The pressure-induced fundamental vibrational spectrum of chlorine at 298°K

This thesis has no abstract

The Role of Theta Oscillations in Human Associative Memory

Human episodic memory consists of bound, highly rich, multisensory experiences. The sensory cortices that process the sensory information that form part of these memories are distributed across the brain in specialised areas. The binding of the information processed by these sensory regions is likely facilitated by long-term potentiation. This mechanism relies on the precise timing of neural activity. Theta oscillations, a dominant, low-frequency neural oscillation in the hippocampus, is a candidate mechanism involved in facilitating the precise timing required for LTP to take place. Indeed, studies in animals have suggested as much. However, evidence for a causal role of theta oscillations in human associative memory formation is lacking. By modulating the luminance of movies and the amplitude of sounds in an associative memory task, we manipulated the degree of phase synchrony between the respective sensory cortices. We show that associative memory was improved if the stimuli were presented in-phase. Through the experiments presented in this thesis, we provide direct evidence of the causal role of theta oscillations in human memory: Human associative memory relies on the phase of a theta-frequency mechanism

Finding a rare fossilized comb jelly reveals new gaps in the fossil record

They look like jellyfish but they aren’t. They seem inoffensive but are efficient predators — occasionally, they even eat fish. They are gelatinous and very delicate — and extremely rarely do they fossilize! Ctenophores, also known as comb jellies, are colourful, translucent animals, that drift through oceanic waters. Unlike jellyfish, ctenophores don’t have stinging cells, and typically capture prey using long, sticky tentacles. Our research describing a fossilized ctenophore from Eastern Canada, published recently in Scientific Reports, suggests that our creature was a very late survivor from the very dawn of animals. It also means that a very controversial idea about early animal evolution can’t be rejected by the fossil record

Theta phase synchronization is the glue that binds human associative memory

Episodic memories are information-rich, often multisensory events that rely on binding different elements [1]. The elements that will constitute a memory episode are processed in specialized but distinct brain modules. The binding of these elements is most likely mediated by fast-acting long-term potentiation (LTP), which relies on the precise timing of neural activity [2]. Theta oscillations in the hippocampus orchestrate such timing as demonstrated by animal studies in vitro [3, 4] and in vivo [5, 6], suggesting a causal role of theta activity for the formation of complex memory episodes, but direct evidence from humans is missing. Here, we show that human episodic memory formation depends on phase synchrony between different sensory cortices at the theta frequency. By modulating the luminance of visual stimuli and the amplitude of auditory stimuli, we directly manipulated the degree of phase synchrony between visual and auditory cortices. Memory for sound-movie associations was significantly better when the stimuli were presented in phase compared to out of phase. This effect was specific to theta (4 Hz) and did not occur in slower (1.7 Hz) or faster (10.5 Hz) frequencies. These findings provide the first direct evidence that episodic memory formation in humans relies on a theta-specific synchronization mechanism

Single-trial phase entrainment of theta oscillations in sensory regions predicts human associative memory performance

Episodic memories are rich in sensory information and often contain integrated information from different sensory modalities. For instance, we can store memories of a recent concert with visual and auditory impressions being integrated in one episode. Theta oscillations have recently been implicated in playing a causal role synchronizing and effectively binding the different modalities together in memory. However, an open question is whether momentary fluctuations in theta synchronization predict the likelihood of associative memory formation for multisensory events. To address this question we entrained the visual and auditory cortex at theta frequency (4 Hz) and in a synchronous or asynchronous manner by modulating the luminance and volume of movies and sounds at 4 Hz, with a phase offset at 0° or 180°. EEG activity from human subjects (both sexes) was recorded while they memorized the association between a movie and a sound. Associative memory performance was significantly enhanced in the 0° compared with the 180° condition. Source-level analysis demonstrated that the physical stimuli effectively entrained their respective cortical areas with a corresponding phase offset. The findings suggested a successful replication of a previous study (Clouter et al., 2017). Importantly, the strength of entrainment during encoding correlated with the efficacy of associative memory such that small phase differences between visual and auditory cortex predicted a high likelihood of correct retrieval in a later recall test. These findings suggest that theta oscillations serve a specific function in the episodic memory system: binding the contents of different modalities into coherent memory episodes

Rhythmic sensory stimulation as a noninvasive tool to study plasticity mechanisms in human episodic memory

In recent years, research in animals has increasingly focused on understanding the role of precise neural timing in inducing synaptic plasticity (the strengthening or weakening of synaptic connections). Human episodic memory is thought to depend on such plasticity. Animal studies have provided valuable insights into mechanisms such as spike-timing-dependent plasticity and theta-phase-dependent plasticity, highlighting the importance of coordinated timing between neural inputs for synaptic changes to occur. Building upon these findings, recent studies employing rhythmic sensory stimulation and electromagnetic stimulation in humans have attempted to link these mechanisms to episodic memory formation. These studies have revealed that memory consolidation relies on the precise co-ordination of timing between neural inputs, particularly in the gamma and theta frequency ranges. This body of work represents a crucial bridge between our understanding of cellular-level mechanisms in animal models and the complex processes underlying human memory

A framework for improving urban soundscapes

Sound in public urban spaces is often considered in negative terms as both intrusive and undesirable - its referred to as noise! However, this issue is multi-facetted and goes much deeper than simply reducing levels. There are many positive aspects of a soundscape. In an attempt to progress thinking on positive soundscapes and move towards more practical planning approaches and decision making tools for soundscape assessment, this paper proposes an approach traditionally used in product development and manufacturing quality - The Kano Model. The approach is captured in the form of a broader framework which covers: the composition of a soundscape in objective terms; the factors affecting whether it might be perceived as positive; and how the Kano model for product development can be used as a means of understanding the range of applicability of approaches to create positive soundscapes (including several novel approaches which are the subject of other papers in this issue). It can be considered to be complementary with previous frameworks, some of which have concentrated on sound sources, others on the factors affecting perception or even as a model for understanding individual evaluation. In this case the motivation behind the framework is to help assess the likely impact of practical interventions on the positive aspects of a soundscape. The framework proposes that the meaning of "positive" for a public space is quite different for three types of people, each with a different level of direct engagement with the soundscape: planners; serious listeners; users of the space. The first two are influenced by the soundscape itself, either in meeting legislation and reducing nuisance, or as an artistic or creative opportunity. However the third, arguably most important group of people, users of the space, are more concerned with the space itself and have their perception of it influenced by the soundscape, which is an inconvenient and highly complex intermediate step. This influence is largely determined by their activity e.g. reading, holding a conversation, shopping or sightseeing. The paper discusses the further implementation of the framework, and how barriers to the wider application of the concept of positive soundscapes might be overcome. It shows how adapting an approach previously used in automotive sound quality can be adapted for urban soundscapes. It concludes with recommendations for taking the framework forward as a practical approach

Carbon black nanoparticles induce type II epithelial cells to release chemotaxins for alveolar macrophages.

Background - Alveolar macrophages are a key cell in dealing with particles deposited in the lungs and in determining the subsequent response to that particle exposure. Nanoparticles are considered a potential threat to the lungs and the mechanism of pulmonary response to nanoparticles is currently under intense scrutiny. The type II alveolar epithelial cell has previously been shown to release chemoattractants which can recruit alveolar macrophages to sites of particle deposition. The aim of this study was to assess the responses of a type II epithelial cell line (L-2) to both fine and nanoparticle exposure in terms of secretion of chemotactic substances capable of inducing macrophage migration.ResultsExposure of type II cells to carbon black nanoparticles resulted in significant release of macrophage chemoattractant compared to the negative control and to other dusts tested (fine carbon black and TiO2 and nanoparticle TiO2) as measured by macrophage migration towards type II cell conditioned medium. SDS-PAGE analysis of the conditioned medium from particle treated type II cells revealed that a higher number of protein bands were present in the conditioned medium obtained from type II cells treated with nanoparticle carbon black compared to other dusts tested. Size-fractionation of the chemotaxin-rich supernatant determined that the chemoattractants released from the epithelial cells were between 5 and 30 kDa in size.ConclusionThe highly toxic nature and reactive surface chemistry of the carbon black nanoparticles has very likely induced the type II cell line to release pro-inflammatory mediators that can potentially induce migration of macrophages. This could aid in the rapid recruitment of inflammatory cells to sites of particle deposition and the subsequent removal of the particles by phagocytic cells such as macrophages and neutrophils. Future studies in this area could focus on the exact identity of the substance(s) released by the type II cells in response to particle exposure