Vol. 36, No. 1

Janus: Otherwise Known As The Death Of Stare Decisis, But Only As It Relates To Unions, by Amanda R. Clark and Susan M. Matta Recent Developmentshttps://scholarship.kentlaw.iit.edu/iperr/1107/thumbnail.jp

Dispersion Compensation in Acoustic Emission Pipeline Leak Location

The general practice of acoustic leak location relies on two different physical phenomena for determining source location: 1) reduction in signal amplitude with increasing distance from the source (attenuation-based methods), and 2) increase in signal transit time with increasing distance from the source (time-of-flight-based methods). The work discussed here describes efforts at ISU directed at gaining first-principle understanding of the underlying physical phenomena of multi-mode dispersion in fluid filled pipes and to developing time-of-flight source location data processing for such dispersive systems. Results are presented for work detailing the characteristics of pipe propagation, as well as the effect of those characteristics on cross-correlation analysis. Theoretical and experimental results are also shown for two approaches which potentially overcome the limitations of cross-correlation techniques

The Architecture of Grosvenor Atterbury

Book Review of The Architecture of Grosvenor Atterbury, by Peter Pennoyer and Anne Walker. ISBN 9780393732221. Reviewed by Amanda C. R. Clark

Young people's experiences of managing Type 1 diabetes at university: a national study of UK university students

Aim: Little is known about the challenges of transitioning from school to university for young people with Type 1 diabetes. In a national survey, we investigated the impact of entering and attending university on diabetes self‐care in students with Type 1 diabetes in all UK universities. Methods: Some 1865 current UK university students aged 18–24 years with Type 1 diabetes, were invited to complete a structured questionnaire. The association between demographic variables and diabetes variables was assessed using logistic regression models. Results: In total, 584 (31%) students from 64 hospitals and 37 university medical practices completed the questionnaire. Some 62% had maintained routine diabetes care with their home team, whereas 32% moved to the university provider. Since starting university, 63% reported harder diabetes management and 44% reported higher HbA1c levels than before university. At university, 52% had frequent hypoglycaemia, 9.6% reported one or more episodes of severe hypoglycaemia and 26% experienced diabetes‐related hospital admissions. Female students and those who changed healthcare provider were approximately twice as likely to report poor glycaemic control, emergency hospital admissions and frequent hypoglycaemia. Females were more likely than males to report stress [odds ratio (OR) 4.78, 95% confidence interval (CI) 3.19–7.16], illness (OR 3.48, 95% CI 2.06–5.87) and weight management issues (OR 3.19, 95% CI 1.99–5.11) as barriers to self‐care. Despite these difficulties, 91% of respondents never or rarely contacted university support services about their diabetes. Conclusion: The study quantifies the high level of risk experienced by students with Type 1 diabetes during the transition to university, in particular, female students and those moving to a new university healthcare provider

Table Grape Cultivar Performance in Oregon's Willamette Valley

Many cultivars of table grapes (Vitis sp.) are grown in Oregon's Willamette Valley, but with the availability of several new cultivars, it is important to compare their performance to well-established standards in this region. Commonly grown cultivars ("established": Canadice, Interlaken, Jupiter, Lakemont, Neptune, Reliance, and Remaily Seedless) along with new cultivars from the University of Arkansas breeding program ("new"; 'Passion', 'Faith', 'Gratitude', 'Hope', 'Joy', and 'Sweet Magic') were planted in Corvallis and Aurora, OR in 2001 ("established") and 2006 ("new") and data collected from 2014 to 2016. Despite differences in growing degree day accumulation and precipitation during the bloom and harvest period, cultivar had a stronger impact than year on traits such as cluster fullness and plant vigor. 'Neptune', 'Canadice', and 'Hope' had the best cluster fill while 'Jupiter' and ` Sweet Magic' had looser clusters. Yield for most cultivars was highest in 2016 and lowest in 2014, and some cultivars performed better at one location than another. 'Faith' and 'Neptune' had consistently high yield at both locations while 'Canadice' had outstanding yield at one location only. 'Interlaken', 'Lakemont', 'Remaily Seedless', and 'Passion' tended to have the lowest yields. Average berry weight ranged from 1.8 to 5.1 g. Large berries contributed to higher yield, except for 'Jupiter' where very poor fruit set resulted in large but very few berries, and in 'Canadice' where berry weight was low, but excellent fruit set coupled with many berries per cluster led to high yield. Total soluble solids (TSS) were often higher in early season than in late-season cultivars, which were sometimes picked before full ripeness to avoid the onset of autumn rain and disease development. Disease pressure ranged from very low in 'Canadice' and 'Neptune' to very high in 'Sweet Magic', 'Reliance', and 'Remaily Seedless', negatively impacting quality at harvest and during storage. Wide ranges in flavor and texture were observed and rated. "Established" cultivars frequently rated higher for flavor intensity than "new" cultivars that were bred to have a mild flavor, considered palatable to a broader range of consumers. Overall, three of the new cultivars (Passion, Faith, and Joy) show promise for production in this region, along with the best performing established cultivars Canadice, Neptune, and Interlaken

Meningococcal Disease in Patients With Human Immunodeficiency Virus Infection: A Review of Cases Reported Through Active Surveillance in the United States, 2000-2008.

BackgroundAlthough human immunodeficiency virus (HIV) infection is an established risk factor for several bacterial infections, the association between HIV infection and meningococcal disease remains unclear.MethodsExpanded chart reviews were completed on persons with meningococcal disease and HIV infection reported from 2000 through 2008 from 9 US sites participating in an active population-based surveillance system for meningococcal disease. The incidence of meningococcal disease among patients meeting Centers for Disease Control and Prevention acquired immune deficiency syndrome (AIDS) surveillance criteria was estimated using data from the National HIV Surveillance System for the participating sites.ResultsThirty-three cases of meningococcal disease in individuals with HIV infection were reported from participating sites, representing 2.0% of all reported meningococcal disease cases. Most (75.8%) persons with HIV infection were adult males aged 25 to 64 years old. Among all meningococcal disease cases aged 25 to 64 years old, case fatality ratios were similar among HIV-infected and HIV-uninfected persons (13.3% vs 10.6%; P = .6). The cumulative, mean incidence of meningococcal disease among patients aged 25 to 64 years old with HIV infection ever classified as AIDS was 3.5 cases per 100000 person years (95% confidence interval [CI], 2.1-5.6), compared with 0.3 cases per 100000 person years (95% CI, 0.3-0.3) for persons of the same age group not reported to have AIDS (relative risk = 12.9; 95% CI, 7.9-20.9).ConclusionsIndividuals with HIV infection meeting the AIDS surveillance case definition have a higher incidence of meningococcal disease compared with the general adult population

Long-term viability and function of transplanted islets macroencapsulated at high density are achieved by enhanced oxygen supply

Transplantation of encapsulated islets can cure diabetes without immunosuppression, but oxygen supply limitations can cause failure. We investigated a retrievable macroencapsulation device wherein islets are encapsulated in a planar alginate slab and supplied with exogenous oxygen from a replenishable gas chamber. Translation to clinically-useful devices entails reduction of device size by increasing islet surface density, which requires increased gas chamber pO Here we show that islet surface density can be substantially increased safely by increasing gas chamber pO to a supraphysiological level that maintains all islets viable and functional. These levels were determined from measurements of pO profiles in islet-alginate slabs. Encapsulated islets implanted with surface density as high as 4,800 islet equivalents/cm in diabetic rats maintained normoglycemia for more than 7 months and provided near-normal intravenous glucose tolerance tests. Nearly 90% of the original viable tissue was recovered after device explantation. Damaged islets failed after progressively shorter times. The required values of gas chamber pO were predictable from a mathematical model of oxygen consumption and diffusion in the device. These results demonstrate feasibility of developing retrievable macroencapsulated devices small enough for clinical use and provide a firm basis for design of devices for testing in large animals and humans

Islands of linkage in an ocean of pervasive recombination reveals two-speed evolution of human cytomegalovirus genomes

Human cytomegalovirus (HCMV) infects most of the population worldwide, persisting throughout the host's life in a latent state with periodic episodes of reactivation. While typically asymptomatic, HCMV can cause fatal disease among congenitally infected infants and immunocompromised patients. These clinical issues are compounded by the emergence of antiviral resistance and the absence of an effective vaccine, the development of which is likely complicated by the numerous immune evasins encoded by HCMV to counter the host's adaptive immune responses, a feature that facilitates frequent super-infections. Understanding the evolutionary dynamics of HCMV is essential for the development of effective new drugs and vaccines. By comparing viral genomes from uncultivated or low-passaged clinical samples of diverse origins, we observe evidence of frequent homologous recombination events, both recent and ancient, and no structure of HCMV genetic diversity at the whole-genome scale. Analysis of individual gene-scale loci reveals a striking dichotomy: while most of the genome is highly conserved, recombines essentially freely and has evolved under purifying selection, 21 genes display extreme diversity, structured into distinct genotypes that do not recombine with each other. Most of these hyper-variable genes encode glycoproteins involved in cell entry or escape of host immunity. Evidence that half of them have diverged through episodes of intense positive selection suggests that rapid evolution of hyper-variable loci is likely driven by interactions with host immunity. It appears that this process is enabled by recombination unlinking hyper-variable loci from strongly constrained neighboring sites. It is conceivable that viral mechanisms facilitating super-infection have evolved to promote recombination between diverged genotypes, allowing the virus to continuously diversify at key loci to escape immune detection, while maintaining a genome optimally adapted to its asymptomatic infectious lifecycle