296 research outputs found
Suicidality as a Discourse of Safety in the Queer Youth Movement
In November 1991, a group of queer teenagers gathered to rally at the Massachusetts State House in Boston. Two years later, the state passed the first law in the nation adding sexual orientation to the list of protected classes in the state\u27s schools. The November rally was the first public expression of what became the safe schools movement, which went on over the following decade to transform the landscape in public education for LGBTQ students. A notable feature of the rally was the staging by the youth of a mass performative act of queer suicide. This paper uses Foucauldian concepts of discourse to place the events of that day, along with the movement it kindled, within the context of broader narratives of safety in LGBTQ community organizing and identity. I argue the success of the strategy taken by the queer youth movement of the early- to mid-1990s is ultimately a result of the reversal of the discourses of pathology historically attending homosexuality
“The Commitment Problem”: Spending to Zero to Maximize the Efficiency of the Collections Budget
The difficulty for a library to spend their collections budget efficiently is a timeless problem. The diversity of a typical budget, with its mix of one-time and continuing funds, for an array of resources that have both regular and sometimes irregular frequencies, provides great challenges. Approval plans, usually expending one-time funds, generate expenditures that contain high variability on a weekly basis. Standing orders for serials fall into the same category. With some effort, it is possible to expend all continuing funds. But it is the commitments that do not result in expenditures, with funds remaining in cash balances that can determine what university administrators call “efficient results.” Acquisitions personnel must take an aggressive approach to commitments with the goal of turning as many possible into expenditures. New expenditures will compensate for the orders that remain committed. Based on the assumption that efficient spending focuses on a library budget’s final cash balance, this article presents a method to consistently achieve a zero or negative cash balance
Fatigue experienced by people with cerebral palsy : A systematic review of assessment tools and decision tree
Purpose
To conduct a systematic review of self- and proxy-report fatigue assessment tools used in studies of people with cerebral palsy (CP) of all ages, and to develop a fatigue assessment tool decision tree for clinicians and researchers.
Materials and methods
Five electronic databases (MEDLINE, PsycInfo, CINAHL, Web of Science and Cochrane) were searched to September 2021 to identify studies assessing self-reported fatigue in people with CP of any age. The assessment tools utilised were extracted and two reviewers appraised the tool characteristics, clinical utility and psychometric properties. A decision tree for selecting fatigue assessment tools was constructed.
Results
Ten assessment tools were identified across thirty-nine studies, three of which are valid and reliable for assessing fatigue severity and impact in people with CP. A four-level fatigue assessment tool decision tree was constructed. No valid and reliable tool for assessing cognitive fatigue was identified; responsiveness has not been evaluated in any tool for people with CP.
Conclusions
Physical fatigue screening and assessment tools for people with CP are available and are presented in our decision tree, however their utility as outcome measures remains unclear. Cognitive fatigue is understudied and poorly understood, further work is required in this area.
IMPLICATIONS FOR REHABILITATION
• Current measurement tools to screen and assess physical fatigue in people with cerebral palsy (CP) are valid and reliable and are presented in our 4-level decision tree to guide assessment tool selection.
• The responsiveness of these measurement tools to screen and assess physical fatigue has not been evaluated, therefore their utility as outcome measures in people with CP is unclear.
• Cognitive fatigue is understudied and poorly understood in people with CP.
• Valid and reliable tools to assess cognitive fatigue in people with CP are not available
Exome-wide association study of pancreatic cancer risk
We conducted a case-control exome-wide association study to discover germline variants in coding regions that affect risk for pancreatic cancer, combining data from 5 studies. We analyzed exome and genome sequencing data from 437 patients with pancreatic cancer (cases) and 1922 individuals not known to have cancer (controls). In the primary analysis, BRCA2 had the strongest enrichment for rare inactivating variants (17/437 cases vs 3/1922 controls) (P=3.27x10(-6); exome-wide statistical significance threshold P<2.5x10(-6)). Cases had more rare inactivating variants in DNA repair genes than controls, even after excluding 13 genes known to predispose to pancreatic cancer (adjusted odds ratio, 1.35, P=.045). At the suggestive threshold (P<.001), 6 genes were enriched for rare damaging variants (UHMK1, AP1G2, DNTA, CHST6, FGFR3, and EPHA1) and 7 genes had associations with pancreatic cancer risk, based on the sequence-kernel association test. We confirmed variants in BRCA2 as the most common high-penetrant genetic factor associated with pancreatic cancer and we also identified candidate pancreatic cancer genes. Large collaborations and novel approaches are needed to overcome the genetic heterogeneity of pancreatic cancer predisposition
Increased risk for abrupt closure during elective PTCA in the post-myocardial infarction period
Angular position of nodes in the superconducting gap of YBCO
The thermal conductivity of a YBCO single crystal has been studied as a
function of the relative orientation of the crystal axes and a magnetic field
rotating in the Cu-O planes. Measurements were carried out at several
temperatures below T_c and at a fixed field of 30 kOe. A four-fold symmetry
characteristic of a superconducting gap with nodes at odd multiples of 45
degrees in k-space was resolved. Experiments were performed to exclude a
possible macroscopic origin for such a four-fold symmetry such as sample shape
or anisotropic pinning. Our results impose an upper limit of 10% on the weight
of the s-wave component of the essentially d-wave superconducting order
parameter of YBCO.Comment: 10 pages, 4 figure
A VSA search for the extended Sunyaev-Zel'dovich Effect in the Corona Borealis Supercluster
We present interferometric imaging at 33 GHz of the Corona Borealis
supercluster, using the extended configuration of the Very Small Array. A total
area of 24 deg^2 has been imaged, with an angular resolution of 11 arcmin and a
sensitivity of 12 mJy/beam. The aim of these observations is to search for
Sunyaev-Zel'dovich (SZ) detections from known clusters of galaxies in this
supercluster and for a possible extended SZ decrement due to diffuse warm/hot
gas in the intercluster medium. We measure negative flux values in the
positions of the ten richest clusters in the region. Collectively, this implies
a 3.0-sigma detection of the SZ effect. In the clusters A2061 and A2065 we find
decrements of approximately 2-sigma. Our main result is the detection of two
strong and resolved negative features at -70+-12 mJy/beam (-157+-27 microK) and
-103+-10 mJy/beam (-230+-23 microK), respectively, located in a region with no
known clusters, near the centre of the supercluster. We discuss their possible
origins in terms of primordial CMB anisotropies and/or SZ signals related to
either unknown clusters or to a diffuse extended warm/hot gas distribution. Our
analyses have revealed that a primordial CMB fluctuation is a plausible
explanation for the weaker feature (probability of 37.82%). For the stronger
one, neither primordial CMB (probability of 0.33%) nor SZ can account alone for
its size and total intensity. The most reasonable explanation, then, is a
combination of both primordial CMB and SZ signal. Finally, we explore what
characteristics would be required for a filamentary structure consisting of
warm/hot diffuse gas in order to produce a significant contribution to such a
spot taking into account the constraints set by X-ray data.Comment: 16 pages, 10 figures. Accepted in MNRA
Follow-up observations at 16 and 33 GHz of extragalactic sources from WMAP 3-year data: I - Spectral properties
We present follow-up observations of 97 point sources from the Wilkinson
Microwave Anisotropy Probe (WMAP) 3-year data, contained within the New
Extragalactic WMAP Point Source (NEWPS) catalogue between declinations of -4
and +60 degrees; the sources form a flux-density-limited sample complete to 1.1
Jy (approximately 5 sigma) at 33 GHz. Our observations were made at 16 GHz
using the Arcminute Microkelvin Imager (AMI) and at 33 GHz with the Very Small
Array (VSA). 94 of the sources have reliable, simultaneous -- typically a few
minutes apart -- observations with both telescopes. The spectra between 13.9
and 33.75 GHz are very different from those of bright sources at low frequency:
44 per cent have rising spectra (alpha < 0.0), where flux density is
proportional to frequency^-alpha, and 93 per cent have spectra with alpha <
0.5; the median spectral index is 0.04. For the brighter sources, the agreement
between VSA and WMAP 33-GHz flux densities averaged over sources is very good.
However, for the fainter sources, the VSA tends to measure lower values for the
flux densities than WMAP. We suggest that the main cause of this effect is
Eddington bias arising from variability.Comment: 12 pages, 13 figures, submitted to MNRA
First results from the Very Small Array -- I. Observational methods
The Very Small Array (VSA) is a synthesis telescope designed to image faint
structures in the cosmic microwave background on degree and sub-degree angular
scales. The VSA has key differences from other CMB interferometers with the
result that different systematic errors are expected. We have tested the
operation of the VSA with a variety of blank-field and calibrator observations
and cross-checked its calibration scale against independent measurements. We
find that systematic effects can be suppressed below the thermal noise level in
long observations; the overall calibration accuracy of the flux density scale
is 3.5 percent and is limited by the external absolute calibration scale.Comment: 9 pages, 10 figures, MNRAS in press (Minor revisions
Risks of cancers for carriers of monoallelic MUTYH mutation with a family history of colorectal cancer
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