Canonical general relativity: Matter fields in a general linear frame

Building on the results of previous work, we demonstrate how matter fields are incorporated into the general linear frame approach to general relativity. When considering the Maxwell one-form field, we find that the system that leads naturally to canonical vierbein general relativity has the extrinsic curvature of the Cauchy surface represented by gravitational as well as non-gravitational degrees of freedom. Nevertheless the metric compatibility conditions are undisturbed, and this apparent derivative-coupling is seen to be an effect of working with (possibly orthonormal) linear frames. The formalism is adapted to consider a Dirac Fermion, where we find that a milder form of this apparent derivative-coupling appears.Comment: 13 pages; uses AMS-latex style file

Field operations with cesium clocks in HF navigation systems

Networks of HF phase comparison marine navigation stations employing cesium clocks are discussed. The largest permanent network is in the Gulf of Mexico where some fourteen base stations are continuously active and others are activated as needed. These HF phase comparison systems, which operate on a single transmission path, require a clock on the mobile unit as well. Inventory consists of upwards of 70 clocks from two different manufacturers. The maintenance of this network as an operating system requires a coordinated effort involving clock preparation, clock environment control, station performance monitoring and field service

Comment on "Observation of neutronless fusion reactions in picosecond laser plasmas"

The paper by Belyaev et al. [Phys. Rev. E {\bf 72}, 026406 (2005)] reported the first experimental observation of alpha particles produced in the thermonuclear reaction $^{11}$B($p,\alpha$)$^{8}$Be induced by laser-irradiation on a $^{11}$B polyethylene (CH$_2$) composite target. The laser used in the experiment is characterized by a picosecond pulse duration and a peak of intensity of 2$\times10^{18}$ W/cm$^2$. We suggest that both the background-reduction method adopted in their detection system and the choice of the detection energy region of the reaction products are possibly inadequate. Consequently the total yield reported underestimates the true yield. Based on their observation, we give an estimation of the total yield to be higher than their conclusion, i.e., of the order of 10$^5 \alpha$ per shot.Comment: 3 figures, accepted for publication in the Comment section of Physical Review

Variable-Speed-of-Light Cosmology and Second Law of Thermodynamics

We examine whether the cosmologies with varying speed of light (VSL) are compatible with the second law of thermodynamics. We find that the VSL cosmology with varying fundamental constant is severely constrained by the second law of thermodynamics, whereas the bimetric cosmological models are less constrained.Comment: 15 pages, LaTeX, Revised version with minor corrections to appear in Phys. Rev.

Does avian malaria reduce fledging success: an experimental test of the selection hypothesis

pre-printLike many parasites, avian haematozoa are often found at lower infection intensities in older birds than young birds. One explanation, known as the "selection" hypothesis, is that infected young birds die before reaching adulthood, thus removing the highest infection intensities from the host population. We tested this hypothesis in the field by experimentally infecting nestling rock pigeons (Columba livia) with the malaria parasite Haemoproteus columbae. We compared the condition and fledging success of infected nestlings to that of uninfected controls. There was no significant difference in the body mass, fledging success, age at fledging, or post-fledging survival of experimental versus control birds. These results were unexpected, given that long-term studies of older pigeons have demonstrated chronic effects of H. columbae. We conclude that H. columbae has little impact on nestling pigeons, even when they are directly infected with the parasite. Our study provides no support for the selection hypothesis that older birds have lower parasite loads because parasites are removed from the population by infected nestlings dying. To our knowledge, this is the first study to test the impact of avian malaria using experimental inoculations under natural conditions

Darwins finches combat introduced nest parasites with fumigated cotton

pre-printIntroduced parasites are a threat to biodiversity when naïve hosts lack effective defenses against such parasites [1]. Several parasites have recently colonized the Galápagos Islands, threatening native bird populations [2]. For example, the introduced parasitic nest fly Philornis downsi (Diptera: Muscidae) has been implicated in the decline of endangered species of Darwin's finches, such as the mangrove finch (Camarhynchus heliobates) [3]. Here, we show that Darwin's finches can be encouraged to "self-fumigate" nests with cotton fibers that have been treated with permethrin. Nests with permethrin-treated cotton had significantly fewer P. downsi than control nests, and nests containing at least one gram of cotton were virtually parasite-free. Nests directly fumigated with permethrin had fewer parasites and fledged more offspring than nests treated with water

Stress-Induced Cocaine Seeking Requires a Beta-2 Adrenergic Receptor-Regulated Pathway from the Ventral Bed Nucleus of the Stria Terminalis That Regulates CRF Actions in the Ventral Tegmental Area

The ventral bed nucleus of the stria terminalis (vBNST) has been implicated in stress-induced cocaine use. Here we demonstrate that, in the vBNST, corticotropin releasing factor (CRF) is expressed in neurons that innervate the ventral tegmental area (VTA), a site where the CRF receptor antagonist antalarmin prevents the reinstatement of cocaine seeking by a stressor, intermittent footshock, following intravenous self-administration in rats. The vBNST receives dense noradrenergic innervation and expresses β adrenergic receptors (ARs). Footshock-induced reinstatement was prevented by bilateral intra-vBNST injection of the β-2 AR antagonist, ICI-118,551, but not the β-1 AR antagonist, betaxolol. Moreover, bilateral intra-vBNST injection of the β-2 AR agonist, clenbuterol, but not the β-1 agonist, dobutamine, reinstated cocaine seeking, suggesting that activation of vBNST β-2 AR is both necessary for stress-induced reinstatement and sufficient to induce cocaine seeking. The contribution of a β-2 AR-regulated vBNST-to-VTA pathway that releases CRF was investigated using a disconnection approach. Injection of ICI-118,551 into the vBNST in one hemisphere and antalarmin into the VTA of the contralateral hemisphere prevented footshock-induced reinstatement, whereas ipsilateral manipulations failed to attenuate stress-induced cocaine seeking, suggesting that β-2 AR regulate vBNST efferents that release CRF into the VTA, activating CRF receptors, and promoting cocaine use. Last, reinstatement by clenbuterol delivered bilaterally into the vBNST was prevented by bilateral vBNST pretreatment with antalarmin, indicating that β-2 AR-mediated actions in the vBNST also require local CRF receptor activation. Understanding the processes through which stress induces cocaine seeking should guide the development of new treatments for addiction

Linearisation Instabilities of the Massive Nonsymmetric Gravitational Theory

The massive nonsymmetric gravitational theory is shown to posses a linearisation instability at purely GR field configurations, disallowing the use of the linear approximation in these situations. It is also shown that arbitrarily small antisymmetric sector Cauchy data leads to singular evolution unless an ad hoc condition is imposed on the initial data hypersurface.Comment: 14 pages, IOP style for submission to CQG. Minor changes and additional background material adde

Integration of microarray analysis into the clinical diagnosis of hematological malignancies: How much can we improve cytogenetic testing?

PurposeTo evaluate the clinical utility, diagnostic yield and rationale of integrating microarray analysis in the clinical diagnosis of hematological malignancies in comparison with classical chromosome karyotyping/fluorescence in situ hybridization (FISH).MethodsG-banded chromosome analysis, FISH and microarray studies using customized CGH and CGH+SNP designs were performed on 27 samples from patients with hematological malignancies. A comprehensive comparison of the results obtained by three methods was conducted to evaluate benefits and limitations of these techniques for clinical diagnosis.ResultsOverall, 89.7% of chromosomal abnormalities identified by karyotyping/FISH studies were also detectable by microarray. Among 183 acquired copy number alterations (CNAs) identified by microarray, 94 were additional findings revealed in 14 cases (52%), and at least 30% of CNAs were in genomic regions of diagnostic/prognostic significance. Approximately 30% of novel alterations detected by microarray were >20 Mb in size. Balanced abnormalities were not detected by microarray; however, of the 19 apparently "balanced" rearrangements, 55% (6/11) of recurrent and 13% (1/8) of non-recurrent translocations had alterations at the breakpoints discovered by microarray.ConclusionMicroarray technology enables accurate, cost-effective and time-efficient whole-genome analysis at a resolution significantly higher than that of conventional karyotyping and FISH. Array-CGH showed advantage in identification of cryptic imbalances and detection of clonal aberrations in population of non-dividing cancer cells and samples with poor chromosome morphology. The integration of microarray analysis into the cytogenetic diagnosis of hematologic malignancies has the potential to improve patient management by providing clinicians with additional disease specific and potentially clinically actionable genomic alterations

Structure Formation Inside Triaxial Dark Matter Halos: Galactic Disks, Bulges and Bars

We investigate the formation and evolution of galactic disks immersed in assembling live DM halos. Disk/halo components have been evolved from the cosmological initial conditions and represent the collapse of an isolated density perturbation. The baryons include gas (which participates in star formation [SF]) and stars. The feedback from the stellar energy release onto the ISM has been implemented. We find that (1) The growing triaxial halo figure tumbling is insignificant and the angular momentum (J) is channeled into the internal circulation; (2) Density response of the disk is out of phase with the DM, thus diluting the inner halo flatness and washing out its prolateness; (3) The total J is neathly conserved, even in models accounting for feedback; (4) The specific J for the DM is nearly constant, while that for baryons is decreasing; (5) Early stage of disk formation resembles the cat's cradle -- a small amorphous disk fueled via radial string patterns; (6) The initially puffed up gas component in the disk thins when the SF rate drops below ~5 Mo/yr; (7) About 40%-60% of the baryons remain outside the SF region; (8) Rotation curves appear to be flat and account for the observed disk/halo contributions; (9) A range of bulge-dominated to bulgeless disks was obtained; Lower density threshold for SF leads to a smaller, thicker disk; Gravitational softening in the gas has a substantial effect on various aspects of galaxy evolution and mimics a number of intrinsic processes within the ISM; (10) The models are characterized by an extensive bar-forming activity; (11) Nuclear bars, dynamically coupled and decoupled form in response to the gas inflow along the primary bars.Comment: 18 pages, 16 figures, accepted by the Astrophysical Journal. Minor revisions. The high-resolution figures can be found at http://www.pa.uky.edu/~shlosman/research/galdyn/figs07a