Continuous-time quantum walks on dynamical percolation graphs

We address continuous-time quantum walks on graphs in the presence of time- and space-dependent noise. Noise is modeled as generalized dynamical percolation, i.e. classical time-dependent fluctuations affecting the tunneling amplitudes of the walker. In order to illustrate the general features of the model, we review recent results on two paradigmatic examples: the dynamics of quantum walks on the line and the effects of noise on the performances of quantum spatial search on the complete and the star graph. We also discuss future perspectives, including extension to many-particle quantum walk, to noise model for on-site energies and to the analysis of different noise spectra. Finally, we address the use of quantum walks as a quantum probe to characterize defects and perturbations occurring in complex, classical and quantum, networks.Comment: 7 pages, 4 figures. Accepted for publication in EPL Perspective

Analisa Pengaruh Kecerdasan Intelektual, Kecerdasan Emosional, Dan Kecerdasan Spiritual Terhadap Kinerja Karyawan Di Hotel “X”

Penelitian ini dimaksudkan untuk mengetahui pengaruh kecerdasan intelektual, kecerdasan emosional, kecerdasan spiritual terhadap kinerja karyawan, serta untuk mengetahui kecerdasan mana yang paling berpengaruh terhadap kinerja karyawan. Penelitian ini dilakukan di hotel “X”. Penelitian ini dilakukan dengan menggunakan metode analisa kuantitatif. Hasil dari penelitian menunjukkan bahwa kecerdasan intelektual, kecerdasan emosional, dan kecerdasan spiritual berpengaruh signifikan terhadap kinerja karyawan, serta faktor kecerdasan yang berpengaruh paling dominan adalah kecerdasan spiritual

Dynamin- and Rab5-Dependent Endocytosis of a Ca²⁺-Activated K⁺ Channel, KCa2.3

Regulation of the number of ion channels at the plasma membrane is a critical component of the physiological response. We recently demonstrated that the Ca2+-activated K+ channel, KCa2.3 is rapidly endocytosed and enters a Rab35- and EPI64C-dependent recycling compartment. Herein, we addressed the early endocytic steps of KCa2.3 using a combination of fluorescence and biotinylation techniques. We demonstrate that KCa2.3 is localized to caveolin-rich domains of the plasma membrane using fluorescence co-localization, transmission electron microscopy and co-immunoprecipitation (co-IP). Further, in cells lacking caveolin-1, we observed an accumulation of KCa2.3 at the plasma membrane as well as a decreased rate of endocytosis, as assessed by biotinylation. We also demonstrate that KCa2.3 and dynamin II are co-localized following endocytosis as well as demonstrating they are associated by co-IP. Further, expression of K44A dynamin II resulted in a 2-fold increase in plasma membrane KCa2.3 as well as a 3-fold inhibition of endocytosis. Finally, we evaluated the role of Rab5 in the endocytosis of KCa2.3. We demonstrate that expression of a dominant active Rab5 (Q79L) results in the accumulation of newly endocytosed KCa2.3 on to the membrane of the Rab5-induced vacuoles. We confirmed this co-localization by co-IP; demonstrating that KCa2.3 and Rab5 are associated. As expected, if Rab5 is required for the endocytosis of KCa2.3, expression of a dominant negative Rab5 (S34N) resulted in an approximate 2-fold accumulation of KCa2.3 at the plasma membrane. This was confirmed by siRNA-mediated knockdown of Rab5. Expression of the dominant negative Rab5 also resulted in a decreased rate of KCa2.3 endocytosis. These results demonstrate that KCa2.3 is localized to a caveolin-rich domain within the plasma membrane and is endocytosed in a dynamin- and Rab5-dependent manner prior to entering the Rab35/EPI64C recycling compartment and returning to the plasma membrane. © 2012 Gao et al

The relationship of telomere length to baseline corticosterone levels in nestlings of an altricial passerine bird in natural populations.

BackgroundEnvironmental stressors increase the secretion of glucocorticoids that in turn can shorten telomeres via oxidative damage. Modification of telomere length, as a result of adversity faced early in life, can modify an individual's phenotype. Studies in captivity have suggested a relationship between glucocorticoids and telomere length in developing individuals, however less is known about that relationship in natural populations.MethodsIn order to evaluate the effect of early environmental stressors on telomere length in natural populations, we compared baseline corticosterone (CORT) levels and telomere length in nestlings of the same age. We collected blood samples for hormone assay and telomere determination from two geographically distinct populations of the Thorn-tailed Rayadito (Aphrastura spinicauda) that differed in brood size; nestlings body mass and primary productivity. Within each population we used path analysis to evaluate the relationship between brood size, body mass, baseline CORT and telomere length.ResultsWithin each distinct population, path coefficients showed a positive relationship between brood size and baseline CORT and a strong and negative correlation between baseline CORT and telomere length. In general, nestlings that presented higher baseline CORT levels tended to present shorter telomeres. When comparing populations it was the low latitude population that presented higher levels of baseline CORT and shorter telomere length.ConclusionsTaken together our results reveal the importance of the condition experienced early in life in affecting telomere length, and the relevance of integrative studies carried out in natural conditions

Non-Markovianity by undersampling in quantum optical simulators

We unveil a novel source of non-Markovianity for the dynamics of quantum systems, which appears when the system does not explore the full set of dynamical trajectories in the interaction with its environment. We term this effect non-Markovianity by undersampling and demonstrate its appearance in the operation of an all-optical quantum simulator involving a polarization qubit interacting with a dephasing fluctuating environment.Comment: Accepted versio

Interaksi Mutu Beton Dan Rasio Volume Bata Ringan Terhadap Kuat Lentur Balok Komposit Beton Dan Bata Ringan

Inovasi beton terus mengalami perkembangan. Salah satu contohnya inovasi tentang beton ringan. Teknologi beton ringan ini bertujuan untuk memperingan struktur bangunan sehingga dapat meminimalisir efek gempa. Penelitian ini menggabungkan dua bahan yaitu beton dan bata ringan menjadi sebuah elemen struktur balok komposit. Penelitian ini didesain dengan dua variabel bebas yaitu mutu beton dan volume bata ringan. Mutu beton yang digunakan adalah 24,57 MPa dan 29,81 MPa sedangkan variasi bata ringan yang digunakan adalah bata ringan dengan tinggi 8,5 cm dan 6,5 cm. Pengujian dimaksudkan untuk mengetahui interaksi mutu beton dan volume bata ringan terhadap kuat lentur balok komposit. Untuk mendapatkan hasil pengujian lentur murni maka balok ditempatkan di atas dua tumpuan sederhana dan dibebani dengan beban terpusat. Berdasarkan hasil uji analisis varian dua arah didapatkan hasil F tabel sebesar 5,32 sedangkan F hitung untuk sumber variasi volume bata ringan sebesar 0,017, F hitung untuk sumber variasi mutu beton sebesar 0,035 ,dan F hitung untuk interaksi kedua sumber variasi sebesar 0,317. Meskipun semua hasil F hitung lebih kecil dari F tabel namun jika F hitung antar ketiganya dibandingkan hasilnya adalah F hitung interaksi antara mutu beton dan volume bata ingan terlihat lebih besar. Hal ini menandakan bahwa terdapat interaksi antara mutu beton dan volume bata ringan terhadap kuat lentur balok meskipun kontras tidak terlihat secara signifikan

Lipid storage and autophagy in melanoma cancer cells

Cancer stem cells (CSC) represent a key cellular subpopulation controlling biological features such as cancer progression in all cancer types. By using melanospheres established from human melanoma patients, we compared less differentiated melanosphere-derived CSC to differentiating melanosphere-derived cells. Increased lipid uptake was found in melanosphere-derived CSC vs. differentiating melanosphere-derived cells, paralleled by strong expression of lipogenic factors Sterol Regulatory Element-Binding Protein-1 (SREBP-1) and Peroxisome Proliferator-Activated Receptor-γ (PPAR-γ). An inverse relation between lipid-storing phenotype and autophagy was also found, since microtubule-associated protein 1A/1B-Light Chain 3 (LC3) lipidation is reduced in melanosphere-derived CSC. To investigate upstream autophagy regulators, Phospho-AMP activated Protein Kinase (P-AMPK) and Phospho-mammalian Target of Rapamycin (P-mTOR) were analyzed; lower P-AMPK and higher P-mTOR expression in melanosphere-derived CSC were found, thus explaining, at least in part, their lower autophagic activity. In addition, co-localization of LC3-stained autophagosome spots and perilipin-stained lipid droplets was demonstrated mainly in differentiating melanosphere-derived cells, further supporting the role of autophagy in lipid droplets clearance. The present manuscript demonstrates an inverse relationship between lipid-storing phenotype and melanoma stem cells differentiation, providing novel indications involving autophagy in melanoma stem cells biology

Kualitas Pengalaman Kuliner Bali Dan Pengaruhnya Terhadap Niat Berperilaku Wisatawan

Banyak wisatawan yang saat ini mengunjungi Bali untuk mengalami pengalaman budaya yang kuat dan juga mencoba masakan khas Bali. Penelitian ini bertujuan untuk mengukur persepsi wisatawan terhadap kualitas makanan tradisional Bali dan pengaruhnya terhadap kepuasan kuliner wisatawan serta kepuasan wisatawan terhadap Bali sebagai destinasi wisata. Survei terhadap 207 responden dilakukan dan data primer yang terkumpul dianalisis dengan menggunakan metode SEM-PLS. Temuan menunjukkan kualitas makanan dapat memicu pemilihan destinasi dan berkontribusi terhadap kepuasan yang dirasakan. Hasil penelitianjuga menggambarkan bahwa kepuasan destinasi dan kuliner dapat memicu niat berperilaku wisatawan seperti mengkonsumsi kembali makanan tradisional Bali, mengunjungi Bali sebagai tempat liburan, atau merekomendasikan orang lain untuk mengkonsumsi makanan Bali atau mengunjungi Bali. Secara keseluruhan, hasil penelitian ini menunjukkan bahwa kualitas pengalaman kuliner yang dialami wisatawan mampu mempengaruhi niat berperilaku dengan melalui kepuasan terhadap pengalaman kuliner dan kepuasan terhadap destinasi secara tidak langsung. Many visitors nowadays are visiting Bali to experience a strong cultural experience and trying Balinese unique cuisines. This research aimed to analyze the effects of quality of Balinese traditional food, tourist culinary experience satisfaction and also destination experience satisfaction towards tourist's behavioral intentions. A questionnaire that involved 207 respondents was completed and being analyzed using SEM-PLS method. The findings indicates quality of food may trigger destination choice and contribute to perceived satisfaction. Second, the findings illustrate that the destination and culinary satisfaction may triggering tourist behavior intention such as reconsume Balinese traditional food, revisit Bali as leisure destination, or recommend other people to try Balinese food or visit Bali. In essence, the results imply that quality of culinary experience affects the tourist behavioural intentions indirectly through the tourist's culinary experience satisfaction and destination experience satisfaction