Prevalence of HPV high and low risk types in cervical samples from the Italian general population: a population based study

<p>Abstract</p> <p>Background</p> <p>This multicenter study describes the type-specific prevalence of HPV infection in the general population from central and southern Italy, comparing the data with previously published Italian studies.</p> <p>Methods</p> <p>Women aged from 25 to 65 who attended cervical cancer screening in five different Italian regions were tested for HPV infection with Hybrid Capture II (HCII) low and high risk probes. Women repeating Pap-test upon unsatisfactory or positive results, or as a post-treatment and post-colposcopy follow-up analysis, were excluded from our study. High risk (HR) HPV positive samples were typed using GP5+/GP6+ primed PCR, followed by Reverse Line Blot for 18 high/intermediate risk HPV types, while low risk (LR) HPV positive samples were tested with type specific primers for HPV6 and HPV11.</p> <p>Results</p> <p>3817 women had a valid HCII test: 350 of them (9.2%) were positive for HR probes, 160 (4.2%) for LR probes, while 57 women were positive for both. Multiple infections were detected in 97 HR HPV positive women. The most common types were HPV 16 (3%), 31 (1.2%), 51 (1%). HPV6 ranked fifth (0.6%), HPV18 ranked tenth (0.5%) and HPV11 sixteenth (0.3%).</p> <p>In Sardinia the prevalence of high-risk infection was 13%, significantly higher than the mean value (p < 0.00005).</p> <p>The distribution of the most frequent types did not significantly differ by centre (p = 0.187) and age (p = 0.085).</p> <p>Conclusions</p> <p>Because cervical cancer incidence and Pap test coverage is lower in southern than in northern Italy, a lower prevalence of high-risk infections in the general population was expected in the south. However, prevalence detected in this study for the south of the country is slightly but significantly higher than the rest of Italy. The consequence may be an epidemic of cervical cancer in the next decades if adequate screening programs are not implemented there.</p

Changing the rules of the game: an analysis of EU influence on electricity and gas liberalization: with a focus on the Baltic Sea Region, and future challenges to EU energy market regulation

This study analyses the expansion of the EU into energy market regulation. It shows that the limits to EU influence and, thereby, EU energy market regulation for the internal energy market, begin where EU influence affects national interests with regard to ensuring energy security. This scientifically established insight bears an important practical implication. The further development of EU energy market regulation as a cornerstone of the internal energy market faces a particular policy challenge: It is necessary to establish a regulatory framework for the internal electricity and gas market, which acknowledges the primacy of national energy security interests. This finding is important in the light of the new and increasing energy policy challenges that some Member States face today, not least as a result of a liberalized energy market. Moreover, in the context of new systemic risks arising from ongoing energy market integration, a politically unstable (in the worst case - collapsing) EU regulatory framework can cause significant social and economic costs for individual Member States. With regard to that, the study points to the increasingly complex policy areas that are made subject to EU integration and calls for more attention to the related regulatory and political risks - also with a view to the current euro crisis. Diese Studie analysiert die Expansion der EU in die Energiemarktregulierung. Sie zeigt, dass die Grenzen des EU Einflusses und damit des EU Regulierungsrahmens für den Energiebinnenmarkt dort beginnen, wo nationale Interessen mit Blick auf die Gewährleistung der Energieversorgungssicherheit tangiert werden. Diese Erkenntnis hat eine wichtige praktische Implikation. Die weitere Ausgestaltung der EU Energiemarktregulierung und damit des Fundaments des Energiebinnenmarktes steht vor einer besonderen politischen Herausforderung: Es gilt einen stabilen gemeinschaftlichen Regulierungsrahmens für den europäischen Strom- und Gasmarkt unter dem Primat nationaler Energiesicherheitsinteressen bereitzustellen. Dies ist von Bedeutung im Lichte wachsender und neuer energiepolitischer Herausforderungen für die einzelnen Mitgliedstaaten, nicht zuletzt als Folge eines liberalisierten Energiemarktes. In Anbetracht neuer systemischer Risiken, die sich aus einem integrierten europäischen Energiemarkt ergeben, kann ein politisch instabiler (im schlimmsten Fall kollabierender) gemeinschaftlicher Regulierungsrahmen für die Mitgliedstaaten hohe soziale und ökonomische Kosten nach sich ziehen. An dieser Stelle verweist die Studie auf die immer komplexeren Integrationsgegenstände der EU und fordert, dass den damit einhergehenden Risiken, regulatorischer und politischer Art, grössere Aufmerksamkeit zu schenken ist - gerade auch mit Blick auf die aktuelle Krise der Gemeinschaftswährung