Complete solutions to the metric of spherically collapsing dust in an expanding spacetime with a cosmological constant

We present semi-analytical solutions to the background equations describing the Lema\^itre-Tolman-Bondi (LTB) metric as well as the homogeneous Friedmann equations, in the presence of dust, curvature and a cosmological constant Lambda. For none of the presented solutions any numerical integration has to be performed. All presented solutions are given for expanding and collapsing phases, preserving continuity in time and radius. Hence, these solutions describe the complete space time of a collapsing spherical object in an expanding universe. In the appendix we present for completeness a solution of the Friedmann equations in the additional presence of radiation, only valid for the Robertson-Walker metric.Comment: 23 pages, one figure. Numerical module for evaluation of the solutions released at http://web.physik.rwth-aachen.de/download/valkenburg/ColLambda/ Matches published version, published under Open Access. Note change of titl

The Milky Way Bulge: Observed properties and a comparison to external galaxies

The Milky Way bulge offers a unique opportunity to investigate in detail the role that different processes such as dynamical instabilities, hierarchical merging, and dissipational collapse may have played in the history of the Galaxy formation and evolution based on its resolved stellar population properties. Large observation programmes and surveys of the bulge are providing for the first time a look into the global view of the Milky Way bulge that can be compared with the bulges of other galaxies, and be used as a template for detailed comparison with models. The Milky Way has been shown to have a box/peanut (B/P) bulge and recent evidence seems to suggest the presence of an additional spheroidal component. In this review we summarise the global chemical abundances, kinematics and structural properties that allow us to disentangle these multiple components and provide constraints to understand their origin. The investigation of both detailed and global properties of the bulge now provide us with the opportunity to characterise the bulge as observed in models, and to place the mixed component bulge scenario in the general context of external galaxies. When writing this review, we considered the perspectives of researchers working with the Milky Way and researchers working with external galaxies. It is an attempt to approach both communities for a fruitful exchange of ideas.Comment: Review article to appear in "Galactic Bulges", Editors: Laurikainen E., Peletier R., Gadotti D., Springer Publishing. 36 pages, 10 figure

The Dynamics of Brane-World Cosmological Models

Brane-world cosmology is motivated by recent developments in string/M-theory and offers a new perspective on the hierarchy problem. In the brane-world scenario, our Universe is a four-dimensional subspace or {\em brane} embedded in a higher-dimensional {\em bulk} spacetime. Ordinary matter fields are confined to the brane while the gravitational field can also propagate in the bulk, leading to modifications of Einstein's theory of general relativity at high energies. In particular, the Randall-Sundrum-type models are self-consistent and simple and allow for an investigation of the essential non-linear gravitational dynamics. The governing field equations induced on the brane differ from the general relativistic equations in that there are nonlocal effects from the free gravitational field in the bulk, transmitted via the projection of the bulk Weyl tensor, and the local quadratic energy-momentum corrections, which are significant in the high-energy regime close to the initial singularity. In this review we discuss the asymptotic dynamical evolution of spatially homogeneous brane-world cosmological models containing both a perfect fluid and a scalar field close to the initial singularity. Using dynamical systems techniques it is found that, for models with a physically relevant equation of state, an isotropic singularity is a past-attractor in all orthogonal spatially homogeneous models (including Bianchi type IX models). In addition, we describe the dynamics in a class of inhomogeneous brane-world models, and show that these models also have an isotropic initial singularity. These results provide support for the conjecture that typically the initial cosmological singularity is isotropic in brane-world cosmology.Comment: Einstein Centennial Review Article: to appear in CJ

Whole-genome sequencing reveals host factors underlying critical COVID-19

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic variation influences the development of illness requiring critical care1 or hospitalization2,3,4 after infection with SARS-CoV-2. The GenOMICC (Genetics of Mortality in Critical Care) study enables the comparison of genomes from individuals who are critically ill with those of population controls to find underlying disease mechanisms. Here we use whole-genome sequencing in 7,491 critically ill individuals compared with 48,400 controls to discover and replicate 23 independent variants that significantly predispose to critical COVID-19. We identify 16 new independent associations, including variants within genes that are involved in interferon signalling (IL10RB and PLSCR1), leucocyte differentiation (BCL11A) and blood-type antigen secretor status (FUT2). Using transcriptome-wide association and colocalization to infer the effect of gene expression on disease severity, we find evidence that implicates multiple genes—including reduced expression of a membrane flippase (ATP11A), and increased expression of a mucin (MUC1)—in critical disease. Mendelian randomization provides evidence in support of causal roles for myeloid cell adhesion molecules (SELE, ICAM5 and CD209) and the coagulation factor F8, all of which are potentially druggable targets. Our results are broadly consistent with a multi-component model of COVID-19 pathophysiology, in which at least two distinct mechanisms can predispose to life-threatening disease: failure to control viral replication; or an enhanced tendency towards pulmonary inflammation and intravascular coagulation. We show that comparison between cases of critical illness and population controls is highly efficient for the detection of therapeutically relevant mechanisms of disease

Introduction to the issue on progress in solid-state, fiber, and tunable sources

The 42 papers in this special issue are focused on progress in solid-state, fiber, and tunable sources. The issue is dedicated to the memory of Theodore H. Maiman, who kicked off the rapid growth of solid-state laser development in 1960. The papers are organized into six subject areas: power scaling strategies; fiber lasers and amplifiers; thin-disk lasers; planar waveguide and thin slab lasers; tunable sources and nonlinear frequency conversion; and progress in laser materials

Stakeholder Mapping in a Collaborative Project for a Sustainable Development

Part 1: Knowledge-Based SustainabilityInternational audienceSustainable development is an approach to development which consists in balancing the different environmental, social and economic needs, where many stakeholders are involved. The collaboration about the objectives set by the business members of the project-leading is decisive, but it can prove to be complicated, since each of the stakeholders can adopt various sustainability strategies and practices. This paper proposes an approach for applying stakeholder map for collaborative strategies in order to support the identification of significant partners and thus their involvement within the projects. A certain focus is provided on sustainability issues. The approach is based upon the audit of the different partners of a network in order to know their sustainable expectations and priorities, and their degrees of influence and dependency. It leads to the identification of eight stakeholders families or types, following their involvement, voluntary or not, faced with sustainable development

A Framework for Production System Design: Insights from Industrial Experience

Part 1: Knowledge-Based Performance ImprovementInternational audienceIn this paper we want to share our findings from our industrial experience in the field of system design, more precisely in production system design. We start by the observation that many rigorous designs of production systems are not facing the implementation success they suggest. We indicate three basic reasons for this: limited stakeholder involvement, lack of out-of-the-box thinking and the dominance of financial and technical evaluation criteria. Based on these findings, we suggest a five step approach: the stakeholder analysis, the definition of key performance indicators, the scenario generation, the scenario ranking and the scenario implementation