radiation
affects not only neointimal formation but also vascular remodeling.
Radioactive stents and catheter-based techniques deliver radiation in
different ways, suggesting that different patterns of remodeling after
each technique may be expected. METHODS AND RESULTS: We analyzed
remodeling in 18 patients after conventional stent implantation, 16
patients after low-activity radioactive stent implantation, 16 patients
after higher activity radioactive stent implantation, and, finally, 17
patients who underwent catheter-based radiation followed by conventional
stent implantation. Intravascular ultrasound with 3D reconstruction was
used after stent implantation and at the 6-month follow-up to assess
remodeling within the stent margins and at its edges. Preprocedural
characteristics were similar between groups. In-stent neointimal
hyperplasia (NIH) was inhibited by high-activity radioactive stent
implantation (NIH 9.0 mm(3)) and by catheter-based radiation followed by
conventional stent implantation (NIH 6.9 mm(3)) compared with low-activity
radioactive stent implantation (NIH 21.2 mm(3)) and conventional stent
implantation (NIH 20.8 mm(3)) (P:=0.008). No difference in plaque or total
vessel volume was seen behind the stent in the conventional, low-activity,
or high-activity stent implantation groups. However, significant increases
in plaque behind the stent (15%) and in total vessel volume (8%) were seen
in the group that underwent catheter-based radiation followed by
conventional stent implantation. All 4 groups demonstrated significant
late lumen loss at the stent edges; however, edge restenosis was seen only
in the group subjected to high-activity stent implantation and appeared to
be due to an increase in plaque and, to a lesser degree, to negative
remodeling. CONCLUSIONS: Distinct differences in the patterns of
remodeling exist between conventional, radioactive, and catheter-based
radiotherapy with stenting
Preserved endothelium-dependent vasodilation in coronary segments previously treated with balloon angioplasty and intracoronary irradiation
BACKGROUND: Abnormal endothelium-dependent coronary vasomotion has been
reported after balloon angioplasty (BA), as well as after intracoronary
radiation. However, the long-term effect on coronary vasomotion is not
known. The aim of this study was to evaluate the long-term vasomotion of
coronary segments treated with BA and brachytherapy. METHODS AND RESULTS:
Patients with single de novo lesions treated either with BA followed by
intracoronary beta-irradiation (according to the Beta Energy Restenosis
Trial-1.5) or with BA alone were eligible. Of these groups, those patients
in stable condition who returned for 6-month angiographic follow-up formed
the study population (n=19, irradiated group and n=11, control group).
Endothelium-dependent coronary vasomotion was assessed by selective
infusion of serial doses of acetylcholine (ACh) proximally to the treated
area. Mean luminal diameter was calculated by quantitative coronary
angiography both in the treated area and in distal segments. Endothelial
dysfunction was defined as a vasoconstriction after the maximal dose of
ACh (10(-6) mol/L). Seventeen irradiated segments (89.5%) demonstrated
normal endothelial function. In contrast, 10 distal nonirradiated segments
(53%) and 5 control segments (45%) demonstrated endothelium-dependent
vasoconstriction (-19+/-17% and -9.0+/-5%, respectively). Mean percentage
of change in mean luminal diameter after ACh was significantly higher in
irradiated segments (P=0.01). CONCLUSIONS: Endothelium-dependent
vasomotion of coronary segments treated with BA followed by beta-radiation
is restored in the majority of stabl
Outcome from balloon induced coronary artery dissection after intracoronary beta radiation
OBJECTIVE: To evaluate the healing of balloon induced coronary artery
dissection in individuals who have received beta radiation treatment and
to propose a new intravascular ultrasound (IVUS) dissection score to
facilitate the comparison of dissection through time. DESIGN:
Retrospective study. SETTING: Tertiary referral centre. PATIENTS: 31
patients with stable angina pectoris, enrolled in the beta energy
restenosis trial (BERT-1.5), were included. After excluding those who
underwent stent implantation, the evaluable population was 22 patients.
INTERVENTIONS: Balloon angioplasty and intracoronary radiation followed by
quantitative coronary angiography (QCA) and IVUS. Repeat QCA and IVUS were
performed at six month follow up. MAIN OUTCOME MEASURES: QCA and IVUS
evidence of healing of dissection. Dissection classification for
angiography was by the National Heart Lung Blood Institute scale. IVUS
proven dissection was defined as partial or complete. The following IVUS
defined characteristics of dissection were described in the affected
coronary segments: length, depth, arc circumference, presence of flap, and
dissection score. Dissection was defined as healed when all features of
dissection had resolved. The calculated dose of radiation received by the
dissected area in those with healed versus non-healed dissection was also
compared. RESULTS: Angiography (type A = 5, B = 7, C = 4) and IVUS proven
(partial = 12, complete = 4) dissections were seen in 16 patients
following intervention. At six month follow up, six and eight unhealed
dissections were seen by angiography (A = 2, B = 4) and IVUS (partial = 7,
complete = 1), respectively. The mean IVUS dissection score was 5.2 (range
3-8) following the procedure, and 4.6 (range 3-7) at follow up. No
correlation was found between the dose prescribed in the treated area and
the presence of unhealed disse
Improved survival of patients with cervical cancer treated with image-guided brachytherapy compared with conventional brachytherapy
Experimentele farmacotherapi
Efficacy and toxicity of chemoradiation with image-guided adaptive brachytherapy for locally advanced cervical cancer
Experimentele farmacotherapi