2,452 research outputs found
Essential oils and volatile emission of eight South African species of Helichrysum grown in uniform environmental conditions
Abstract This paper reported for the first time the aroma profile and essential oil composition of eight species of Helichrysum endemic in South Africa but grown in Italy (CREA-Sanremo collection). The volatiles of all the studied Helichrysum were dominated by monoterpene hydrocarbons, except for H. basalticum, where sesquiterpene hydrocarbons was the main class of compounds with ÎČ-caryophyllene (13.7%) and α-guaiene (11.9%) as major components. Despite the great diversity of compounds obtained in the volatile emission (more than 130), only four compounds were responsible for at least 34% of the identified fraction. These compounds were: sabinene (16.0%), ÎČ-caryophyllene and α-guaiene in H. basalticum; sabinene (57.7%) in H. foetidum; (Z)-ÎČ-ocimene (34.6%), tricyclene (16.2%) and myrcene (10.0%) in H. incanatum; myrcene (29.3%), tricyclene (21.5%) and limonene in H. indicum; tricyclene (32.1%) and (E)-3-hexanol acetate (20.1%) in H. montanum; limonene (10.3%), sabinene (8.9%), 1-decene (7.6%) and 1-hexanol (7.0%) in H. mutabile; α- and ÎČ-pinene in H. patulum (27.6% and 44.9%, respectively) and α-pinene (36.3%) and α-fanchene(15.6%) in H. setosum. The EOs composition of these species was also different from each other with sesquiterpene compounds as the prevalent class. Valerianol (16.3%, os, in H. basalticum), ledol (16.3%, os, in H. foetidum), ÎČ-caryophyllene (11.0% and 13.4%, sh, in H. indicum and H. patulum, respectively), viridiflorol (18.3%, os, in H. montanum) and valerianol (30.1%, os in H. setosum) were found to be the main constituents. It is worthy to highlighting that the H. incarnatum EO showed a similar behaviour to that of the spontaneous emission with a predominance of monoterpene hydrocarbons (60.7% in EO vs 81.4% in VOC), both represented by (Z)-ÎČ-ocimene as main constituent
NPY Levels In Type 1 Diabetic Men of Different Duration.
Background: The aim of the present study was to evaluate whether the different duration of type 1 diabetes mellitus influences basal NPY secretion. Design: The NPY concentrations were measured in sixty-eight men with insulin-dependent diabetes mellitus (IDDM) (duration: group 1 (n.21) <5 years (range 2-4 years); group 2 (n.24) >5 years and <10 years (range: 6-9 years); group 3 (n.29) >10 years (range: 11-14 years)) and in age matched normal control subjects (n. 30). Results: The NPY levels were significantly lower in group 3 than in group 2 and 1 and in the control group, in group 2 than in group 1 and in the control group and in group 1 than control group. Conclusion: These results support the view that the duration of diabetes may have a modulatory role in the decreased basal NPY secretion observed in diabetics
Cryogenic Characterization of FBK HD Near-UV Sensitive SiPMs
We report on the characterization of near-ultraviolet high density silicon
photomultiplier (\SiPM) developed at Fondazione Bruno Kessler (\FBK) at
cryogenic temperature. A dedicated setup was built to measure the primary dark
noise and correlated noise of the \SiPMs\ between 40 and 300~K. Moreover, an
analysis program and data acquisition system were developed to allow the
precise characterization of these parameters, some of which can vary up to 7
orders of magnitude between room temperature and 40~K. We demonstrate that it
is possible to operate the \FBK\ near-ultraviolet high density \SiPMs\ at
temperatures lower than 100~K with a dark rate below 0.01 cps/mm and total
correlated noise probability below 35\% at an over-voltage of 6~V. These
results are relevant for the development of future cryogenic particle detectors
using \SiPMs\ as photosensors
A similar 24âh blood pressure control is obtained by zofenopril and candesartan in primary hypertensive patients
Objective. To compare the antihypertensive effect of treatment with zofenopril vs candesartan by office and ambulatory blood pressure (BP). Design and methods. Following a 2âweek washâout from previous treatment, 236 grade IâII primary hypertensive patients were randomized doubleâblind to 12â
weeks treatment with zofenopril 30â
mg or candesartan 8â
mg od. After 4â
weeks, treatment was doubled in responder nonânormalized (office systolic BPâ©Ÿ140â
mmHg and office diastolic BP reduction â©Ÿ10â
mmHg) or nonâresponder patients (office systolic BPâ©Ÿ140â
mmHg and office diastolic BP reduction <10â
mmHg). Following a further 4â
weeks, nonâresponder or nonânormalized patients were withdrawn. Results. In the intentionâtoâtreat population, office systolic BP and diastolic BP reductions after 12â
weeks of treatment were similar between the two groups (zofenopril: 21±11/15±8â
mmHg, n = 114 vs C: 20±11/15±7â
mmHg, n = 122; p = NS). In the 163 patients of the perâprotocol population, office BP dropped by 22±11/15±8â
mmHg (zofenopril) an..
Circulating Levels of Proprotein Convertase Subtilisin/Kexin Type 9 and Arterial Stiffness in a Large Population Sample: Data From the Brisighella Heart Study
Proprotein convertase subtilisin/kexin type 9 (PCSK9) circulating levels are significantly associated with an increased risk of cardiovascular events. This study aimed to evaluate the relationship between circulating levels of PCSK9 and arterial stiffness, an early instrumental biomarker of cardiovascular disease risk, in a large sample of overall healthy participants
Preexisting Oral Anticoagulant Therapy Ameliorates Prognosis in Hospitalized COVID-19 Patients
Objective: Altered coagulation parameters in COVID-19 patients is associated with a poor prognosis. We tested whether COVID-19 patients on chronic oral anticoagulants (cOACs) for thromboembolism prophylaxis could receive protection from developing more severe phenotypes of the disease. Approach and Results: We searched the database of the SARS-RAS study (Clinicaltrials.gov: NCT04331574), a cross-sectional observational multicenter nationwide survey in Italy designed by the Italian Society of Hypertension. The database counts 2,377 charts of Italian COVID-19 patients in 26 hospitals. We calculated the Charlson comorbidity index (CCI), which is associated with death in COVID-19 patients. In our population (n = 2,377, age 68.2 ± 0.4 years, CCI: 3.04 ± 0.04), we confirm that CCI is associated with increased mortality [OR: 1.756 (1.628-1.894)], admission to intensive care units [ICU; OR: 1.074 (1.017-1.134)], and combined hard events [CHE; OR: 1.277 (1.215-1.342)]. One hundred twenty-five patients were on cOACs (age: 79.3 ± 0.9 years, CCI: 4.35 ± 0.13); despite the higher CCI, cOACs patients presented with a lower risk of admissions to the ICU [OR 0.469 (0.250-0.880)] but not of death [OR: 1.306 (0.78-2.188)] or CHE [OR: 0.843 (0.541-1.312)]. In multivariable logistic regression, cOACs confirmed their protective effect on ICU admission and CHE. The CCI remains the most important risk factor for ICU admission, death, and CHE. Conclusions: Our data support a mechanism for the continuation of cOAC therapy after hospital admission for those patients who are on chronic treatment. Our preliminary results suggest the prophylactic use of direct cOACs in patients with elevated CCI score at the time of the COVID-19 pandemic even in absence of other risks of thromboembolism
Poor reactivity of posterior electroencephalographic alpha rhythms during the eyes open condition in patients with dementia due to Parkinson's disease
Here, we hypothesized that the reactivity of posterior resting-state electroencephalographic (rsEEG) alpha rhythms during the transition from eyes-closed to -open condition might be lower in patients with Parkinson's disease dementia (PDD) than in patients with Alzheimer's disease dementia (ADD). A Eurasian database provided clinical-demographic-rsEEG datasets in 73 PDD patients, 35 ADD patients, and 25 matched cognitively unimpaired (Healthy) persons. The eLORETA freeware was used to estimate cortical rsEEG sources. Results showed substantial (greater than â10%) reduction (reactivity) in the posterior alpha source activities from the eyes-closed to the eyes-open condition in 88% of the Healthy seniors, 57% of the ADD patients, and only 35% of the PDD patients. In these alpha-reactive participants, there was lower reactivity in the parietal alpha source activities in the PDD group than in the healthy control seniors and the ADD patients. These results suggest that PDD patients show poor reactivity of mechanisms desynchronizing posterior rsEEG alpha rhythms in response to visual inputs. That neurophysiological biomarker may provide an endpoint for (non) pharmacological interventions for improving vigilance regulation in those patients.European Consortium of Dementia ; IRCCS San Raffaele Rome ; World Medical Association ; Ministero della Salute ; Sapienza UniversitĂ di Rom
Three-Dimensional Radiographic Evaluation of the Malar Bone Engagement Available for Ideal Zygomatic Implant Placement
Zygomatic implant rehabilitation is a challenging procedure that requires an accurate prosthetic and implant plan. The aim of this study was to evaluate the malar bone available for three-dimensional zygomatic implant placement on the possible trajectories exhibiting optimal occlusal emergence. After a preliminary analysis on 30 computed tomography (CT) scans of dentate patients to identify the ideal implant emergencies, we used 80 CT scans of edentulous patients to create two sagittal planes representing the possible trajectories of the anterior and posterior zygomatic implants. These planes were rotated clockwise on the ideal emergence points and three different hypothetical implant trajectories per zygoma were drawn for each slice. Then, the engageable malar bone and intra- and extra-sinus paths were measured. It was possible to identify the ideal implant emergences via anatomical landmarks with a high predictability. Significant differences were evident between males and females, between implants featuring anterior and those featuring posterior emergences, and between the different trajectories. The use of internal trajectories provided better bone engagement but required a higher intra-sinus path. A significant association was found between higher intra-sinus paths and lower crestal bone heights
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