Surficial materials of the York Harbor quadrangle, Maine

Maine Geological Survey, Open-File Map 98-166https://digitalmaine.com/mgs_maps/1645/thumbnail.jp

Surficial materials of the York Beach quadrangle, Maine

Maine Geological Survey, Open-File Map 98-167https://digitalmaine.com/mgs_maps/1710/thumbnail.jp

Investigating Collaborative Data Practices: a Case Study on Artificial Intelligence for Healthcare Research

Developing artificial intelligence (AI) tools for healthcare is a collaborative effort, bringing data scientists, clinicians, patients and other disciplines together. In this paper, we explore the collaborative data practices of research consortia tasked with applying AI tools to understand and manage multiple long-term conditions in the UK. Through an inductive thematic analysis of 13 semi-structured interviews with participants of these consortia, we aimed to understand how collaboration happens based on the tools used, communication processes and settings, as well as the conditions and obstacles for collaborative work. Our findings reveal the adaptation of tools that are used for sharing knowledge and the tailoring of information based on the audience, particularly those from a clinical or patient perspective. Limitations on the ability to do this were also found to be imposed by the use of electronic healthcare records and access to datasets. We identified meetings as the key setting for facilitating exchanges between disciplines and allowing for the blending and creation of knowledge. Finally, we bring to light the conditions needed to facilitate collaboration and discuss how some of the challenges may be navigated in future work.Comment: 17 page

Illinoian and Late Wisconsin Tills in Eastern New England: a Transect from Northeastern Massachusetts to West-Central Maine

Guidebook for field trips in southern and west-central Maine, October 13, 14 and 15, 1989: New England Intercollegiate Geological Conference 81st annual meeting: Trip A-

Novel application of behavioral assays allows dissociation of joint pathology from systemic extra-articular alterations induced by inflammatory arthritis

Introduction: Although rheumatoid arthritis (RA) is a disease of articular joints, patients often suffer from co-morbid neuropsychiatric changes, such as anxiety, that may reflect links between heightened systemic inflammation and abnormal regulation of the hypothalamic-pituitary-adrenal (HPA) axis. Here, we apply behavioral neuroscience methods to assess the impact of antigen-induced arthritis (AIA) on behavioral performance in wild type (WT) and interleukin-10 deficient (Il10-/-) mice. Our aim was to identify limb-specific motor impairments, as well as neuropsychological responses to inflammatory arthritis. Methods: Behavioral testing was performed longitudinally in WT and Il10-/- mice before and after the induction of arthritic joint pathology. Footprint analysis, beam walking and open field assessment determined a range of motor, exploratory and anxiety-related parameters. Specific gene changes in HPA axis tissues were analyzed using qPCR. Results: Behavioral assessment revealed transient motor and exploratory impairments in mice receiving AIA, coinciding with joint swelling. Hind limb coordination deficits were independent of joint pathology. Behavioral impairments returned to baseline by 10 days post-AIA in WT mice. Il10-/- mice demonstrated comparable levels of swelling and joint pathology as WT mice up to 15 days post-AIA, but systemic differences were evident in mRNA expression in HPA axis tissues from Il10-/- mice post-AIA. Interestingly, the behavioral profile of Il10-/- mice revealed a significantly longer time post-AIA for activity and anxiety-related behaviors to recover. Conclusions: The novel application of sensitive behavioral tasks has enabled dissociation between behaviors that occur due to transient joint-specific pathology and those generated by more subtle systemic alterations that manifest post-AIA

Benefits for children with suspected cancer from routine whole-genome sequencing

Clinical whole-genome sequencing (WGS) has been shown to deliver potential benefits to children with cancer and to alter treatment in high-risk patient groups. It remains unknown whether offering WGS to every child with suspected cancer can change patient management. We collected WGS variant calls and clinical and diagnostic information from 281 children (282 tumors) across two English units (n = 152 from a hematology center, n = 130 from a solid tumor center) where WGS had become a routine test. Our key finding was that variants uniquely attributable to WGS changed the management in ~7% (20 out of 282) of cases while providing additional disease-relevant findings, beyond standard-of-care molecular tests, in 108 instances for 83 (29%) cases. Furthermore, WGS faithfully reproduced every standard-of-care molecular test (n = 738) and revealed several previously unknown genomic features of childhood tumors. We show that WGS can be delivered as part of routine clinical care to children with suspected cancer and can change clinical management by delivering unexpected genomic insights. Our experience portrays WGS as a clinically impactful assay for routine practice, providing opportunities for assay consolidation and for delivery of molecularly informed patient care.</p

Surficial geology of the Cape Elizabeth 7.5-minute quadrangle, Cumberland County, Maine

Maine Geological Survey, Open-File Report 99-111https://digitalmaine.com/mgs_publications/1236/thumbnail.jp

Surficial geology of the Prouts Neck quadrangle, Maine

Maine Geological Survey, Open-File Map 99-97https://digitalmaine.com/mgs_maps/1998/thumbnail.jp

Surficial geology of the Prouts Neck 7.5-minute quadrangle, Cumberland and York Counties, Maine

Maine Geological Survey, Open-File Report 99-128https://digitalmaine.com/mgs_publications/1235/thumbnail.jp