5,593 research outputs found

    Moral Turbulence and the Infusion of Multimodal Character Education Strategies in American Elementary Schools

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    Pockets of American society are marked by increase in violent crime with concurrent decline in moral character. This phenomenon is infiltrating the nation’s school system as evidenced by growing numbers of aggressive incidents in the classroom. As a result, there is an increasingly accepted need for effective character education programs in the schools as a means to help change the décolleté trajectory of the behavior of the nation’s school children. While more money and growing numbers of legislation have been put forth to support such an endeavor, research is still lacking as to what activities, skills, goals, and approaches would be best incorporated for optimal outcomes. This article makes a case for assessing the effectiveness of a multimodal approach incorporating cognitive, social, and sociocultural learning elements is than a single approach using cognitive elements alone, and considers the complexity of a Christian perspective on character education in schools

    The Very Light Jet Arrives: Stakeholders and Their Perceptions

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    This article summarizes the initial results of a systematic study that addressed issues related to the direct and indirect market impact of very light jet (VLJ) aircraft. Although reports in the popular press offer wide-ranging estimates of the impact that these new jets will have on existing air travel, no systematic data exists that may be of use to all potential stakeholders. This introductory study serves to describe potential VLJ users and their perceptions of this new type of aircraft

    Performance Evaluation of Load-Balanced Routing via Bounded Randomization

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    Future computer networks are expected to carry bursty traffic. Shortest-path routing protocols such as OSPF and RIP have t he disadvantage of causing bottlenecks due to their inherent single-path routing. That is, the uniformly selected shortest path between a source and a destination may become highly congested even when many other paths have low utilization. We propose a family of routing schemes that distribute data traffic over the whole network via bounded randomization; in this way, they remove bottlenecks and consequently improve network performance. For each data message to be sent from a source s to a destination d, each of the proposed routing protocols randomly choose an intermediate node e from a selected set of network nodes, and routes the data message along a shortest path from s to e. Then, it routes the data message via a shortest path from e to d. Intuitively, we would expect that this increase the effective bandwidth between each source-destination pair. Our simulation results indicate that the family of proposed load-balanced routing protocols distribute traffic evenly over the whole network and, in consequence, increases network performance with respect to throughput, message loss, message delay and link utilization. Moreover, implementing our scheme requires only a simple extension to any shortest-path routing protocol

    Role of Dicer Enzyme in the Regulation of Store Operated Calcium Entry (SOCE) in CD4+ T Cells

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    Background/Aims: Activation of T cell receptors (TCRs) in CD4+ T cells leads to a cascade of signalling reactions including increase of intracellular calcium (Ca2+) levels with subsequent Ca2+ dependent stimulation of gene expression, proliferation, cell motility and cytokine release. The increase of cytosolic Ca2+ results from intracellular Ca2+ release with subsequent activation of store-operated Ca2+ entry (SOCE). Previous studies suggested miRNAs are required for the development and functions of CD4+ T cells. An enzyme called Dicer is required during the process of manufacturing mature miRNAs from the precursor miRNAs. In this study, we explored whether loss of Dicer in CD4+ T cells affects SOCE and thus Ca2+ dependent regulation of cellular functions. Methods: We tested the expression of Orai1 by q-RT-PCR and flow cytometry. Further, we measured SOCE by an inverted phase-contrast microscope with the Incident-light fluorescence illumination system using Fura-2. Intracellular Ca2+ was also measured by flow cytometry using Ca2+ sensitive dye Fluo-4. Results: We found that in Dicer deficient (DicerΔ/Δ) mice Orai1 was downregulated at mRNA and protein level in CD4+ T cells. Further, SOCE was significantly smaller in DicerΔ/Δ CD4+ T cells than in CD4+ T cells isolated from wild-type (Dicerfl/fl) mice. Conclusion: Our data suggest that miRNAs are required for adequate Ca2+ entry into CD4+ T cells and thus triggering of Ca2+ sensitive immune functions

    Polysaccharide Processing and Presentation by the MHCII Pathway

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    AbstractThe adaptive immune system functions through the combined action of antigen-presenting cells (APCs) and T cells. Specifically, class I major histocompatibility complex antigen presentation to CD8+ T cells is limited to proteosome-generated peptides from intracellular pathogens while the class II (MHCII) endocytic pathway presents only proteolytic peptides from extracellular pathogens to CD4+ T cells. Carbohydrates have been thought to stimulate immune responses independently of T cells; however, zwitterionic polysaccharides (ZPSs) from the capsules of some bacteria can activate CD4+ T cells. Here we show that ZPSs are processed to low molecular weight carbohydrates by a nitric oxide-mediated mechanism and presented to T cells through the MHCII endocytic pathway. Furthermore, these carbohydrates bind to MHCII inside APCs for presentation to T cells. Our observations begin to elucidate the mechanisms by which some carbohydrates induce important immunologic responses through T cell activation, suggesting a fundamental shift in the MHCII presentation paradigm

    E-Cigarettes: Prevalence and Attitudes in Great Britain

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    Introduction: Electronic cigarettes (e-cigarettes) are a means of recreational nicotine use that can potentially eliminate the need to smoke tobacco. Little is known about the prevalence of use or smokers' attitudes toward e-cigarettes. This study describes use of and attitudes toward e-cigarettes in Britain. Methods: Respondents from three surveys were recruited from a panel of adults in Britain. Preliminary online and face-to-face qualitative research informed the development of a smokers' survey (486 smokers who had used e-cigarettes and 894 smokers who had not). Representative samples of adults in Britain were then constructed from the panel for population surveys in 2010 (12,597 adults, including 2,297 smokers) and 2012 (12,432 adults, including 2,093 smokers), generating estimates of the prevalence of e-cigarette use and trial in Great Britain. Results: Awareness, trial, and current use increased between 2010 and 2012; for example, current use more than doubled from 2.7% of smokers in 2010 to 6.7% in 2012. The proportion of ever-users currently using e-cigarettes was around one-third in both years. In 2012, 1.1% of ex-smokers reported current e-cigarette use, and a further 2.7% reported past use. Approximately 0.5% of never-smokers reported having tried e-cigarettes. Conclusions: While we found evidence supporting the view that e-cigarette use may be a bridge to quitting, we found very little evidence of e-cigarette use among adults who had never smoked. British smokers would benefit from information about the effective use, risks, and benefits of e-cigarettes, as this might enable the use of e-cigarettes to improve public health

    Kentucky\u27s Coal Industry: Historical Trends and Future Opportunities

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    Coal has been produced in Kentucky since the late 18th century. In the early years, all mining was by underground methods, but surface mining became the dominant method during and after World War II. In recent years, surface-mine production in both fields has decreased while underground mining has increased. In the last half of this century, the traditional steam coal market for locomotives has virtually disappeared, leaving electric power generation and coking coal for the steel industry as the principal markets. More than half of all coal produced in the State has been produced in the last 25 years. Whether this level of production can be profitably sustained is questionable. More than 50 percent of the coal in eastern Kentucky is Jess than 28 in. thick, while more than 69 percent of the coal in western Kentucky is greater than 42 in. thick. Although eastern Kentucky\u27s resources are thinner, they have a lower sulfur content and higher calorific value than western Kentucky\u27s. Traditional resource estimates have overestimated the amount of coal that can actually be mined because they have not taken into account factors such as competing land uses and geologic and engineering constraints. KGS is participating in national programs to estimate coal availability and recoverability. Results of selected study areas suggest that as little as 50 percent of the original resource is available for mining, whereas only 20 percent is economically recoverable. It is uncertain yet whether these averages are indicative of all of Kentucky\u27s coal resources. Regional assessments of Kentucky\u27s most important coals, which incorporate coal availability methods, are under way. A number of regulatory and taxation issues will have an impact on the coal industry in Kentucky, but how much of an impact is uncertain. These issues include the Clean Air Act Amendments, liability for unreel aimed surface mines, regulatory flexibility to permit changes in postmine land use, and changes in the State\u27s workers\u27 compensation law. Advances in thin-seam and remote-mining technology will be crucial, particularly in eastern Kentucky, where most of the remaining coal occurs in thin seams. improvements in coal-preparation technology could make Kentucky\u27s higher sulfur coals more attractive. There may be potential for extraction of methane gas from coal beds, as an energy by-product. Detailed knowledge of the physical and chemical character of Kentucky\u27s coal beds will be vital in their development. Acquisition of this knowledge could be facilitated by cooperation among private industry, public agencies, and research institutes

    Impact of deforestation on solid and dissolved organic matter characteristics of tropical peat forests: implications for carbon release

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    This study compares the organic chemistry of peat beneath one of last remaining pristine tropical peat forests in Southeast Asia with a neighbouring peat dome that has been deforested, but not intentionally drained, in the Belait district of Brunei Darussalam, Borneo. We characterized the solid and dissolved organic matter collected from the two domes, through a combination of methods including elemental analysis, phenolic content and Fourier transform infrared spectroscopy (FTIR) investigation of solid peat, as well as optical characterisation (absorbance, fluorescence) of dissolved organic matter (DOM). The peat had a high content of lignin, consistent with its origin from the Shorea albida trees on the domes. Dissolved organic carbon (DOC) concentration in the pore water was significantly greater in the deforested site (79.9 ± 5.5 mg l[superscript −1]) than the pristine site (62.2 ± 2.2 mg l[superscript −1]). The dissolved organic matter was richer in nitrogen and phenolics in the deforested site. The optical properties (Fluorescence Index) indicated a modification of DOM cycling in the deforested site (enhanced decomposition of the peat and fresh litter). Comparison of the solid peat composition between the two sites also suggests effects of deforestation: sulphur, nitrogen and phenolic contents were higher in the deforested site. Taken together, these observations are consistent with peat enhanced decomposition in the deforested site, even without engineered drainage.Singapore-MIT Alliance for Research and Technology. Center for Environmental Sensing and Modelin
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