Recent thermodynamic results from lattice QCD analyzed within a quasi-particle model

The thermodynamic behavior of QCD matter at high temperature is currently studied by lattice QCD theory. The main features are the fast rise of the energy density $\epsilon$ around the critical temperature $T_c$ and the large trace anomaly of the energy momentum tensor $< \Theta_\mu^\mu >=\epsilon - 3 P$ which hints at a strongly interacting system. Such features can be accounted for by employing a massive quasi-particle model with a temperature-dependent bag constant. Recent lattice QCD calculations with physical quark masses by the Wuppertal-Budapest group have shown a slower increase of $\epsilon$ and a smaller $<\Theta_\mu^\mu>$ peak with respect to previous results from the hotQCD collaboration. We investigate the implications of such differences from the point of view of a quasi-particle model, also discussing light and strange quark number susceptibilities. Furthermore, we predict the impact of these discrepancies on the temperature-dependence of the transport properties of matter, like the shear and bulk viscosities.Comment: 18 pages, 9 figures; version accepted in Phys. Rev.D; calculation with relaxation time \tau \sim g^4 ln g has been adde

Coexistence of two main folded G-quadruplexes within a single G-rich domain in the EGFR promoter

EGFR is an oncogene which codifies for a tyrosine kinase receptor that represents an important target for anticancer therapy. Indeed, several human cancers showed an upregulation of the activity of this protein. The promoter of this gene contains some G-rich domains, thus representing a yet unexplored point of intervention to potentially silence this gene. Here, we explore the conformational equilibria of a 30-nt long sequence located at position -272 (EGFR-272). By merging spectroscopic and electrophoretic analysis performed on the wild-type sequence as well as on a wide panel of related mutants, we were able to prove that in potassium ion containing solution this sequence folds into two main G-quadruplex structures, one parallel and one hybrid. They show comparable thermal stabilities and affinities for the metal ion and, indeed, they are always co-present in solution. The folding process is driven by a hairpin occurring in the domain corresponding to the terminal loop which works as an important stabilizing element for both the identified G-quadruplex arrangements

The Gambler’s Fallacy in Problem and Non-Problem Gamblers

Background and aims: Although numerous correlational studies have shown an association between cognitive distortions and problem gambling, only a few behavioral studies have investigated this topic by comparing problem (PGs) and non-problem gamblers (N-PGs). This quasi-experiment investigated the occurrence in both groups of a widespread cognitive distortion, the gambler’s fallacy (GF), using a fictitious roulette game. Moreover, it investigated whether the GF increased the bet amount and whether impulsivity and sensation seeking were associated with the GF. Methods: Two indices of the GF were used: a cognitive index, the probability estimate of each outcome (black/red) after manipulating the final run length (the same outcome occurring four times/once), and a behavioral index, the choice of the outcome on which to bet. A total of 320 (160 PGs and 160 N-PGs) unpaid male volunteers, aged between 18 and 68, participated in this study. Hypotheses: Erroneous probability estimates should mediate the effect of longer runs on the alternation choice (i.e., the choice of an outcome different from the previous one) to support the occurrence of GF. The GF should increase betting. PGs should be more prone than N-PGs to GF. Results: The choice of the outcome depended on both cognitive (erroneous probability estimates) and affective (preference for red) factors. PGs bet more than N-PGs but they were not more prone than N-PGs to incurring GF. Although impulsivity and sensation seeking were more intense in PGs than in N-PGs, they scarcely affected GF. Discussion and conclusions: Overall, our results corroborate the tested model of the GF that links mistaken probability estimates, choice of the outcome on which to bet, and bet amount. However, they are similar to PGs and N-PGs and fail to corroborate the hypothesis that the GF is more evident in PGs

A two-dimensional model of a solid-state regenerator based on combined electrocaloric-elastocaloric effect

Abstract Solid-state refrigeration technologies are considered nowadays emerging alternative to vapor compression refrigeration. In this paper is introduced a two-dimensional model of solid-state refrigerator, which employs materials experiencing a combined electrocaloric-elastocaloric effect and it operates at room temperature. A numerical investigation is performed to explore the energetic performance of the refrigerators. The results reveal that PbTiO 3 as elastocaloric refrigerant confers the best performances in terms of COP; the highest cooling power estimated are proper of combined elastocaloric-electrocaloric effect, with increments around +65% than employing PbTiO 3 in single electrocaloric/elastocaloric refrigeration, on equal operative conditions

Searching for variable stars in Galactic Open Clusters

A long-term project, aiming at systematic search for variable stars in Galactic Open Clusters, was started at the Geneva Observatory in 2002. We have been observing regularly a sample of twenty-seven Galactic Open Clusters in the U, B, V Geneva filters. The goal is to identify and to study their variable stars, as well as the connection between the variable stars in a cluster and the cluster properties. We present the status of this work in progress, and show preliminary results for one of these clusters, IC 4651.Comment: To appear in the proceedings of Stellar Pulsation: Challenges for theory and observations Conference, Santa Fe, NM, US

Regret and Other Emotions Related to Decision-Making: Antecedents, Appraisals, and Phenomenological Aspects

Objectives: The mainstream position on regret in psychological literature is that its necessary conditions are agency and responsibility, that is, to choose freely but badly. Without free choice, other emotions, such as disappointment, are deemed to be elicited when the outcome is worse than expected. In two experiments, we tested the opposite hypothesis that being forced by external circumstances to choose an option inconsistent with one’s own intentions is an important source of regret and a core component of its phenomenology, regardless of the positivity/negativity of the post-decision outcome. Along with regret, four post-decision emotions – anger toward oneself, disappointment, anger toward circumstances, and satisfaction – were investigated to examine their analogies and differences to regret with regard to antecedents, appraisals, and phenomenological aspects. Methods: Through the scenario methodology, we manipulated three variables: choice (free/forced), outcome (positive/negative), and time (short/long time after decision-making). Moreover, we investigated whether responsibility, decision justifiability, and some phenomenological aspects (self-attribution, other attribution, and contentment) mediated the effect exerted by choice, singularly or in interaction with outcome and time, on the five emotions. Each study was conducted with 336 participants, aged 18–60. Results: The results of both studies were similar and supported our hypothesis. In particular, regret elicited by forced choice was always high, regardless of the valence of outcome, whereas free choice elicited regret was high only with a negative outcome. Moreover, regret was unaffected by responsibility and decision justifiability, whereas it was affected by the three phenomenological dimensions. Conclusion: Our results suggest that (1) the prevailing theory of regret is too binding, since it posits as necessary some requirements which are not; (2) the antecedents and phenomenology of regret are broader than it is generally believed; (3) decision-making produces a complex emotional constellation, where the different emotions, singularly and/or in combination, constitute the affective responses to the different aspects of decision-making