149 research outputs found
Affirmative Action in American Law Schools: A Critical Response to Richard Sander\u27s A Reply to Critics
Richard Sanderâs Stanford Law Review article, âA Systemic Analysis of Affirmative Action in American Law Schools,â has generated considerable attention and criticism. This included a critical essay in the May 2005 Stanford Law Review by the four of us, as well as others in the same issue by Professors Ian Ayres and Richard Brooks, Michele Landis Dauber, and David Wilkins. Sanderâs âA Reply to Criticsâ also appeared in the same issue. For those following this empirical debate about the costs and benefits of affirmative action, we provide this working paper as a response to Sanderâs âA Reply to Critics.â We show the weaknesses in the logic that underlies many of Sanderâs assumptions and arguments and show that his reply does not salvage the case against affirmative action that he claimed to have made in his Stanford article. Rather, Sanderâs reply explicitly or implicitly repudiates much of the methodology and many of the claims he made in âSystemic Analysis,â even as he clings firmly to its conclusion and compounds earlier analytic mistakes with new ones
Affirmative Action in American Law Schools: A Critical Response to Richard Sander\u27s A Reply to Critics
Richard Sanderâs Stanford Law Review article, âA Systemic Analysis of Affirmative Action in American Law Schools,â has generated considerable attention and criticism. This included a critical essay in the May 2005 Stanford Law Review by the four of us, as well as others in the same issue by Professors Ian Ayres and Richard Brooks, Michele Landis Dauber, and David Wilkins. Sanderâs âA Reply to Criticsâ also appeared in the same issue. For those following this empirical debate about the costs and benefits of affirmative action, we provide this working paper as a response to Sanderâs âA Reply to Critics.â We show the weaknesses in the logic that underlies many of Sanderâs assumptions and arguments and show that his reply does not salvage the case against affirmative action that he claimed to have made in his Stanford article. Rather, Sanderâs reply explicitly or implicitly repudiates much of the methodology and many of the claims he made in âSystemic Analysis,â even as he clings firmly to its conclusion and compounds earlier analytic mistakes with new ones
The Real Impact of Eliminating Affirmative Action in American Law Schools: An Empirical Critique of Richard Sander\u27s Study
In 1970, there were about 4000 African American lawyers in the United States. Today there are more than 40,000. The great majority of the 40,000 have attended schools that were once nearly all-white, and most were the beneficiaries of affirmative action in their admission to law school. American law schools and the American bar can justly take pride in the achievements of affirmative action: the training of tens of thousands of African American (as well as Latino, Asian American, and Native American) practitioners, community leaders, judges, and law professors; the integration of the American bar; the services that minority attorneys have provided to minority individuals and organizations once poorly serviced by white lawyers; and the educational benefits that law students of all backgrounds derive from studying in a racially diverse environment. But not every student admitted through affirmative action realizes his or her ambition to practice law. Of the African American students who entered law school in the fall of 1991, the one year for which we have good data, about 43% either did not graduate or graduated but had not passed a bar exam within two years of graduation. Only 17% of the white students in the 1991 cohort suffered either of these fates. In A Systemic Analysis of Affirmative Action in American Law Schools (Systemic Analysis), Professor Richard Sander argues that if affirmative action were eliminated in law school admissions, the rate at which African American students fail to graduate and pass the bar would be reduced substantially without any concomitant loss in the numbers of African Americans joining the bar. He acknowledges that fewer African American students would be admitted to law school, but predicts that those who were admitted would graduate and pass the bar at much higher rates because they would no longer be attending schools where the competition was too stiff for them. Sander builds to an astonishing forecast: that the number of black lawyers produced by American law schools each year and subsequently passing the bar would probably increase if those schools collectively stopped using racial preferences. In particular, he predicts that the cohort entering law school in 2001 would have produced 7.9% more new black lawyers entering the bar.5 We agree with Sander that the high rate at which African American students fail to graduate and fail to pass the bar is alarming.6 Indeed, we take the problem so seriously that despite the high value we place on racial diversity within law schools, the four of us would not support affirmative action as currently practiced in law school admissions if we believed that employing race-neutral admissions criteria would in fact lead to a net increase in the number of African Americans passing the bar.7 We find, however, that while Sander has appropriately forced us and others to take a hard look at the actual workings of affirmative action, he has significantly overestimated the costs of affirmative action and failed to demonstrate benefits from ending it. The conclusions in Systemic Analysis rest on a series of statistical errors, oversights, and implausible assumptions. It is these empirical shortcomings that we address in this Response
Food consumption trends and drivers
A picture of food consumption (availability) trends and projections to 2050, both globally and for different regions of the world, along with the drivers largely responsible for these observed consumption trends are the subject of this review. Throughout the world, major shifts in dietary patterns are occurring, even in the consumption of basic staples towards more diversified diets. Accompanying these changes in food consumption at a global and regional level have been considerable health consequences. Populations in those countries undergoing rapid transition are experiencing nutritional transition. The diverse nature of this transition may be the result of differences in socio-demographic factors and other consumer characteristics. Among other factors including urbanization and food industry marketing, the policies of trade liberalization over the past two decades have implications for health by virtue of being a factor in facilitating the ânutrition transitionâ that is associated with rising rates of obesity and chronic diseases such as cardiovascular disease and cancer. Future food policies must consider both agricultural and health sectors, thereby enabling the development of coherent and sustainable policies that will ultimately benefit agriculture, human health and the environment
Dynamics of GLP-1R peptide agonist engagement are correlated with kinetics of G protein activation
The glucagon-like peptide-1 receptor (GLP-1R) has broad physiological roles and is a validated target for treatment of metabolic disorders. Despite recent advances in GLP-1R structure elucidation, detailed mechanistic understanding of how different peptides generate profound differences in G protein-mediated signalling is still lacking. Here we combine cryo-electron microscopy, molecular dynamics simulations, receptor mutagenesis and pharmacological assays, to interrogate the mechanism and consequences of GLP-1R binding to four peptide agonists; glucagon-like peptide-1, oxyntomodulin, exendin-4 and exendin-P5. These data reveal that distinctions in peptide N-terminal interactions and dynamics with the GLP-1R transmembrane domain are reciprocally associated with differences in the allosteric coupling to G proteins. In particular, transient interactions with residues at the base of the binding cavity correlate with enhanced kinetics for G protein activation, providing a rationale for differences in G protein-mediated signalling efficacy from distinct agonists
Activation of the GLP-1 receptor by a non-peptidic agonist
Class B G-protein-coupled receptors are major targets for the treatment of chronic diseases, including diabetes and obesity1. Structures of active receptors reveal peptide agonists engage deep within the receptor core, leading to an outward movement of extracellular loop 3 and the tops of transmembrane helices 6 and 7, an inward movement of transmembrane helix 1, reorganization of extracellular loop 2 and outward movement of the intracellular side of transmembrane helix 6, resulting in G-protein interaction and activation2,3,4,5,6. Here we solved the structure of a non-peptide agonist, TT-OAD2, bound to the glucagon-like peptide-1 (GLP-1) receptor. Our structure identified an unpredicted non-peptide agonist-binding pocket in which reorganization of extracellular loop 3 and transmembrane helices 6 and 7 manifests independently of direct ligand interaction within the deep transmembrane domain pocket. TT-OAD2 exhibits biased agonism, and kinetics of G-protein activation and signalling that are distinct from peptide agonists. Within the structure, TT-OAD2 protrudes beyond the receptor core to interact with the lipid or detergent, providing an explanation for the distinct activation kinetics that may contribute to the clinical efficacy of this compound series. This work alters our understanding of the events that drive the activation of class B receptors
The impact of family structure and disruption on intergenerational emotional exchange in Eastern Europe
Demographic trends across Europe involve a decrease in fertility and mortality rates, and an increase in divorce and stepfamily formation. Life courses and living arrangements have become less standardized and the structure of families has changed. In this article, we examine to what extent contemporary family structure and composition resulting from demographic changes affect emotional exchange between children and their parents, both from adult child to parent and from parent to child. Because the general level of well-being has been shown to be lower in Eastern Europe, thereby potentially affecting emotional exchange within families, we focus our research on Eastern Europe. We use the âconservation of resources theoryâ to derive hypotheses on how family structure may affect intergenerational emotional exchange. Family ties are assumed to be important resources of affection that people want to obtain and retain throughout their lives. Data from the Generations and Gender Survey (GGS) are used to test our hypotheses. In general, our data offer more support for the idea that families are resilient than for the often heard assumption that families are in decline as a consequence of the changed family structure and composition
Fontes de informação sobre nutrição e saĂșde utilizadas por estudantes de uma universidade privada de SĂŁo Paulo
An overview of the recent developments on fructooligosaccharide production and applications
Over the past years, many researchers have suggested
that deficiencies in the diet can lead to disease states
and that some diseases can be avoided through an adequate
intake of relevant dietary components. Recently, a great interest
in dietary modulation of the human gut has been registered.
Prebiotics, such as fructooligosaccharides (FOS), play a key
role in the improvement of gut microbiota balance and in
individual health. FOS are generally used as components of
functional foods, are generally regarded as safe (generally
recognized as safe statusâfrom the Food and Drug Administration,
USA), and worth about 150⏠per kilogram. Due to
their nutrition- and health-relevant properties, such as moderate
sweetness, low carcinogenicity, low calorimetric value,
and low glycemic index, FOS have been increasingly used
by the food industry. Conventionally, FOS are produced
through a two-stage process that requires an enzyme production
and purification step in order to proceed with the chemical
reaction itself. Several studies have been conducted on the
production of FOS, aiming its optimization toward the development
of more efficient production processes and their potential
as food ingredients. The improvement of FOS yield and
productivity can be achieved by the use of different fermentative
methods and different microbial sources of FOS producing
enzymes and the optimization of nutritional and
culture parameter; therefore, this review focuses on the latest
progresses in FOS research such as its production, functional
properties, and market data.Agencia de Inovacao (AdI)-Project BIOLIFE reference PRIME 03/347. Ana Dominguez acknowledges Fundacao para a Ciencia e a Tecnologia, Portugal, for her PhD grant reference SFRH/BD/23083/2005
A Forked River Runs Through Law School: Toward Understanding Race, Gender, Age, and Related Gaps in Law School Performance and Bar Passage
Analyses of the National Longitudinal Bar Passage Study (N = 27,478), demonstrate that law schools enlarge entering academic differences across race, age, disability, and socioeconomic origins rather than reduce them, and that academic differences in turn impact bar passage. Such differences cannot be reduced to (1) academic preparation, effort, or distractions; (2) instructional or law school-type characteristics; (3) social class; or (4) acceptance of an elitist legal ethos. Rather, results suggest that (1) women, minorities, and other atypical law students confront stigmatization throughout legal education;(2) for women (entering law school in 1991), this stigmatization is new, rejected, and consequently unassociated with law school outcomes; (3) for minorities, this stigmatization is continuous with prior socialization, making resistance difficult and consequent impact sizable; and (4) for other atypical law students, this stigmatization varies with visibility of difference, as do resistance and impact. Implications for social stigma theory and legal education are discussed
- âŠ