Detection of 13th chromosome deletion frequency by fluorescent in situ hybridization method in patients with multiple myeloma

INTRODUCTION: Multiple myeloma (MM) is a malignant hematological disease characterized by malignant proliferation of a single plasma cell clone leading to monoclonal protein in plasma or urine. Presence of monoallelic loss of chromosome 13 (del13) or loss of long arm (del13q) indicates poor prognostic outcome in patients treated with standard chemotherapy. Del13/del13q is detected by FISH method in approximately half of newly diagnosed MM patients. METHODS: 42 patients diagnosed with MM according to the criteria of the International myeloma working group and treated at research and education hospital, were included in this study. Clinical, laboratory, pathological data were analyzed retrospectively and genetic data obtained by FISH method. RESULTS: 26 patients were female (61.9%) and 16 were male (38.1%). The mean age was 62. Del13 results were obtained in 30 of 42 patients, while positive in 6 patients (20%) negative in 24 patients (80%). Among the 30 patients with chromosome 13 results, 4 had IgA, 19 had IgG type monoclonal protein. All of the 6 patients with del13 were IgG myeloma (2 kappa, 3 lambda). DISCUSSION AND CONCLUSION: Compared to the recent studies, del13 is lower in our study. In many studies, del13 has been found in rates ranging from 30-50%. Although the rate of 20% we found is lower than the data in the literature, it is valuable in terms of reflecting the frequency of del13 in myeloma patients. Therefore, we strongly recommend that conventional karyotyping and FISH analysis of common chromosomal abnormalities be performed in newly diagnosed MM patients

Synthesis and characterization of mixed ligand chiral nanoclusters

Chiral mixed ligand silver nanoclusters were synthesized in the presence of a chiral and an achiral ligand. The ratio of the ligands was changed to track the formation of these clusters. While the chiral ligand lead to nanoparticles, Presence of the achiral ligand induced the formation of nanoclusters with chiral properties

The efficacy of cinacalcet in the treatment of hyperparathyroidism in Turkish hemodialysis patient population

WOS: 000393291900012OBJECTIVE: Cinacalcet reduces parathyroid hormone levels by increasing the sensitivity of the parathyroid gland to calcium. in this study, we firstly aimed to evaluate the efficacy of cinacalcet in Turkish hemodialysis patients. MATERIAL and METHODS: 4483 hemodialysis patients were screened and 469 patients who had used cinacalcet were included in the study. the patients were divided into 4 groups according to drug usage durations (Group 1: 3 months, Group 2: 6 months, Group 3: 9 months and Group 4: 12 months). the patients' Parathormone, Ca, P and CaxP levels at the 3rd, 6th, 9th and 12th months were compared to the start of treatment and previous months. RESULTS: the levels of Parathormone, Ca, P and CaxP significantly decreased compared to their initial levels in all groups (from 1412 pg/ml to 1222 pg/mL for Parathormone, p< 0,001) in the 3rd month. However, this reduction was not continued in the subsequent months (Parathormone: 1381 pg/ml for the 12th month). CONCLUSION: Cinacalcet may not provide adequate benefit in control of hyperparathyroidism in Turkish hemodialysis patient population

Şans ve şanssızlık bir arada: İnternal juguler ven kateterizasyonu sonrasında ortaya çıkan kalp tamponadı olgusu

Prior to serious surgical interventions, central venous catheterization (CVC) is used with such purposes as obtaining venous tract and hemodynamic monitorization as well as applying medicine. Although it is rare, serious complications might develop after catheterization. A 72-year-old female patient who was being prepared for coronary bypass surgery was inserted a CVC into right internal jugular vein. Her pericardium was opened upon the bradycardia that developed following the sternotomy, and it was observed that hemopericardium had developed. The tip of the central catheter was seen on vena cava superior and was pushed back by the surgery team. Cannulations were completed quickly and the pump was entered, vena cava was repaired and surgery was completed and then the patient was transferred to intensive care unit. In this article cardiac tamponade, which is a rare but potentially fatal complication associated with CVC, has been presented