Alien Registration- Cloutier, Joseph N. (Lewiston, Androscoggin County)

https://digitalmaine.com/alien_docs/29716/thumbnail.jp

Attitudes and motivation for learning English among elementary francophone students

Canadian society allows for group traditions and supports a rich variety of cultures. The pluralistic nature of this country makes it beneficial for a growing number of children and adults to acquire a second language. Parents of school children and prospective employers see this as an important endeavor. Several reasons might explain this. Firstly, the acquisition of a second language may be perceived as increasing chances of securing employment. Secondly, many people want to retain their cultural identity. For example, many adults who come from French speaking families have lost the ability to speak their maternal language fluently. Later, and for different reasons, they may want their children to learn the language that they (the parents) have lost. As a result, they may place their children in schools where the indigenous culture and language can be cultivated. For years now educational communities have witnessed the expansion and growth of second language programs in elementary and secondary schools across the country (Ontario Ministry of Education, 1976; 1977). These have been strongly supported by both federal and provincial governments. Evidence of the promotion of English/French bilingualism and biculturalism in Canada, particularly in Ontario, is highly visible. One only has to look at the hundreds of research projects the government has funded to investigate factors related to the acquisition of a second language (Ontario Ministry of Education, 1979; 1983; 1994). Furthermore, the subventions and interest generated by the government to investigate factors related to the acquisition of a second language has prompted several researchers to study motivational characteristics of students in second language programs. There are various reasons why students study and persist in studying a second language. It is the purpose of this study to investigate affective components, such as competence, interest and utility, shown to be involved in second language learning. Hopefully, then, any contribution that this study can make to the understanding of attitudinal and motivational variables in second language acquisition will be an asset to the educational community

Brinell Limit Testing Machine - Final Design Report

In keeping with the California Polytechnic State University motto of “Learn by Doing”, this project was performed by Mechanical Engineering students Joe Cloutier, Josh Kessler, and Mike Jaskulsky II as their senior project. Starting in the Fall 2009 quarter and reaching completion with the end of the Spring 2010 quarter, this project provided these students with experience in application of a formal engineering design process in the solving of an open-ended engineering design problem, in developing and maintaining an engineering project schedule, as well as providing further experience working on an engineering team. As the engineers of Parker Aerospace seek to use different metals in their high performance bearing applications than have traditionally been used in the past, often the data does not exist for them to be able to accurately design against brinelling. To provide their engineers with this data, Parker Aerospace proposed the following as a senior project to Cal Poly’s seniors. They requested that a team of engineering students would design, fabricate, assemble, and validate through testing a machine that would determine the loads at the onset of brinelling for different metals and would allow for multiple measurements to be taken from each set of sample materials tested. Some of the secondary design requirements were for the test fixture to be portable, small enough to be used as a desktop unit, be able to accommodate a thermal chamber around the test area, and also provide measurements of the total deformation of the sample materials when under load. Also, time allowing, Parker Aerospace requested that the senior project team devote the last part of the last quarter to using the machine to provide data for a number of materials that they will provide. The loads that the test machine would need to deliver to test all material samples to the onset of brinelling were determined through hertzian contact stress analysis. These calculated loads were then used to determine the deflection of the sample materials, allowing for the sizing of structural components and selection of necessary sensors. The design for the fixture was developed around the initial design concept displayed in the Project Proposal by Parker Aerospace. After developing a number of different designs and variations of specific components of the fixture, the best of these design variations were presented to a panel of Parker Aerospace’s engineers during a Preliminary Design Review. From these designs, a final design was selected and various modifications were made as suggested by Parker. A final design was decided on and the rest of the project was completed by the end of the Spring quarter

Developing a toolkit for promoting responsible conduct in research-creation

Cette affiche présente les travaux liés à la Trousse sur la conduite responsable en recherche-création, disponible sur Papyrus

Effects of intravenous theophylline on exercise-induced myocardial ischemia: II. A concentration-dependent phenomenon

AbstractObjectives. The effects of varying concentrations of theophylline on exercise-induced myocardial ischemia were evaluated in patients with stable coronary artery disease.Background. Theophylline is a competitive antagonist of adenosine and may have potential as an anti-ischemic medication. It is not known whether these effects on myocardial ischemia are concentration dependent.Methods. In a double-blind, randomized, crossover manner, 11 patients received, at 1-week intervals, placebo and each of three theophylline doses by intravenous infusion for 45 min. Graded exercise testing was performed before randomization and immediately after each infusion. Concurrent anti-ischemic medications were withheld for 24 h before each exercise test. Serum theophylline concentrations achieved were 3.9 ± 1.0 mg/liter (low), 8.2 ± 1.8 mg/liter (medium) and 13.2 ± 2.3 mg/liter (high).Results. Compared with placebo, none of the three theophylline infusions produced a significant alteration in rest heart rate, blood pressure, mean frequency or severity of ventricular ectopic activity or noncardiac symptoms. The time to onset of ischemia was progressively increased, with medium and high concentrations achieving statistical significance. Similar patterns were observed for oxygen uptake and the heart rate-systolic blood pressure product at the onset of ischemia. Total exercise duration was significantly prolonged with the medium and high concentrations.Conclusions. It is concluded that administration of varying doses of theophylline before exercise produces a clinically significant and concentration-dependent improvement in the indicators of myocardial ischemia in patients with chronic stable coronary artery disease

Responsible Conduct of Research in Research-Creation: Moving into Uncharted Terrain

Responsible conduct of research (RCR) is ubiquitous, and present in most areas of research. One area that has received little attention is Research-Creation (RC): • an emergent eld at the interface of academic research and creative activities • in Quebec, Canada, RC is de ned as “research activities or approaches that foster the creation or interpretation/ performance of literary or artistic works of all types” Researcher-Creators – who are at the same time researchers and practising artists, musicians, or designers – may be faced with very di erent issues or challenges from colleagues in the rest of academia. • How do researcher-creators reconcile their dual obligations to creation and to research? • Are the usual research ethics guidelines (e.g., TCPS2, ICH relevant and how do they apply? • How do the creative/artistic dimensions of research a ect evaluations by grant committees and REBs? To better understand how RCR issues are articulated in the very heterogeneous RC community, we combine here results from a literature review and an international survey on RCR in RC.FRQ Action concerté

TOI 540 b: A Planet Smaller than Earth Orbiting a Nearby Rapidly Rotating Low-mass Star

We present the discovery of TOI 540 b, a hot planet slightly smaller than Earth orbiting the low-mass star 2MASS J05051443-4756154. The planet has an orbital period of $P = 1.239149$ days ($\pm$ 170 ms) and a radius of $r = 0.903 \pm 0.052 R_{\rm Earth}$, and is likely terrestrial based on the observed mass-radius distribution of small exoplanets at similar insolations. The star is 14.008 pc away and we estimate its mass and radius to be $M = 0.159 \pm 0.014 M_{\rm Sun}$ and $R = 0.1895 \pm 0.0079 R_{\rm Sun}$, respectively. The star is distinctive in its very short rotational period of $P_{\rm rot} = 17.4264 +/- 0.0094$ hours and correspondingly small Rossby number of 0.007 as well as its high X-ray-to-bolometric luminosity ratio of $L_X / L_{\rm bol} = 0.0028$ based on a serendipitous XMM-Newton detection during a slew operation. This is consistent with the X-ray emission being observed at a maximum value of $L_X / L_{\rm bol} \simeq 10^{-3}$ as predicted for the most rapidly rotating M dwarfs. TOI 540 b may be an alluring target to study atmospheric erosion due to the strong stellar X-ray emission. It is also among the most accessible targets for transmission and emission spectroscopy and eclipse photometry with JWST, and may permit Doppler tomography with high-resolution spectroscopy during transit. This discovery is based on precise photometric data from TESS and ground-based follow-up observations by the MEarth team.Comment: 18 pages, 7 figures. Accepted for publication in The Astronomical Journa

Breast cancer in systemic lupus

OBJECTIVE: There is a decreased breast cancer risk in systemic lupus erythematosus (SLE) versus the general population. We assessed a large sample of SLE patients, evaluating demographic and clinical characteristics and breast cancer risk. METHODS: We performed case-cohort analyses within a multi-center international SLE sample. We calculated the breast cancer hazard ratio (HR) in female SLE patients, relative to demographics, reproductive history, family history of breast cancer, and time-dependent measures of anti-dsDNA positivity, cumulative disease activity, and drugs, adjusted for SLE duration. RESULTS: There were 86 SLE breast cancers and 4498 female SLE cancer-free controls. Patients were followed on average for 7.6 years. Versus controls, SLE breast cancer cases tended to be white and older. Breast cancer cases were similar to controls regarding anti-dsDNA positivity, disease activity, and most drug exposures over time. In univariate and multivariate models, the principal factor associated with breast cancers was older age at cohort entry. CONCLUSIONS: There was little evidence that breast cancer risk in this SLE sample was strongly driven by any of the clinical factors that we studied. Further search for factors that determine the lower risk of breast cancer in SLE may be warranted

Resistance to TGFβ suppression and improved anti-tumor responses in CD8⁺ T cells lacking PTPN22

Transforming growth factor β (TGFβ) is important in maintaining self-tolerance and inhibits T cell reactivity. We show that CD8⁺ T cells that lack the tyrosine phosphatase Ptpn22, a major predisposing gene for autoimmune disease, are resistant to the suppressive effects of TGFβ. Resistance to TGFβ suppression, while disadvantageous in autoimmunity, helps Ptpn22‾/‾ T cells to be intrinsically superior at clearing established tumors that secrete TGFβ. Mechanistically, loss of Ptpn22 increases the capacity of T cells to produce IL-2, which overcomes TGFβ-mediated suppression. These data suggest that a viable strategy to improve anti-tumor adoptive cell therapy may be to engineer tumor-restricted T cells with mutations identified as risk factors for autoimmunity