Pump-and-probe lidar for in-situ probing of atmospheric chemistry

A computer simulation of some chem. scenarios are presented to obtain preliminary information on what can be learned from pump-and-probe lidar expts., i.e., in situ laser flash photolysis in the troposphere. The decay of the OH concn. following the flash photolysis by different spatially resolved techniques is done under different conditions where the significant chem. and meteorol. parameters were sep. measured, so that model calcs. can be compared with time-dependent OH concns. The scenarios, within the limits of the simplified chem. model, are only realistic for a static atm. without turbulence or diffusion, i.e., at short delays after the laser flash perturbation. Relaxation/recovery of the atm. species occurs on different time scales according to the strength of the perturbation or the species involved. Several transient species were detected during system recovery back to steady state

Amlodipine once-daily in systemic hypertension

The calcium channel blocker nifedipine is widely used in children with systemic hypertension: however, because of the short duration of action, three to four daily doses of the standard preparation are required. Amlodipine once-daily, a calcium channel blocker structurally related to nifedipine with an excellent bioavailability and a long elimination half-time, has been shown to reduce blood pressure in adults. No information is available on the use of amlodipine in childhood. The effects of amlodipine once-daily (5 to 10 mg) were therefore assessed in 28 paediatric patients with hypertension. Amlodipine was withdrawn in five patients who experienced oedema and flushing. In the remaining 23 patients blood pressure was significantly reduced 3 weeks after amlodipine (on average by 7/5 mm Hg) and further decreased at 12 weeks (by 21/12 mm Hg). Heart rate and body weight were unchanged. In eight patients concomitantly treated with cyclosporine, the blood level of this agent was stable throughout the study, thus not requiring any dose adjustment. CONCLUSION: The study illustrates the antihypertensive properties of amlodipine once-daily in paediatric hypertension. Amlodipine appears particularly indicated in patients concomitantly treated with cyclosporine

Arturo Toscanini: il direttore e l'artista mediatico

Il volume analizza la formazione del repertorio sinfonico e operistico di Toscanini attraverso le testimonianze e le incisioni. Aggiunge indagini nuove sui rapporti con la regia, con i cantanti e con i solisti, e riconsidera la sua attivit\ue0 radiofonica negli Stati Uniti