Clayville Rural Life Center and Museum - Publications Series I - Living History Resource List #05: Metal Trades and Crafts

This resource list pertains to the study of metal trades and crafts. The list is divided into two parts: Bibliography and the Conservation and Testing of Metal Artifacts. The Bibliography is further divided into four sections: Primary Production and General; Blacksmithing: Tools, Processes, and Products; Pewter and Pewtersmithing; and Tinware and Tinsmithing. The list contains both primary and secondary sources and their locations. 10p.published or submitted for publicationis peer reviewe

Clayville Rural Life Center and Museum - Publications Series I - Living History Resource List #12: Inns, Taverns and Hotels in the Midwest to 1860: Materials Useful for the Study of Their Architecture and Functions, and a Checklist of Surviving Buildings in Illinois and in the Midwest

This resource list contains sources pertaining to Inns, Taverns, and Hotels in the Midwest to 1860. The publication is divided into three parts: a bibliography, existing structures in Illinois, and existing structures in the Midwest. The bibliography is divided into three parts: the United States, the Midwest, and Illinois. Sources listed include secondary, primary, and archival resources. 14p.published or submitted for publicationis peer reviewe

Adjuvantation of Influenza Vaccines to Induce Cross-Protective Immunity

Influenza poses a huge threat to global public health. Influenza vaccines are the most effective and cost-effective means to control influenza. Current influenza vaccines mainly induce neutralizing antibodies against highly variable globular head of hemagglutinin and lack cross-protection. Vaccine adjuvants have been approved to enhance seasonal influenza vaccine efficacy in the elderly and spare influenza vaccine doses. Clinical studies found that MF59 and AS03-adjuvanted influenza vaccines could induce cross-protective immunity against non-vaccine viral strains. In addition to MF59 and AS03 adjuvants, experimental adjuvants, such as Toll-like receptor agonists, saponin-based adjuvants, cholera toxin and heat-labile enterotoxin-based mucosal adjuvants, and physical adjuvants, are also able to broaden influenza vaccine-induced immune responses against non-vaccine strains. This review focuses on introducing the various types of adjuvants capable of assisting current influenza vaccines to induce cross-protective immunity in preclinical and clinical studies. Mechanisms of licensed MF59 and AS03 adjuvants to induce cross-protective immunity are also introduced. Vaccine adjuvants hold a great promise to adjuvant influenza vaccines to induce cross-protective immunity

Possible failure of novel direct-acting oral anticoagulants in management of pulmonary embolism: a case report

BACKGROUND: The relative effectiveness of vitamin K antagonists compared with novel oral anticoagulants in treating pulmonary embolism remains unclear. Recent trials comparing the efficacy of vitamin K antagonists with factor Xa inhibitors for the treatment of pulmonary emboli have been non-inferiority studies based primarily on risk reduction (such as bleeding events), rather than resolution of specific diseases such as pulmonary embolism. Consequently, there is a lack of evidence indicating which of these agents are more effective. Here, we present a case where pulmonary emboli were treated with novel oral anticoagulants followed by warfarin to discuss the potential limitations in the use of novel oral anticoagulants as prevention or treatment of thromboembolism and the continued role for warfarin in this setting. CASE PRESENTATION: A 34-year-old African American woman presented to our clinic with shortness of breath and pleuritic chest pain several months post-surgery. She was identified as having multiple bilateral pulmonary embolisms and was treated with several novel oral anticoagulants, which failed to resolve the clots. Complete resolution was achieved upon switching to warfarin. CONCLUSIONS: The patient described in this report failed to respond to novel oral anticoagulant therapy, but her emboli resolved when she was treated with warfarin. This study challenges the notion that factor Xa inhibitors are better alternatives to vitamin K anticoagulants in the treatment of pulmonary emboli based on their safety profile and ease of use alone. As a result, further post-marketing investigations into the efficacy of these agents in the management of pulmonary emboli may be warranted

Clayville Rural Life Center and Museum - Publications Series I - Living History Resource List #01: General Technology Bibliography: The Midwest and its Roots

This resource list contains sources for technological innovations and their origins. The bibliography is divided into nine sections: United States, Midwest, Illinois, New England Roots, Southern Roots, Mid-Atlantic Roots, French Roots, British Roots, and General. The sources listed contain information on technology in American History, its uses, and its impact on life. Books, periodicals, and primary sources are listed in the bibliography. 6p.published or submitted for publicationnot peer reviewe

Clayville Rural Life Center and Museum - Publications Series I - Living History Resource List #10: Garden Seeds for the 1850s

This resource list pertains to garden seeds that would have been popular in the 1850s. The list is divided into two sections. The first is a list of garden seeds recommended for use in Springfield, Illinois. This was found in the "Transactions of the Illinois State Agricultural Society" (vol. 3 - 1857) by Simeon Francis. The second section describes how the garden was recreated at Clayville using two sources: "The Young Gardener's Assistant" by Thomas Bridgeman and "On Practical Gardening in Illinois" by Simeon Francis. 6p.published or submitted for publicationis peer reviewe

Clayville Rural Life Center and Museum - Publications Series I - Living History Resource List #14: The Historic Landscapes of the Midwest: Materials for Determining Their Appearances over Time, and for Preserving and Reconstructing Them

This resource list is not intended to be an exhaustive bibliography on all aspects of historic preservation, prairie restoration, historic gardening and landscaping. Rather it is designed to be suggestive of the kinds of materials which are available to do all of these praiseworthy activities, and even more important, to indicate that they really belong together in researching historic environments and in planning their preservation, restoration, and reconstruction. 13p.National Endowment for the Humanitiespublished or submitted for publicationis peer reviewe

Clayville Rural Life Center and Museum - Publications Series I - Living History Resource List #08: Food and Food Habits Bibliography, The Midwest and Its Roots

This resource list contains sources for food and food habits in the early United States. The bibliography is divided into ten sections: United States, Midwest, Illinois, New England Roots, Southern Roots, Mid-Atlantic Roots, French Roots, British Roots, Germany and Central Europe, and Scandinavian Roots. The list contains both primary and secondary sources. 7p.published or submitted for publicationis peer reviewe

Clayville Rural Life Center and Museum - Publications Series I - Living History Resource List #11: Museum and Historic Preservation Methods

This is a basic list of readily available books and other literature on museum and historic preservation methods. It is particularly intended for those interested in open air museums and living history museums. However, it should be useful for any museum professionals, university teachers, students and volunteers. This list is divided into four sections: General Museum and Historic Preservation Methods; Indoor Museums; Historic Structures; and Open Air Museums and Living History Museums. 22p.published or submitted for publicationis peer reviewe

Clayville Rural Life Center and Museum - Publications Series I - Living History Resource List #13: Farming and Inns in the Midwest to 1860: Materials for the Study of the Farming Activities Associated with Inns and Taverns

This resource list contains a bibliography of sources that pertain to the study of farming activities associated with inns and taverns. The bibliography is divided into three sections: the United States, the Midwest, and Illinois. Sources include both secondary and primary sources and other archival reserach. Also listed are the location of the primary sources. 8p.published or submitted for publicationis peer reviewe