A broadband THz receiver for low background space applications

We have developed a sensitive bolometric receiver for low background space applications. In a 10 percent bandwidth at 1 THz, this receiver is approximately 100 times more sensitive than a quantum limited heterodyne receiver with a 1 GHz IF bandwidth. This receiver is designed to be used for the long wavelength band (200-700 microns) in the MIPS instrument on NASA's SIRTF satellite. The bolometers are cooled to 100 mK by an adiabatic demagnetization refrigerator. Roughly 60 g of cesium chrome alum salt is partially demagnetized to 100 mK, followed by a slow regulated downramp to compensate for the heat leak. The hold time of the ADR system is about 18 hours with a temperature stability of delta T(sub rms) approx. equals 10 micro-K. The composite bolometers have electrical responsivities of 10(exp 9)V/W and electrical NEP's of about 3x10(exp -17) W/square root of Hz. The bolometer signals are read out by JFET preamplifiers located on the helium plate and operated at 120 K. We have addressed a number of space qualification issues, such as the development of an analog magnet controller, construction of a cryogenic shake-table for bolometers and selection of the paramagnetic salt CCA which can survive a bakeout at 50 C. The receiver is scheduled to be flown in the spring of 1992 on a balloon telescope. This flight has a dual purpose. One is to provide realistic test of the capabilities of the new receiver. The other is to search for anisotropies in the cosmic microwave background on scales of a few degrees

The medical student

The Medical Student was published from 1888-1921 by the students of Boston University School of Medicine

Synthetic routes to treprostinil N-acyl methylsulfonamide

The synthesis of the prodrug candidate, treprostinil N-acyl methylsulfonamide 5 was accomplished from treprostinil 2 utilising protecting group strategies. A more direct synthesis for the prodrug was also achieved using a treprostinil triol precursor 12 and bromoacetyl acylmethylsulfonamide 14. The overall yield of treprostinil N-acyl sulfonamide 5 directly from the triol precursor 12 is similar to the protecting group strategies because deprotonation of the acidic proton in the bromoacetyl acylmethylsulfonamide 14 reduces electrophilicity. However, the more direct route using the treprostinil triol precursor holds greater promise as a strategy to prepare a wide range of treprostinil prodrug candidates. Treprostinil N-acyl methylsulfonamide prodrug 5 exhibited a 30-fold decrease in the potency at the human prostacyclin (IP) receptor compared to treprostinil 2 in an in vitro cyclic AMP assay

Inflammation and endothelial function: Direct vascular effects of human C-reactive protein on nitric oxide bioavailability

Background - Circulating concentrations of the sensitive inflammatory marker C-reactive protein (CRP) predict future cardiovascular events, and CRP is elevated during sepsis and inflammation, when vascular reactivity may be modulated. We therefore investigated the direct effect of CRP on vascular reactivity. Methods and Results - The effects of isolated, pure human CRP on vasoreactivity and protein expression were studied in vascular rings and cells in vitro, and effects on blood pressure were studied in rats in vivo. The temporal relationship between changes in CRP concentration and brachial flow-mediated dilation was also studied in humans after vaccination with Salmonella typhi capsular polysaccharide, a model of inflammatory endothelial dysfunction. In contrast to some previous reports, highly purified and well-characterized human CRP specifically induced hyporeactivity to phenylephrine in rings of human internal mammary artery and rat aorta that was mediated through physiological antagonism by nitric oxide (NO). CRP did not alter endothelial NO synthase protein expression but increased protein expression of GTP cyclohydrolase-1, the rate-limiting enzyme in the synthesis of tetrahydrobiopterin, the NO synthase cofactor. In the vaccine model of inflammatory endothelial dysfunction in humans, increased CRP concentration coincided with the resolution rather than the development of endothelial dysfunction, consistent with the vitro findings; however, administration of human CRP to rats had no effect on blood pressure. Conclusions - Pure human CRP has specific, direct effects on vascular function in vitro via increased NO production; however, further clarification of the effect, if any, of CRP on vascular reactivity in humans in vivo will require clinical studies using specific inhibitors of CRP. © 2005 American Heart Association, Inc

Measurements of Anisotropy in the Cosmic Microwave Background Radiation at 0.5 Degree Angular Scales Near the Star Gamma Ursae Minoris

We present results from a four frequency observation of a 6 x 0.6 degree strip of the sky centered near the star Gamma Ursae Minoris during the fourth flight of the Millimeter-wave Anisotropy eXperiment (MAX). The observation was made with a 1.4 degree peak-to-peak sinusoidal chop in all bands. The FWHM beam sizes were 0.55 +/- 0.05 degrees at 3.5 cm-1 and 0.75 +/-0.05 degrees at 6, 9, and 14 cm-1. During this observation significant correlated structure was observed at 3.5, 6 and 9 cm-1 with amplitudes similar to those observed in the GUM region during the second and third flights of MAX. The frequency spectrum is consistent with CMB and inconsistent with thermal emission from interstellar dust. The extrapolated amplitudes of synchrotron and free-free emission are too small to account for the amplitude of the observed structure. If all of the structure is attributed to CMB anisotropy with a Gaussian autocorrelation function and a coherence angle of 25', then the most probable values of DeltaT/TCMB in the 3.5, 6, and 9 cm-1 bands are 4.3 (+2.7, -1.6) x 10-5, 2.8 (+4.3, -1.1) x 10-5, and 3.5 (+3.0, -1.6) x 10-5 (95% confidence upper and lower limits), respectively.Comment: 16 pages, postscrip

Measurements of Anisotropy in the Cosmic Microwave Background Radiation at Degree Angular Scales Near the Stars Sigma Hercules and Iota Draconis

We present results from two four-frequency observations centered near the stars Sigma Hercules and Iota Draconis during the fourth flight of the Millimeter-wave Anisotropy eXperiment (MAX). The observations were made of 6 x 0.6-degree strips of the sky with 1.4-degree peak to peak sinusoidal chop in all bands. The FWHM beam sizes were 0.55+/-0.05 degrees at 3.5 cm-1 and a 0.75+/-0.05 degrees at 6, 9, and 14 cm-1. Significant correlated structures were observed at 3.5, 6 and 9 cm-1. The spectra of these signals are inconsistent with thermal emission from known interstellar dust populations. The extrapolated amplitudes of synchrotron and free-free emission are too small to account for the amplitude of the observed structures. If the observed structures are attributed to CMB anisotropy with a Gaussian autocorrelation function and a coherence angle of 25', then the most probable values are DT/TCMB = (3.1 +1.7-1.3) x 10^-5 for the Sigma Hercules scan, and DT/TCMB = (3.3 +/- 1.1) x 10^-5 for the Iota Draconis scan (95% confidence upper and lower limits). Finally a comparison of all six MAX scans is presented.Comment: 13 pages, postscript file, 2 figure

Pulmonary vasoconstrictor action of KCNQ potassium channel blockers

KCNQ channels have been widely studied in the nervous system, heart and inner ear, where they have important physiological functions. Recent reports indicate that KCNQ channels may also be expressed in portal vein where they are suggested to influence spontaneous contractile activity. The biophysical properties of K+ currents mediated by KCNQ channels resemble a current underlying the resting K+ conductance and resting potential of pulmonary artery smooth muscle cells. We therefore investigated a possible role of KCNQ channels in regulating the function of pulmonary arteries by determining the ability of the selective KCNQ channel blockers, linopirdine and XE991, to promote pulmonary vasoconstriction. Linopirdine and XE991 both contracted rat and mouse pulmonary arteries but had little effect on mesenteric arteries. In each case the maximum contraction was almost as large as the response to 50 mM K+. Linopirdine had an EC50 of around 1 μM and XE991 was almost 10-fold more potent. Neither removal of the endothelium nor exposure to phentolamine or α,β-methylene ATP, to block α1-adrenoceptors or P2X receptors, respectively, affected the contraction. Contraction was abolished in Ca2+-free solution and in the presence of 1 μM nifedipine or 10 μM levcromakalim

Microwave Spectroscopy

Contains research objectives and reports on four research projects.Signal Corps Contract DA36-039-sc-7489

Optical binding of particles with or without the presence of a flat dielectric surface

Optical fields can induce forces between microscopic objects, thus giving rise to new structures of matter. We study theoretically these optical forces between two spheres, either isolated in water, or in presence of a flat dielectric surface. We observe different behavior in the binding force between particles at large and at small distances (in comparison with the wavelength) from each other. This is due to the great contribution of evanescent waves at short distances. We analyze how the optical binding depends of the size of the particles, the material composing them, the wavelength and, above all, on the polarization of the incident beam. We also show that depending on the polarization, the force between small particles at small distances changes its sign. Finally, the presence of a substrate surface is analyzed showing that it only slightly changes the magnitudes of the forces, but not their qualitative nature, except when one employs total internal reflection, case in which the particles are induced to move together along the surface.Comment: 8 pages, 9 figures, and 1 tabl

Nucleation in Systems with Elastic Forces

Systems with long-range interactions when quenced into a metastable state near the pseudo-spinodal exhibit nucleation processes that are quite different from the classical nucleation seen near the coexistence curve. In systems with long-range elastic forces the description of the nucleation process can be quite subtle due to the presence of bulk/interface elastic compatibility constraints. We analyze the nucleation process in a simple 2d model with elastic forces and show that the nucleation process generates critical droplets with a different structure than the stable phase. This has implications for nucleation in many crystal-crystal transitions and the structure of the final state