Management and treatment of sinonasal inverted papilloma

Aims: The aim of this paper is to describe the surgical experience of 35 patients with Inverted Papilloma (IP) of paranasal sinuses and its recurrence rate after a year of follow-up. Materials: A retrospective chart review was performed on patients presenting with IP of paranasal sinuses. Thirty-five patients comprised the focus of this study. For all patients was performed a pre-surgery TC, and for more 5 patients it was necessary to perform a Magnetic Resonance (MR) with gadolinium. Results: Among 35 patients selected, 18 patients underwent to open surgery, 4 patients had a combined approach with endoscopy and open surgery, while 13 patients were managed only with an endoscopic approach, with a minimum of 1 year of follow-up. Our results highlighted that the global percentage of success 12 months after the treatment was 93% and it not vary according to the tipology of the approach used if a radical excision of the lesion is achieved. More in depth, among 35 cases, only 2 patients were found to have recurrences and were treated with coronal and endoscopic approach. Conclusion: It is fundamental to underline that surgery must be carried on in a radical manner to treat these tend to recur. A complete removal of the lesion and bone peripheral border filing are essential to perform a correct and definitive treatment. Also, endoscopic approach can be taken into account when tumors are localized median to a sagittal plan crossing the orbit median wall and when they did not massively compromised paranasal sinus walls

Aesthetic restoration in maxillo-mandibular malformations: the role of genioplasty

Aim: The aim of this study was to determinate how orthognatic surgery aids to cure many skull and face abnormalities and to help re-establishing the correct occlusive relation thanks to the repositioning of the maxillo-mandibular skeleton basis. Methods: The study included 183 male patients and 338 female patients, with an average age of 23 years. The sample series was divided according to specific pathologies. All patients underwent surgical procedures and the therapeutic strategy was determined based on the anomalies presented. Results: 113 patients had a II class dental skeletal occlusion, 180 patients had a III class dental-skeletal occlusion and 222 patients had skull-facial abnormalities. 5 patients underwent only a genioplasty, 82 patients underwent a genioplasty associated with BSSO, 175 patients underwent a genioplasty associated with Le Fort I osteotomy and the remaining 253 patients underwent a genioplasty associated with BSSO and Le Fort I osteotomy. Conclusion: The experience shows that genioplasty has been successfully introduced in orthognathic surgical therapeutic procedures, for dental-skeleton abnormalities and mandibular asymmetries treatment. In recent years, the evolution of computer systems has allowed an accurate assessment and programming, by means of the three-dimensional display, which are of great help in the course of diagnosis and evaluation of the displacements to be carried out, in order to obtain optimal aesthetic results

When and how? Freshwater mussel recolonization in Lake Orta

Thanks to a video posted on a social network, live mussels of Unio elongatulus, have been recorded from Lake Orta (Italy) over one century after the last (and only) report. With its long and well documented history of pollution, Lake Orta offers the opportunity to document the post-extirpation recovery of freshwater unionid mussels. This case evidences that recovery/recolonization is possible despite a high devastation in the past, and permits to evaluate how fast recolonization may occur, in which way, and in what conditions. The answer to the \u27how fast\u27 was sought by estimating the age of the larger and seemingly older individuals of the population. To address the \u27in which way\u27 we compared the haplotypes of Lake Orta specimens of Unio elongatulus (the only species present) with those of surrounding populations. We concluded that, since Lake Orta lacks a direct connection with the putative source populations, colonizing mussels were almost certainly transported by fish carrying glochidia that were used for lake restocking after liming. Data from the long-term monitoring of water chemistry and sediments have allowed defining what conditions proved to be suitable for survival making possible the start of mussels recovery. But not only water and sediment quality matters for mussels recovery, which was delayed by nearly ten years after the reappearance of fish. This delay reflects the need of the whole trophic chain to be reestablished to allow the survival of the suitable and healthy host-fish populations necessary for mussels reproduction

Il costo del capitale

l capitolo e' dedicato ad approfondire il tema della stima dei tassi di interesse da impiegare nella valutazione d'azienda, tema propedeutico e preliminare alla scelta del metodo valutativo principale e di quello di controllo. Si tratta di un argomento molto dibattuto nella teoria e nella pratica: per questa ragione, in questa sede, la trattazione ha privilegiato il contesto applicativo delle operazioni di acquisizioni di partecipazioni in imprese non finanziarie da parte di intermediari finanziari operanti nel vasto comparto del private equity

The role of social networks and citizen science in environmental research: the unexpected revival of freshwater mussels in Lake Orta

Social networks are increasingly used for many conservation and environmental educational purposes. The usefulness for ecological studies is exemplified by the casual discovery of the recovery of freshwater mussels in Lake Orta. Mussels were extirpated by severe industrial pollution soon after 1926 and over the following decades their recovery was prevented by acidification and increase of metal concentrations. Even after the improvement of water conditions obtained by limning, the lack of mussels was taken for granted based on the legacy effects of accumulated toxins in the sediments, and on the limited potential for most extirpated species of mussels to naturally recolonize. The probability of mussel\u27s recovery in Lake Orta was considered poor also for the apparent lack of access to restocking populations, which is essential to start the natural recolonization of an area. Because of the assumption that mussels were absent and of the difficulties of locating mussels their recolonization went unnoticed for about 15 years. Only in 2014 the casual discovery of mussels in Lake Orta was made possible thanks to an amateur video posted on YouTube and delivered to one of us through Facebook: this highlights once more the potential role of social networks for conservation and environmental issues. Freshwater mussels are challenging to locate because they are often rare, spatially clustered, and difficult to detect. The recolonization of Lake Orta went unnoticed probably due to the limited extent of the colonized area, low density and, at least initially, the small size of individuals. In such cases the contribution of citizen science can be crucial to provide the reporting even of small populations present in restricted areas and/or not easily accessible. An extensive search along the lake perimeter is being performed through the volunteer collaboration of local SCUBA divers and an online survey through social networks

Study of high-pT charged particle suppression in PbPb compared to pp collisions at sqrt(sNN)=2.76 TeV.

The transverse momentum spectra of charged particles have been measured in pp and PbPb collisions at sqrt(sNN) = 2.76 TeV by the CMS experiment at the LHC. In the transverse momentum range pt = 5-10 GeV/c, the charged particle yield in the most central PbPb collisions is suppressed by up to a factor of 5 compared to the pp yield scaled by the number of incoherent nucleon-nucleon collisions. At higher pt, this suppression is significantly reduced, approaching roughly a factor of 2 for particles with pt in the range pt=40-100 GeV/c

A particular temper: mineralogical and petrographic characterisation of ceramic fabrics with glauconitic inclusions

This paper focuses on the mineralogical and petrographic characterisation of ceramic fabrics rich in glauconitic pellets, found out in a few local productions of European and Mediterranean sites dated from Prehistory to the Middle Ages. The main distinguishing features of glauconitic inclusions are their rounded shape, dark colour and peculiar chemical composition. During the firing – as also evidenced by a few preliminary experimental tests on glauconitic sediments – the pellets change in colour (from green to red or black in thin section) because of the oxidation of divalent iron and their texture becomes more homogeneous, up to the partial or complete vitrification at moderately high temperatures.Dans cet article, on présente la caractérisation minéralogique et pétrographique des pâtes céramiques riches en pellets glauconitiques, trouvées dans quelques productions locales de sites européens et méditerranéens d’age préhistorique à médiéval. Les plus importants éléments discriminants des pellets glauconitiques sont leur forme arrondie, leur couleur rouge ou noire et leur composition chimique particulière. Durant la cuisson, comme quelques tests préliminaires sur sédiments glauconitiques l’ont confirmé, les pellets changent de couleur (de vert à rouge ou noir en lame mince), à cause de l’oxydation du fer bivalent, et leur texture devient plus homogène, jusqu’à la vitrification partielle ou totale à des températures relativement hautes

Bioelectrical Impedance Vector Analysis and Brain Natriuretic Peptide in the Evaluation of Patients with Chronic Kidney Disease in Hemodialitic Treatment

Introduction: Setting dry weight (DW) in hemodialysis (HD) patients is still a hard issue. Several clinical, hematochemical, and instrumental parameters have been considered. In the last years, bioelectrical impedance vector analysis (BIVA) became the main method to evaluate body composition and water body percentage. However, it is still difficult to assess the nutritional status and identify a correct DW in HD patients. Aim: The aim of the study was to set DW and nutritional status, combining BIVA with phase angle (PhA) and serum brain natriuretic peptide (BNP) in HD patients. Methods: We evaluated PhA and BNP modifications before (T0), after HD section (T1), and after 60 days (T2), in all patients treated in our HD center. Results: A total of 50 patients (36 males) with a mean age of 70.1 ± 8.85 years were recruited. We did not report significant changes in BNP and PhA between T0 and T1, while they were significantly different between T0 and T2. We also reported a significant difference between T0 and T2 in ECW/TBW, while we did not show significant variations in ECM/BMC between T0, T1, and T2 indicating a stability of the nutritional status. PhA, BNP, and ECW/TBW returned to a normal value in patients in which we reached a DW, also considering clinical parameters such as blood pressure and antihypertensive therapy. The weight loss obtained with the evaluation of the BIVA and the BNP was 1.2–5.7 kg, greater than that calculated empirically which stood at around 0.9–4.3 kg. Conclusion: We suggest to carry out BIVA with PhA combined with BNP to assess an adequate DW and evaluate a correct nutritional status in HD patients

Time to change the single-centre approach to management of patients with tuberculosis: a novel network platform with automatic data import and data sharing

Time to change the single-centre approach to TB http://ow.ly/lCeM30hBcbB

Demographic, tumor and clinical features of clinical trials versus clinical practice patients with HER2-positive early breast cancer: results of a prospective study

Several randomized clinical trials (RCTs) have demonstrated the efficacy of trastuzumab-based adjuvant therapy in HER2-positive breast cancer (BC). However, RCT patients may not invariably be representative of patients routinely seen in clinical practice (CP). To address this issue, we compared the clinical and tumor features of RCT and CP patients with HER2-positive BC