Zika Virus: Can Artificial Contraception Be Condoned?

As the Zika virus pandemic continues to bring worry and fear to health officials and medical scientists, Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) have recommended that residents of the Zika-infected countries, e.g., Brazil, and those who have traveled to the area should delay having babies which may involve artificial contraceptive, particularly condom. This preventive policy, however, is seemingly at odds with the Roman Catholic Church’s position on the contraceptive. As least since the promulgation of Paul VI’s 1968 encyclical, Humanae Vitae, the Church has explicitly condemned artificial birth control as intrinsic evil. However, the current pontiff, Pope Francis, during his recent visit to Latin America, remarked that the use of artificial contraception may not be in contradiction to the teaching of Humanae Vitae while drawing a parallel between the current Zika Crisis and the 1960’s Belgian Congo Nun Controversy. The pope mentioned that the traditional ethical principle of the lesser of two evils may be the doctrine that justified the exceptions. The authors of this paper attempt to expand the theological rationale of the pope’s suggestion. In so doing, the authors rely on casuistical reasoning as an analytic tool that compares the Belgian Congo Nun case and the given Zika case, and suggest that the former is highly similar to, if not the same as, the latter in terms of normative moral feature. That is, in both cases the use of artificial contraception is theologically justified in reference to the criteria that the doctrine of the lesser of two evils requires. The authors wish that the paper would provide a solid theological-ethical ground based on which condom-use as the most immediate and effective preventive measure can be recommended in numerous Catholic hospitals as well as among Catholic communities in the world, particularly the most Zika-affected and largest Catholic community in the world, Brazil – 123 million present Brazilian citizens are reported to be Roman Catholic

Simple models of genomic variation in human SNP density

<p>Abstract</p> <p>Background</p> <p>Descriptive hierarchical Poisson models and population-genetic coalescent mixture models are used to describe the observed variation in single-nucleotide polymorphism (SNP) density from samples of size two across the human genome.</p> <p>Results</p> <p>Using empirical estimates of recombination rate across the human genome and the observed SNP density distribution, we produce a maximum likelihood estimate of the genomic heterogeneity in the scaled mutation rate <it>θ</it>. Such models produce significantly better fits to the observed SNP density distribution than those that ignore the empirically observed recombinational heterogeneities.</p> <p>Conclusion</p> <p>Accounting for mutational and recombinational heterogeneities can allow for empirically sound null distributions in genome scans for "outliers", when the alternative hypotheses include fundamentally historical and unobserved phenomena.</p

Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency

Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followed by a 6-month open-label phase. Seventeen patients with AGHD received either recombinant human growth hormone (rGH) (0.4 mg injection daily) or placebo for 12 weeks, underwent washout for 2 weeks, and were then crossed over to the alternative treatment for a further 12 weeks. Cardiac magnetic resonance imaging, echocardiography, and cardiopulmonary exercise testing were performed at baseline, 12 weeks, 26 weeks, and the end of the open phase (12 months). The results were compared with those of 16 age- and sex-matched control subjects. Results At baseline, patients with AGHD had a significantly higher systolic blood pressure, ejection fraction, and left ventricular mass than the control group, even when corrected for body surface area. Treatment with rGH normalised the insulin-like growth factor 1 concentration without an effect on exercise capacity, cardiac structure, or cardiac function. Conclusion Administration of rGH therapy for 6 to 9 months failed to normalise the functional and structural cardiac differences observed in patients with AGHD when compared with a control group

Thin Fisher Zeroes

Biskup et al. [Phys. Rev. Lett. 84 (2000) 4794] have recently suggested that the loci of partition function zeroes can profitably be regarded as phase boundaries in the complex temperature or field planes. We obtain the Fisher zeroes for Ising and Potts models on non-planar (``thin'') regular random graphs using this approach, and note that the locus of Fisher zeroes on a Bethe lattice is identical to the corresponding random graph. Since the number of states appears as a parameter in the Potts solution the limiting locus of chromatic zeroes is also accessible.Comment: 10 pages, 4 figure

Immunocompetent murine models for the study of glioblastoma immunotherapy.

Glioblastoma remains a lethal diagnosis with a 5-year survival rate of less than 10%. (NEJM 352:987-96, 2005) Although immunotherapy-based approaches are capable of inducing detectable immune responses against tumor-specific antigens, improvements in clinical outcomes are modest, in no small part due to tumor-induced immunosuppressive mechanisms that promote immune escape and immuno-resistance. Immunotherapeutic strategies aimed at bolstering the immune response while neutralizing immunosuppression will play a critical role in improving treatment outcomes for glioblastoma patients. In vivo murine models of glioma provide an invaluable resource to achieving that end, and their use is an essential part of the preclinical workup for novel therapeutics that need to be tested in animal models prior to testing experimental therapies in patients. In this article, we review five contemporary immunocompetent mouse models, GL261 (C57BL/6), GL26 (C57BL/6) CT-2A (C57BL/6), SMA-560 (VM/Dk), and 4C8 (B6D2F1), each of which offer a suitable platform for testing novel immunotherapeutic approaches

The Relationship of Field Burn Severity Measures To Satellite-derived Burned Area Reflectance Classification (Barc) Maps

Preliminary results are presented from ongoing research on spatial variability of fire effects on soils and vegetation from the Black Mountain Two and Cooney Ridge wildfires, which burned in western Montana during the 2003 fire season. Extensive field fractional cover data were sampled to assess the efficacy of quantitative satellite image-derived indicators of burn severity. The objective of this study was to compare the field burn severity measures to the digital numbers used to produce Burned Area Reflectance Classification (BARC) maps. Canopy density was the field variable most highly correlated to BARC data derived from either SPOT Multispectral (XS) or Landsat Thematic Mapper (TM) imagery. Among the other field variables, old litter depth and duff depth correlated better with the satellite data than did old litter cover. Ash cover correlated most poorly. Old litter cover correlated better with the satellite data than did exposed mineral soil or rock cover, but combining the mineral soil and rock cover fractions into a single inorganic cover fraction improved the correlation to a comparable level. Most field variables, with the notable exception of ash, tended to vary more at low and moderate severity sites than at high severity sites. Semivariograms of the field variables revealed spatial autocorrelation across the spatial scales sampled (2 – 130 m), which the 20 m or 30 m resolution satellite imagery only weakly detected. Future analyses will be broadened to quantify burn severity characteristics in other forest types and to consider erosion processes, such as soil water infiltration following fire

The Relationship of Field Burn Severity Measures To Satellite-derived Burned Area Reflectance Classification (Barc) Maps

Preliminary results are presented from ongoing research on spatial variability of fire effects on soils and vegetation from the Black Mountain Two and Cooney Ridge wildfires, which burned in western Montana during the 2003 fire season. Extensive field fractional cover data were sampled to assess the efficacy of quantitative satellite image-derived indicators of burn severity. The objective of this study was to compare the field burn severity measures to the digital numbers used to produce Burned Area Reflectance Classification (BARC) maps. Canopy density was the field variable most highly correlated to BARC data derived from either SPOT Multispectral (XS) or Landsat Thematic Mapper (TM) imagery. Among the other field variables, old litter depth and duff depth correlated better with the satellite data than did old litter cover. Ash cover correlated most poorly. Old litter cover correlated better with the satellite data than did exposed mineral soil or rock cover, but combining the mineral soil and rock cover fractions into a single inorganic cover fraction improved the correlation to a comparable level. Most field variables, with the notable exception of ash, tended to vary more at low and moderate severity sites than at high severity sites. Semivariograms of the field variables revealed spatial autocorrelation across the spatial scales sampled (2 – 130 m), which the 20 m or 30 m resolution satellite imagery only weakly detected. Future analyses will be broadened to quantify burn severity characteristics in other forest types and to consider erosion processes, such as soil water infiltration following fire

EFFECT OF IMPACT SURFACE ON EQUESTRIAN FALLS

This study examines the effect of impact surface on head kinematic response and maximum principal strain (MPS) for equestrian falls. A helmeted Hybrid Ill headform was dropped unrestrained onto three impact surfaces (steel, turf and sand) and three locations. Peak resultant linear acceleration, rotational acceleration and duration of the impact events were measured. A finite element brain model was used to calculate MPS. The results revealed that drops onto steel produced higher peak linear acceleration, rotational acceleration and MPS but lower impact durations than drops to turf and sand. However, despite lower MPS values, turf and sand impacts compared to steel impacts still represented a risk of concussion. This suggests that equestrian helmets standards do not properly account for the loading conditions experienced in equestrian accidents